4ADMA

Crystal structure of rv1098c in complex with meso-tartrate
Total Genus 178
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
178
sequence length
459
structure length
450
Chain Sequence
NYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords FUMARATE HYDRATASE CLASS II
publication title Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Lyase
total genus 178
structure length 450
sequence length 459
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2011-12-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4admA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4admA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4admA02
4NSLA 3E04A 1YFMA 1FUPA 1Y2MA 2OHYA 2HVGA 1K62A 2PTQA 2J91A 2RJRA 3RRPA 1YFEA 1J3UA 2YIIA 1U16A 1RE5A 4APAA 1B8FA 1GKMA 1Q5NA 2O7BA 3TV2A 2NYNA 1FUOA 4C5SA 4V2QA 1KQ7A 5EYTA 1C3CA 1K7WA 3RD8A 2VD6A 2O7EA 3OCFA 3QBPA 3KDZA 2X75A 5EYVA 1VDKA 3CZOA 1AUWA 2QGAB 4ADLA 3GZHA 1DOFA 5HW2A 1W27A 1FURA 2NYFA 4EEIA 1JSWA 4CQ5A 1EB4A 1TJWA 3R6VA 3NZ4A 5D6BA 1FUQA 1C3UA 4NLEA 2O6YA 4APBA 1TJUA 1T6JA 4HGVA 4MX2A 2O78A 5F92A 3C8TA 1TJ7A 1YISA 1GKJA 3UNVA 3NO9A 4V2RA 2RJSA 2O7DA 1U15A 4C5UA 1TJVA 1HY0A 3OCEA 4FLCA 1HY1A 1GK3A 4C5RA 5F91A 3KDYA 4FFXA 2PTSA 3GTDA 4ADMA 3R6QA 4EFCA 1GK2A 4BAAA 3R6YA 3BHGA 2E9FA 2FUSA 2PFMA 2PTRA 1DCNA 2O7FA 2QVEA 4BABA 1XWOA 4C6GA 1I0AA 1T6PA
chains in the Genus database with same CATH superfamily
4NSLA 1XMCA 3E04A 5M0IA 1XL8A 1YFMA 1FUPA 1Y2MA 2OHYA 1MH9A 4L6CA 2HVGA 1K62A 2PTQA 2J91A 2RJRA 3RRPA 1YFEA 4MWOA 5H8WA 2JAOA 1J3UA 2I7DA 2YIIA 1U16A 1RE5A 4APAA 1B8FA 1GKMA 4YIKA 3U13A 1Q5NA 2O7BA 2D28C 3TV2A 2YV5A 2NYNA 1FUOA 4C5SA 4V2QA 4WNLA 1KQ7A 5EYTA 1C3CA 1K7WA 3RD8A 4L6AA 2VD6A 3BWVA 2O7EA 3OCFA 3QBPA 3KDZA 2X75A 2VL7A 5EYVA 1Z4KA 1VDKA 3CZOA 1AUWA 2QGAB 4NFLA 4ADLA 3GZHA 1DOFA 5HW2A 5M0JA 1W27A 3CRW1 2VSFA 1FURA 2NYFA 4EEIA 1JSWA 4CQ5A 3F4RA 1EB4A 1TJWA 2JAWA 3R6VA 3NZ4A 2JARA 1XL7A 5D6BA 4IQJM 1XMDA 1Z4QA 1FUQA 1C3UA 4NLEA 2O6YA 4APBA 1TJUA 1XLYA 3F4TA 1T6JA 1U0LA 4HGVA 4L57A 4MX2A 2O78A 5F92A 3CRVA 3C8TA 1TJ7A 3U19A 1YISA 1GKJA 3UNVA 3NO9A 4YIHA 4V2RA 2RJSA 1IW7D 2O7DA 1U15A 4C5UA 1Z4LA 2JAUA 1TJVA 1HY0A 3OCEA 4E88A 4FLCA 1T9HA 1HY1A 4MUMA 1GK3A 4C5RA 3F4SA 1Z4PX 5F91A 2RCNA 3KDYA 1Q92A 4FFXA 2PTSA 2FENA 3GTDA 4ADMA 1Z4JA 3R6QA 4EFCA 1GK2A 4BAAA 3R6YA 1Z4IA 3BHGA 1Z4MA 2D27A 2E9FA 2FUSA 2PFMA 2PTRA 1DCNA 2O7FA 4A15A 2QVEA 4BABA 1XWOA 2FELA 4C6GA 1I0AA 3CI0K 1Q91A 1T6PA
