The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
110
|
sequence length |
454
|
structure length |
454
|
Chain Sequence |
LNLDPVQLTFYAGPNGSQFGFSLDFHKDSHGRVAIVVGAPRTLGPSQEETGGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKARQGLGASVVSWSDVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNTLSRIYVENDFSWDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLAQAPVADIFSSYRPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVAVGEFDGDLNTTEYVVGAPTWSWTLGAVEILDSYYQRLHRLRGEQMASYFGHSVAVTDVNGDGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQPRGPHALGAPSLLLTGTQLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLRSRPSQVLDSPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQPVV
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Structure-Guided Design of a High-Affinity Platelet Integrin alphaIIbbeta3 Receptor Antagonist That Disrupts Mg2+ Binding to the MIDAS
pubmed doi rcsb |
| molecule tags |
Cell adhesion
|
| source organism |
Homo sapiens
|
| molecule keywords |
Integrin alpha-IIb
|
| total genus |
110
|
| structure length |
454
|
| sequence length |
454
|
| chains with identical sequence |
C
|
| ec nomenclature | |
| pdb deposition date | 2011-07-25 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF01839 | FG-GAP | FG-GAP repeat |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Beta | 7 Propeller | Methylamine Dehydrogenase; Chain H | Integrin alpha, N-terminal |
#chains in the Genus database with same CATH superfamily 4MMX A; 2VC2 A; 3ZE1 A; 3FCS A; 4Z7N A; 4IRZ A; 3ZE0 A; 4G1E A; 5E6R A; 3ZDY A; 3V4V A; 1L5G A; 1M1X A; 4MMZ A; 4G1M A; 2VDN A; 3NID A; 4WK2 A; 5FFG A; 2VDM A; 3ZDZ A; 4WJK A; 3VI4 A; 2VDR A; 4UM8 A; 4O02 A; 3T3M A; 5E6U A; 2VDK A; 5E6S A; 5FFO A; 4WK0 A; 3K72 A; 3VI3 A; 3T3P A; 1JV2 A; 1TYE A; 2VDL A; 4Z7Q A; 4MMY A; 3NIF A; 4WK4 A; 5HDB A; 4NEN A; 2VDO A; 3K71 A; 3ZDX A; 1U8C A; 3K6S A; 3NIG A; 2VDQ A; 3IJE A; 2VDP A; 3FCU A; 3ZE2 A; 3V4P A; 4UM9 A; 4Z7O A; #chains in the Genus database with