4ADMA

Crystal structure of rv1098c in complex with meso-tartrate
Total Genus 178
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
178
sequence length
459
structure length
450
Chain Sequence
NYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords FUMARATE HYDRATASE CLASS II
publication title Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Lyase
total genus 178
structure length 450
sequence length 459
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2011-12-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4admA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4admA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4admA02
1FUPA 5F91A 2J91A 4NLEA 2O7FA 2YIIA 1FUOA 4EFCA 2E9FA 4CQ5A 5F92A 4C5RA 3RRPA 3TV2A 1FURA 3OCEA 3C8TA 2HVGA 5D6BA 3R6YA 1J3UA 1GKMA 2O7DA 1YFEA 5HW2A 4C6GA 4ADLA 1GKJA 1T6PA 1XWOA 2PFMA 1I0AA 1HY0A 3CZOA 1DCNA 1YFMA 4V2RA 1GK2A 4APBA 4C5SA 3KDYA 3NZ4A 1GK3A 1EB4A 2O6YA 4EEIA 5EYTA 1TJVA 2VD6A 4MX2A 3UNVA 1TJUA 3BHGA 1K7WA 4FLCA 3R6QA 2QGAB 1HY1A 1C3UA 1YISA 4HGVA 3OCFA 3GZHA 2QVEA 4NSLA 2PTQA 2PTSA 1AUWA 4APAA 3KDZA 2NYFA 1RE5A 2PTRA 4BAAA 1TJ7A 1U16A 4BABA 2RJRA 3NO9A 1VDKA 4ADMA 1W27A 2NYNA 5EYVA 4C5UA 3GTDA 4FFXA 2X75A 2OHYA 2O7BA 1JSWA 1Q5NA 1Y2MA 1K62A 2RJSA 1KQ7A 2O78A 3R6VA 1DOFA 3E04A 1C3CA 1U15A 1FUQA 2FUSA 2O7EA 1TJWA 4V2QA 3QBPA 1T6JA 1B8FA 3RD8A
chains in the Genus database with same CATH superfamily
2YV5A 2VL7A 1FUPA 5F91A 2J91A 2FENA 4NLEA 2O7FA 1Z4MA 2YIIA 1FUOA 4EFCA 2E9FA 4CQ5A 5F92A 4C5RA 4L6CA 3RRPA 3TV2A 1FURA 3OCEA 3C8TA 3F4RA 4L6AA 2HVGA 5D6BA 3R6YA 1J3UA 1GKMA 2O7DA 3F4TA 5HW2A 3CRVA 4C6GA 3BWVA 4ADLA 1GKJA 1T6PA 1XWOA 2PFMA 4E88A 2FELA 1Z4IA 2D27A 1I0AA 2JAOA 4MUMA 1HY0A 2RCNA 3CZOA 1DCNA 1YFMA 1Z4KA 3RD8A 2D28C 4V2RA 1GK2A 4APBA 4C5SA 3KDYA 3NZ4A 1GK3A 3U13A 1Z4PX 2JARA 3F4SA 1Z4LA 1EB4A 2O6YA 1XLYA 5M0IA 4EEIA 4A15A 5EYTA 1TJVA 2VD6A 1Q92A 4MX2A 1XL8A 3UNVA 1TJUA 1T9HA 3BHGA 1K7WA 4FLCA 3R6QA 2QGAB 1HY1A 5M0JA 1C3UA 1YISA 4HGVA 4YIKA 3OCFA 3GZHA 4MWOA 1Z4JA 2QVEA 4NSLA 2PTQA 2PTSA 1AUWA 4APAA 3KDZA 2NYFA 1RE5A 2JAUA 2PTRA 1TJ7A 4YIHA 3CI0K 4IQJM 1U16A 4BAAA 4BABA 1XL7A 1XMCA 2I7DA 1Z4QA 2RJRA 1MH9A 3NO9A 1VDKA 4ADMA 1W27A 2NYNA 5EYVA 4C5UA 4NFLA 2VSFA 3GTDA 4FFXA 2X75A 2OHYA 2O7BA 1JSWA 1Q5NA 3CRW1 1Y2MA 1K62A 2RJSA 1KQ7A 2O78A 3R6VA 1DOFA 3E04A 1Q91A 1XMDA 1IW7D 3U19A 5H8WA 1C3CA 1U15A 1FUQA 2FUSA 2O7EA 1TJWA 4V2QA 1U0LA 4WNLA 3QBPA 4L57A 2JAWA 1T6JA 1B8FA 1YFEA