chains in the Genus database with same CATH topology
4NSLA 3E04A 1YFMA 1FUPA 1Y2MA 2OHYA 2HVGA 1K62A 2PTQA 2J91A 2RJRA 3RRPA 1YFEA 1J3UA 2YIIA 1U16A 1RE5A 4APAA 1B8FA 1GKMA 1Q5NA 2O7BA 3TV2A 2NYNA 1FUOA 4C5SA 4V2QA 1KQ7A 5EYTA 1C3CA 1K7WA 3RD8A 2VD6A 2O7EA 3OCFA 3QBPA 3KDZA 2X75A 5EYVA 1VDKA 3CZOA 1AUWA 2QGAB 4ADLA 3GZHA 1DOFA 5HW2A 1W27A 1FURA 2NYFA 4EEIA 1JSWA 4CQ5A 1EB4A 1TJWA 3R6VA 3NZ4A 5D6BA 1FUQA 1C3UA 4NLEA 2O6YA 4APBA 1TJUA 1T6JA 4HGVA 4MX2A 2O78A 5F92A 3C8TA 1TJ7A 1YISA 1GKJA 3UNVA 3NO9A 4V2RA 2RJSA 2O7DA 1U15A 4C5UA 1TJVA 1HY0A 3OCEA 4FLCA 1HY1A 1GK3A 4C5RA 5F91A 3KDYA 4FFXA 2PTSA 3GTDA 4ADMA 3R6QA 4EFCA 1GK2A 4BAAA 3R6YA 3BHGA 2E9FA 2FUSA 2PFMA 2PTRA 1DCNA 2O7FA 2QVEA 4BABA 1XWOA 4C6GA 1I0AA 1T6PA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4NSL A;  3E04 A;  1YFM A;  1FUP A;  1Y2M A;  2OHY A;  2HVG A;  1K62 A;  2PTQ A;  2J91 A;  2RJR A;  3RRP A;  1YFE A;  1J3U A;  2YII A;  1U16 A;  1RE5 A;  4APA A;  1B8F A;  1GKM A;  1Q5N A;  2O7B A;  3TV2 A;  2NYN A;  1FUO A;  4C5S A;  4V2Q A;  1KQ7 A;  5EYT A;  1C3C A;  1K7W A;  3RD8 A;  2VD6 A;  2O7E A;  3OCF A;  3QBP A;  3KDZ A;  2X75 A;  5EYV A;  1VDK A;  3CZO A;  1AUW A;  2QGA B;  4ADL A;  3GZH A;  1DOF A;  5HW2 A;  1W27 A;  1FUR A;  2NYF A;  4EEI A;  1JSW A;  4CQ5 A;  1EB4 A;  1TJW A;  3R6V A;  3NZ4 A;  5D6B A;  1FUQ A;  1C3U A;  4NLE A;  2O6Y A;  4APB A;  1TJU A;  1T6J A;  4HGV A;  4MX2 A;  2O78 A;  5F92 A;  3C8T A;  1TJ7 A;  1YIS A;  1GKJ A;  3UNV A;  3NO9 A;  4V2R A;  2RJS A;  2O7D A;  1U15 A;  4C5U A;  1TJV A;  1HY0 A;  3OCE A;  4FLC A;  1HY1 A;  1GK3 A;  4C5R A;  5F91 A;  3KDY A;  4FFX A;  2PTS A;  3GTD A;  4ADM A;  3R6Q A;  4EFC A;  1GK2 A;  4BAA A;  3R6Y A;  3BHG A;  2E9F A;  2FUS A;  2PFM A;  2PTR A;  1DCN A;  2O7F A;  2QVE A;  4BAB A;  1XWO A;  4C6G A;  1I0A A;  1T6P A; 
#chains in the Genus database with same CATH topology
 4NSL A;  1XMC A;  3E04 A;  5M0I A;  1XL8 A;  1YFM A;  1FUP A;  1Y2M A;  2OHY A;  1MH9 A;  4L6C A;  2HVG A;  1K62 A;  2PTQ A;  2J91 A;  2RJR A;  3RRP A;  1YFE A;  4MWO A;  5H8W A;  2JAO A;  1J3U A;  2I7D A;  2YII A;  1U16 A;  1RE5 A;  4APA A;  1B8F A;  1GKM A;  4YIK A;  3U13 A;  1Q5N A;  2O7B A;  2D28 C;  3TV2 A;  2YV5 A;  2NYN A;  1FUO A;  4C5S A;  4V2Q A;  4WNL A;  