4AOYA

Open ctidh. the complex structures of isocitrate dehydrogenase from clostridium thermocellum and desulfotalea psychrophila, support a new active site locking mechanism
Total Genus 122
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
122
sequence length
400
structure length
376
Chain Sequence
SKIKMKVPLVEMDGDEMTRIIWRLIKENLLEPYIELNTEYYDLGLENRDKTEDQVTIDAARAIQKYGVGVKCATITPNAQRVEEYNLKKMWKSPNGTIRAILDGTVFRAPIVVNSIKPFVKGWKKPISIARHKNVEYYVPSAGKAELVFTSENGEVSRQTIHEFDGPGVIMGMHNTDKSIRSFARACFNYALDMNQDLWFSTKDTISKTYDHRFKDIFQEIYENEYKEKFEAKNLQYFYTLIDDAVARIIRSEGGMVWACKNDGDVMSDMVASAFGSLAMMTSVLVSPDGKYEFEATSTNSMATIFAWTGALKKRGELDGIKELVDFATKLEQASVQTIENGVMTKDLASLSEVPEKKIVNTEDFLKEIRKTFEGM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase
molecule keywords ISOCITRATE DEHYDROGENASE [NADP]
publication title The complex structures of isocitrate dehydrogenase from Clostridium thermocellum and Desulfotalea psychrophila suggest a new active site locking mechanism.
pubmed doi rcsb
total genus 122
structure length 376
sequence length 400
chains with identical sequence B, C, D
ec nomenclature ec 1.1.1.42: Isocitrate dehydrogenase (NADP(+)).
pdb deposition date 2012-03-30
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.718.10 Alpha Beta 3-Layer(aba) Sandwich Isopropylmalate Dehydrogenase Isopropylmalate Dehydrogenase 4aoyA00
4IWHA 4AJ3A 1BL5A 2Y40A 5GREA 6ICDA 1PB1A 3UF6A 2E5MA 5HN3A 1XAAA 2G4OA 3VL3A 5I95A 5J33A 4YB4A 3BLVB 1PB3A 4KZOA 3AH3A 1T0LA 4I3LA 5GREB 1HJ6A 3VMJA 1PS7A 4AJCA 1OSJA 2E0CA 5GRHB 9ICDA 5DE1A 3WZWA 5L57A 2UXRA 3TY3A 4XS3A 2QFYA 1R8KA 3TY4A 3LXYA 1XKDA 2D1CA 1YXOA 3VMLA 1IDMA 4JA8A 1G2UA 4UMYA 2D4VA 3VMKA 3MASB 4F7IA 1VLCA 1DR8A 1TYOA 2IV0A 3ICDA 1SJSA 3UDUA 5GRHA 4ICDA 1YCOA 4XRXA 3BLVA 1GRPA 1ISOA 1WALA 1XADA 3FLKA 1XGVA 4BNPA 2HI1A 1PS6A 3VL6A 4HCXA 3MASA 1ZORA 2AYQA 1CW1A 5GRIA 1DPZA 1DR0A 2Y42A 3INMA 1V94A 3U1HA 1V5BA 3UDOA 2QFXA 3WZXA 1AI3A 4AOUA 1IPDA 5L58A 5I96A 4WUOA 4Y1PA 1PTMA 3US8A 7ICDA 5GRIB 3MARA 3TSNA 3ASJA 4P69C 5HN5A 3LCBC 4AJBA 1IDFA 4AJAA 