4AOVA

Dpidh-nadp. the complex structures of isocitrate dehydrogenase from clostridium thermocellum and desulfotalea psychrophila, support a new active site locking mechanism
Total Genus 153
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
153
sequence length
402
structure length
401
Chain Sequence
MKIQMKTPLVELDGDEMTRVLWPLIKDKLLLPFIDLQTEYYDLGIEERDRTNDQITIDAAEAIKKYGVGVKNATITPNQDRVEEYGLKEQWKSPNATVRAMLDGTVFRKPIMVKNIKPSVRSWQKPIVVGRHAYGDFYKNAEIFAEAGGKLEIVVTDKNGKETRQTIMEVDEPAIVQGIHNTVASIGHFARACFEYSLDQKIDCWFATKDTISKQYDQRFKIIFEEIFAQEYKEKFAAAGIEYFYTLIDDVVARMMKTEGGMLWACKNYDGDVMSDMVASAFGSLAMMSSVLVSPYGYFEYEAAHGTVQRHYYQHLKGERTSTNPVALIYAWTGALRKRGELDGTPDLCAFCDSLEAITIECIESGYMTGDLARICEPAAIKVLDSIEFIDELGKRLQQLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Oxidoreductase
molecule keywords ISOCITRATE DEHYDROGENASE [NADP]
publication title The Complex Structures of Isocitrate Dehydrogenase from Clostridium Thermocellum and Desulfotalea Psychrophila Suggest a New Active Site Locking Mechanism
pubmed doi rcsb
source organism Desulfotalea psychrophila
total genus 153
structure length 401
sequence length 402
ec nomenclature ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date 2012-03-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00180 Iso_dh Isocitrate/isopropylmalate dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 4aovA00
1WPWA 3MASA 1G2UA 4L06A 1V53A 2Y41A 4ATYA 1AI2A 5L58A 1XABA 5HN5A 2E5MA 1AI3A 1W0DA 3VKZA 1GC8A 2IV0A 5GREB 3FMXX 3ICDA 1PS6A 4KZOA 5GRFA 5J34A 5HN6A 1PTMA 8ICDA 4AJCA 1PB3A 5J32A 4IWHA 1OSJA 3BLXA 2Y3ZA 1HJ6A 5GRIA 1IDEA 5K11A 2QFXA 4AJAA 1HQSA 3WZYA 3VMLA 4AOVA 5L57A 1PB1A 1YXOA 4AJ3A 1ZORA 1GROA 3MARA 3US8A 4WUOA 1V94A 4HCXA 4Y1PA 5I96A 4AOUA 3BLVB 3TNGA 4XRXA 5I95A 2E0CA 3LXYA 3VMJA 3UDUA 5GRHB 4UMYA 1IPDA 1CM7A 3AH3A 2ZTWA 4AJRA 1ISOA 3VL3A 1U7NA 5HN3A 1HEXA 4YB4A 3R8WA 5GREA 1CW7A 2UXRA 1OSIA 5J33A 1P8FA 1TYOA 1XADA 1IDDA 4ICDA 3VMKA 1DPZA 2QFVA 1WALA 1GRPA 7ICDA 2D1CA 1PS7A 2QFWA 2Y40A 3TY3A 1DR0A 4L03A 1A05A 2QFYA 3BLVA 1R8KA 