4A5WB

Crystal structure of c5b6
Total Genus 96
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
96
sequence length
913
structure length
871
Chain Sequence
CFCDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRCPINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPCIPSKLCKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDERDCGRTKAVCTRKYNPIPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTVKSSRTSNPYRVPANLENVGFEVQTAEDDLKTDFYKDLTSLQGGSSFSVPIFYSSKRSENINHNSAFKQAIQASHKKDSSFIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNSALYSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEELKNSGLTEEEAKHCVRIETHRCTTNKLSEKHEGSFIQGAEKSISLIRGGEEKTFSEWLESVKENPAVIDFELAPIVDLVRNIPCAVTKRNNLRKALQEYAAKFDPCQCAPCPNNGRPTLSGTECLCVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDCTFSIMENNGQPCINDDEEMKEVDLPEIEADSGCPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGNSWTPPISNSLTCEKDTLTKLKGHCQLGQKQSGSECICMSPEEDCSHHSEDLCVFDTDSNDYFTSPACKFLAEKCLNNQQLHFLHIGSCQDGRQLEWGLERTRLSSNSTKKESCGYDTCYDWEKCSASTSKCVCLLPPQCFKGGNQLYCVKMGSSTSEKTLNICEVGTIRCANRKMEILHPGKCLA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords COMPLEMENT C5
publication title Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5B6 and Sc5B9.
pubmed doi rcsb
molecule tags Immune system
total genus 96
structure length 871
sequence length 913
ec nomenclature
pdb deposition date 2011-10-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00057 Ldl_recept_a Low-density lipoprotein receptor domain class A
B PF00084 Sushi Sushi repeat (SCR repeat)
B PF00090 TSP_1 Thrombospondin type 1 domain
B PF01823 MACPF MAC/Perforin domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4a5wB03
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4a5wB04
2.20.100.10 Mainly Beta Single Sheet TSP-1 type 1 repeat Thrombospondin type-1 (TSP1) repeat 4a5wB01
1E88A 4B2SA 2MCZA 4WJG2 1C1ZA 4AYMA 1SS2A 1H2PP 3VDJA 3ZD1A 3EJHA 3ZRZA 2RKYA 1OJWA 4C16A 4LOTA 4F4OC 1OK9A 2CG6A 3R6BA 2KRIA 1LY2A 2RLPA 2V8EA 3L89M 3OP8A 2RKZA 1TPNA 1MD8A 1VVDA 3KZJA 2JGWA 1OJVA 4A5WB 1GKNA 1UOTP 2CG7A 1ELVA 2XRBA 3ZD2A 2JRAA 5HYUB 2W80A 5HYPA 1SZLA 2EHFA 4AYDA 2W81A 1E8BA 1QO6A 2RL0A 2IZ3A 1U5MA 3VDKA 2KMSA 3GXEA 1MD7A 1HFHA 4PZ5A 1OJYA 3R62A 3M7PA 3IX0A 2RLQA 3O8EB 2BZMA 4IGDA 1G4GA 2EC3A 4HQNA 1H04P 1Q3XA 1HFIA 3TVJA 3OXUD 4CSYA 2UWNA 4DJZA 3VDLA 3CALA 1OK2A 1VEXA 4J38B 2O39C 2YBYA 4FXGG 2B5ID 3GOVA 1CKLA 1HCCA 2QY0A 3KXVA 3NFPI 1QGBA 