5LGEA 1W0DA 2QFVA 4L06A 3VL4A 4AOVA 2ZTWA 1U7NA 2Y3ZA 2QFWA 3U9EA 3VL7A 4AJRA 4UMXA 1T09A 5GRFB 8ICDA 5ICDA 5K10A 2UXQA 3MAPA 3FMXX 3R8WA 1CNZA 1CW7A 3BLXA 5HN4A 5K11A 1CM7A 1WPWA 4L04A 3TNGA 4JQPA 5GRLB 4ATYA 1IKAA 1X0LA 1GROA 1XACA 2DHTA 4AOYA 3VKZA 2Y41A 3BLXB 5GRFA 1GC9A 1LWDA 1VI1A 4L03A 5HN6A 1CW4A 3DMSA 3VL2A 1AI2A 4AJSA 1A05A 4I3KA 3WZVA 1OSIA 1IDCA 1IDEA 3WZYA 5GRLA 1P8FA 5J32A 1V53A 4XXVA 5J34A 1HQSA 1GC8A 1HEXA 1IDDA 1XABA
chains in the Genus database with same CATH superfamily
4IWHA 4AJ3A 1BL5A 2Y40A 5GREA 6ICDA 1PB1A 3UF6A 2E5MA 5HN3A 1XAAA 2G4OA 3VL3A 5I95A 5J33A 4YB4A 3BLVB 1PB3A 4KZOA 3AH3A 1T0LA 4I3LA 5GREB 1HJ6A 3VMJA 1PS7A 4AJCA 1OSJA 2E0CA 5GRHB 9ICDA 5DE1A 3WZWA 5L57A 2UXRA 3TY3A 4XS3A 2QFYA 1R8KA 3TY4A 3LXYA 1XKDA 2D1CA 1YXOA 3VMLA 1IDMA 4JA8A 1G2UA 4UMYA 2D4VA 3VMKA 3MASB 4F7IA 1VLCA 1DR8A 1TYOA 2IV0A 3ICDA 1SJSA 3UDUA 5GRHA 4ICDA 1YCOA 4XRXA 3BLVA 1GRPA 1ISOA 1WALA 1XADA 3FLKA 1XGVA 4BNPA 2HI1A 1PS6A 3VL6A 4HCXA 3MASA 1ZORA 2AYQA 1CW1A 5GRIA 1DPZA 1DR0A 2Y42A 3INMA 1V94A 3U1HA 1V5BA 3UDOA 2QFXA 3WZXA 1AI3A 4AOUA 1IPDA 5L58A 5I96A 4WUOA 4Y1PA 1PTMA 3US8A 7ICDA 5GRIB 3MARA 3TSNA 3ASJA 4P69C 5HN5A 3LCBC 4AJBA 1IDFA 4AJAA 5LGEA 1W0DA 2QFVA 4L06A 3VL4A 4AOVA 2ZTWA 1U7NA 2Y3ZA 2QFWA 3U9EA 3VL7A 4AJRA 4UMXA 1T09A 5GRFB 8ICDA 5ICDA 5K10A 2UXQA 3MAPA 3FMXX 3R8WA 1CNZA 1CW7A 3BLXA 5HN4A 5K11A 1CM7A 1WPWA 4L04A 3TNGA 4JQPA 5GRLB 4ATYA 1IKAA 1X0LA 1GROA 1XACA 2DHTA 4AOYA 3VKZA 2Y41A 3BLXB 5GRFA 1GC9A 1LWDA 1VI1A 4L03A 5HN6A 1CW4A 3DMSA 3VL2A 1AI2A 4AJSA 1A05A 4I3KA 3WZVA 1OSIA 1IDCA 1IDEA 3WZYA 5GRLA 1P8FA 5J32A 1V53A 4XXVA 5J34A 1HQSA 1GC8A 1HEXA 1IDDA 1XABA
chains in the Genus database with same CATH topology
4IWHA 4AJ3A 1BL5A 2Y40A 5GREA 6ICDA 1PB1A 3UF6A 2E5MA 5HN3A 1XAAA 2G4OA 3VL3A 5I95A 5J33A 4YB4A 3BLVB 1PB3A 4KZOA 3AH3A 1T0LA 4I3LA 5GREB 1HJ6A 3VMJA 1PS7A 4AJCA 1OSJA 2E0CA 5GRHB 9ICDA 5DE1A 3WZWA 5L57A 2UXRA 3TY3A 4XS3A 2QFYA 1R8KA 3TY4A 3LXYA 1XKDA 2D1CA 1YXOA 3VMLA 1IDMA 4JA8A 1G2UA 4UMYA 2D4VA 3VMKA 3MASB 4F7IA 1VLCA 1DR8A 1TYOA 2IV0A 