5LGEA 1XACA 2DHTA 3WZXA 4F7IA 4JQPA 1SJSA 4AOYA 3BLXB 2AYQA 6ICDA 3UF6A 2UXQA 5GRIB 4L04A 2Y42A 1CNZA 1V5BA 1XGVA 4AJBA 3WZVA 5GRLB 3TSNA 3DMSA 4XXVA 4UMXA 3VL7A 1IKAA 1YCOA 1T0LA 3MASB 1VLCA 4P69C 1X0LA 3FLKA 3UDOA 4AJSA 4XS3A 1IDFA 2D4VA 9ICDA 3VL2A 1IDCA 5K10A 5GRFB 5ICDA 3LCBC 1XAAA 4BNPA 4I3LA 3U1HA 4I3KA 1DR8A 1BL5A 1T09A 5GRHA 1LWDA 3ASJA 1VI1A 5DE1A 1CW1A 3VL6A 3MAPA 3U9EA 2G4OA 3INMA 1GC9A 5GRLA 3VL4A 5HN4A 1CW4A 1IDMA 1XKDA 3TY4A 3WZWA 2HI1A 4JA8A
chains in the Genus database with same CATH superfamily
1WPWA 3MASA 1G2UA 4L06A 1V53A 2Y41A 4ATYA 1AI2A 5L58A 1XABA 5HN5A 2E5MA 1AI3A 1W0DA 3VKZA 1GC8A 2IV0A 5GREB 3FMXX 3ICDA 1PS6A 4KZOA 5GRFA 5J34A 5HN6A 1PTMA 8ICDA 4AJCA 1PB3A 5J32A 4IWHA 1OSJA 3BLXA 2Y3ZA 1HJ6A 5GRIA 1IDEA 5K11A 2QFXA 4AJAA 1HQSA 3WZYA 3VMLA 4AOVA 5L57A 1PB1A 1YXOA 4AJ3A 1ZORA 1GROA 3MARA 3US8A 4WUOA 1V94A 4HCXA 4Y1PA 5I96A 4AOUA 3BLVB 3TNGA 4XRXA 5I95A 2E0CA 3LXYA 3VMJA 3UDUA 5GRHB 4UMYA 1IPDA 1CM7A 3AH3A 2ZTWA 4AJRA 1ISOA 3VL3A 1U7NA 5HN3A 1HEXA 4YB4A 3R8WA 5GREA 1CW7A 2UXRA 1OSIA 5J33A 1P8FA 1TYOA 1XADA 1IDDA 4ICDA 3VMKA 1DPZA 2QFVA 1WALA 1GRPA 7ICDA 2D1CA 1PS7A 2QFWA 2Y40A 3TY3A 1DR0A 4L03A 1A05A 2QFYA 3BLVA 1R8KA 5LGEA 1XACA 2DHTA 3WZXA 4F7IA 4JQPA 1SJSA 4AOYA 3BLXB 2AYQA 6ICDA 3UF6A 2UXQA 5GRIB 4L04A 2Y42A 1CNZA 1V5BA 1XGVA 4AJBA 3WZVA 5GRLB 3TSNA 3DMSA 4XXVA 4UMXA 3VL7A 1IKAA 1YCOA 1T0LA 3MASB 1VLCA 4P69C 1X0LA 3FLKA 3UDOA 4AJSA 4XS3A 1IDFA 2D4VA 9ICDA 3VL2A 1IDCA 5K10A 5GRFB 5ICDA 3LCBC 1XAAA 4BNPA 4I3LA 3U1HA 4I3KA 1DR8A 1BL5A 1T09A 5GRHA 1LWDA 3ASJA 1VI1A 5DE1A 1CW1A 3VL6A 3MAPA 3U9EA 2G4OA 3INMA 1GC9A 5GRLA 3VL4A 5HN4A 1CW4A 1IDMA 1XKDA 3TY4A 3WZWA 2HI1A 4JA8A
chains in the Genus database with same CATH topology
1WPWA 3MASA 1G2UA 4L06A 1V53A 2Y41A 4ATYA 1AI2A 5L58A 1XABA 5HN5A 2E5MA 1AI3A 1W0DA 3VKZA 1GC8A 2IV0A 5GREB 3FMXX 3ICDA 1PS6A 4KZOA 5GRFA 5J34A 5HN6A 1PTMA 8ICDA 4AJCA 1PB3A 5J32A 4IWHA 1OSJA 3BLXA 2Y3ZA 1HJ6A 5GRIA 1IDEA 5K11A 2QFXA 4AJAA 1HQSA 3WZYA 3VMLA 4AOVA 5L57A 1PB1A 1YXOA 4AJ3A 1ZORA 1GROA 3MARA 3US8A 