3PIPS

Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
175
structure length
175
Chain Sequence
MELTAKPRTPKQKLDESMIAAVAYNKENNVSFALDRKAFDRAFRQQSTTGLFDITVEGGETFPALVKAVQMDKRKRAPIHVDFYMVTYGEPVEVSVPVHTTGRSQGEVQGGLVDIVVHNLQIVAPGPRRIPQELVVDVTKMNIGDHITAGDIKLPEGCTLAADPELTVVSVLPPR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit.
pubmed doi rcsb
molecule tags Ribosome/antibiotic
molecule keywords RIBOSOMAL 23S RNA
total genus 15
structure length 175
sequence length 175
ec nomenclature
pdb deposition date 2010-11-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF01386 Ribosomal_L25p Ribosomal L25p family
S PF14693 Ribosomal_TL5_C Ribosomal protein TL5, C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.10 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Ribosomal Protein L25; Chain P 3pipS01
2.170.120.20 Mainly Beta Beta Complex RNA Polymerase Alpha Subunit; Chain A, domain 2 Ribosomal protein L25, beta domain 3pipS02
4IO9S 1EXDA 2HZ7A 4WFBS 5IZNA 4WCES 1ZJWA 1QTQA 2RD2A 5HL7S 1EUQA 1QRUA 5GADW 4WFNS 5JVGS 2RE8A 3AIIA 5GAHW 4IOAS 3DLLS 4JYZA 1DFUP 5GAGW 2ZJPS 5GAEW 1O0CA 1D6KA 5BNZA 4U67S 4H3SA 1GTRA 4P2BA 3PIOS 1QRSA 2ZJQS 4IOCS 1QRTA 5JVHS 2ZJRS 4JXZA 3PIPS 4UY88 1B75A 5DM6S 1FEUA 3J7ZV 3CF5S 4WF9S 4JXXA 1O0BA 1NYLA 4WFAS 5DM7S 1EUYA 1GTSA
chains in the Genus database with same CATH superfamily
4YFKA 2PPBA 2HZ7A 3S15C 3M3YC 3I4NC 3H0GC 2A6HA 5IZNA 2PA8D 4OIQA 3S2HC 3S1NC 1QRUA 4XSZA 5GADW 4E8BA 4A3JC 2NVXC 2EGVA 4JK1A 1Z85A 4BBSC 3W2WB 4QJVA 2PI8A 1O0CA 1NXZA 5GAEW 2Y0SD 4H3SA 4P2BA 3CQZC 3PIOS 4OINA 4MEXA 1VHKA 4XLPA 2NVTC 2ZJRS 2WAQD 4JXZA 4A3IC 2WB1D 5IP9C 2JA6C 1SMYA 5TMFA 1TWCC 3J7ZV 4WF9S 1BDFA 4AYBD 4OIRA 2PJJA 4JXXA 4Y7NC 3GTKC 3HOYC 3RZOC 1NYLA 3GTLC 2EGWA 1EUYA 4KN4A 2R93C 1GTSA 3WODA 4C3JC 3GTOC 5C4XC 2KQ1A 3GTPC 3W2VB 3S17C 4Q5SA 4C3HC 2B63C 4WCES 2NWAA 3GTMC 5IP7C 2E2JC 3PO3C 4MEYA 3S2DC 4LK0A 2RD2A 5FLMC 4YFXA 3K7AC 4WFNS 2PICA 2RE8A 5JVGS 3AIIA 3GTGC 4C3IC 2CX8A 4JYZA 1DFUP 4XSXA 2KXYA 4G7HA 1QRSA 2A69A 2ZJQS 4IOCS 1QRTA 2PNWA 3HKZD 4LK1A 4QIWD 5TMCA 3RZDC 3EQLA 4YFNA 2CW0A 2JA5C 4BBRC 2R7ZC 4BY7C 3CF5S 1IW7A 1I3QC 2L5NA 3S16C 2KPUA 2A6EA 2G6GA 4J3CA 1TWGC 4G7OA 4H4KA 1EXDA 3I4MC 4A3CC 3LYWA 4OIOA 1V6ZA 2VUMC 4LLGA 3DXJA 4A3GC 2O5IA 5GAHW 2PMZD 3H3VD 1K83C 3DLLS 1R9TC 2NVYC 2AE0X 5GAGW 4L69A 2ZJPS 1D6KA 3X1LB 5BNZA 2L3UA 4MQ9A 4C2MC 