3ICDA 1SJSA 3UDUA 5GRHA 4ICDA 1YCOA 4XRXA 3BLVA 1GRPA 1ISOA 1WALA 1XADA 3FLKA 1XGVA 4BNPA 2HI1A 1PS6A 3VL6A 4HCXA 3MASA 1ZORA 2AYQA 1CW1A 5GRIA 1DPZA 1DR0A 2Y42A 3INMA 1V94A 3U1HA 1V5BA 3UDOA 2QFXA 3WZXA 1AI3A 4AOUA 1IPDA 5L58A 5I96A 4WUOA 4Y1PA 1PTMA 3US8A 7ICDA 5GRIB 3MARA 3TSNA 3ASJA 4P69C 5HN5A 3LCBC 4AJBA 1IDFA 4AJAA 5LGEA 1W0DA 2QFVA 4L06A 3VL4A 4AOVA 2ZTWA 1U7NA 2Y3ZA 2QFWA 3U9EA 3VL7A 4AJRA 4UMXA 1T09A 5GRFB 8ICDA 5ICDA 5K10A 2UXQA 3MAPA 3FMXX 3R8WA 1CNZA 1CW7A 3BLXA 5HN4A 5K11A 1CM7A 1WPWA 4L04A 3TNGA 4JQPA 5GRLB 4ATYA 1IKAA 1X0LA 1GROA 1XACA 2DHTA 4AOYA 3VKZA 2Y41A 3BLXB 5GRFA 1GC9A 1LWDA 1VI1A 4L03A 5HN6A 1CW4A 3DMSA 3VL2A 1AI2A 4AJSA 1A05A 4I3KA 3WZVA 1OSIA 1IDCA 1IDEA 3WZYA 5GRLA 1P8FA 5J32A 1V53A 4XXVA 5J34A 1HQSA 1GC8A 1HEXA 1IDDA 1XABA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IWH A;  4AJ3 A;  1BL5 A;  2Y40 A;  5GRE A;  6ICD A;  1PB1 A;  3UF6 A;  2E5M A;  5HN3 A;  1XAA A;  2G4O A;  3VL3 A;  5I95 A;  5J33 A;  4YB4 A;  3BLV B;  1PB3 A;  4KZO A;  3AH3 A;  1T0L A;  4I3L A;  5GRE B;  1HJ6 A;  3VMJ A;  1PS7 A;  4AJC A;  1OSJ A;  2E0C A;  5GRH B;  9ICD A;  5DE1 A;  3WZW A;  5L57 A;  2UXR A;  3TY3 A;  4XS3 A;  2QFY A;  1R8K A;  3TY4 A;  3LXY A;  1XKD A;  2D1C A;  1YXO A;  3VML A;  1IDM A;  4JA8 A;  1G2U A;  4UMY A;  2D4V A;  3VMK A;  3MAS B;  4F7I A;  1VLC A;  1DR8 A;  1TYO A;  2IV0 A;  3ICD A;  1SJS A;  3UDU A;  5GRH A;  4ICD A;  1YCO A;  4XRX A;  3BLV A;  1GRP A;  1ISO A;  1WAL A;  1XAD A;  3FLK A;  1XGV A;  4BNP A;  2HI1 A;  1PS6 A;  3VL6 A;  4HCX A;  3MAS A;  1ZOR A;  2AYQ A;  1CW1 A;  5GRI A;  1DPZ A;  1DR0 A;  2Y42 A;  3INM A;  1V94 A;  3U1H A;  1V5B A;  3UDO A;  2QFX A;  3WZX A;  1AI3 A;  4AOU A;  1IPD A;  5L58 A;  5I96 A;  4WUO A;  4Y1P A;  1PTM A;  3US8 A;  7ICD A;  5GRI B;  3MAR A;  3TSN A;  3ASJ A;  4P69 C;  5HN5 A;  3LCB C;  4AJB A;  1IDF A;  4AJA A;  5LGE A;  1W0D A;  2QFV A;  4L06 A;  3VL4 A;  4AOV A;  2ZTW A;  1U7N A;  2Y3Z A;  2QFW A;  3U9E A;  3VL7 A;  4AJR A;  4UMX A;  1T09 A;  5GRF B;  8ICD A;  5ICD A;  5K10 A;  2UXQ A;  3MAP