4WUOA 1V94A 4HCXA 4Y1PA 5I96A 4AOUA 3BLVB 3TNGA 4XRXA 5I95A 2E0CA 3LXYA 3VMJA 3UDUA 5GRHB 4UMYA 1IPDA 1CM7A 3AH3A 2ZTWA 4AJRA 1ISOA 3VL3A 1U7NA 5HN3A 1HEXA 4YB4A 3R8WA 5GREA 1CW7A 2UXRA 1OSIA 5J33A 1P8FA 1TYOA 1XADA 1IDDA 4ICDA 3VMKA 1DPZA 2QFVA 1WALA 1GRPA 7ICDA 2D1CA 1PS7A 2QFWA 2Y40A 3TY3A 1DR0A 4L03A 1A05A 2QFYA 3BLVA 1R8KA 5LGEA 1XACA 2DHTA 3WZXA 4F7IA 4JQPA 1SJSA 4AOYA 3BLXB 2AYQA 6ICDA 3UF6A 2UXQA 5GRIB 4L04A 2Y42A 1CNZA 1V5BA 1XGVA 4AJBA 3WZVA 5GRLB 3TSNA 3DMSA 4XXVA 4UMXA 3VL7A 1IKAA 1YCOA 1T0LA 3MASB 1VLCA 4P69C 1X0LA 3FLKA 3UDOA 4AJSA 4XS3A 1IDFA 2D4VA 9ICDA 3VL2A 1IDCA 5K10A 5GRFB 5ICDA 3LCBC 1XAAA 4BNPA 4I3LA 3U1HA 4I3KA 1DR8A 1BL5A 1T09A 5GRHA 1LWDA 3ASJA 1VI1A 5DE1A 1CW1A 3VL6A 3MAPA 3U9EA 2G4OA 3INMA 1GC9A 5GRLA 3VL4A 5HN4A 1CW4A 1IDMA 1XKDA 3TY4A 3WZWA 2HI1A 4JA8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WPW A;  3MAS A;  1G2U A;  4L06 A;  1V53 A;  2Y41 A;  4ATY A;  1AI2 A;  5L58 A;  1XAB A;  5HN5 A;  2E5M A;  1AI3 A;  1W0D A;  3VKZ A;  1GC8 A;  2IV0 A;  5GRE B;  3FMX X;  3ICD A;  1PS6 A;  4KZO A;  5GRF A;  5J34 A;  5HN6 A;  1PTM A;  8ICD A;  4AJC A;  1PB3 A;  5J32 A;  4IWH A;  1OSJ A;  3BLX A;  2Y3Z A;  1HJ6 A;  5GRI A;  1IDE A;  5K11 A;  2QFX A;  4AJA A;  1HQS A;  3WZY A;  3VML A;  4AOV A;  5L57 A;  1PB1 A;  1YXO A;  4AJ3 A;  1ZOR A;  1GRO A;  3MAR A;  3US8 A;  4WUO A;  1V94 A;  4HCX A;  4Y1P A;  5I96 A;  4AOU A;  3BLV B;  3TNG A;  4XRX A;  5I95 A;  2E0C A;  3LXY A;  3VMJ A;  3UDU A;  5GRH B;  4UMY A;  1IPD A;  1CM7 A;  3AH3 A;  2ZTW A;  4AJR A;  1ISO A;  3VL3 A;  1U7N A;  5HN3 A;  1HEX A;  4YB4 A;  3R8W A;  5GRE A;  1CW7 A;  2UXR A;  1OSI A;  5J33 A;  1P8F A;  1TYO A;  1XAD A;  1IDD A;  4ICD A;  3VMK A;  1DPZ A;  2QFV A;  1WAL A;  1GRP A;  7ICD A;  2D1C A;  1PS7 A;  2QFW A;  2Y40 A;  3TY3 A;  1DR0 A;  4L03 A;  1A05 A;  2QFY A;  3BLV A;  1R8K A;  5LGE A;  1XAC A;  2DHT A;  3WZX A;  4F7I A;  4JQP A;  1SJS A;  4AOY A;  3BLX B;  2AYQ A;  6ICD A;  3UF6 A;  2UXQ A;  5GRI B;  4L04 A;  2Y42 A;  1CNZ A;  1V5B A;  1XGV A;  4AJB A;  3WZV