3PKCA

M. tuberculosis metap with bengamide analog y08, in mn form
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
281
structure length
281
Chain Sequence
RTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Methionine aminopeptidase
publication title Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidases by Bengamide Derivatives.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
total genus 86
structure length 281
sequence length 281
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2010-11-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 3pkcA01
3BIPA 1BOAA 4IECA 1JAWA 1KQ9A 2Q8KA 1CHMA 2NQ6A 5CIKA 2GU5A 1C27A 2GA2A 2HOWA 3S6BA 1YW9A 1YW8A 2EVCA 4IKRA 1XGOA 1O0XA 4IDYA 2BHCA 1B6AA 3FM3A 3TB5A 2BWTA 1C23A 1R5GA 5CDEA 4U70A 4U75A 2BN7A 4RZYA 2BWSA 2V3XA 2GG2A 4B28A 2BH3A 4S2TP 1WL6A 2G6PA 2GTXA 3FMRA 3PKAA 4RGZ1 1W7VA 4S01A 2V6CA 1PV9A 4IU6A 1C21A 4HXXA 1XGMA 1QXYA 4IKSA 2MATA 4RZZA 4U69A 1N51A 3D27A 2Q95A 1YJ3A 4ZNGA 2BB7A 3CB5A 4FKCA 4IPAA 1W2MA 1YW7A 2EA4A 2BWUA 2GGBA 3IU8A 3IG4A 2BHAA 3CTZA 4FO7A 4PV4A 4IF7A 2BWXA 3RORA 3PKEA 5JI6A 4U6JA 2GG7A 2V3YA 1KP0A 1WN1A 3RVAA 4JUQA 5FCFA 4A6VA 4IKTA 1XGSA 5CDLA 4U73A 1QXZA 2ZSGA 1B59A 2GG5A 3MR1A 4QR8A 2GU7A 4S2RP 5E5BA 2ADUA 2Q96A 4ZWPA 4PNCA 2BWVA 1C24A 4S00A 2EVOA 4ZWOA 2GU4A 3TAVA 2B3KA 4KM3A 2EA2A 5CLSA 1WBQA 3CB6A 2DFIA 4U6WA 4U76A 5CDVA 1KQ0A 1A16A 3Q6DA 4U1BA 3BITA 1WY2A 5CNXA 5FCHA 4U71A 2EVMA 2GGCA 2BWWA 2GG3A 2GZ5A 1XGNA 1YVMA 1R58A 2OKNA 2P99A 4A6WA 4EGEA 4FUKA 1R5HA 4ZWUA 4FLIA 2BWYA 1QZYA 2Q94A 2P9AA 1WLRA 2BHBA 2Q92A 4R60A 2GG9A 1QXWA 2B3HA 3MATA 4FLJA 1C22A 2GG0A 3PKCA 3IU7A 4Z7MA 1BN5A 2IW2A 4FO8A 3IU9A 5D6FA 2GG8A 3L24A 5JHUA 3PKBA 1WKMA 3FMQA 2NQ7A 1M35A 4U6CA 5CE6A 5D6EA 2P98A 4U6EA 2BHDA 3PKDA 2V3ZA 5JFRA 4OOKA 4FLLA 3BIQA 1XNZA 2B3LA 1MATA 3L7GA 1WL9A 4U6ZA 4FLKA 4MATA 3MX6A 1Y1NA 2OAZA 2Q93A 2GU6A 4IKUA
chains in the Genus database with same CATH superfamily
