4AMOA

Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis reveals the molecular basis of substrate specificity
Total Genus 124
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
124
sequence length
401
structure length
371
Chain Sequence
PDHELVVCGAPDAAALTGLLTRVRAAATALSRPELTDLAAGLAAAHRGDVPARFAAAVRDADGLVAALDRALGHLAEGGRRLLDAGRGLFLVVGGPLRVGLLFPGQAAPVPVDTAVAQPAIIADSLAGIRWLDRLGARPVGALGHSLGELAALSWAGALDADDTLALARARGEAMSVATEAPSGMLSLRADLAAARELAAGTGAVVAVDNGERHVVVAGTRPELDRVAEAARHAGIEATPLAVSHAFHSPLMAPAAEALRRAAGRLPWRRPERPVASTVTGAWWADEDPVEVLVRQLTGPVRFREALGLLDADLLVEVGPGRMLSALAEAAGRTAVSLDAGAASAAGMAAGTAALFAAGAVDDATPFFAGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords DYNE8
publication title Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis.
pubmed doi rcsb
source organism Micromonospora chersina
total genus 124
structure length 371
sequence length 401
ec nomenclature
pdb deposition date 2012-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00698 Acyl_transf_1 Acyl transferase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.366.20 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 4amoA00
4AMMA 4AMNA 3TZZA 3TZWA 3TZXA 3TZYA 4AMOA 4AMPA
chains in the Genus database with same CATH superfamily
3HJVA 2G2OA 4QBUA 3TZZA 3IM9A 3R97A 3TZWA 3G87A 5CZDA 3HMJG 5CZCA 3RGIA 2VKZG 3QATA 4AMMA 2HG4A 2JFDA 3HHDA 3TQEA 2G2YA 2PFFB 4RL1A 3TZXA 4RR5A 2CUYA 3H0PA 3K89A 5DZ6A 2H1YA 2C2NA 1MLAA 2G1HA 2G2ZA 3EZOA 2VZ9A 3SBMA 4AMNA 3TZYA 2VZ8A 4AMPA 2JFKA 2UV8G 3IM8A 5DZ7A 2QO3A 1NM2A 2QC3A 3PTWA 4AMOA 2QJ3A
chains in the Genus database with same CATH topology
4AMMA 4AMNA 3TZZA 3TZWA 3TZXA 3TZYA 4AMOA 4AMPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AMM A;  4AMN A;  3TZZ A;  3TZW A;  3TZX A;  3TZY A;  4AMO A;  4AMP A; 
#chains in the Genus database with same CATH topology
 3HJV A;  2G2O A;  4QBU A;  3TZZ A;  3IM9 A;  3R97 A;  3TZW A;  3G87 A;  5CZD A;  3HMJ G;  5CZC A;  3RGI A;  2VKZ G;  3QAT A;  4AMM A;  2HG4 A;  2JFD A;  3HHD A;  3TQE A;  2G2Y A;  2PFF B;  4RL1 A;  3TZX A;  4RR5 A;  2CUY A;  3H0P A;  3K89 A;  5DZ6 A;  2H1Y A;  2C2N A;  1MLA A;  2G1H A;  2G2Z A;  3EZO A;  2VZ9 A;  3SBM A;  4AMN A;  3TZY A;  2VZ8 A;  4AMP A;  2JFK A;  2UV8 G;  3IM8 A;  5DZ7 A;  2QO3 A;  1NM2 A;  2QC3 A;  3PTW A;  4AMO A;  2QJ3 A; 
#chains in the Genus database with same CATH homology
 4AMM A;  4AMN A;  3TZZ A;  3TZW A;  3TZX A;  3TZY A;  4AMO A;  4AMP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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