4AMNA

Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis reveals the molecular basis of substrate specificity
Total Genus 126
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
126
sequence length
401
structure length
384
Chain Sequence
PDHELVVCGAPDAAALTGLLTRVRAAATALSRPELTDLAAGLAAAHRGDVPARFAAAVRDADGLVAALDRALGHLAEGGRRLLDAGRGLFLVVGGPLRVGLLFPGQAAPVHADRGALGHLPAEPVDTAVAQPAIIADSLAGIRWLDRLGARPVGALGHSLGELAALSWAGALDADDTLALARARGEAMSAATEAPSGMLSLRADLAAARELAAGTGAVVAVDNGERHVVVAGTRPELDRVAEAARHAGIEATPLAVSHAFHSPLMAPAAEALRRAAGRLPWRRPERPVASTVTGAWWADEDPVEVLVRQLTGPVRFREALGLLDADLLVEVGPGRMLSALAEAAGRTAVSLDAGAASAAGMAAGTAALFAAGAVDDATPFFAGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
source organism Micromonospora chersina
publication title Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis.
pubmed doi rcsb
molecule keywords DYNE8
total genus 126
structure length 384
sequence length 401
ec nomenclature
pdb deposition date 2012-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00698 Acyl_transf_1 Acyl transferase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.366.20 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 4amnA00
3TZXA 4AMNA 4AMOA 4AMMA 3TZYA 3TZWA 4AMPA 3TZZA
chains in the Genus database with same CATH superfamily
3R97A 4AMOA 2G1HA 5DZ6A 2C2NA 2JFKA 3IM8A 3G87A 3K89A 4RL1A 4QBUA 2VZ8A 4AMPA 2HG4A 1NM2A 2CUYA 3TZXA 2H1YA 2G2YA 3HJVA 2VZ9A 3SBMA 3EZOA 3TZWA 3H0PA 3PTWA 3TZYA 2G2ZA 4AMNA 5CZDA 2QJ3A 4AMMA 5CZCA 2QO3A 3IM9A 2PFFB 3RGIA 3HHDA 1MLAA 2G2OA 2UV8G 3HMJG 2JFDA 3QATA 4RR5A 2VKZG 3TZZA 3TQEA 2QC3A 5DZ7A
chains in the Genus database with same CATH topology
3TZXA 4AMNA 4AMOA 4AMMA 3TZYA 3TZWA 4AMPA 3TZZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TZX A;  4AMN A;  4AMO A;  4AMM A;  3TZY A;  3TZW A;  4AMP A;  3TZZ A; 
#chains in the Genus database with same CATH topology
 3R97 A;  4AMO A;  2G1H A;  5DZ6 A;  2C2N A;  2JFK A;  3IM8 A;  3G87 A;  3K89 A;  4RL1 A;  4QBU A;  2VZ8 A;  4AMP A;  2HG4 A;  1NM2 A;  2CUY A;  3TZX A;  2H1Y A;  2G2Y A;  3HJV A;  2VZ9 A;  3SBM A;  3EZO A;  3TZW A;  3H0P A;  3PTW A;  3TZY A;  2G2Z A;  4AMN A;  5CZD A;  2QJ3 A;  4AMM A;  5CZC A;  2QO3 A;  3IM9 A;  2PFF B;  3RGI A;  3HHD A;  1MLA A;  2G2O A;  2UV8 G;  3HMJ G;  2JFD A;  3QAT A;  4RR5 A;  2VKZ G;  3TZZ A;  3TQE A;  2QC3 A;  5DZ7 A; 
#chains in the Genus database with same CATH homology
 3TZX A;  4AMN A;  4AMO A;  4AMM A;  3TZY A;  3TZW A;  4AMP A;  3TZZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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