4ADMA

Crystal structure of rv1098c in complex with meso-tartrate
Total Genus 178
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
178
sequence length
459
structure length
450
Chain Sequence
NYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Lyase
molecule keywords FUMARATE HYDRATASE CLASS II
total genus 178
structure length 450
sequence length 459
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2011-12-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4admA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4admA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4admA02
4EFCA 4V2QA 3CZOA 2RJRA 2YIIA 2NYFA 1YISA 2FUSA 3OCEA 1K7WA 3GTDA 1W27A 5HW2A 4FLCA 1FUOA 3R6VA 1GK2A 2E9FA 1FUPA 4CQ5A 2O7FA 1T6PA 1EB4A 1XWOA 1AUWA 3BHGA 1TJ7A 4NLEA 3KDZA 4BAAA 4EEIA 1VDKA 4APBA 1YFEA 5F92A 1YFMA 1HY0A 3NZ4A 4APAA 2O78A 1RE5A 2PTQA 1TJVA 3C8TA 3E04A 1DOFA 1FUQA 3RD8A 4HGVA 1B8FA 3NO9A 1T6JA 1KQ7A 1TJWA 1FURA 1I0AA 2NYNA 5D6BA 2O7DA 4C5UA 1U15A 3OCFA 1J3UA 1HY1A 1C3CA 1DCNA 3GZHA 2O7BA 4V2RA 2VD6A 2PTRA 4NSLA 3UNVA 1K62A 4C5RA 1Y2MA 3QBPA 2QGAB 5F91A 2J91A 1U16A 4ADLA 2QVEA 2RJSA 2O7EA 1GKJA 3R6QA 2OHYA 1TJUA 4BABA 4ADMA 1C3UA 4MX2A 2O6YA 4C6GA 3TV2A 4C5SA 2PTSA 1GKMA 3RRPA 5EYTA 5EYVA 3KDYA 4FFXA 2X75A 1JSWA 1GK3A 2PFMA 3R6YA 2HVGA 1Q5NA
chains in the Genus database with same CATH superfamily
2YV5A 4L6AA 4EFCA 4V2QA 1Z4JA 3CZOA 2RJRA 1T9HA 2YIIA 2NYFA 1YISA 4E88A 5M0IA 2FUSA 3OCEA 1K7WA 3GTDA 1W27A 5HW2A 4FLCA 1FUOA 3R6VA 1GK2A 2E9FA 1FUPA 4CQ5A 2D28C 2O7FA 1T6PA 1EB4A 1XWOA 1Z4KA 1XLYA 1AUWA 3BHGA 4A15A 4NLEA 1TJ7A 1Z4MA 1XL7A 4IQJM 3KDZA 4EEIA 4BAAA 2JARA 4WNLA 4L6CA 1VDKA 4APBA 1YFEA 5F92A 1XL8A 4YIHA 1Q92A 1YFMA 2I7DA 4L57A 3R6YA 2VSFA 4MWOA 2JAWA 1HY0A 3U13A 1Q91A 3NZ4A 1Z4IA 4APAA 2D27A 1RE5A 2O78A 2PTQA 1TJVA 3C8TA 4YIKA 3E04A 1Z4LA 3U19A 1DOFA 1FUQA 3RD8A 4HGVA 1Z4PX 3NO9A 1B8FA 1T6JA 2FENA 1KQ7A 1U0LA 1TJWA 1FURA 1I0AA 2NYNA 5D6BA 2O7DA 4C5UA 5M0JA 1U15A 3OCFA 1J3UA 5H8WA 1HY1A 1C3CA 1DCNA 2JAOA 3GZHA 2O7BA 4V2RA 3CRW1 2VD6A 2PTRA 4NSLA 3UNVA 1K62A 1XMDA 3F4TA 4C5RA 3BWVA 1Y2MA 3QBPA 2JAUA 2QGAB 5F91A 3F4RA 2J91A 1U16A 3CI0K 4ADLA 2QVEA 2RJSA 2FELA 2O7EA 1GKJA 3R6QA 3CRVA 2OHYA 1TJUA 4BABA 4ADMA 1C3UA 4NFLA 4MX2A 1XMCA 2O6YA 2VL7A 4C6GA 3F4SA 3TV2A 4C5SA 2PTSA 1GKMA 1Z4QA 3RRPA 5EYTA 2RCNA 5EYVA 1MH9A 3KDYA 2X75A 4FFXA 1JSWA 4MUMA 2PFMA 1GK3A 2HVGA 1IW7D 1Q5NA