same CATH topology 1PI6 A; 2CO0 C; 3V5W B; 4Z7N A; 5C2V B; 1YFQ A; 4G1E A; 2I3S A; 3I7P A; 2IUP A; 4JD2 C; 1ERJ A; 1QFM A; 2AH0 A; 3CIK B; 3MUN A; 4NSX A; 3VI4 A; 2H14 A; 2HU7 A; 1RI6 A; 3VA6 A; 4E5Z A; 4AMY A; 5FFO A; 5K1C C; 5HE0 B; 4K3I D; 3UVN A; 1JMX B; 2UZY B; 3NIF A; 1H2Z A; 4J81 A; 1N6E A; 3PSC B; 3PXW D; 5EM2 B; 3SVW D; 4JSP C; 4CY2 A; 4LGN A; 1VZ3 A; 2OK4 A; 2YMU A; 1S4U X; 3V4P A; 1JMZ B; 5M5V A; 3FCS A; 1L0Q A; 4JSX C; 4GQ1 A; 4Y5R D; 2HES X; 2J55 H; 4CZY A; 4PNK B; 5CXB B; 5C92 A; 4A2L A; 3O4J A; 1GOG A; 2B5N A; 3F3F A; 1M1X A; 2XL3 A; 2GC4 A; 4WK2 A; 4Z8L A; 4I79 A; 3ZWL B; 5KDO B; 5IC7 A; 2P9L C; 5E6S A; 3JB9 L; 2CN3 A; 2QC5 A; 4GQB B; 3OKW A; 4MK0 B; 2HYE A; 2PM6 B; 3UKU C; 1UOQ A; 4MMY A; 3PE7 A; 3K27 A; 4D6V A; 2H6N A; 3N0E A; 4CI3 A; 4QQE A; 2BBK H; 5B4W A; 1A12 A; 3V7D B; 3EI4 B; 2UZX B; 3IJ1 A; 3AL8 B; 4NC4 A; 4A11 B; 1SQJ A; 4A0A B; 4DNU A; 2VZ1 A; 3IUJ A; 3RSE C; 5AMS A; 1MG2 A; 2GNQ A; 4MMZ A; 1O6G A; 2I3T A; 5CYK A; 1GOH A; 2B5L A; 4GM8 A; 3L4M D; 3OF7 A; 4FAV D; 3I7O A; 5E6U A; 3JZG A; 1VE7 A; 3BG0 A; 4ERY A; 4OWR A; 3EQ9 A; 4A7J A; 3K26 A; 3NIG A; 4QT8 A; 2YNP A; 5HE1 B; 3UVO A; 3EG6 A; 3A0F A; 1VE6 A; 3C9C A; 1TBG A; 2VC2 A; 3NVN A; 4H5J A; 3SCY A; 4AEZ A; 4O3T B; 2XDW A; 3ZDY A; 5A2Q g; 5EM2 A; 3ULE C; 1XKS A; 4A0B B; 5H1M A; 4HDJ A; 4AN0 A; 2YNO A; 4ZOZ A; 4L9O A; 5C9Z B; 5CXB A; 5M5S A; 2P9N C; 3I2N A; 5HYN B; 3MZL A; 1E8M A; 3K71 A; 2XZG A; 3IUQ A; 2H68 A; 1U4C A; 3FCU A; 5EMJ B; 4KFM B; 2H3X A; 4AOW A; 2P9P C; 2TRC B; 5FKS A; 2EIE A; 3C99 A; 5FXY A; 4J87 A; 1P22 A; 3I7H A; 3F3G A; 4GM9 A; 2AGW A; 2VDM A; 2AQ5 A; 2QZP A; 2EIB A; 3IJ0 A; 4TZ4 A; 2O9K A; 3EI4 A; 3QHY B; 2H9P A; 4JT5 C; 4U7A A; 3DDU A; 4A11 A; 3JAM g; 3RMZ D; 4A0A A; 4J77 A; 3ZDX A; 5FLX g; 5IT9 g; 1QNI A; 4AN1 A; 4GMB A; 4PC0 A; 1VYH C; 3SBQ A; 4J82 A; 3GD1 I; 2H6Q A; 3AH8 B; 4X63 B; 4IRZ A; 4LG9 A; 5E6R A; 2MTA H; 2CE8 A; 2AGL A; 4O2W A; 4G1M A; 4FA4 D; 2I0T A; 5FKQ A; 4QAM A; 2VDK A; 4BH6 A; 3J81 g; 5GSA A; 3GFC A; 5H17 A; 1JV2 A; 