3BIPA 1BOAA 4IECA 1JAWA 1KQ9A 2Q8KA 1CHMA 2NQ6A 5CIKA 2GU5A 1C27A 2GA2A 2HOWA 3S6BA 1YW9A 1YW8A 2EVCA 4IKRA 1XGOA 1O0XA 4IDYA 2BHCA 1B6AA 3FM3A 3TB5A 2BWTA 1C23A 1R5GA 5CDEA 4U70A 4U75A 2BN7A 4RZYA 2BWSA 2V3XA 2GG2A 4B28A 2BH3A 4S2TP 1WL6A 2G6PA 2GTXA 3FMRA 3PKAA 4RGZ1 1W7VA 4S01A 2V6CA 1PV9A 4IU6A 1C21A 4HXXA 1XGMA 1QXYA 4IKSA 2MATA 4RZZA 4U69A 1N51A 3D27A 2Q95A 1YJ3A 4ZNGA 2BB7A 3CB5A 4FKCA 4IPAA 1W2MA 1YW7A 2EA4A 2BWUA 2GGBA 3IU8A 3IG4A 2BHAA 3CTZA 4FO7A 4PV4A 4IF7A 2BWXA 3RORA 3PKEA 5JI6A 4U6JA 2GG7A 2V3YA 1KP0A 1WN1A 3RVAA 4JUQA 5FCFA 4A6VA 4IKTA 1XGSA 5CDLA 4U73A 1QXZA 2ZSGA 1B59A 2GG5A 3MR1A 4QR8A 2GU7A 4S2RP 5E5BA 2ADUA 2Q96A 4ZWPA 4PNCA 2BWVA 1C24A 4S00A 2EVOA 4ZWOA 2GU4A 3TAVA 2B3KA 4KM3A 2EA2A 5CLSA 1WBQA 3CB6A 2DFIA 4U6WA 4U76A 5CDVA 1KQ0A 1A16A 3Q6DA 4U1BA 3BITA 1WY2A 5CNXA 5FCHA 4U71A 2EVMA 2GGCA 2BWWA 2GG3A 2GZ5A 1XGNA 1YVMA 1R58A 2OKNA 2P99A 4A6WA 4EGEA 4FUKA 1R5HA 4ZWUA 4FLIA 2BWYA 1QZYA 2Q94A 2P9AA 1WLRA 2BHBA 2Q92A 4R60A 2GG9A 1QXWA 2B3HA 3MATA 4FLJA 1C22A 2GG0A 3PKCA 3IU7A 4Z7MA 1BN5A 2IW2A 4FO8A 3IU9A 5D6FA 2GG8A 3L24A 5JHUA 3PKBA 1WKMA 3FMQA 2NQ7A 1M35A 4U6CA 5CE6A 5D6EA 2P98A 4U6EA 2BHDA 3PKDA 2V3ZA 5JFRA 4OOKA 4FLLA 3BIQA 1XNZA 2B3LA 1MATA 3L7GA 1WL9A 4U6ZA 4FLKA 4MATA 3MX6A 1Y1NA 2OAZA 2Q93A 2GU6A 4IKUA
chains in the Genus database with same CATH topology
3BIPA 1BOAA 4IECA 1JAWA 1KQ9A 2Q8KA 1CHMA 2NQ6A 5CIKA 2GU5A 1C27A 2GA2A 2HOWA 3S6BA 1YW9A 1YW8A 2EVCA 4IKRA 1XGOA 1O0XA 4IDYA 2BHCA 1B6AA 3FM3A 3TB5A 2BWTA 1C23A 1R5GA 5CDEA 4U70A 4U75A 2BN7A 4RZYA 2BWSA 2V3XA 2GG2A 4B28A 2BH3A 4S2TP 1WL6A 2G6PA 2GTXA 3FMRA 3PKAA 4RGZ1 1W7VA 4S01A 2V6CA 1PV9A 4IU6A 1C21A 4HXXA 1XGMA 1QXYA 4IKSA 2MATA 4RZZA 4U69A 1N51A 3D27A 2Q95A 1YJ3A 4ZNGA 2BB7A 3CB5A 4FKCA 4IPAA 1W2MA 1YW7A 2EA4A 2BWUA 2GGBA 3IU8A 3IG4A 2BHAA 3CTZA 4FO7A 4PV4A 4IF7A 2BWXA 3RORA 3PKEA 5JI6A 4U6JA 2GG7A 2V3YA 1KP0A 1WN1A 3RVAA 4JUQA 5FCFA 4A6VA 4IKTA 1XGSA 5CDLA 4U73A 1QXZA 2ZSGA 1B59A 2GG5A 3MR1A 4QR8A 2GU7A 4S2RP 5E5BA 2ADUA 2Q96A 4ZWPA 4PNCA 2BWVA 1C24A 4S00A 2EVOA 4ZWOA 2GU4A 3TAVA 2B3KA 4KM3A 2EA2A 5CLSA 1WBQA 3CB6A 2DFIA 4U6WA 4U76A 5CDVA 1KQ0A 1A16A 3Q6DA 4U1BA 3BITA 1WY2A 5CNXA 5FCHA 4U71A 2EVMA 2GGCA 2BWWA 2GG3A 2GZ5A 1XGNA 1YVMA 1R58A 2OKNA 2P99A 4A6WA 4EGEA 4FUKA 1R5HA 4ZWUA 4FLIA 2BWYA 1QZYA 2Q94A 2P9AA 1WLRA 2BHBA 