A;  3FMX X;  3R8W A;  1CNZ A;  1CW7 A;  3BLX A;  5HN4 A;  5K11 A;  1CM7 A;  1WPW A;  4L04 A;  3TNG A;  4JQP A;  5GRL B;  4ATY A;  1IKA A;  1X0L A;  1GRO A;  1XAC A;  2DHT A;  4AOY A;  3VKZ A;  2Y41 A;  3BLX B;  5GRF A;  1GC9 A;  1LWD A;  1VI1 A;  4L03 A;  5HN6 A;  1CW4 A;  3DMS A;  3VL2 A;  1AI2 A;  4AJS A;  1A05 A;  4I3K A;  3WZV A;  1OSI A;  1IDC A;  1IDE A;  3WZY A;  5GRL A;  1P8F A;  5J32 A;  1V53 A;  4XXV A;  5J34 A;  1HQS A;  1GC8 A;  1HEX A;  1IDD A;  1XAB A; 
#chains in the Genus database with same CATH topology
 4IWH A;  4AJ3 A;  1BL5 A;  2Y40 A;  5GRE A;  6ICD A;  1PB1 A;  3UF6 A;  2E5M A;  5HN3 A;  1XAA A;  2G4O A;  3VL3 A;  5I95 A;  5J33 A;  4YB4 A;  3BLV B;  1PB3 A;  4KZO A;  3AH3 A;  1T0L A;  4I3L A;  5GRE B;  1HJ6 A;  3VMJ A;  1PS7 A;  4AJC A;  1OSJ A;  2E0C A;  5GRH B;  9ICD A;  5DE1 A;  3WZW A;  5L57 A;  2UXR A;  3TY3 A;  4XS3 A;  2QFY A;  1R8K A;  3TY4 A;  3LXY A;  1XKD A;  2D1C A;  1YXO A;  3VML A;  1IDM A;  4JA8 A;  1G2U A;  4UMY A;  2D4V A;  3VMK A;  3MAS B;  4F7I A;  1VLC A;  1DR8 A;  1TYO A;  2IV0 A;  3ICD A;  1SJS A;  3UDU A;  5GRH A;  4ICD A;  1YCO A;  4XRX A;  3BLV A;  1GRP A;  1ISO A;  1WAL A;  1XAD A;  3FLK A;  1XGV A;  4BNP A;  2HI1 A;  1PS6 A;  3VL6 A;  4HCX A;  3MAS A;  1ZOR A;  2AYQ A;  1CW1 A;  5GRI A;  1DPZ A;  1DR0 A;  2Y42 A;  3INM A;  1V94 A;  3U1H A;  1V5B A;  3UDO A;  2QFX A;  3WZX A;  1AI3 A;  4AOU A;  1IPD A;  5L58 A;  5I96 A;  4WUO A;  4Y1P A;  1PTM A;  3US8 A;  7ICD A;  5GRI B;  3MAR A;  3TSN A;  3ASJ A;  4P69 C;  5HN5 A;  3LCB C;  4AJB A;  1IDF A;  4AJA A;  5LGE A;  1W0D A;  2QFV A;  4L06 A;  3VL4 A;  4AOV A;  2ZTW A;  1U7N A;  2Y3Z A;  2QFW A;  3U9E A;  3VL7 A;  4AJR A;  4UMX A;  1T09 A;  5GRF B;  8ICD A;  5ICD A;  5K10 A;  2UXQ A;  3MAP A;  3FMX X;  3R8W A;  1CNZ A;  1CW7 A;  3BLX A;  5HN4 A;  5K11 A;  1CM7 A;  1WPW A;  4L04 A;  3TNG A;  4JQP A;  5GRL B;  4ATY A;  1IKA A;  1X0L A;  1GRO A;  1XAC A;  2DHT A;  4AOY A;  3VKZ A;  2Y41 A;  3BLX B;  5GRF A;  1GC9 A;  1LWD A;  1VI1 A;  4L03 A;  5HN6 A;  1CW4 A;  3DMS A;  3VL2 A;  1AI2 A;  4AJS A;  1A05 A;  4I3K A;  3WZV A;  1OSI A;  1IDC A;  1IDE A;  3WZY A;  5GRL A;  1P8F A;  5J32 A;  1V53 A;  4XXV A;  5J34 A;  1HQS A;  1GC8 A;  1HEX A;  1IDD A;  1XAB A; 