4AYIA 4K12A 1GHQB 1OK3A 3RJ3D 4YNXA 3ERBA 1OK1A 2XRDA 2LOJA 3SW0X 1O9AA 3OEDC 1LSLA 1ZJKA 1H03P 4B2RA 2A55A 2XWJI 1G4FA 1E5GA 2ERJA 4KKDA 5HZPB 1Z92B 1H2QP 3MQLA 2WIIC 4HQOA 2MCYA 2YRAA 2JGXA 3INBC 4AYEA 3T5OA 1FBRA 1TPMA 5JPMG 4HQLA 2XQWC 4LOSA 4ZH1D 2CKUA 5HYTB 5I0QB 1QUBA 4JHSA 1SRZA 1NWVA 2G7IA 4ONTD 2IZ4A 1PPQA 1TPGA 4MUCA 2XWBF 1GPZA 3IU3I 1GKGA 1VVCA 5FO8C
chains in the Genus database with same CATH superfamily
1E88A 4B2SA 2MCZA 4WJG2 2Y8SA 1C1ZA 4AYMA 1SS2A 1H2PP 3VDJA 3ZD1A 3EJHA 3ZRZA 2RKYA 2Y8TA 1OJWA 3ZLEA 4C16A 4LOTA 2X2ZA 4F4OC 1OK9A 2CG6A 3R6BA 2KRIA 1LY2A 2RLPA 2V8EA 3L89M 3OP8A 2RKZA 5DN5A 3WSXA 1TPNA 1MD8A 4PO7A 1VVDA 3KZJA 2JGWA 1OJVA 4A5WB 1GKNA 3ZLDA 1UOTP 2CG7A 1ELVA 2XRBA 3ZD2A 2JRAA 3F6KA 5HYUB 2W80A 5HYPA 1SZLA 2EHFA 4AYDA 2W81A 2ZYCA 1E8BA 1QO6A 2RL0A 2IZ3A 1U5MA 3VDKA 2KMSA 3GXEA 1MD7A 1HFHA 4PZ5A 1OJYA 3R62A 3M7PA 3IX0A 2RLQA 3O8EB 2BZMA 4IGDA 3WSYA 1G4GA 2EC3A 4HQNA 1H04P 1Q3XA 1HFIA 3NJAA 3TVJA 3OXUD 4CSYA 2UWNA 4DJZA 4MSLA 3VDLA 3CALA 1OK2A 1VEXA 4J38B 2O39C 2YBYA 4FXGG 2B5ID 4APLA 3GOVA 1CKLA 1HCCA 2QY0A 3KXVA 3NFPI 1QGBA 2Y8RA 4AYIA 4K12A 4N7EA 1GHQB 1OK3A 4BWCA 3RJ3D 4YNXA 3ERBA 5DN4A 1OK1A 2XRDA 2LOJA 3SW0X 1O9AA 3OEDC 1LSLA 1ZJKA 1H03P 4B2RA 2A55A 1RLHA 2XWJI 2I2LA 1G4FA 1E5GA 2ERJA 4KKDA 5HZPB 1Z92B 1H2QP 3MQLA 2WIIC 4HQOA 2MCYA 2YRAA 2JGXA 3INBC 3K3TA 3T5OA 4AYEA 1FBRA 1TPMA 5JPMG 4HQLA 2XQWC 4LOSA 4ZH1D 2CKUA 5HYTB 5I0QB 1QUBA 4JHSA 1SRZA 1NWVA 2G7IA 4ONTD 2IZ4A 1PPQA 1TPGA 4MUCA 3VWOA 2XWBF 1GPZA 4YIZA 3IU3I 3FGRA 1GKGA 1VVCA 3FGTA 5FO8C 3CI0J
chains in the Genus database with same CATH topology
1E88A 4B2SA 2MCZA 4WJG2 1C1ZA 4AYMA 1SS2A 1H2PP 3VDJA 3ZD1A 3EJHA 3ZRZA 2RKYA 1OJWA 4C16A 4LOTA 4F4OC 1OK9A 2CG6A 3R6BA 2KRIA 1LY2A 2RLPA 2V8EA 3L89M 3OP8A 2RKZA 1TPNA 1MD8A 1VVDA 3KZJA 2JGWA 1OJVA 4A5WB 1GKNA 1UOTP 2CG7A 1ELVA 2XRBA 3ZD2A 2JRAA 5HYUB 2W80A 5HYPA 1SZLA 2EHFA 4AYDA 2W81A 1E8BA 1QO6A 2RL0A 2IZ3A 1U5MA 3VDKA 2KMSA 3GXEA 1MD7A 1HFHA 4PZ5A 1OJYA 3R62A 3M7PA 3IX0A 2RLQA 3O8EB 2BZMA 4IGDA 1G4GA 2EC3A 4HQNA 1H04P 1Q3XA 1HFIA 3TVJA 3OXUD 4CSYA 2UWNA 4DJZA 3VDLA 3CALA 1OK2A 1VEXA 4J38B 2O39C 2YBYA 4FXGG 2B5ID 3GOVA 1CKLA 1HCCA 2QY0A 3KXVA 3NFPI 1QGBA 4AYIA 4K12A 1GHQB 1OK3A 3RJ3D 4YNXA 3ERBA 1OK1A 2XRDA 2LOJA 3SW0X 1O9AA 3OEDC 1LSLA 1ZJKA 1H03P 4B2RA 2A55A 2XWJI 1G4FA 1E5GA 2ERJA 4KKDA 5HZPB 1Z92B 1H2QP 3MQLA 2WIIC 4HQOA 2MCYA 2YRAA 2JGXA 3INBC 4AYEA 3T5OA 1FBRA 1TPMA 5JPMG 4HQLA 2XQWC 4LOSA 4ZH1D 2CKUA 5HYTB 