4ADMA

Crystal structure of rv1098c in complex with meso-tartrate
Total Genus 178
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
178
sequence length
459
structure length
450
Chain Sequence
NYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Lyase
molecule keywords FUMARATE HYDRATASE CLASS II
total genus 178
structure length 450
sequence length 459
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2011-12-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4admA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4admA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4admA02
2O7BA 1T6PA 2O7EA 4C5SA 2RJRA 4C5UA 4V2RA 1TJVA 1GKMA 1XWOA 3R6VA 3QBPA 3OCFA 1I0AA 2PTQA 1TJWA 1FURA 1TJUA 1RE5A 2VD6A 2PTSA 2E9FA 2NYNA 2YIIA 1VDKA 4ADMA 1J3UA 5EYTA 3C8TA 4EEIA 2PTRA 5EYVA 3CZOA 1U15A 4NSLA 2X75A 5HW2A 4HGVA 4APBA 5F92A 4MX2A 4FFXA 3NZ4A 1YFEA 2O7FA 2O7DA 2HVGA 1Q5NA 3GZHA 4EFCA 5F91A 1C3CA 1TJ7A 2RJSA 3RRPA 1KQ7A 3GTDA 3RD8A 3R6YA 4CQ5A 1DOFA 2FUSA 4C5RA 2O78A 4ADLA 3KDYA 3OCEA 1HY1A 1YISA 2PFMA 4NLEA 2O6YA 3BHGA 3NO9A 1Y2MA 4FLCA 4BABA 5D6BA 1HY0A 4V2QA 4APAA 1FUPA 2NYFA 1GK2A 3E04A 2QVEA 3TV2A 2OHYA 3R6QA 1FUOA 1W27A 1EB4A 1K62A 1GK3A 1B8FA 1GKJA 1YFMA 2J91A 4C6GA 1C3UA 4BAAA 2QGAB 3UNVA 1FUQA 1AUWA 1T6JA 3KDZA 1JSWA 1DCNA 1K7WA 1U16A
chains in the Genus database with same CATH superfamily
2O7BA 1T6PA 2O7EA 1Z4PX 4YIHA 4C5SA 2D28C 4IQJM 2RJRA 1Z4QA 4C5UA 4V2RA 1TJVA 1XLYA 4L57A 1GKMA 1XWOA 3R6VA 3QBPA 4WNLA 4L6CA 3OCFA 1I0AA 2PTQA 1TJWA 1FURA 1TJUA 1RE5A 1U0LA 2VD6A 2PTSA 3U13A 2E9FA 2JAWA 2NYNA 2FELA 2YIIA 4E88A 1Z4IA 2JARA 1VDKA 4ADMA 4MUMA 1J3UA 5EYTA 3C8TA 4EEIA 2PTRA 5EYVA 4A15A 1Z4LA 1K7WA 3CZOA 1U15A 5M0IA 4NSLA 2X75A 4L6AA 5HW2A 1Z4JA 4HGVA 4APBA 5F92A 4MX2A 4FFXA 3NZ4A 1YFEA 2O7FA 2O7DA 2I7DA 2HVGA 1Q5NA 3GZHA 4EFCA 5F91A 1C3CA 1TJ7A 3U19A 3CI0K 2RJSA 3RRPA 2JAOA 1KQ7A 2D27A 3GTDA 3RD8A 3R6YA 4CQ5A 1DOFA 2FUSA 4C5RA 1Q91A 2O78A 4ADLA 3KDYA 3OCEA 1HY1A 1YISA 4NFLA 2PFMA 4NLEA 2O6YA 3BHGA 3NO9A 1Y2MA 3CRVA 4FLCA 3F4SA 2RCNA 4BABA 1T9HA 5D6BA 1HY0A 5H8WA 2VSFA 4V2QA 4APAA 1FUPA 2NYFA 1GK2A 1IW7D 2FENA 3E04A 2QVEA 1MH9A 2JAUA 2YV5A 5M0JA 1Z4KA 3TV2A 2OHYA 3R6QA 3CRW1 1XMCA 1FUOA 1EB4A 1W27A 1K62A 1GK3A 1XMDA 1B8FA 1GKJA 1YFMA 1XL8A 2J91A 1XL7A 4C6GA 1C3UA 4BAAA 2QGAB 3UNVA 1FUQA 3BWVA 4MWOA 3F4RA 1AUWA 1T6JA 3KDZA 1JSWA 1DCNA 3F4TA 4YIKA 1Z4MA 1U16A 2VL7A 1Q92A