A;  5GRL B;  3TSN A;  3DMS A;  4XXV A;  4UMX A;  3VL7 A;  1IKA A;  1YCO A;  1T0L A;  3MAS B;  1VLC A;  4P69 C;  1X0L A;  3FLK A;  3UDO A;  4AJS A;  4XS3 A;  1IDF A;  2D4V A;  9ICD A;  3VL2 A;  1IDC A;  5K10 A;  5GRF B;  5ICD A;  3LCB C;  1XAA A;  4BNP A;  4I3L A;  3U1H A;  4I3K A;  1DR8 A;  1BL5 A;  1T09 A;  5GRH A;  1LWD A;  3ASJ A;  1VI1 A;  5DE1 A;  1CW1 A;  3VL6 A;  3MAP A;  3U9E A;  2G4O A;  3INM A;  1GC9 A;  5GRL A;  3VL4 A;  5HN4 A;  1CW4 A;  1IDM A;  1XKD A;  3TY4 A;  3WZW A;  2HI1 A;  4JA8 A; 
#chains in the Genus database with same CATH topology
 1WPW A;  3MAS A;  1G2U A;  4L06 A;  1V53 A;  2Y41 A;  4ATY A;  1AI2 A;  5L58 A;  1XAB A;  5HN5 A;  2E5M A;  1AI3 A;  1W0D A;  3VKZ A;  1GC8 A;  2IV0 A;  5GRE B;  3FMX X;  3ICD A;  1PS6 A;  4KZO A;  5GRF A;  5J34 A;  5HN6 A;  1PTM A;  8ICD A;  4AJC A;  1PB3 A;  5J32 A;  4IWH A;  1OSJ A;  3BLX A;  2Y3Z A;  1HJ6 A;  5GRI A;  1IDE A;  5K11 A;  2QFX A;  4AJA A;  1HQS A;  3WZY A;  3VML A;  4AOV A;  5L57 A;  1PB1 A;  1YXO A;  4AJ3 A;  1ZOR A;  1GRO A;  3MAR A;  3US8 A;  4WUO A;  1V94 A;  4HCX A;  4Y1P A;  5I96 A;  4AOU A;  3BLV B;  3TNG A;  4XRX A;  5I95 A;  2E0C A;  3LXY A;  3VMJ A;  3UDU A;  5GRH B;  4UMY A;  1IPD A;  1CM7 A;  3AH3 A;  2ZTW A;  4AJR A;  1ISO A;  3VL3 A;  1U7N A;  5HN3 A;  1HEX A;  4YB4 A;  3R8W A;  5GRE A;  1CW7 A;  2UXR A;  1OSI A;  5J33 A;  1P8F A;  1TYO A;  1XAD A;  1IDD A;  4ICD A;  3VMK A;  1DPZ A;  2QFV A;  1WAL A;  1GRP A;  7ICD A;  2D1C A;  1PS7 A;  2QFW A;  2Y40 A;  3TY3 A;  1DR0 A;  4L03 A;  1A05 A;  2QFY A;  3BLV A;  1R8K A;  5LGE A;  1XAC A;  2DHT A;  3WZX A;  4F7I A;  4JQP A;  1SJS A;  4AOY A;  3BLX B;  2AYQ A;  6ICD A;  3UF6 A;  2UXQ A;  5GRI B;  4L04 A;  2Y42 A;  1CNZ A;  1V5B A;  1XGV A;  4AJB A;  3WZV A;  5GRL B;  3TSN A;  3DMS A;  4XXV A;  4UMX A;  3VL7 A;  1IKA A;  1YCO A;  1T0L A;  3MAS B;  1VLC A;  4P69 C;  1X0L A;  3FLK A;  3UDO A;  4AJS A;  4XS3 A;  1IDF A;  2D4V A;  9ICD A;  3VL2 A;  1IDC A;  5K10 A;  5GRF B;  5ICD A;  3LCB C;  1XAA A;  4BNP A;  4I3L A;  3U1H A;  4I3K A;  1DR8 A;  1BL5 A;  1T09 A;  5GRH A;  1LWD A;  3ASJ A;  1VI1 A;  5DE1 A;  1CW1 A;  3VL6 A;  3MAP A;  3U9E A;  2G4O A;  3INM A;  1GC9 A;  5GRL A;  3VL4 A;  5HN4 A;  1CW4 A;  1IDM A;  1XKD A;  3TY4 A;  3WZW A;  2HI1 A;  4JA8 A; 