chains in the Genus database with same CATH topology
4EFCA 4V2QA 3CZOA 2RJRA 2YIIA 2NYFA 1YISA 2FUSA 3OCEA 1K7WA 3GTDA 1W27A 5HW2A 4FLCA 1FUOA 3R6VA 1GK2A 2E9FA 1FUPA 4CQ5A 2O7FA 1T6PA 1EB4A 1XWOA 1AUWA 3BHGA 1TJ7A 4NLEA 3KDZA 4BAAA 4EEIA 1VDKA 4APBA 1YFEA 5F92A 1YFMA 1HY0A 3NZ4A 4APAA 2O78A 1RE5A 2PTQA 1TJVA 3C8TA 3E04A 1DOFA 1FUQA 3RD8A 4HGVA 1B8FA 3NO9A 1T6JA 1KQ7A 1TJWA 1FURA 1I0AA 2NYNA 5D6BA 2O7DA 4C5UA 1U15A 3OCFA 1J3UA 1HY1A 1C3CA 1DCNA 3GZHA 2O7BA 4V2RA 2VD6A 2PTRA 4NSLA 3UNVA 1K62A 4C5RA 1Y2MA 3QBPA 2QGAB 5F91A 2J91A 1U16A 4ADLA 2QVEA 2RJSA 2O7EA 1GKJA 3R6QA 2OHYA 1TJUA 4BABA 4ADMA 1C3UA 4MX2A 2O6YA 4C6GA 3TV2A 4C5SA 2PTSA 1GKMA 3RRPA 5EYTA 5EYVA 3KDYA 4FFXA 2X75A 1JSWA 1GK3A 2PFMA 3R6YA 2HVGA 1Q5NA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EFC A;  4V2Q A;  3CZO A;  2RJR A;  2YII A;  2NYF A;  1YIS A;  2FUS A;  3OCE A;  1K7W A;  3GTD A;  1W27 A;  5HW2 A;  4FLC A;  1FUO A;  3R6V A;  1GK2 A;  2E9F A;  1FUP A;  4CQ5 A;  2O7F A;  1T6P A;  1EB4 A;  1XWO A;  1AUW A;  3BHG A;  1TJ7 A;  4NLE A;  3KDZ A;  4BAA A;  4EEI A;  1VDK A;  4APB A;  1YFE A;  5F92 A;  1YFM A;  1HY0 A;  3NZ4 A;  4APA A;  2O78 A;  1RE5 A;  2PTQ A;  1TJV A;  3C8T A;  3E04 A;  1DOF A;  1FUQ A;  3RD8 A;  4HGV A;  1B8F A;  3NO9 A;  1T6J A;  1KQ7 A;  1TJW A;  1FUR A;  1I0A A;  2NYN A;  5D6B A;  2O7D A;  4C5U A;  1U15 A;  3OCF A;  1J3U A;  1HY1 A;  1C3C A;  1DCN A;  3GZH A;  2O7B A;  4V2R A;  2VD6 A;  2PTR A;  4NSL A;  3UNV A;  1K62 A;  4C5R A;  1Y2M A;  3QBP A;  2QGA B;  5F91 A;  2J91 A;  1U16 A;  4ADL A;  2QVE A;  2RJS A;  2O7E A;  1GKJ A;  3R6Q A;  2OHY A;  1TJU A;  4BAB A;  4ADM A;  1C3U A;  4MX2 A;  2O6Y A;  4C6G A;  3TV2 A;  4C5S A;  2PTS A;  1GKM A;  3RRP A;  5EYT A;  5EYV A;  3KDY A;  4FFX A;  2X75 A;  1JSW A;  1GK3 A;  2PFM A;  3R6Y A;  2HVG A;  1Q5N A; 
#chains in the Genus database with same CATH topology
 2YV5 A;  4L6A A;  4EFC A;  4V2Q A;  1Z4J A;  3CZO A;  2RJR A;  1T9H A;  2YII A;  2NYF A;  1YIS A;  4E88 A;  5M0I A;  2FUS A;  3OCE A;  1K7W A;  3GTD A;  1W27 A;  5HW2 A;  4FLC A;  1FUO A;  3R6V A;  1GK2 A;  2E9F A;  1FUP A;  4CQ5 A;  2D28 C;  2O7F A;  1T6P A;  1EB4 A;  1XWO A;  1Z4K A;  1XLY A;  1AUW A;  3BHG A;  4A15 A;  4NLE A;  1TJ7 A;  1Z4M A;  1XL7 A;  4IQJ M;  3KDZ A;  4EEI A;  