5C3EC 4BY1C 4KMUA 3HOVC 3S1QC 3KW2A 1I6HC 4A93C 4X6AC 2GAEA 2Z0YA 2JA8C 1TWHC 2A68A 3PIPS 4UY88 5IYBC 4G7ZA 1SFOC 4A3EC 5DM6S 1FEUA 5D4DA 4BXXC 1I50C 3S1MC 5DM7S 4Q4ZA 1YNNA 4A3BC 4IO9S 4V194 1UDXA 2JA7C 5HQHA 2BE5A 4OIPA 4WFBS 1VHYA 4ZH4A 1ZJWA 1QTQA 5HL7S 1EUQA 1TWAC 4A3DC 1HQMA 3HOWC 4YG2A 5IYCC 5C4JC 2YU9C 3M4OC 3PO2C 4KN7A 1YNJA 1ZYRA 4IOAS 4A3LC 2O5JA 4A3FC 1GTRA 3HOUC 3GTJC 3HOZC 4XLNA 4U67S 2E2IC 4NOIA 4LJZA 3CZBA 3HOXC 2G5DA 5JVHS 1TWFC 2E2HC 2R92C 2NVQC 5C44C 4GZYA 3FKIC 1B75A 1I6VA 3GTQC 1WCMC 1Y1WC 1O0BA 1Y1VC 3S14C 4WFAS 4Y52C 3S1RC 5IYDC 4A3MC 4A3KC
chains in the Genus database with same CATH topology
4IO9S 1EXDA 2HZ7A 3W2VB 1UDXA 4V194 4WFBS 5IZNA 4WCES 1ZJWA 1QTQA 2RD2A 5HL7S 1EUQA 1QRUA 5GADW 4WFNS 5JVGS 2RE8A 3AIIA 5GAHW 4IOAS 3DLLS 4JYZA 1DFUP 3W2WB 5GAGW 2ZJPS 5GAEW 1O0CA 1D6KA 5BNZA 4H3SA 4U67S 1GTRA 4P2BA 3X1LB 3PIOS 1QRSA 2ZJQS 4IOCS 1QRTA 5JVHS 2ZJRS 4JXZA 3PIPS 4UY88 1B75A 5DM6S 1FEUA 3J7ZV 3CF5S 4WF9S 4JXXA 1O0BA 1NYLA 4WFAS 5DM7S 1EUYA 1GTSA 4H4KA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IO9 S;  1EXD A;  2HZ7 A;  4WFB S;  5IZN A;  4WCE S;  1ZJW A;  1QTQ A;  2RD2 A;  5HL7 S;  1EUQ A;  1QRU A;  5GAD W;  4WFN S;  5JVG S;  2RE8 A;  3AII A;  5GAH W;  4IOA S;  3DLL S;  4JYZ A;  1DFU P;  5GAG W;  2ZJP S;  5GAE W;  1O0C A;  1D6K A;  5BNZ A;  4U67 S;  4H3S A;  1GTR A;  4P2B A;  3PIO S;  1QRS A;  2ZJQ S;  4IOC S;  1QRT A;  5JVH S;  2ZJR S;  4JXZ A;  3PIP S;  4UY8 8;  1B75 A;  5DM6 S;  1FEU A;  3J7Z V;  3CF5 S;  4WF9 S;  4JXX A;  1O0B A;  1NYL A;  4WFA S;  5DM7 S;  1EUY A;  1GTS A; 
#chains in the Genus database with same CATH topology
 4YFK A;  2PPB A;  2HZ7 A;  3S15 C;  3M3Y C;  3I4N C;  3H0G C;  2A6H A;  5IZN A;  2PA8 D;  4OIQ A;  3S2H C;  3S1N C;  1QRU A;  4XSZ A;  5GAD W;  4E8B A;  4A3J C;  2NVX C;  2EGV A;  4JK1 A;  1Z85 A;  4BBS C;  3W2W B;  4QJV A;  2PI8 A;  1O0C A;  1NXZ A;  5GAE W;  2Y0S D;  4H3S A;  4P2B A;  3CQZ C;  3PIO S;  4OIN A;  4MEX A;  1VHK A;  4XLP A;  2NVT C;  2ZJR S;  2WAQ D;  4JXZ A;  4A3I C;  2WB1 D;  5IP9 C;  2JA6 C;  1SMY A;  5TMF A;  1TWC C;  3J7Z V;  4WF9 S;  1BDF A;  4AYB D;  4OIR A;  2PJJ A;  4JXX A;  4Y7N C;  3GTK C;  3HOY C;  3RZO C;  1NYL A;  3GTL C;  2EGW A;  1EUY A;  4KN4 A;  2R93 C;  1GTS A;  3WOD A;  4C3J C;  3GTO C;  5C4X C;  2KQ1 A;  3GTP C;  3W2V B;  3S17 C;  4Q5S A;  4C3H C;  2B63 C;  4WCE S;  2NWA