4AOYA

Open ctidh. the complex structures of isocitrate dehydrogenase from clostridium thermocellum and desulfotalea psychrophila, support a new active site locking mechanism
Total Genus 122
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
122
sequence length
400
structure length
376
Chain Sequence
SKIKMKVPLVEMDGDEMTRIIWRLIKENLLEPYIELNTEYYDLGLENRDKTEDQVTIDAARAIQKYGVGVKCATITPNAQRVEEYNLKKMWKSPNGTIRAILDGTVFRAPIVVNSIKPFVKGWKKPISIARHKNVEYYVPSAGKAELVFTSENGEVSRQTIHEFDGPGVIMGMHNTDKSIRSFARACFNYALDMNQDLWFSTKDTISKTYDHRFKDIFQEIYENEYKEKFEAKNLQYFYTLIDDAVARIIRSEGGMVWACKNDGDVMSDMVASAFGSLAMMTSVLVSPDGKYEFEATSTNSMATIFAWTGALKKRGELDGIKELVDFATKLEQASVQTIENGVMTKDLASLSEVPEKKIVNTEDFLKEIRKTFEGM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
molecule keywords ISOCITRATE DEHYDROGENASE [NADP]
publication title The complex structures of isocitrate dehydrogenase from Clostridium thermocellum and Desulfotalea psychrophila suggest a new active site locking mechanism.
pubmed doi rcsb
total genus 122
structure length 376
sequence length 400
chains with identical sequence B, C, D
ec nomenclature ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date 2012-03-30
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 4aoyA00
3FLKA 5J33A 1CW4A 2DHTA 5GRFA 5HN5A 1IDFA 4JQPA 4AOVA 1A05A 3LXYA 4P69C 1CM7A 1XADA 1GC9A 1OSJA 3UF6A 3INMA 3MASB 4L03A 5GRHB 1ZORA 1PS7A 2AYQA 2QFWA 1AI2A 4AOUA 8ICDA 1PB3A 5HN3A 5GRIA 1U7NA 5L57A 3VL4A 3WZYA 1LWDA 1OSIA 5GRFB 4AJCA 1GROA 3VMKA 4AJAA 1IDMA 3ICDA 3WZWA 2E5MA 4AJBA 2D4VA 3U1HA 3LCBC 5ICDA 1XABA 1DR0A 1XACA 1TYOA 1CW7A 2D1CA 3BLVA 4AOYA 4Y1PA 1VLCA 4HCXA 4IWHA 5I96A 5K10A 5GRIB 2Y42A 5L58A 1WPWA 1IDCA 3MAPA 1HQSA 4ATYA 1T09A 3UDOA 9ICDA 1G2UA 4AJRA 1DR8A 5HN6A 1CW1A 1IKAA 5I95A 3BLVB 1T0LA 1X0LA 1IDDA 3DMSA 3R8WA 1YCOA 1IPDA 4WUOA 1IDEA 1PTMA 3ASJA 3US8A 4I3LA 1WALA 1YXOA 5GREA 2QFYA 1PB1A 2HI1A 4XS3A 4XRXA 3WZVA 3TY4A 3VMLA 3WZXA 3AH3A 4BNPA 1AI3A 2Y40A 1ISOA 3U9EA 2Y41A 1PS6A 1XGVA 1V53A 2G4OA 2ZTWA 4JA8A 4KZOA 4UMXA 2UXRA 5K11A 