5I0QB 1QUBA 4JHSA 1SRZA 1NWVA 2G7IA 4ONTD 2IZ4A 1PPQA 1TPGA 4MUCA 2XWBF 1GPZA 3IU3I 1GKGA 1VVCA 5FO8C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1E88 A;  4B2S A;  2MCZ A;  4WJG 2;  1C1Z A;  4AYM A;  1SS2 A;  1H2P P;  3VDJ A;  3ZD1 A;  3EJH A;  3ZRZ A;  2RKY A;  1OJW A;  4C16 A;  4LOT A;  4F4O C;  1OK9 A;  2CG6 A;  3R6B A;  2KRI A;  1LY2 A;  2RLP A;  2V8E A;  3L89 M;  3OP8 A;  2RKZ A;  1TPN A;  1MD8 A;  1VVD A;  3KZJ A;  2JGW A;  1OJV A;  4A5W B;  1GKN A;  1UOT P;  2CG7 A;  1ELV A;  2XRB A;  3ZD2 A;  2JRA A;  5HYU B;  2W80 A;  5HYP A;  1SZL A;  2EHF A;  4AYD A;  2W81 A;  1E8B A;  1QO6 A;  2RL0 A;  2IZ3 A;  1U5M A;  3VDK A;  2KMS A;  3GXE A;  1MD7 A;  1HFH A;  4PZ5 A;  1OJY A;  3R62 A;  3M7P A;  3IX0 A;  2RLQ A;  3O8E B;  2BZM A;  4IGD A;  1G4G A;  2EC3 A;  4HQN A;  1H04 P;  1Q3X A;  1HFI A;  3TVJ A;  3OXU D;  4CSY A;  2UWN A;  4DJZ A;  3VDL A;  3CAL A;  1OK2 A;  1VEX A;  4J38 B;  2O39 C;  2YBY A;  4FXG G;  2B5I D;  3GOV A;  1CKL A;  1HCC A;  2QY0 A;  3KXV A;  3NFP I;  1QGB A;  4AYI A;  4K12 A;  1GHQ B;  1OK3 A;  3RJ3 D;  4YNX A;  3ERB A;  1OK1 A;  2XRD A;  2LOJ A;  3SW0 X;  1O9A A;  3OED C;  1LSL A;  1ZJK A;  1H03 P;  4B2R A;  2A55 A;  2XWJ I;  1G4F A;  1E5G A;  2ERJ A;  4KKD A;  5HZP B;  1Z92 B;  1H2Q P;  3MQL A;  2WII C;  4HQO A;  2MCY A;  2YRA A;  2JGX A;  3INB C;  4AYE A;  3T5O A;  1FBR A;  1TPM A;  5JPM G;  4HQL A;  2XQW C;  4LOS A;  4ZH1 D;  2CKU A;  5HYT B;  5I0Q B;  1QUB A;  4JHS A;  1SRZ A;  1NWV A;  2G7I A;  4ONT D;  2IZ4 A;  1PPQ A;  1TPG A;  4MUC A;  2XWB F;  1GPZ A;  3IU3 I;  1GKG A;  1VVC A;  5FO8 C; 
#chains in the Genus database with same CATH topology
 1E88 A;  4B2S A;  2MCZ A;  4WJG 2;  2Y8S A;  1C1Z A;  4AYM A;  1SS2 A;  1H2P P;  3VDJ A;  3ZD1 A;  3EJH A;  3ZRZ A;  2RKY A;  2Y8T A;  1OJW A;  3ZLE A;  4C16 A;  4LOT A;  2X2Z A;  4F4O C;  1OK9 A;  2CG6 A;  3R6B A;  2KRI A;  1LY2 A;  2RLP A;  2V8E A;  3L89 M;  3OP8 A;  2RKZ A;  5DN5 A;  3WSX A;  1TPN A;  1MD8 A;  4PO7 A;  1VVD A;  3KZJ A;  2JGW A;  1OJV A;  4A5W B;  1GKN A;  3ZLD A;  1UOT P;  2CG7 A;  1ELV A;  2XRB A;  3ZD2 A;  2JRA A;  3F6K A;  5HYU B;  2W80 A;  5HYP A;  1SZL A;  2EHF A;  4AYD A;  2W81 A;  2ZYC A;  1E8B A;  1QO6 A;  2RL0 A;  2IZ3 A;  1U5M A;  3VDK A;  2KMS A;  3GXE A;  1MD7 A;  1HFH A;  4PZ5 A;  1OJY A;  3R62 A;  3M7P A;  3IX0 A;  2RLQ A;  3O8E B;  2BZM A;  4IGD A;  3WSY A;  1G4G A;  2EC3 A;  4HQN A;  1H04 P;  1Q3X A;  1HFI A;  3NJA A;  3TVJ A;  3OXU D;  4CSY