A;  3GTM C;  5IP7 C;  2E2J C;  3PO3 C;  4MEY A;  3S2D C;  4LK0 A;  2RD2 A;  5FLM C;  4YFX A;  3K7A C;  4WFN S;  2PIC A;  2RE8 A;  5JVG S;  3AII A;  3GTG C;  4C3I C;  2CX8 A;  4JYZ A;  1DFU P;  4XSX A;  2KXY A;  4G7H A;  1QRS A;  2A69 A;  2ZJQ S;  4IOC S;  1QRT A;  2PNW A;  3HKZ D;  4LK1 A;  4QIW D;  5TMC A;  3RZD C;  3EQL A;  4YFN A;  2CW0 A;  2JA5 C;  4BBR C;  2R7Z C;  4BY7 C;  3CF5 S;  1IW7 A;  1I3Q C;  2L5N A;  3S16 C;  2KPU A;  2A6E A;  2G6G A;  4J3C A;  1TWG C;  4G7O A;  4H4K A;  1EXD A;  3I4M C;  4A3C C;  3LYW A;  4OIO A;  1V6Z A;  2VUM C;  4LLG A;  3DXJ A;  4A3G C;  2O5I A;  5GAH W;  2PMZ D;  3H3V D;  1K83 C;  3DLL S;  1R9T C;  2NVY C;  2AE0 X;  5GAG W;  4L69 A;  2ZJP S;  1D6K A;  3X1L B;  5BNZ A;  2L3U A;  4MQ9 A;  4C2M C;  5C3E C;  4BY1 C;  4KMU A;  3HOV C;  3S1Q C;  3KW2 A;  1I6H C;  4A93 C;  4X6A C;  2GAE A;  2Z0Y A;  2JA8 C;  1TWH C;  2A68 A;  3PIP S;  4UY8 8;  5IYB C;  4G7Z A;  1SFO C;  4A3E C;  5DM6 S;  1FEU A;  5D4D A;  4BXX C;  1I50 C;  3S1M C;  5DM7 S;  4Q4Z A;  1YNN A;  4A3B C;  4IO9 S;  4V19 4;  1UDX A;  2JA7 C;  5HQH A;  2BE5 A;  4OIP A;  4WFB S;  1VHY A;  4ZH4 A;  1ZJW A;  1QTQ A;  5HL7 S;  1EUQ A;  1TWA C;  4A3D C;  1HQM A;  3HOW C;  4YG2 A;  5IYC C;  5C4J C;  2YU9 C;  3M4O C;  3PO2 C;  4KN7 A;  1YNJ A;  1ZYR A;  4IOA S;  4A3L C;  2O5J A;  4A3F C;  1GTR A;  3HOU C;  3GTJ C;  3HOZ C;  4XLN A;  4U67 S;  2E2I C;  4NOI A;  4LJZ A;  3CZB A;  3HOX C;  2G5D A;  5JVH S;  1TWF C;  2E2H C;  2R92 C;  2NVQ C;  5C44 C;  4GZY A;  3FKI C;  1B75 A;  1I6V A;  3GTQ C;  1WCM C;  1Y1W C;  1O0B A;  1Y1V C;  3S14 C;  4WFA S;  4Y52 C;  3S1R C;  5IYD C;  4A3M C;  4A3K C; 
#chains in the Genus database with same CATH homology
 4IO9 S;  1EXD A;  2HZ7 A;  3W2V B;  1UDX A;  4V19 4;  4WFB S;  5IZN A;  4WCE S;  1ZJW A;  1QTQ A;  2RD2 A;  5HL7 S;  1EUQ A;  1QRU A;  5GAD W;  4WFN S;  5JVG S;  2RE8 A;  3AII A;  5GAH W;  4IOA S;  3DLL S;  4JYZ A;  1DFU P;  3W2W B;  5GAG W;  2ZJP S;  5GAE W;  1O0C A;  1D6K A;  5BNZ A;  4H3S A;  4U67 S;  1GTR A;  4P2B A;  3X1L B;  3PIO S;  1QRS A;  2ZJQ S;  4IOC S;  1QRT A;  5JVH S;  2ZJR S;  4JXZ A;  3PIP S;  4UY8 8;  1B75 A;  5DM6 S;  1FEU A;  3J7Z V;  3CF5 S;  4WF9 S;  4JXX A;  1O0B A;  1NYL A;  4WFA S;  5DM7 S;  1EUY A;  1GTS A;  4H4K A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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