4BAA A;  2JAR A;  4WNL A;  4L6C A;  1VDK A;  4APB A;  1YFE A;  5F92 A;  1XL8 A;  4YIH A;  1Q92 A;  1YFM A;  2I7D A;  4L57 A;  3R6Y A;  2VSF A;  4MWO A;  2JAW A;  1HY0 A;  3U13 A;  1Q91 A;  3NZ4 A;  1Z4I A;  4APA A;  2D27 A;  1RE5 A;  2O78 A;  2PTQ A;  1TJV A;  3C8T A;  4YIK A;  3E04 A;  1Z4L A;  3U19 A;  1DOF A;  1FUQ A;  3RD8 A;  4HGV A;  1Z4P X;  3NO9 A;  1B8F A;  1T6J A;  2FEN A;  1KQ7 A;  1U0L A;  1TJW A;  1FUR A;  1I0A A;  2NYN A;  5D6B A;  2O7D A;  4C5U A;  5M0J A;  1U15 A;  3OCF A;  1J3U A;  5H8W A;  1HY1 A;  1C3C A;  1DCN A;  2JAO A;  3GZH A;  2O7B A;  4V2R A;  3CRW 1;  2VD6 A;  2PTR A;  4NSL A;  3UNV A;  1K62 A;  1XMD A;  3F4T A;  4C5R A;  3BWV A;  1Y2M A;  3QBP A;  2JAU A;  2QGA B;  5F91 A;  3F4R A;  2J91 A;  1U16 A;  3CI0 K;  4ADL A;  2QVE A;  2RJS A;  2FEL A;  2O7E A;  1GKJ A;  3R6Q A;  3CRV A;  2OHY A;  1TJU A;  4BAB A;  4ADM A;  1C3U A;  4NFL A;  4MX2 A;  1XMC A;  2O6Y A;  2VL7 A;  4C6G A;  3F4S A;  3TV2 A;  4C5S A;  2PTS A;  1GKM A;  1Z4Q A;  3RRP A;  5EYT A;  2RCN A;  5EYV A;  1MH9 A;  3KDY A;  2X75 A;  4FFX A;  1JSW A;  4MUM A;  2PFM A;  1GK3 A;  2HVG A;  1IW7 D;  1Q5N A; 
#chains in the Genus database with same CATH homology
 4EFC A;  4V2Q A;  3CZO A;  2RJR A;  2YII A;  2NYF A;  1YIS A;  2FUS A;  3OCE A;  1K7W A;  3GTD A;  1W27 A;  5HW2 A;  4FLC A;  1FUO A;  3R6V A;  1GK2 A;  2E9F A;  1FUP A;  4CQ5 A;  2O7F A;  1T6P A;  1EB4 A;  1XWO A;  1AUW A;  3BHG A;  1TJ7 A;  4NLE A;  3KDZ A;  4BAA A;  4EEI A;  1VDK A;  4APB A;  1YFE A;  5F92 A;  1YFM A;  1HY0 A;  3NZ4 A;  4APA A;  2O78 A;  1RE5 A;  2PTQ A;  1TJV A;  3C8T A;  3E04 A;  1DOF A;  1FUQ A;  3RD8 A;  4HGV A;  1B8F A;  3NO9 A;  1T6J A;  1KQ7 A;  1TJW A;  1FUR A;  1I0A A;  2NYN A;  5D6B A;  2O7D A;  4C5U A;  1U15 A;  3OCF A;  1J3U A;  1HY1 A;  1C3C A;  1DCN A;  3GZH A;  2O7B A;  4V2R A;  2VD6 A;  2PTR A;  4NSL A;  3UNV A;  1K62 A;  4C5R A;  1Y2M A;  3QBP A;  2QGA B;  5F91 A;  2J91 A;  1U16 A;  4ADL A;  2QVE A;  2RJS A;  2O7E A;  1GKJ A;  3R6Q A;  2OHY A;  1TJU A;  4BAB A;  4ADM A;  1C3U A;  4MX2 A;  2O6Y A;  4C6G A;  3TV2 A;  4C5S A;  2PTS A;  1GKM A;  3RRP A;  5EYT A;  5EYV A;  3KDY A;  4FFX A;  2X75 A;  1JSW A;  1GK3 A;  2PFM A;  3R6Y A;  2HVG A;  1Q5N A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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