chains in the Genus database with same CATH topology
2O7BA 1T6PA 2O7EA 4C5SA 2RJRA 4C5UA 4V2RA 1TJVA 1GKMA 1XWOA 3R6VA 3QBPA 3OCFA 1I0AA 2PTQA 1TJWA 1FURA 1TJUA 1RE5A 2VD6A 2PTSA 2E9FA 2NYNA 2YIIA 1VDKA 4ADMA 1J3UA 5EYTA 3C8TA 4EEIA 2PTRA 5EYVA 3CZOA 1U15A 4NSLA 2X75A 5HW2A 4HGVA 4APBA 5F92A 4MX2A 4FFXA 3NZ4A 1YFEA 2O7FA 2O7DA 2HVGA 1Q5NA 3GZHA 4EFCA 5F91A 1C3CA 1TJ7A 2RJSA 3RRPA 1KQ7A 3GTDA 3RD8A 3R6YA 4CQ5A 1DOFA 2FUSA 4C5RA 2O78A 4ADLA 3KDYA 3OCEA 1HY1A 1YISA 2PFMA 4NLEA 2O6YA 3BHGA 3NO9A 1Y2MA 4FLCA 4BABA 5D6BA 1HY0A 4V2QA 4APAA 1FUPA 2NYFA 1GK2A 3E04A 2QVEA 3TV2A 2OHYA 3R6QA 1FUOA 1W27A 1EB4A 1K62A 1GK3A 1B8FA 1GKJA 1YFMA 2J91A 4C6GA 1C3UA 4BAAA 2QGAB 3UNVA 1FUQA 1AUWA 1T6JA 3KDZA 1JSWA 1DCNA 1K7WA 1U16A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2O7B A;  1T6P A;  2O7E A;  4C5S A;  2RJR A;  4C5U A;  4V2R A;  1TJV A;  1GKM A;  1XWO A;  3R6V A;  3QBP A;  3OCF A;  1I0A A;  2PTQ A;  1TJW A;  1FUR A;  1TJU A;  1RE5 A;  2VD6 A;  2PTS A;  2E9F A;  2NYN A;  2YII A;  1VDK A;  4ADM A;  1J3U A;  5EYT A;  3C8T A;  4EEI A;  2PTR A;  5EYV A;  3CZO A;  1U15 A;  4NSL A;  2X75 A;  5HW2 A;  4HGV A;  4APB A;  5F92 A;  4MX2 A;  4FFX A;  3NZ4 A;  1YFE A;  2O7F A;  2O7D A;  2HVG A;  1Q5N A;  3GZH A;  4EFC A;  5F91 A;  1C3C A;  1TJ7 A;  2RJS A;  3RRP A;  1KQ7 A;  3GTD A;  3RD8 A;  3R6Y A;  4CQ5 A;  1DOF A;  2FUS A;  4C5R A;  2O78 A;  4ADL A;  3KDY A;  3OCE A;  1HY1 A;  1YIS A;  2PFM A;  4NLE A;  2O6Y A;  3BHG A;  3NO9 A;  1Y2M A;  4FLC A;  4BAB A;  5D6B A;  1HY0 A;  4V2Q A;  4APA A;  1FUP A;  2NYF A;  1GK2 A;  3E04 A;  2QVE A;  3TV2 A;  2OHY A;  3R6Q A;  1FUO A;  1W27 A;  1EB4 A;  1K62 A;  1GK3 A;  1B8F A;  1GKJ A;  1YFM A;  2J91 A;  4C6G A;  1C3U A;  4BAA A;  2QGA B;  3UNV A;  1FUQ A;  1AUW A;  1T6J A;  3KDZ A;  1JSW A;  1DCN A;  1K7W A;  1U16 A; 
#chains in the Genus database with same CATH topology
 2O7B A;  1T6P A;  2O7E A;  1Z4P X;  4YIH A;  4C5S A;  2D28 C;  4IQJ M;  2RJR A;  1Z4Q A;  4C5U A;  4V2R A;  1TJV A;  1XLY A;  4L57 A;  1GKM A;  1XWO A;  3R6V A;  3QBP A;  4WNL A;  4L6C A;  3OCF A;  1I0A A;  2PTQ A;  1TJW A;  1FUR A;  1TJU A;  1RE5 A;  1U0L A;  2VD6 A;  2PTS A;  3U13 A;  2E9F A;  2JAW A;  2NYN A;  2FEL A;  2YII A;  4E88 A;  1Z4I A;  2JAR A;  1VDK A;  4ADM A;  4MUM A;  