3RV8A

Structure of a m. tuberculosis salicylate synthase, mbti, in complex with an inhibitor with cyclopropyl r-group
Total Genus 129
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
129
sequence length
436
structure length
418
Chain Sequence
SSSIPMPAGVNPADLAAELAAVVTESVDEDYLLYECDGQWVLAAGVQAMVELDSDELRVIRDGVTRRQQWSGRPGAALGEAVDRLLLETDQAFGWVAFEFGVHRYGLQQRLAPHTPLARVFSPRTRIMVSEKEIRLFDAGIRHREAIDRLLATGVREVPQSRSVDVSDDPSGFRRRVAVAVDEIAAGRYHKVILSRCVEVPFAIDFPLTYRLGRRHNTPVRSFLLQLGGIRALGYSPELVTAVRADGVVITEPLAGTDDLESNSKEIVEHAISVRSSLEEITDIAEPGSAAVIDFMTVRVQHLGSTIRARLDPSSDRMAALEALFPAVTASGIPKAAGVEAIFRLDECPRGLYSGAVVMLSADGGLDAALTLRAAYQVGGRTWLRAGAGIIEESEPEREFEETCEKLSTLTPYLVARQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Isomerase/isomerase inhibitor
molecule keywords Isochorismate synthase/isochorismate-pyruvate lyase mbtI
publication title Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis
pubmed doi rcsb
source organism Mycobacterium tuberculosis
total genus 129
structure length 418
sequence length 436
chains with identical sequence B, C, D
ec nomenclature ec 4.2.99.21: Isochorismate lyase.
pdb deposition date 2011-05-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00425 Chorismate_bind chorismate binding enzyme
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.60.120.10 Alpha Beta 4-Layer Sandwich Anthranilate synthase Anthranilate synthase 3rv8A00
2FN0A 3HWOA 5JXZA 3LOGA 2G5FA 3R75A 5JY4A 1I7SA 5CWAA 2EUAA 3RV6A 3BZMA 1I1QA 3VEHA 3RV8A 5JY9A 1K0EA 3H9MA 1K0GA 3GSEA 5JZDA 2FN1A 2I6YA 5JY8A 5KCKA 3ST6A 3RV9A 3R74A 3BZNA 3OS6A 5JY4B 1I7QA 3RV7A 4GRHA 1QDLA 3R76A
chains in the Genus database with same CATH superfamily
2FN0A 3HWOA 5JXZA 3LOGA 2G5FA 3R75A 5JY4A 1I7SA 5CWAA 2EUAA 3RV6A 3BZMA 1I1QA 3VEHA 3RV8A 5JY9A 1K0EA 3H9MA 1K0GA 3GSEA 5JZDA 2FN1A 2I6YA 5JY8A 5KCKA 3ST6A 3RV9A 3R74A 3BZNA 3OS6A 5JY4B 1I7QA 3RV7A 4GRHA 1QDLA 3R76A
chains in the Genus database with same CATH topology
2FN0A 3HWOA 5JXZA 3LOGA 2G5FA 3R75A 5JY4A 1I7SA 5CWAA 2EUAA 3RV6A 3BZMA 1I1QA 3VEHA 3RV8A 5JY9A 1K0EA 3H9MA 1K0GA 3GSEA 5JZDA 2FN1A 2I6YA 5JY8A 5KCKA 3ST6A 3RV9A 3R74A 3BZNA 3OS6A 5JY4B 1I7QA 3RV7A 4GRHA 1QDLA 3R76A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FN0 A;  3HWO A;  5JXZ A;  3LOG A;  2G5F A;  3R75 A;  5JY4 A;  1I7S A;  5CWA A;  2EUA A;  3RV6 A;  3BZM A;  1I1Q A;  3VEH A;  3RV8 A;  5JY9 A;  1K0E A;  3H9M A;  1K0G A;  3GSE A;  5JZD A;  2FN1 A;  2I6Y A;  5JY8 A;  5KCK A;  3ST6 A;  3RV9 A;  3R74 A;  3BZN A;  3OS6 A;  5JY4 B;  1I7Q A;  3RV7 A;  4GRH A;  1QDL A;  3R76 A; 
#chains in the Genus database with same CATH topology
 2FN0 A;  3HWO A;  5JXZ A;  3LOG A;  2G5F A;  3R75 A;  5JY4 A;  1I7S A;  5CWA A;  2EUA A;  3RV6 A;  3BZM A;  1I1Q A;  3VEH A;  3RV8 A;  5JY9 A;  1K0E A;  3H9M A;  1K0G A;  3GSE A;  5JZD A;  2FN1 A;  2I6Y A;  5JY8 A;  5KCK A;  3ST6 A;  3RV9 A;  3R74 A;  3BZN A;  3OS6 A;  5JY4 B;  1I7Q A;  3RV7 A;  4GRH A;  1QDL A;  3R76 A; 
#chains in the Genus database with same CATH homology
 2FN0 A;  3HWO A;  5JXZ A;  3LOG A;  2G5F A;  3R75 A;  5JY4 A;  1I7S A;  5CWA A;  2EUA A;  3RV6 A;  3BZM A;  1I1Q A;  3VEH A;  3RV8 A;  5JY9 A;  1K0E A;  3H9M A;  1K0G A;  3GSE A;  5JZD A;  2FN1 A;  2I6Y A;  5JY8 A;  5KCK A;  3ST6 A;  3RV9 A;  3R74 A;  3BZN A;  3OS6 A;  5JY4 B;  1I7Q A;  3RV7 A;  4GRH A;  1QDL A;  3R76 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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