chains in the Genus database with same CATH topology
1FUPA 5F91A 2J91A 4NLEA 2O7FA 2YIIA 1FUOA 4EFCA 2E9FA 4CQ5A 5F92A 4C5RA 3RRPA 3TV2A 1FURA 3OCEA 3C8TA 2HVGA 5D6BA 3R6YA 1J3UA 1GKMA 2O7DA 1YFEA 5HW2A 4C6GA 4ADLA 1GKJA 1T6PA 1XWOA 2PFMA 1I0AA 1HY0A 3CZOA 1DCNA 1YFMA 4V2RA 1GK2A 4APBA 4C5SA 3KDYA 3NZ4A 1GK3A 1EB4A 2O6YA 4EEIA 5EYTA 1TJVA 2VD6A 4MX2A 3UNVA 1TJUA 3BHGA 1K7WA 4FLCA 3R6QA 2QGAB 1HY1A 1C3UA 1YISA 4HGVA 3OCFA 3GZHA 2QVEA 4NSLA 2PTQA 2PTSA 1AUWA 4APAA 3KDZA 2NYFA 1RE5A 2PTRA 4BAAA 1TJ7A 1U16A 4BABA 2RJRA 3NO9A 1VDKA 4ADMA 1W27A 2NYNA 5EYVA 4C5UA 3GTDA 4FFXA 2X75A 2OHYA 2O7BA 1JSWA 1Q5NA 1Y2MA 1K62A 2RJSA 1KQ7A 2O78A 3R6VA 1DOFA 3E04A 1C3CA 1U15A 1FUQA 2FUSA 2O7EA 1TJWA 4V2QA 3QBPA 1T6JA 1B8FA 3RD8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FUP A;  5F91 A;  2J91 A;  4NLE A;  2O7F A;  2YII A;  1FUO A;  4EFC A;  2E9F A;  4CQ5 A;  5F92 A;  4C5R A;  3RRP A;  3TV2 A;  1FUR A;  3OCE A;  3C8T A;  2HVG A;  5D6B A;  3R6Y A;  1J3U A;  1GKM A;  2O7D A;  1YFE A;  5HW2 A;  4C6G A;  4ADL A;  1GKJ A;  1T6P A;  1XWO A;  2PFM A;  1I0A A;  1HY0 A;  3CZO A;  1DCN A;  1YFM A;  4V2R A;  1GK2 A;  4APB A;  4C5S A;  3KDY A;  3NZ4 A;  1GK3 A;  1EB4 A;  2O6Y A;  4EEI A;  5EYT A;  1TJV A;  2VD6 A;  4MX2 A;  3UNV A;  1TJU A;  3BHG A;  1K7W A;  4FLC A;  3R6Q A;  2QGA B;  1HY1 A;  1C3U A;  1YIS A;  4HGV A;  3OCF A;  3GZH A;  2QVE A;  4NSL A;  2PTQ A;  2PTS A;  1AUW A;  4APA A;  3KDZ A;  2NYF A;  1RE5 A;  2PTR A;  4BAA A;  1TJ7 A;  1U16 A;  4BAB A;  2RJR A;  3NO9 A;  1VDK A;  4ADM A;  1W27 A;  2NYN A;  5EYV A;  4C5U A;  3GTD A;  4FFX A;  2X75 A;  2OHY A;  2O7B A;  1JSW A;  1Q5N A;  1Y2M A;  1K62 A;  2RJS A;  1KQ7 A;  2O78 A;  3R6V A;  1DOF A;  3E04 A;  1C3C A;  1U15 A;  1FUQ A;  2FUS A;  2O7E A;  1TJW A;  4V2Q A;  3QBP A;  1T6J A;  1B8F A;  3RD8 A; 
#chains in the Genus database with same CATH topology
 2YV5 A;  2VL7 A;  1FUP A;  5F91 A;  2J91 A;  2FEN A;  4NLE A;  2O7F A;  1Z4M A;  2YII A;  1FUO A;  4EFC A;  2E9F A;  4CQ5 A;  5F92 A;  4C5R A;  4L6C A;  3RRP A;  3TV2 A;  1FUR A;  3OCE A;  3C8T A;  3F4R A;  4L6A A;  2HVG A;  5D6B A;  3R6Y A;  1J3U A;  1GKM A;  2O7D A;  3F4T A;  5HW2 A;  3CRV A;  4C6G A;  3BWV A;  4ADL A;  1GKJ A;  1T6P A;  1XWO A;  2PFM A;  4E88 A;  