4ERZ A; 1B9X A; 3OKT A; 4J78 A; 4E54 B; 3EQ7 A; 3W15 A; 2PM7 B; 2IWF A; 4A0B A; 4R7A B; 3IJE A; 3OL2 B; 3L4O D; 4Y7R A; 3ZE2 A; 2HJB A; 2OIZ A; 3V9F A; 2EIC A; 2AH1 A; 4DNW A; 1XIP A; 3OKY B; 2G99 A; 3ZE0 A; 3NVX A; 4ERQ A; 5THA A; 4PSX B; 4L3G D; 2W18 A; 1E8N A; 1U2V C; 4J73 A; 3IUL A; 3SBR A; 3U4Y A; 2VDR A; 4O02 A; 4D0K A; 3VI3 A; 4PBY A; 3BWS A; 2Z2N A; 3MVD K; 3AL9 A; 3SBP A; 3EI3 B; 2OK6 A; 3PVU B; 5EAR A; 1GOT B; 3EU7 A; 4J0W A; 4N14 A; 4O1Q D; 1C9L A; 4D9S A; 3I7N A; 3ORV D; 5H14 A; 4QL1 A; 4CI2 A; 4L3H D; 4A08 B; 1PGU A; 3IKO A; 4A2M A; 2CE9 A; 3PSL A; 2G9A A; 4BCC A; 1L5G A; 5GXI A; 4XYI A; 3NID A; 4J86 A; 2H13 A; 3UKR C; 3E0C A; 3C5M A; 3RN1 D; 2HKR A; 1R5M A; 4WK4 A; 4FB1 D; 2OVQ B; 3RFG A; 4IMM A; 3EWE A; 3O4H A; 5TF2 A; 2IAA A; 4GZ8 A; 3DXM C; 1JTD B; 3IJC A; 3I7K A; 2P9I C; 4J84 A; 3DSM A; 2HU8 A; 4QRJ A; 3JZN A; 4ES0 A; 1FWX A; 4E54 A; 4IA9 A; 3JRO A; 4O3U B; 2IWK A; 4O45 A; 1UTC A; 5GMK n; 3UVL A; 3OL2 A; 3SHF A; 4BL0 A; 2VDN A; 1H2X A; 1JOF A; 4UM8 A; 3T3M A; 3OKY A; 1PEV A; 5GXH A; 2AGZ A; 3NVQ A; 4NBM A; 2B4E A; 5TEE A; 3UR4 A; 3I7L A; 4NEN A; 1NR0 A; 3IUR A; 3O4G A; 1JJU B; 1MG3 A; 5FKR A; 2BCJ B; 2IUQ A; 3IVM A; 4GGA A; 4MMX A; 5FQD A; 5EMM B; 4K3J B; 2H9N A; 4ZN4 A; 4RE5 A; 3I89 A; 3EI3 A; 3V4V A; 4CI8 A; 1T2X A; 2B5M A; 4J8B A; 4X61 B; 1E5T A; 3DM0 A; 2J57 G; 4A08 A; 4Z7Q A; 4J0X A; 3AL8 A; 1C9I A; 4YVD A; 3O4I A; 2VDO A; 5M5R A; 4BCD A; 2H6K A; 2HJ4 A; 4BUJ C; 5AFU 3; 1H2W A; 3FM0 A; 5HE2 B; 2XU7 A; 3PVW B; 2I0S A; 2IUV A; 2OVP B; 4L1Q D; 3JRP A; 2P9S C; 4FWW A; 4FHL A; 3MKQ A; 1TYQ C; 1H2Y A; 4L1M A; 4BP9 A; 1UOO A; 3FRX A; 3RN0 D; 1GXR A; 3SWS D; 5FKT A; 4J8G A; 3KRX B; 3SXT D; 3IUN A; 3FGB A; 4EWR A; 2OVR B; 3DXK C; 2H9M A; 3OTT A; 5IGO A; 3EQ8 A; 4X3E A; 1U8C A; 1BPO A; 5EML B; 4XYH A; 3SN6 B; 2PM9 B; 2Q7Q A; 2PBI B; 4AMZ A; 3ZE1 A; 2WQ8 A; 5C86 A; 2OJY A; 4FA9 D; 5TEF A; 5FA5 B; 4CZX A; 3N0D A; 5FFG A; 1Q47 A; 4NAA A; 1GP2 B; 4CZV A; 3C75 H; 1GOF A; 3MKS B; 2JKX A; 3MXX A; 2XYI A; 4GQ2 P; 3JPX A; 3MUO A; 