#chains in the Genus database with same CATH homology
 1WPW A;  3MAS A;  1G2U A;  4L06 A;  1V53 A;  2Y41 A;  4ATY A;  1AI2 A;  5L58 A;  1XAB A;  5HN5 A;  2E5M A;  1AI3 A;  1W0D A;  3VKZ A;  1GC8 A;  2IV0 A;  5GRE B;  3FMX X;  3ICD A;  1PS6 A;  4KZO A;  5GRF A;  5J34 A;  5HN6 A;  1PTM A;  8ICD A;  4AJC A;  1PB3 A;  5J32 A;  4IWH A;  1OSJ A;  3BLX A;  2Y3Z A;  1HJ6 A;  5GRI A;  1IDE A;  5K11 A;  2QFX A;  4AJA A;  1HQS A;  3WZY A;  3VML A;  4AOV A;  5L57 A;  1PB1 A;  1YXO A;  4AJ3 A;  1ZOR A;  1GRO A;  3MAR A;  3US8 A;  4WUO A;  1V94 A;  4HCX A;  4Y1P A;  5I96 A;  4AOU A;  3BLV B;  3TNG A;  4XRX A;  5I95 A;  2E0C A;  3LXY A;  3VMJ A;  3UDU A;  5GRH B;  4UMY A;  1IPD A;  1CM7 A;  3AH3 A;  2ZTW A;  4AJR A;  1ISO A;  3VL3 A;  1U7N A;  5HN3 A;  1HEX A;  4YB4 A;  3R8W A;  5GRE A;  1CW7 A;  2UXR A;  1OSI A;  5J33 A;  1P8F A;  1TYO A;  1XAD A;  1IDD A;  4ICD A;  3VMK A;  1DPZ A;  2QFV A;  1WAL A;  1GRP A;  7ICD A;  2D1C A;  1PS7 A;  2QFW A;  2Y40 A;  3TY3 A;  1DR0 A;  4L03 A;  1A05 A;  2QFY A;  3BLV A;  1R8K A;  5LGE A;  1XAC A;  2DHT A;  3WZX A;  4F7I A;  4JQP A;  1SJS A;  4AOY A;  3BLX B;  2AYQ A;  6ICD A;  3UF6 A;  2UXQ A;  5GRI B;  4L04 A;  2Y42 A;  1CNZ A;  1V5B A;  1XGV A;  4AJB A;  3WZV A;  5GRL B;  3TSN A;  3DMS A;  4XXV A;  4UMX A;  3VL7 A;  1IKA A;  1YCO A;  1T0L A;  3MAS B;  1VLC A;  4P69 C;  1X0L A;  3FLK A;  3UDO A;  4AJS A;  4XS3 A;  1IDF A;  2D4V A;  9ICD A;  3VL2 A;  1IDC A;  5K10 A;  5GRF B;  5ICD A;  3LCB C;  1XAA A;  4BNP A;  4I3L A;  3U1H A;  4I3K A;  1DR8 A;  1BL5 A;  1T09 A;  5GRH A;  1LWD A;  3ASJ A;  1VI1 A;  5DE1 A;  1CW1 A;  3VL6 A;  3MAP A;  3U9E A;  2G4O A;  3INM A;  1GC9 A;  5GRL A;  3VL4 A;  5HN4 A;  1CW4 A;  1IDM A;  1XKD A;  3TY4 A;  3WZW A;  2HI1 A;  4JA8 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...