4AMMA

Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis reveals the molecular basis of substrate specificity
Total Genus 130
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
130
sequence length
401
structure length
384
Chain Sequence
PDHELVVCGAPDAAALTGLLTRVRAAATALSRPELTDLAAGLAAAHRGDVPARFAAAVRDADGLVAALDRALGHLAEGGRRLLDAGRGLFLVVGGPLRVGLLFPGQAAPVHADRGALGHKPAEPVDTAVAQPAIIADSLAGIRWLDRLGARPVGALGHSLGELAALSWAGALDADDTLALARARGEAMSAATEAPSGMLSLRADLAAARELAAGTGAVVAVDNGERHVVVAGTRPELDRVAEAARHAGIEATPLAVSHAFHSPLMAPAAEALRRAAGRLPWRRPERPVASTVTGAWWADEDPVEVLVRQLTGPVRFREALGLLDADLLVEVGPGRMLSALAEAAGRTAVSLDAGAASAAGMAAGTAALFAAGAVDDATPFFAGR
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords DYNE8
publication title Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis.
pubmed doi rcsb
source organism Micromonospora chersina
total genus 130
structure length 384
sequence length 401
ec nomenclature
pdb deposition date 2012-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00698 Acyl_transf_1 Acyl transferase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.366.20 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 4ammA00
4AMNA 4AMMA 3TZYA 3TZZA 3TZXA 4AMPA 3TZWA 4AMOA
chains in the Genus database with same CATH superfamily
3TZYA 3TZZA 3H0PA 2CUYA 3TZXA 2PFFB 4AMPA 3HJVA 5CZCA 3PTWA 2HG4A 3EZOA 4RL1A 2C2NA 1NM2A 2JFKA 2VKZG 4RR5A 5DZ7A 4QBUA 4AMMA 2G2YA 3K89A 3IM8A 2VZ9A 4AMNA 3HHDA 2G2OA 3G87A 2JFDA 2QC3A 3TZWA 2UV8G 1MLAA 5CZDA 2QO3A 3SBMA 2QJ3A 4AMOA 3RGIA 3QATA 3HMJG 2G1HA 5DZ6A 2VZ8A 3R97A 2G2ZA 3IM9A 2H1YA 3TQEA
chains in the Genus database with same CATH topology
4AMNA 4AMMA 3TZYA 3TZZA 3TZXA 4AMPA 3TZWA 4AMOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AMN A;  4AMM A;  3TZY A;  3TZZ A;  3TZX A;  4AMP A;  3TZW A;  4AMO A; 
#chains in the Genus database with same CATH topology
 3TZY A;  3TZZ A;  3H0P A;  2CUY A;  3TZX A;  2PFF B;  4AMP A;  3HJV A;  5CZC A;  3PTW A;  2HG4 A;  3EZO A;  4RL1 A;  2C2N A;  1NM2 A;  2JFK A;  2VKZ G;  4RR5 A;  5DZ7 A;  4QBU A;  4AMM A;  2G2Y A;  3K89 A;  3IM8 A;  2VZ9 A;  4AMN A;  3HHD A;  2G2O A;  3G87 A;  2JFD A;  2QC3 A;  3TZW A;  2UV8 G;  1MLA A;  5CZD A;  2QO3 A;  3SBM A;  2QJ3 A;  4AMO A;  3RGI A;  3QAT A;  3HMJ G;  2G1H A;  5DZ6 A;  2VZ8 A;  3R97 A;  2G2Z A;  3IM9 A;  2H1Y A;  3TQE A; 
#chains in the Genus database with same CATH homology
 4AMN A;  4AMM A;  3TZY A;  3TZZ A;  3TZX A;  4AMP A;  3TZW A;  4AMO A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...