2Q92A 4R60A 2GG9A 1QXWA 2B3HA 3MATA 4FLJA 1C22A 2GG0A 3PKCA 3IU7A 4Z7MA 1BN5A 2IW2A 4FO8A 3IU9A 5D6FA 2GG8A 3L24A 5JHUA 3PKBA 1WKMA 3FMQA 2NQ7A 1M35A 4U6CA 5CE6A 5D6EA 2P98A 4U6EA 2BHDA 3PKDA 2V3ZA 5JFRA 4OOKA 4FLLA 3BIQA 1XNZA 2B3LA 1MATA 3L7GA 1WL9A 4U6ZA 4FLKA 4MATA 3MX6A 1Y1NA 2OAZA 2Q93A 2GU6A 4IKUA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3BIP A;  1BOA A;  4IEC A;  1JAW A;  1KQ9 A;  2Q8K A;  1CHM A;  2NQ6 A;  5CIK A;  2GU5 A;  1C27 A;  2GA2 A;  2HOW A;  3S6B A;  1YW9 A;  1YW8 A;  2EVC A;  4IKR A;  1XGO A;  1O0X A;  4IDY A;  2BHC A;  1B6A A;  3FM3 A;  3TB5 A;  2BWT A;  1C23 A;  1R5G A;  5CDE A;  4U70 A;  4U75 A;  2BN7 A;  4RZY A;  2BWS A;  2V3X A;  2GG2 A;  4B28 A;  2BH3 A;  4S2T P;  1WL6 A;  2G6P A;  2GTX A;  3FMR A;  3PKA A;  4RGZ 1;  1W7V A;  4S01 A;  2V6C A;  1PV9 A;  4IU6 A;  1C21 A;  4HXX A;  1XGM A;  1QXY A;  4IKS A;  2MAT A;  4RZZ A;  4U69 A;  1N51 A;  3D27 A;  2Q95 A;  1YJ3 A;  4ZNG A;  2BB7 A;  3CB5 A;  4FKC A;  4IPA A;  1W2M A;  1YW7 A;  2EA4 A;  2BWU A;  2GGB A;  3IU8 A;  3IG4 A;  2BHA A;  3CTZ A;  4FO7 A;  4PV4 A;  4IF7 A;  2BWX A;  3ROR A;  3PKE A;  5JI6 A;  4U6J A;  2GG7 A;  2V3Y A;  1KP0 A;  1WN1 A;  3RVA A;  4JUQ A;  5FCF A;  4A6V A;  4IKT A;  1XGS A;  5CDL A;  4U73 A;  1QXZ A;  2ZSG A;  1B59 A;  2GG5 A;  3MR1 A;  4QR8 A;  2GU7 A;  4S2R P;  5E5B A;  2ADU A;  2Q96 A;  4ZWP A;  4PNC A;  2BWV A;  1C24 A;  4S00 A;  2EVO A;  4ZWO A;  2GU4 A;  3TAV A;  2B3K A;  4KM3 A;  2EA2 A;  5CLS A;  1WBQ A;  3CB6 A;  2DFI A;  4U6W A;  4U76 A;  5CDV A;  1KQ0 A;  1A16 A;  3Q6D A;  4U1B A;  3BIT A;  1WY2 A;  5CNX A;  5FCH A;  4U71 A;  2EVM A;  2GGC A;  2BWW A;  2GG3 A;  2GZ5 A;  1XGN A;  1YVM A;  1R58 A;  2OKN A;  2P99 A;  4A6W A;  4EGE A;  4FUK A;  1R5H A;  4ZWU A;  4FLI A;  2BWY A;  1QZY A;  2Q94 A;  2P9A A;  1WLR A;  2BHB A;  2Q92 A;  4R60 A;  2GG9 A;  1QXW A;  2B3H A;  3MAT A;  4FLJ A;  1C22 A;  2GG0 A;  3PKC A;  3IU7 A;  4Z7M A;  1BN5 A;  2IW2 A;  4FO8 A;  3IU9 A;  5D6F A;  2GG8 A;  3L24 A;  5JHU A;  3PKB A;  1WKM A;  3FMQ A;  2NQ7 A;  1M35 A;  4U6C A;  5CE6 A;  5D6E A;  2P98 A;  4U6E A;  2BHD A;  3PKD A;  2V3Z A;  5JFR A;  4OOK A;  4FLL A;  3BIQ A;  1XNZ A;  2B3L A;  1MAT A;  3L7G A;  1WL9 A;  4U6Z A;  4FLK A;  4MAT A;  3MX6 A;  1Y1N A;  2OAZ A;  2Q93 A;  2GU6 A;  4IKU A; 