1KQ7 A;  5EYT A;  1C3C A;  1K7W A;  3RD8 A;  4L6A A;  2VD6 A;  3BWV A;  2O7E A;  3OCF A;  3QBP A;  3KDZ A;  2X75 A;  2VL7 A;  5EYV A;  1Z4K A;  1VDK A;  3CZO A;  1AUW A;  2QGA B;  4NFL A;  4ADL A;  3GZH A;  1DOF A;  5HW2 A;  5M0J A;  1W27 A;  3CRW 1;  2VSF A;  1FUR A;  2NYF A;  4EEI A;  1JSW A;  4CQ5 A;  3F4R A;  1EB4 A;  1TJW A;  2JAW A;  3R6V A;  3NZ4 A;  2JAR A;  1XL7 A;  5D6B A;  4IQJ M;  1XMD A;  1Z4Q A;  1FUQ A;  1C3U A;  4NLE A;  2O6Y A;  4APB A;  1TJU A;  1XLY A;  3F4T A;  1T6J A;  1U0L A;  4HGV A;  4L57 A;  4MX2 A;  2O78 A;  5F92 A;  3CRV A;  3C8T A;  1TJ7 A;  3U19 A;  1YIS A;  1GKJ A;  3UNV A;  3NO9 A;  4YIH A;  4V2R A;  2RJS A;  1IW7 D;  2O7D A;  1U15 A;  4C5U A;  1Z4L A;  2JAU A;  1TJV A;  1HY0 A;  3OCE A;  4E88 A;  4FLC A;  1T9H A;  1HY1 A;  4MUM A;  1GK3 A;  4C5R A;  3F4S A;  1Z4P X;  5F91 A;  2RCN A;  3KDY A;  1Q92 A;  4FFX A;  2PTS A;  2FEN A;  3GTD A;  4ADM A;  1Z4J A;  3R6Q A;  4EFC A;  1GK2 A;  4BAA A;  3R6Y A;  1Z4I A;  3BHG A;  1Z4M A;  2D27 A;  2E9F A;  2FUS A;  2PFM A;  2PTR A;  1DCN A;  2O7F A;  4A15 A;  2QVE A;  4BAB A;  1XWO A;  2FEL A;  4C6G A;  1I0A A;  3CI0 K;  1Q91 A;  1T6P A; 
#chains in the Genus database with same CATH homology
 4NSL A;  3E04 A;  1YFM A;  1FUP A;  1Y2M A;  2OHY A;  2HVG A;  1K62 A;  2PTQ A;  2J91 A;  2RJR A;  3RRP A;  1YFE A;  1J3U A;  2YII A;  1U16 A;  1RE5 A;  4APA A;  1B8F A;  1GKM A;  1Q5N A;  2O7B A;  3TV2 A;  2NYN A;  1FUO A;  4C5S A;  4V2Q A;  1KQ7 A;  5EYT A;  1C3C A;  1K7W A;  3RD8 A;  2VD6 A;  2O7E A;  3OCF A;  3QBP A;  3KDZ A;  2X75 A;  5EYV A;  1VDK A;  3CZO A;  1AUW A;  2QGA B;  4ADL A;  3GZH A;  1DOF A;  5HW2 A;  1W27 A;  1FUR A;  2NYF A;  4EEI A;  1JSW A;  4CQ5 A;  1EB4 A;  1TJW A;  3R6V A;  3NZ4 A;  5D6B A;  1FUQ A;  1C3U A;  4NLE A;  2O6Y A;  4APB A;  1TJU A;  1T6J A;  4HGV A;  4MX2 A;  2O78 A;  5F92 A;  3C8T A;  1TJ7 A;  1YIS A;  1GKJ A;  3UNV A;  3NO9 A;  4V2R A;  2RJS A;  2O7D A;  1U15 A;  4C5U A;  1TJV A;  1HY0 A;  3OCE A;  4FLC A;  1HY1 A;  1GK3 A;  4C5R A;  5F91 A;  3KDY A;  4FFX A;  2PTS A;  3GTD A;  4ADM A;  3R6Q A;  4EFC A;  1GK2 A;  4BAA A;  3R6Y A;  3BHG A;  2E9F A;  2FUS A;  2PFM A;  2PTR A;  1DCN A;  2O7F A;  2QVE A;  4BAB A;  1XWO A;  4C6G A;  1I0A A;  1T6P A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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