1N6D A; 2YNN A; 4LG8 A; 5M61 A; 4J79 A; 1K32 A; 5IGQ A; 3QI0 A; 2YBA A; 2GC7 A; 4PBZ A; 3UVK A; 4ZOY A; 4O9D A; 2CNX A; 4PSW B; 4WJK A; 3IIW A; 5K19 A; 4CY3 A; 1K8K C; 4AX4 A; 1SQ9 A; 3OW8 A; 3K72 A; 3T3P A; 5I5I A; 3DWL C; 3I8C A; 5I5M A; 3EI2 B; 3J80 g; 1K3I A; 4ZOV A; 2VDQ A; 3HFQ A; 4A09 B; 1QFS A; 5I5J A; 2CN2 A; 2EID A; 4UM9 A; 4Z7O A; 1NEX B; 3RFH A; 4CI1 A; 4FA5 D; 1A0R B; 4XEI C; 3CFV A; 3EI1 B; 4JT6 C; 5EAL A; 3GC3 B; 3PXT D; 2IUR A; 3SFZ A; 1VZ2 A; 2PM9 A; 2YB8 B; 5CXC B; 1OMW B; 3KRW B; 2EBS A; 3IUM A; 4JSN C; 1TYE A; 2VDL A; 3I8E A; 2XL2 A; 2J56 H; 4BP8 A; 5HDB A; 4FA1 D; 1SHY B; 2Z2O A; 3MMY A; 3BG1 A; 3CFS B; 3RRM C; 4G55 A; 4CC9 A; 3GRE A; 2Z2P A; 4X60 B; 4E5Z B; 5HQG A; 2HKM A; 4JSV C; 3VH0 A; 2P9U C; 4U1E I; 4RE6 A; 2H9L A; 3ODT A; 3UVM A; 3ZDZ A; 3AFC A; 5M5T A; 4CY1 A; 3IIY A; 2P9K C; 1I2M B; 2HXC A; 3KCI A; 3SMR A; 4ESG A; 4JXM A; 2QXV A; 3JZH A; 4ZOX A; 3RLM D; 3EMH A; 2BKL A; 5EAM A; 3P4F A; 3PXS D; 5AJA A; 4GGD A; 3B7F A; 2VZ3 A; 4JHP C; 5EAP A; 2CO0 A; 2HU5 A; 4PXW A; 2QR5 A; 1YR2 A; 3F3P A; 5EMK B; 3EI2 A; 4UI9 R; 5HE3 B; 5C2W B; 2I0R A; 4JHN A; 1MDA H; 1XHM A; 4A09 A; 2H47 A; 4G56 B; 4CY5 A; 1UOP A; 5M5U A; 5TDH B; 5IJ8 E; 4WK0 A; 1B9Y A; 3EI1 A; 4BCB A; 5JWZ A; 5IJ7 E; 1N6F A; 1OLZ A; 3VGZ A; 4FAN D; 4GM3 A; 1O6F A; 2AGY A; 2XE4 A; 3SLE D; 4OZU A; 3K6S A; 2AGX A; 4GGC A; 1GG2 B; 2VDP A; 3SJL D; 5CXC A; 5CYK B; 4DNV A; 4H5I A; 1PBY B; 3MZK A; 5SXM A; #chains in the Genus database with same CATH homology 4MMX A; 2VC2 A; 3ZE1 A; 3FCS A; 4Z7N A; 4IRZ A; 3ZE0 A; 4G1E A; 5E6R A; 3ZDY A; 3V4V A; 1L5G A; 1M1X A; 4MMZ A; 4G1M A; 2VDN A; 3NID A; 4WK2 A; 5FFG A; 2VDM A; 3ZDZ A; 4WJK A; 3VI4 A; 2VDR A; 4UM8 A; 4O02 A; 3T3M A; 5E6U A; 2VDK A; 5E6S A; 5FFO A; 4WK0 A; 3K72 A; 3VI3 A; 3T3P A; 1JV2 A; 1TYE A; 2VDL A; 4Z7Q A; 4MMY A; 3NIF A; 4WK4 A; 5HDB A; 4NEN A; 2VDO A; 3K71 A; 3ZDX A; 1U8C A; 3K6S A; 3NIG A; 2VDQ A; 3IJE A; 2VDP A; 3FCU A; 3ZE2 A; 3V4P A; 4UM9 A; 4Z7O A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