2FEL A;  1Z4I A;  2D27 A;  1I0A A;  2JAO A;  4MUM A;  1HY0 A;  2RCN A;  3CZO A;  1DCN A;  1YFM A;  1Z4K A;  3RD8 A;  2D28 C;  4V2R A;  1GK2 A;  4APB A;  4C5S A;  3KDY A;  3NZ4 A;  1GK3 A;  3U13 A;  1Z4P X;  2JAR A;  3F4S A;  1Z4L A;  1EB4 A;  2O6Y A;  1XLY A;  5M0I A;  4EEI A;  4A15 A;  5EYT A;  1TJV A;  2VD6 A;  1Q92 A;  4MX2 A;  1XL8 A;  3UNV A;  1TJU A;  1T9H A;  3BHG A;  1K7W A;  4FLC A;  3R6Q A;  2QGA B;  1HY1 A;  5M0J A;  1C3U A;  1YIS A;  4HGV A;  4YIK A;  3OCF A;  3GZH A;  4MWO A;  1Z4J A;  2QVE A;  4NSL A;  2PTQ A;  2PTS A;  1AUW A;  4APA A;  3KDZ A;  2NYF A;  1RE5 A;  2JAU A;  2PTR A;  1TJ7 A;  4YIH A;  3CI0 K;  4IQJ M;  1U16 A;  4BAA A;  4BAB A;  1XL7 A;  1XMC A;  2I7D A;  1Z4Q A;  2RJR A;  1MH9 A;  3NO9 A;  1VDK A;  4ADM A;  1W27 A;  2NYN A;  5EYV A;  4C5U A;  4NFL A;  2VSF A;  3GTD A;  4FFX A;  2X75 A;  2OHY A;  2O7B A;  1JSW A;  1Q5N A;  3CRW 1;  1Y2M A;  1K62 A;  2RJS A;  1KQ7 A;  2O78 A;  3R6V A;  1DOF A;  3E04 A;  1Q91 A;  1XMD A;  1IW7 D;  3U19 A;  5H8W A;  1C3C A;  1U15 A;  1FUQ A;  2FUS A;  2O7E A;  1TJW A;  4V2Q A;  1U0L A;  4WNL A;  3QBP A;  4L57 A;  2JAW A;  1T6J A;  1B8F A;  1YFE A; 
#chains in the Genus database with same CATH homology
 1FUP A;  5F91 A;  2J91 A;  4NLE A;  2O7F A;  2YII A;  1FUO A;  4EFC A;  2E9F A;  4CQ5 A;  5F92 A;  4C5R A;  3RRP A;  3TV2 A;  1FUR A;  3OCE A;  3C8T A;  2HVG A;  5D6B A;  3R6Y A;  1J3U A;  1GKM A;  2O7D A;  1YFE A;  5HW2 A;  4C6G A;  4ADL A;  1GKJ A;  1T6P A;  1XWO A;  2PFM A;  1I0A A;  1HY0 A;  3CZO A;  1DCN A;  1YFM A;  4V2R A;  1GK2 A;  4APB A;  4C5S A;  3KDY A;  3NZ4 A;  1GK3 A;  1EB4 A;  2O6Y A;  4EEI A;  5EYT A;  1TJV A;  2VD6 A;  4MX2 A;  3UNV A;  1TJU A;  3BHG A;  1K7W A;  4FLC A;  3R6Q A;  2QGA B;  1HY1 A;  1C3U A;  1YIS A;  4HGV A;  3OCF A;  3GZH A;  2QVE A;  4NSL A;  2PTQ A;  2PTS A;  1AUW A;  4APA A;  3KDZ A;  2NYF A;  1RE5 A;  2PTR A;  4BAA A;  1TJ7 A;  1U16 A;  4BAB A;  2RJR A;  3NO9 A;  1VDK A;  4ADM A;  1W27 A;  2NYN A;  5EYV A;  4C5U A;  3GTD A;  4FFX A;  2X75 A;  2OHY A;  2O7B A;  1JSW A;  1Q5N A;  1Y2M A;  1K62 A;  2RJS A;  1KQ7 A;  2O78 A;  3R6V A;  1DOF A;  3E04 A;  1C3C A;  1U15 A;  1FUQ A;  2FUS A;  2O7E A;  1TJW A;  4V2Q A;  3QBP A;  1T6J A;  1B8F A;  3RD8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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