1J3U A;  5EYT A;  3C8T A;  4EEI A;  2PTR A;  5EYV A;  4A15 A;  1Z4L A;  1K7W A;  3CZO A;  1U15 A;  5M0I A;  4NSL A;  2X75 A;  4L6A A;  5HW2 A;  1Z4J A;  4HGV A;  4APB A;  5F92 A;  4MX2 A;  4FFX A;  3NZ4 A;  1YFE A;  2O7F A;  2O7D A;  2I7D A;  2HVG A;  1Q5N A;  3GZH A;  4EFC A;  5F91 A;  1C3C A;  1TJ7 A;  3U19 A;  3CI0 K;  2RJS A;  3RRP A;  2JAO A;  1KQ7 A;  2D27 A;  3GTD A;  3RD8 A;  3R6Y A;  4CQ5 A;  1DOF A;  2FUS A;  4C5R A;  1Q91 A;  2O78 A;  4ADL A;  3KDY A;  3OCE A;  1HY1 A;  1YIS A;  4NFL A;  2PFM A;  4NLE A;  2O6Y A;  3BHG A;  3NO9 A;  1Y2M A;  3CRV A;  4FLC A;  3F4S A;  2RCN A;  4BAB A;  1T9H A;  5D6B A;  1HY0 A;  5H8W A;  2VSF A;  4V2Q A;  4APA A;  1FUP A;  2NYF A;  1GK2 A;  1IW7 D;  2FEN A;  3E04 A;  2QVE A;  1MH9 A;  2JAU A;  2YV5 A;  5M0J A;  1Z4K A;  3TV2 A;  2OHY A;  3R6Q A;  3CRW 1;  1XMC A;  1FUO A;  1EB4 A;  1W27 A;  1K62 A;  1GK3 A;  1XMD A;  1B8F A;  1GKJ A;  1YFM A;  1XL8 A;  2J91 A;  1XL7 A;  4C6G A;  1C3U A;  4BAA A;  2QGA B;  3UNV A;  1FUQ A;  3BWV A;  4MWO A;  3F4R A;  1AUW A;  1T6J A;  3KDZ A;  1JSW A;  1DCN A;  3F4T A;  4YIK A;  1Z4M A;  1U16 A;  2VL7 A;  1Q92 A; 
#chains in the Genus database with same CATH homology
 2O7B A;  1T6P A;  2O7E A;  4C5S A;  2RJR A;  4C5U A;  4V2R A;  1TJV A;  1GKM A;  1XWO A;  3R6V A;  3QBP A;  3OCF A;  1I0A A;  2PTQ A;  1TJW A;  1FUR A;  1TJU A;  1RE5 A;  2VD6 A;  2PTS A;  2E9F A;  2NYN A;  2YII A;  1VDK A;  4ADM A;  1J3U A;  5EYT A;  3C8T A;  4EEI A;  2PTR A;  5EYV A;  3CZO A;  1U15 A;  4NSL A;  2X75 A;  5HW2 A;  4HGV A;  4APB A;  5F92 A;  4MX2 A;  4FFX A;  3NZ4 A;  1YFE A;  2O7F A;  2O7D A;  2HVG A;  1Q5N A;  3GZH A;  4EFC A;  5F91 A;  1C3C A;  1TJ7 A;  2RJS A;  3RRP A;  1KQ7 A;  3GTD A;  3RD8 A;  3R6Y A;  4CQ5 A;  1DOF A;  2FUS A;  4C5R A;  2O78 A;  4ADL A;  3KDY A;  3OCE A;  1HY1 A;  1YIS A;  2PFM A;  4NLE A;  2O6Y A;  3BHG A;  3NO9 A;  1Y2M A;  4FLC A;  4BAB A;  5D6B A;  1HY0 A;  4V2Q A;  4APA A;  1FUP A;  2NYF A;  1GK2 A;  3E04 A;  2QVE A;  3TV2 A;  2OHY A;  3R6Q A;  1FUO A;  1W27 A;  1EB4 A;  1K62 A;  1GK3 A;  1B8F A;  1GKJ A;  1YFM A;  2J91 A;  4C6G A;  1C3U A;  4BAA A;  2QGA B;  3UNV A;  1FUQ A;  1AUW A;  1T6J A;  3KDZ A;  1JSW A;  1DCN A;  1K7W A;  1U16 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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