1HEXA 4L06A 1V94A 3BLXA 5GREB 5LGEA 2UXQA 3VMJA 4UMYA 3UDUA 5DE1A 5GRLA 3VKZA 5J32A 3TSNA 1XAAA 1V5BA 4AJSA 1R8KA 5J34A 3MARA 2E0CA 1GC8A 1VI1A 2IV0A 3VL3A 5HN4A 1P8FA 3FMXX 4XXVA 4I3KA 1W0DA 3TNGA 2QFVA 3VL7A 1SJSA 3BLXB 6ICDA 4ICDA 2Y3ZA 5GRLB 1GRPA 4YB4A 1HJ6A 2QFXA 4F7IA 1DPZA 1BL5A 7ICDA 3MASA 5GRHA 1XKDA 3VL6A 1CNZA 3TY3A 4AJ3A 3VL2A 4L04A
chains in the Genus database with same CATH superfamily
3FLKA 5J33A 1CW4A 2DHTA 5GRFA 5HN5A 1IDFA 4JQPA 4AOVA 1A05A 3LXYA 4P69C 1CM7A 1XADA 1GC9A 1OSJA 3UF6A 3INMA 3MASB 4L03A 5GRHB 1ZORA 1PS7A 2AYQA 2QFWA 1AI2A 4AOUA 8ICDA 1PB3A 5HN3A 5GRIA 1U7NA 5L57A 3VL4A 3WZYA 1LWDA 1OSIA 5GRFB 4AJCA 1GROA 3VMKA 4AJAA 1IDMA 3ICDA 3WZWA 2E5MA 4AJBA 2D4VA 3U1HA 3LCBC 5ICDA 1XABA 1DR0A 1XACA 1TYOA 1CW7A 2D1CA 3BLVA 4AOYA 4Y1PA 1VLCA 4HCXA 4IWHA 5I96A 5K10A 5GRIB 2Y42A 5L58A 1WPWA 1IDCA 3MAPA 1HQSA 4ATYA 1T09A 3UDOA 9ICDA 1G2UA 4AJRA 1DR8A 5HN6A 1CW1A 1IKAA 5I95A 3BLVB 1T0LA 1X0LA 1IDDA 3DMSA 3R8WA 1YCOA 1IPDA 4WUOA 1IDEA 1PTMA 3ASJA 3US8A 4I3LA 1WALA 1YXOA 5GREA 2QFYA 1PB1A 2HI1A 4XS3A 4XRXA 3WZVA 3TY4A 3VMLA 3WZXA 3AH3A 4BNPA 1AI3A 2Y40A 1ISOA 3U9EA 2Y41A 1PS6A 1XGVA 1V53A 2G4OA 2ZTWA 4JA8A 4KZOA 4UMXA 2UXRA 5K11A 1HEXA 4L06A 1V94A 3BLXA 5GREB 5LGEA 2UXQA 3VMJA 4UMYA 3UDUA 5DE1A 5GRLA 3VKZA 5J32A 3TSNA 1XAAA 1V5BA 4AJSA 1R8KA 5J34A 3MARA 2E0CA 1GC8A 1VI1A 2IV0A 3VL3A 5HN4A 1P8FA 3FMXX 4XXVA 4I3KA 1W0DA 3TNGA 2QFVA 3VL7A 1SJSA 3BLXB 6ICDA 4ICDA 2Y3ZA 5GRLB 1GRPA 4YB4A 1HJ6A 2QFXA 4F7IA 1DPZA 1BL5A 7ICDA 3MASA 5GRHA 1XKDA 3VL6A 1CNZA 3TY3A 4AJ3A 3VL2A 4L04A
chains in the Genus database with same CATH topology
3FLKA 5J33A 1CW4A 2DHTA 5GRFA 5HN5A 1IDFA 4JQPA 4AOVA 1A05A 3LXYA 4P69C 1CM7A 1XADA 1GC9A 1OSJA 3UF6A 3INMA 3MASB 4L03A 5GRHB 1ZORA 1PS7A 2AYQA 2QFWA 1AI2A 4AOUA 8ICDA 1PB3A 5HN3A 5GRIA 1U7NA 5L57A 3VL4A 3WZYA 1LWDA 1OSIA 5GRFB 4AJCA 1GROA 3VMKA 4AJAA 1IDMA 3ICDA 3WZWA 2E5MA 4AJBA 2D4VA 3U1HA 3LCBC 5ICDA 1XABA 1DR0A 1XACA 1TYOA 1CW7A 2D1CA 3BLVA 4AOYA 4Y1PA 1VLCA 4HCXA 4IWHA 5I96A 5K10A 5GRIB 2Y42A 5L58A 1WPWA 