A;  2UWN A;  4DJZ A;  4MSL A;  3VDL A;  3CAL A;  1OK2 A;  1VEX A;  4J38 B;  2O39 C;  2YBY A;  4FXG G;  2B5I D;  4APL A;  3GOV A;  1CKL A;  1HCC A;  2QY0 A;  3KXV A;  3NFP I;  1QGB A;  2Y8R A;  4AYI A;  4K12 A;  4N7E A;  1GHQ B;  1OK3 A;  4BWC A;  3RJ3 D;  4YNX A;  3ERB A;  5DN4 A;  1OK1 A;  2XRD A;  2LOJ A;  3SW0 X;  1O9A A;  3OED C;  1LSL A;  1ZJK A;  1H03 P;  4B2R A;  2A55 A;  1RLH A;  2XWJ I;  2I2L A;  1G4F A;  1E5G A;  2ERJ A;  4KKD A;  5HZP B;  1Z92 B;  1H2Q P;  3MQL A;  2WII C;  4HQO A;  2MCY A;  2YRA A;  2JGX A;  3INB C;  3K3T A;  3T5O A;  4AYE A;  1FBR A;  1TPM A;  5JPM G;  4HQL A;  2XQW C;  4LOS A;  4ZH1 D;  2CKU A;  5HYT B;  5I0Q B;  1QUB A;  4JHS A;  1SRZ A;  1NWV A;  2G7I A;  4ONT D;  2IZ4 A;  1PPQ A;  1TPG A;  4MUC A;  3VWO A;  2XWB F;  1GPZ A;  4YIZ A;  3IU3 I;  3FGR A;  1GKG A;  1VVC A;  3FGT A;  5FO8 C;  3CI0 J; 
#chains in the Genus database with same CATH homology
 1E88 A;  4B2S A;  2MCZ A;  4WJG 2;  1C1Z A;  4AYM A;  1SS2 A;  1H2P P;  3VDJ A;  3ZD1 A;  3EJH A;  3ZRZ A;  2RKY A;  1OJW A;  4C16 A;  4LOT A;  4F4O C;  1OK9 A;  2CG6 A;  3R6B A;  2KRI A;  1LY2 A;  2RLP A;  2V8E A;  3L89 M;  3OP8 A;  2RKZ A;  1TPN A;  1MD8 A;  1VVD A;  3KZJ A;  2JGW A;  1OJV A;  4A5W B;  1GKN A;  1UOT P;  2CG7 A;  1ELV A;  2XRB A;  3ZD2 A;  2JRA A;  5HYU B;  2W80 A;  5HYP A;  1SZL A;  2EHF A;  4AYD A;  2W81 A;  1E8B A;  1QO6 A;  2RL0 A;  2IZ3 A;  1U5M A;  3VDK A;  2KMS A;  3GXE A;  1MD7 A;  1HFH A;  4PZ5 A;  1OJY A;  3R62 A;  3M7P A;  3IX0 A;  2RLQ A;  3O8E B;  2BZM A;  4IGD A;  1G4G A;  2EC3 A;  4HQN A;  1H04 P;  1Q3X A;  1HFI A;  3TVJ A;  3OXU D;  4CSY A;  2UWN A;  4DJZ A;  3VDL A;  3CAL A;  1OK2 A;  1VEX A;  4J38 B;  2O39 C;  2YBY A;  4FXG G;  2B5I D;  3GOV A;  1CKL A;  1HCC A;  2QY0 A;  3KXV A;  3NFP I;  1QGB A;  4AYI A;  4K12 A;  1GHQ B;  1OK3 A;  3RJ3 D;  4YNX A;  3ERB A;  1OK1 A;  2XRD A;  2LOJ A;  3SW0 X;  1O9A A;  3OED C;  1LSL A;  1ZJK A;  1H03 P;  4B2R A;  2A55 A;  2XWJ I;  1G4F A;  1E5G A;  2ERJ A;  4KKD A;  5HZP B;  1Z92 B;  1H2Q P;  3MQL A;  2WII C;  4HQO A;  2MCY A;  2YRA A;  2JGX A;  3INB C;  4AYE A;  3T5O A;  1FBR A;  1TPM A;  5JPM G;  4HQL A;  2XQW C;  4LOS A;  4ZH1 D;  2CKU A;  5HYT B;  5I0Q B;  1QUB A;  4JHS A;  1SRZ A;  1NWV A;  2G7I A;  4ONT D;  2IZ4 A;  1PPQ A;  1TPG A;  4MUC A;  2XWB F;  1GPZ A;  3IU3 I;  1GKG A;  1VVC A;  5FO8 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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