4AMNA

Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis reveals the molecular basis of substrate specificity
Total Genus 126
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
126
sequence length
401
structure length
384
Chain Sequence
PDHELVVCGAPDAAALTGLLTRVRAAATALSRPELTDLAAGLAAAHRGDVPARFAAAVRDADGLVAALDRALGHLAEGGRRLLDAGRGLFLVVGGPLRVGLLFPGQAAPVHADRGALGHLPAEPVDTAVAQPAIIADSLAGIRWLDRLGARPVGALGHSLGELAALSWAGALDADDTLALARARGEAMSAATEAPSGMLSLRADLAAARELAAGTGAVVAVDNGERHVVVAGTRPELDRVAEAARHAGIEATPLAVSHAFHSPLMAPAAEALRRAAGRLPWRRPERPVASTVTGAWWADEDPVEVLVRQLTGPVRFREALGLLDADLLVEVGPGRMLSALAEAAGRTAVSLDAGAASAAGMAAGTAALFAAGAVDDATPFFAGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords DYNE8
publication title Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis.
pubmed doi rcsb
source organism Micromonospora chersina
total genus 126
structure length 384
sequence length 401
ec nomenclature
pdb deposition date 2012-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00698 Acyl_transf_1 Acyl transferase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.366.20 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 4amnA00
4AMNA 4AMOA 3TZYA 4AMPA 3TZWA 4AMMA 3TZZA 3TZXA
chains in the Genus database with same CATH superfamily
2QC3A 5CZCA 2HG4A 2QO3A 3IM9A 2G2YA 1MLAA 3QATA 3IM8A 3TZWA 3TQEA 3RGIA 2QJ3A 2JFDA 3H0PA 2VZ9A 4AMNA 3K89A 4RL1A 5DZ6A 4AMOA 2CUYA 4AMPA 4RR5A 3TZXA 2H1YA 4AMMA 2VZ8A 1NM2A 3R97A 2VKZG 2JFKA 4QBUA 2C2NA 3EZOA 3G87A 3HHDA 3PTWA 3HMJG 2PFFB 5CZDA 3TZYA 2G2OA 2G2ZA 2UV8G 5DZ7A 3TZZA 3HJVA 3SBMA 2G1HA
chains in the Genus database with same CATH topology
4AMNA 4AMOA 3TZYA 4AMPA 3TZWA 4AMMA 3TZZA 3TZXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AMN A;  4AMO A;  3TZY A;  4AMP A;  3TZW A;  4AMM A;  3TZZ A;  3TZX A; 
#chains in the Genus database with same CATH topology
 2QC3 A;  5CZC A;  2HG4 A;  2QO3 A;  3IM9 A;  2G2Y A;  1MLA A;  3QAT A;  3IM8 A;  3TZW A;  3TQE A;  3RGI A;  2QJ3 A;  2JFD A;  3H0P A;  2VZ9 A;  4AMN A;  3K89 A;  4RL1 A;  5DZ6 A;  4AMO A;  2CUY A;  4AMP A;  4RR5 A;  3TZX A;  2H1Y A;  4AMM A;  2VZ8 A;  1NM2 A;  3R97 A;  2VKZ G;  2JFK A;  4QBU A;  2C2N A;  3EZO A;  3G87 A;  3HHD A;  3PTW A;  3HMJ G;  2PFF B;  5CZD A;  3TZY A;  2G2O A;  2G2Z A;  2UV8 G;  5DZ7 A;  3TZZ A;  3HJV A;  3SBM A;  2G1H A; 
#chains in the Genus database with same CATH homology
 4AMN A;  4AMO A;  3TZY A;  4AMP A;  3TZW A;  4AMM A;  3TZZ A;  3TZX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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