1IDCA 3MAPA 1HQSA 4ATYA 1T09A 3UDOA 9ICDA 1G2UA 4AJRA 1DR8A 5HN6A 1CW1A 1IKAA 5I95A 3BLVB 1T0LA 1X0LA 1IDDA 3DMSA 3R8WA 1YCOA 1IPDA 4WUOA 1IDEA 1PTMA 3ASJA 3US8A 4I3LA 1WALA 1YXOA 5GREA 2QFYA 1PB1A 2HI1A 4XS3A 4XRXA 3WZVA 3TY4A 3VMLA 3WZXA 3AH3A 4BNPA 1AI3A 2Y40A 1ISOA 3U9EA 2Y41A 1PS6A 1XGVA 1V53A 2G4OA 2ZTWA 4JA8A 4KZOA 4UMXA 2UXRA 5K11A 1HEXA 4L06A 1V94A 3BLXA 5GREB 5LGEA 2UXQA 3VMJA 4UMYA 3UDUA 5DE1A 5GRLA 3VKZA 5J32A 3TSNA 1XAAA 1V5BA 4AJSA 1R8KA 5J34A 3MARA 2E0CA 1GC8A 1VI1A 2IV0A 3VL3A 5HN4A 1P8FA 3FMXX 4XXVA 4I3KA 1W0DA 3TNGA 2QFVA 3VL7A 1SJSA 3BLXB 6ICDA 4ICDA 2Y3ZA 5GRLB 1GRPA 4YB4A 1HJ6A 2QFXA 4F7IA 1DPZA 1BL5A 7ICDA 3MASA 5GRHA 1XKDA 3VL6A 1CNZA 3TY3A 4AJ3A 3VL2A 4L04A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3FLK A;  5J33 A;  1CW4 A;  2DHT A;  5GRF A;  5HN5 A;  1IDF A;  4JQP A;  4AOV A;  1A05 A;  3LXY A;  4P69 C;  1CM7 A;  1XAD A;  1GC9 A;  1OSJ A;  3UF6 A;  3INM A;  3MAS B;  4L03 A;  5GRH B;  1ZOR A;  1PS7 A;  2AYQ A;  2QFW A;  1AI2 A;  4AOU A;  8ICD A;  1PB3 A;  5HN3 A;  5GRI A;  1U7N A;  5L57 A;  3VL4 A;  3WZY A;  1LWD A;  1OSI A;  5GRF B;  4AJC A;  1GRO A;  3VMK A;  4AJA A;  1IDM A;  3ICD A;  3WZW A;  2E5M A;  4AJB A;  2D4V A;  3U1H A;  3LCB C;  5ICD A;  1XAB A;  1DR0 A;  1XAC A;  1TYO A;  1CW7 A;  2D1C A;  3BLV A;  4AOY A;  4Y1P A;  1VLC A;  4HCX A;  4IWH A;  5I96 A;  5K10 A;  5GRI B;  2Y42 A;  5L58 A;  1WPW A;  1IDC A;  3MAP A;  1HQS A;  4ATY A;  1T09 A;  3UDO A;  9ICD A;  1G2U A;  4AJR A;  1DR8 A;  5HN6 A;  1CW1 A;  1IKA A;  5I95 A;  3BLV B;  1T0L A;  1X0L A;  1IDD A;  3DMS A;  3R8W A;  1YCO A;  1IPD A;  4WUO A;  1IDE A;  1PTM A;  3ASJ A;  3US8 A;  4I3L A;  1WAL A;  1YXO A;  5GRE A;  2QFY A;  1PB1 A;  2HI1 A;  4XS3 A;  4XRX A;  3WZV A;  3TY4 A;  3VML A;  3WZX A;  3AH3 A;  4BNP A;  1AI3 A;  2Y40 A;  1ISO A;  3U9E A;  2Y41 A;  1PS6 A;  1XGV A;  1V53 A;  2G4O A;  2ZTW A;  4JA8 A;  4KZO A;  4UMX A;  2UXR A;  5K11 A;  1HEX A;  4L06 A;  1V94 A;  3BLX A;  5GRE B;  5LGE A;  2UXQ A;  3VMJ A;  4UMY A;  3UDU A;  5DE1 A;  