#chains in the Genus database with same CATH topology
 3BIP A;  1BOA A;  4IEC A;  1JAW A;  1KQ9 A;  2Q8K A;  1CHM A;  2NQ6 A;  5CIK A;  2GU5 A;  1C27 A;  2GA2 A;  2HOW A;  3S6B A;  1YW9 A;  1YW8 A;  2EVC A;  4IKR A;  1XGO A;  1O0X A;  4IDY A;  2BHC A;  1B6A A;  3FM3 A;  3TB5 A;  2BWT A;  1C23 A;  1R5G A;  5CDE A;  4U70 A;  4U75 A;  2BN7 A;  4RZY A;  2BWS A;  2V3X A;  2GG2 A;  4B28 A;  2BH3 A;  4S2T P;  1WL6 A;  2G6P A;  2GTX A;  3FMR A;  3PKA A;  4RGZ 1;  1W7V A;  4S01 A;  2V6C A;  1PV9 A;  4IU6 A;  1C21 A;  4HXX A;  1XGM A;  1QXY A;  4IKS A;  2MAT A;  4RZZ A;  4U69 A;  1N51 A;  3D27 A;  2Q95 A;  1YJ3 A;  4ZNG A;  2BB7 A;  3CB5 A;  4FKC A;  4IPA A;  1W2M A;  1YW7 A;  2EA4 A;  2BWU A;  2GGB A;  3IU8 A;  3IG4 A;  2BHA A;  3CTZ A;  4FO7 A;  4PV4 A;  4IF7 A;  2BWX A;  3ROR A;  3PKE A;  5JI6 A;  4U6J A;  2GG7 A;  2V3Y A;  1KP0 A;  1WN1 A;  3RVA A;  4JUQ A;  5FCF A;  4A6V A;  4IKT A;  1XGS A;  5CDL A;  4U73 A;  1QXZ A;  2ZSG A;  1B59 A;  2GG5 A;  3MR1 A;  4QR8 A;  2GU7 A;  4S2R P;  5E5B A;  2ADU A;  2Q96 A;  4ZWP A;  4PNC A;  2BWV A;  1C24 A;  4S00 A;  2EVO A;  4ZWO A;  2GU4 A;  3TAV A;  2B3K A;  4KM3 A;  2EA2 A;  5CLS A;  1WBQ A;  3CB6 A;  2DFI A;  4U6W A;  4U76 A;  5CDV A;  1KQ0 A;  1A16 A;  3Q6D A;  4U1B A;  3BIT A;  1WY2 A;  5CNX A;  5FCH A;  4U71 A;  2EVM A;  2GGC A;  2BWW A;  2GG3 A;  2GZ5 A;  1XGN A;  1YVM A;  1R58 A;  2OKN A;  2P99 A;  4A6W A;  4EGE A;  4FUK A;  1R5H A;  4ZWU A;  4FLI A;  2BWY A;  1QZY A;  2Q94 A;  2P9A A;  1WLR A;  2BHB A;  2Q92 A;  4R60 A;  2GG9 A;  1QXW A;  2B3H A;  3MAT A;  4FLJ A;  1C22 A;  2GG0 A;  3PKC A;  3IU7 A;  4Z7M A;  1BN5 A;  2IW2 A;  4FO8 A;  3IU9 A;  5D6F A;  2GG8 A;  3L24 A;  5JHU A;  3PKB A;  1WKM A;  3FMQ A;  2NQ7 A;  1M35 A;  4U6C A;  5CE6 A;  5D6E A;  2P98 A;  4U6E A;  2BHD A;  3PKD A;  2V3Z A;  5JFR A;  4OOK A;  4FLL A;  3BIQ A;  1XNZ A;  2B3L A;  1MAT A;  3L7G A;  1WL9 A;  4U6Z A;  4FLK A;  4MAT A;  3MX6 A;  1Y1N A;  2OAZ A;  2Q93 A;  2GU6 A;  4IKU A; 