#chains in the Genus database with same CATH homology
 4IWH A;  4AJ3 A;  1BL5 A;  2Y40 A;  5GRE A;  6ICD A;  1PB1 A;  3UF6 A;  2E5M A;  5HN3 A;  1XAA A;  2G4O A;  3VL3 A;  5I95 A;  5J33 A;  4YB4 A;  3BLV B;  1PB3 A;  4KZO A;  3AH3 A;  1T0L A;  4I3L A;  5GRE B;  1HJ6 A;  3VMJ A;  1PS7 A;  4AJC A;  1OSJ A;  2E0C A;  5GRH B;  9ICD A;  5DE1 A;  3WZW A;  5L57 A;  2UXR A;  3TY3 A;  4XS3 A;  2QFY A;  1R8K A;  3TY4 A;  3LXY A;  1XKD A;  2D1C A;  1YXO A;  3VML A;  1IDM A;  4JA8 A;  1G2U A;  4UMY A;  2D4V A;  3VMK A;  3MAS B;  4F7I A;  1VLC A;  1DR8 A;  1TYO A;  2IV0 A;  3ICD A;  1SJS A;  3UDU A;  5GRH A;  4ICD A;  1YCO A;  4XRX A;  3BLV A;  1GRP A;  1ISO A;  1WAL A;  1XAD A;  3FLK A;  1XGV A;  4BNP A;  2HI1 A;  1PS6 A;  3VL6 A;  4HCX A;  3MAS A;  1ZOR A;  2AYQ A;  1CW1 A;  5GRI A;  1DPZ A;  1DR0 A;  2Y42 A;  3INM A;  1V94 A;  3U1H A;  1V5B A;  3UDO A;  2QFX A;  3WZX A;  1AI3 A;  4AOU A;  1IPD A;  5L58 A;  5I96 A;  4WUO A;  4Y1P A;  1PTM A;  3US8 A;  7ICD A;  5GRI B;  3MAR A;  3TSN A;  3ASJ A;  4P69 C;  5HN5 A;  3LCB C;  4AJB A;  1IDF A;  4AJA A;  5LGE A;  1W0D A;  2QFV A;  4L06 A;  3VL4 A;  4AOV A;  2ZTW A;  1U7N A;  2Y3Z A;  2QFW A;  3U9E A;  3VL7 A;  4AJR A;  4UMX A;  1T09 A;  5GRF B;  8ICD A;  5ICD A;  5K10 A;  2UXQ A;  3MAP A;  3FMX X;  3R8W A;  1CNZ A;  1CW7 A;  3BLX A;  5HN4 A;  5K11 A;  1CM7 A;  1WPW A;  4L04 A;  3TNG A;  4JQP A;  5GRL B;  4ATY A;  1IKA A;  1X0L A;  1GRO A;  1XAC A;  2DHT A;  4AOY A;  3VKZ A;  2Y41 A;  3BLX B;  5GRF A;  1GC9 A;  1LWD A;  1VI1 A;  4L03 A;  5HN6 A;  1CW4 A;  3DMS A;  3VL2 A;  1AI2 A;  4AJS A;  1A05 A;  4I3K A;  3WZV A;  1OSI A;  1IDC A;  1IDE A;  3WZY A;  5GRL A;  1P8F A;  5J32 A;  1V53 A;  4XXV A;  5J34 A;  1HQS A;  1GC8 A;  1HEX A;  1IDD A;  1XAB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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