5GRL A;  3VKZ A;  5J32 A;  3TSN A;  1XAA A;  1V5B A;  4AJS A;  1R8K A;  5J34 A;  3MAR A;  2E0C A;  1GC8 A;  1VI1 A;  2IV0 A;  3VL3 A;  5HN4 A;  1P8F A;  3FMX X;  4XXV A;  4I3K A;  1W0D A;  3TNG A;  2QFV A;  3VL7 A;  1SJS A;  3BLX B;  6ICD A;  4ICD A;  2Y3Z A;  5GRL B;  1GRP A;  4YB4 A;  1HJ6 A;  2QFX A;  4F7I A;  1DPZ A;  1BL5 A;  7ICD A;  3MAS A;  5GRH A;  1XKD A;  3VL6 A;  1CNZ A;  3TY3 A;  4AJ3 A;  3VL2 A;  4L04 A; 
#chains in the Genus database with same CATH topology
 3FLK A;  5J33 A;  1CW4 A;  2DHT A;  5GRF A;  5HN5 A;  1IDF A;  4JQP A;  4AOV A;  1A05 A;  3LXY A;  4P69 C;  1CM7 A;  1XAD A;  1GC9 A;  1OSJ A;  3UF6 A;  3INM A;  3MAS B;  4L03 A;  5GRH B;  1ZOR A;  1PS7 A;  2AYQ A;  2QFW A;  1AI2 A;  4AOU A;  8ICD A;  1PB3 A;  5HN3 A;  5GRI A;  1U7N A;  5L57 A;  3VL4 A;  3WZY A;  1LWD A;  1OSI A;  5GRF B;  4AJC A;  1GRO A;  3VMK A;  4AJA A;  1IDM A;  3ICD A;  3WZW A;  2E5M A;  4AJB A;  2D4V A;  3U1H A;  3LCB C;  5ICD A;  1XAB A;  1DR0 A;  1XAC A;  1TYO A;  1CW7 A;  2D1C A;  3BLV A;  4AOY A;  4Y1P A;  1VLC A;  4HCX A;  4IWH A;  5I96 A;  5K10 A;  5GRI B;  2Y42 A;  5L58 A;  1WPW A;  1IDC A;  3MAP A;  1HQS A;  4ATY A;  1T09 A;  3UDO A;  9ICD A;  1G2U A;  4AJR A;  1DR8 A;  5HN6 A;  1CW1 A;  1IKA A;  5I95 A;  3BLV B;  1T0L A;  1X0L A;  1IDD A;  3DMS A;  3R8W A;  1YCO A;  1IPD A;  4WUO A;  1IDE A;  1PTM A;  3ASJ A;  3US8 A;  4I3L A;  1WAL A;  1YXO A;  5GRE A;  2QFY A;  1PB1 A;  2HI1 A;  4XS3 A;  4XRX A;  3WZV A;  3TY4 A;  3VML A;  3WZX A;  3AH3 A;  4BNP A;  1AI3 A;  2Y40 A;  1ISO A;  3U9E A;  2Y41 A;  1PS6 A;  1XGV A;  1V53 A;  2G4O A;  2ZTW A;  4JA8 A;  4KZO A;  4UMX A;  2UXR A;  5K11 A;  1HEX A;  4L06 A;  1V94 A;  3BLX A;  5GRE B;  5LGE A;  2UXQ A;  3VMJ A;  4UMY A;  3UDU A;  5DE1 A;  5GRL A;  3VKZ A;  5J32 A;  3TSN A;  1XAA A;  1V5B A;  4AJS A;  1R8K A;  5J34 A;  3MAR A;  2E0C A;  1GC8 A;  1VI1 A;  2IV0 A;  3VL3 A;  5HN4 A;  1P8F A;  3FMX X;  4XXV A;  4I3K A;  1W0D A;  3TNG A;  2QFV A;  3VL7 A;  1SJS A;  3BLX B;  6ICD A;  4ICD A;  2Y3Z A;  5GRL B;  1GRP A;  4YB4 A;  1HJ6 A;  2QFX A;  4F7I A;  1DPZ A;  1BL5 A;  7ICD A;  3MAS A;  5GRH A;  1XKD A;  3VL6 A;  1CNZ A;  3TY3 A;  4AJ3 A;  3VL2 A;  4L04 A; 