#chains in the Genus database with same CATH homology
 3BIP A;  1BOA A;  4IEC A;  1JAW A;  1KQ9 A;  2Q8K A;  1CHM A;  2NQ6 A;  5CIK A;  2GU5 A;  1C27 A;  2GA2 A;  2HOW A;  3S6B A;  1YW9 A;  1YW8 A;  2EVC A;  4IKR A;  1XGO A;  1O0X A;  4IDY A;  2BHC A;  1B6A A;  3FM3 A;  3TB5 A;  2BWT A;  1C23 A;  1R5G A;  5CDE A;  4U70 A;  4U75 A;  2BN7 A;  4RZY A;  2BWS A;  2V3X A;  2GG2 A;  4B28 A;  2BH3 A;  4S2T P;  1WL6 A;  2G6P A;  2GTX A;  3FMR A;  3PKA A;  4RGZ 1;  1W7V A;  4S01 A;  2V6C A;  1PV9 A;  4IU6 A;  1C21 A;  4HXX A;  1XGM A;  1QXY A;  4IKS A;  2MAT A;  4RZZ A;  4U69 A;  1N51 A;  3D27 A;  2Q95 A;  1YJ3 A;  4ZNG A;  2BB7 A;  3CB5 A;  4FKC A;  4IPA A;  1W2M A;  1YW7 A;  2EA4 A;  2BWU A;  2GGB A;  3IU8 A;  3IG4 A;  2BHA A;  3CTZ A;  4FO7 A;  4PV4 A;  4IF7 A;  2BWX A;  3ROR A;  3PKE A;  5JI6 A;  4U6J A;  2GG7 A;  2V3Y A;  1KP0 A;  1WN1 A;  3RVA A;  4JUQ A;  5FCF A;  4A6V A;  4IKT A;  1XGS A;  5CDL A;  4U73 A;  1QXZ A;  2ZSG A;  1B59 A;  2GG5 A;  3MR1 A;  4QR8 A;  2GU7 A;  4S2R P;  5E5B A;  2ADU A;  2Q96 A;  4ZWP A;  4PNC A;  2BWV A;  1C24 A;  4S00 A;  2EVO A;  4ZWO A;  2GU4 A;  3TAV A;  2B3K A;  4KM3 A;  2EA2 A;  5CLS A;  1WBQ A;  3CB6 A;  2DFI A;  4U6W A;  4U76 A;  5CDV A;  1KQ0 A;  1A16 A;  3Q6D A;  4U1B A;  3BIT A;  1WY2 A;  5CNX A;  5FCH A;  4U71 A;  2EVM A;  2GGC A;  2BWW A;  2GG3 A;  2GZ5 A;  1XGN A;  1YVM A;  1R58 A;  2OKN A;  2P99 A;  4A6W A;  4EGE A;  4FUK A;  1R5H A;  4ZWU A;  4FLI A;  2BWY A;  1QZY A;  2Q94 A;  2P9A A;  1WLR A;  2BHB A;  2Q92 A;  4R60 A;  2GG9 A;  1QXW A;  2B3H A;  3MAT A;  4FLJ A;  1C22 A;  2GG0 A;  3PKC A;  3IU7 A;  4Z7M A;  1BN5 A;  2IW2 A;  4FO8 A;  3IU9 A;  5D6F A;  2GG8 A;  3L24 A;  5JHU A;  3PKB A;  1WKM A;  3FMQ A;  2NQ7 A;  1M35 A;  4U6C A;  5CE6 A;  5D6E A;  2P98 A;  4U6E A;  2BHD A;  3PKD A;  2V3Z A;  5JFR A;  4OOK A;  4FLL A;  3BIQ A;  1XNZ A;  2B3L A;  1MAT A;  3L7G A;  1WL9 A;  4U6Z A;  4FLK A;  4MAT A;  3MX6 A;  1Y1N A;  2OAZ A;  2Q93 A;  2GU6 A;  4IKU A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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