4AMPA

Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis reveals the molecular basis of substrate specificity
Total Genus 128
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
128
sequence length
401
structure length
372
Chain Sequence
PDHELVVCGAPDAAALTGLLTRVRAAATALSRPELTDLAAGLAAAHRGDVPARFAAAVRDADGLVAALDRALGHLAEGGRRLLDAGRGLFLVVGGPLRVGLLFPGQAAPVHPVDTAVAQPAIIADSLAGIRWLDRLGARPVGALGHSLGELAALSWAGALDADDTLALARARGEAMSAATEAPSGMLSLRADLAAARELAAGTGAVVAVDNGERHVVVAGTRPELDRVAEAARHAGIEATPLAVSHAFHSPLMAPAAEALRRAAGRLPWRRPERPVASTVTGAWWADEDPVEVLVRQLTGPVRFREALGLLDADLLVEVGPGRMLSALAEAAGRTAVSLDAGAASAAGMAAGTAALFAAGAVDDATPFFAGR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
molecule keywords DYNE8
publication title Crystal Structure of the Acyltransferase Domain of the Iterative Polyketide Synthase in Enediyne Biosynthesis.
pubmed doi rcsb
source organism Micromonospora chersina
total genus 128
structure length 372
sequence length 401
ec nomenclature
pdb deposition date 2012-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00698 Acyl_transf_1 Acyl transferase domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.366.20 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 Malonyl-Coenzyme A Acyl Carrier Protein; domain 2 4ampA00
4AMMA 3TZXA 3TZYA 4AMPA 3TZZA 4AMNA 3TZWA 4AMOA
chains in the Genus database with same CATH superfamily
3HMJG 5CZDA 3R97A 3HHDA 3H0PA 3TZZA 3G87A 2QC3A 2G2ZA 3TZXA 2QO3A 2JFDA 3IM8A 4RL1A 2HG4A 3IM9A 2VZ9A 3EZOA 1MLAA 2VKZG 4AMOA 5CZCA 2PFFB 3TZWA 2C2NA 2G1HA 2UV8G 1NM2A 4AMPA 2JFKA 3K89A 3TQEA 2QJ3A 4AMNA 2CUYA 2G2OA 4RR5A 5DZ7A 4AMMA 4QBUA 3TZYA 5DZ6A 3RGIA 2G2YA 3PTWA 2VZ8A 2H1YA 3QATA 3SBMA 3HJVA
chains in the Genus database with same CATH topology
4AMMA 3TZXA 3TZYA 4AMPA 3TZZA 4AMNA 3TZWA 4AMOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AMM A;  3TZX A;  3TZY A;  4AMP A;  3TZZ A;  4AMN A;  3TZW A;  4AMO A; 
#chains in the Genus database with same CATH topology
 3HMJ G;  5CZD A;  3R97 A;  3HHD A;  3H0P A;  3TZZ A;  3G87 A;  2QC3 A;  2G2Z A;  3TZX A;  2QO3 A;  2JFD A;  3IM8 A;  4RL1 A;  2HG4 A;  3IM9 A;  2VZ9 A;  3EZO A;  1MLA A;  2VKZ G;  4AMO A;  5CZC A;  2PFF B;  3TZW A;  2C2N A;  2G1H A;  2UV8 G;  1NM2 A;  4AMP A;  2JFK A;  3K89 A;  3TQE A;  2QJ3 A;  4AMN A;  2CUY A;  2G2O A;  4RR5 A;  5DZ7 A;  4AMM A;  4QBU A;  3TZY A;  5DZ6 A;  3RGI A;  2G2Y A;  3PTW A;  2VZ8 A;  2H1Y A;  3QAT A;  3SBM A;  3HJV A; 
#chains in the Genus database with same CATH homology
 4AMM A;  3TZX A;  3TZY A;  4AMP A;  3TZZ A;  4AMN A;  3TZW A;  4AMO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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