#chains in the Genus database with same CATH homology
 3FLK A;  5J33 A;  1CW4 A;  2DHT A;  5GRF A;  5HN5 A;  1IDF A;  4JQP A;  4AOV A;  1A05 A;  3LXY A;  4P69 C;  1CM7 A;  1XAD A;  1GC9 A;  1OSJ A;  3UF6 A;  3INM A;  3MAS B;  4L03 A;  5GRH B;  1ZOR A;  1PS7 A;  2AYQ A;  2QFW A;  1AI2 A;  4AOU A;  8ICD A;  1PB3 A;  5HN3 A;  5GRI A;  1U7N A;  5L57 A;  3VL4 A;  3WZY A;  1LWD A;  1OSI A;  5GRF B;  4AJC A;  1GRO A;  3VMK A;  4AJA A;  1IDM A;  3ICD A;  3WZW A;  2E5M A;  4AJB A;  2D4V A;  3U1H A;  3LCB C;  5ICD A;  1XAB A;  1DR0 A;  1XAC A;  1TYO A;  1CW7 A;  2D1C A;  3BLV A;  4AOY A;  4Y1P A;  1VLC A;  4HCX A;  4IWH A;  5I96 A;  5K10 A;  5GRI B;  2Y42 A;  5L58 A;  1WPW A;  1IDC A;  3MAP A;  1HQS A;  4ATY A;  1T09 A;  3UDO A;  9ICD A;  1G2U A;  4AJR A;  1DR8 A;  5HN6 A;  1CW1 A;  1IKA A;  5I95 A;  3BLV B;  1T0L A;  1X0L A;  1IDD A;  3DMS A;  3R8W A;  1YCO A;  1IPD A;  4WUO A;  1IDE A;  1PTM A;  3ASJ A;  3US8 A;  4I3L A;  1WAL A;  1YXO A;  5GRE A;  2QFY A;  1PB1 A;  2HI1 A;  4XS3 A;  4XRX A;  3WZV A;  3TY4 A;  3VML A;  3WZX A;  3AH3 A;  4BNP A;  1AI3 A;  2Y40 A;  1ISO A;  3U9E A;  2Y41 A;  1PS6 A;  1XGV A;  1V53 A;  2G4O A;  2ZTW A;  4JA8 A;  4KZO A;  4UMX A;  2UXR A;  5K11 A;  1HEX A;  4L06 A;  1V94 A;  3BLX A;  5GRE B;  5LGE A;  2UXQ A;  3VMJ A;  4UMY A;  3UDU A;  5DE1 A;  5GRL A;  3VKZ A;  5J32 A;  3TSN A;  1XAA A;  1V5B A;  4AJS A;  1R8K A;  5J34 A;  3MAR A;  2E0C A;  1GC8 A;  1VI1 A;  2IV0 A;  3VL3 A;  5HN4 A;  1P8F A;  3FMX X;  4XXV A;  4I3K A;  1W0D A;  3TNG A;  2QFV A;  3VL7 A;  1SJS A;  3BLX B;  6ICD A;  4ICD A;  2Y3Z A;  5GRL B;  1GRP A;  4YB4 A;  1HJ6 A;  2QFX A;  4F7I A;  1DPZ A;  1BL5 A;  7ICD A;  3MAS A;  5GRH A;  1XKD A;  3VL6 A;  1CNZ A;  3TY3 A;  4AJ3 A;  3VL2 A;  4L04 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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