4APAA

Crystal structure of mycobacterium tuberculosis fumarase (rv1098c) s318a in apo form
Total Genus 173
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
173
sequence length
459
structure length
440
Chain Sequence
NYRIEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLLSIEDLDRRLDVLAMAKAE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords FUMARATE HYDRATASE CLASS II
publication title Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Hydrolase
total genus 173
structure length 440
sequence length 459
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2012-03-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4apaA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4apaA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4apaA02
1K62A 3TV2A 3UNVA 1T6JA 2YIIA 4CQ5A 4V2RA 1DOFA 1K7WA 2O6YA 4EEIA 3GTDA 3C8TA 5F91A 1KQ7A 2NYNA 4C5SA 1XWOA 2O7DA 1T6PA 4EFCA 1C3UA 2PTQA 1Y2MA 4NSLA 1GKMA 2RJSA 1J3UA 2O78A 1FUPA 3R6VA 2O7FA 3BHGA 1YFMA 2QGAB 1VDKA 4BAAA 1YISA 3KDYA 3R6QA 4ADMA 1TJWA 3GZHA 5HW2A 3QBPA 2PFMA 4C6GA 1Q5NA 1TJUA 1C3CA 4MX2A 4APBA 1EB4A 1RE5A 3OCFA 2NYFA 2QVEA 4APAA 4BABA 3R6YA 1HY1A 5EYVA 1TJ7A 3CZOA 3RD8A 2HVGA 4HGVA 3OCEA 1TJVA 2J91A 1FUQA 5EYTA 3E04A 2FUSA 4V2QA 4ADLA 2X75A 2PTSA 1B8FA 1U15A 1GK3A 2RJRA 4FLCA 1U16A 1I0AA 2O7BA 2E9FA 1GKJA 3KDZA 3RRPA 1DCNA 5F92A 5D6BA 2VD6A 4FFXA 2OHYA 1FURA 1GK2A 2PTRA 1YFEA 3NZ4A 3NO9A 4NLEA 1W27A 1HY0A 2O7EA 4C5RA 1FUOA 1AUWA 1JSWA 4C5UA
chains in the Genus database with same CATH superfamily
1K62A 3TV2A 1XL8A 3UNVA 1T6JA 2YIIA 4CQ5A 4V2RA 1DOFA 1K7WA 3U19A 1Z4KA 4L57A 3CRW1 2O6YA 4EEIA 3GTDA 3C8TA 5F91A 1KQ7A 2D27A 1XLYA 1Z4JA 4MWOA 2NYNA 2JAOA 4L6AA 4C5SA 2FELA 1XWOA 2YV5A 2O7DA 1Q92A 1T6PA 4EFCA 1C3UA 2PTQA 1Y2MA 4NSLA 1GKMA 2RJSA 1J3UA 2O78A 1FUPA 3R6VA 2VSFA 2O7FA 4E88A 3F4SA 3BHGA 1YFMA 2I7DA 2QGAB 1VDKA 5M0JA 4MUMA 3CI0K 4BAAA 4NFLA 2FENA 1YISA 3KDYA 3R6QA 4ADMA 1TJWA 4IQJM 2JAWA 3GZHA 2JARA 3BWVA 5HW2A 1XL7A 3QBPA 2PFMA 4C6GA 5M0IA 1Q5NA 1TJUA 1C3CA 1IW7D 4MX2A 4APBA 1EB4A 3CRVA 1RE5A 3OCFA 4YIHA 2NYFA 2QVEA 4APAA 4BABA 3R6YA 1HY1A 3F4TA 5EYVA 1TJ7A 3CZOA 2JAUA 3F4RA 1Z4PX 3RD8A 2HVGA 1Z4IA 2VL7A 5H8WA 4HGVA 3OCEA 4WNLA 1U0LA 1TJVA 1Q91A 2RCNA 1MH9A 2J91A 1FUQA 5EYTA 3E04A 2FUSA 4L6CA 4ADLA 2X75A 2PTSA 4V2QA 1B8FA 1XMDA 1U15A 1GK3A 2RJRA 1T9HA 4FLCA 1U16A 1I0AA 1Z4QA 1Z4MA 2O7BA 2E9FA 1GKJA 3KDZA 2D28C 3RRPA 1DCNA 5F92A 5D6BA 2VD6A 4A15A 4FFXA 2OHYA 1FURA 1GK2A 1XMCA 2PTRA 4YIKA 1YFEA 3NZ4A 3NO9A 4NLEA 1W27A 1HY0A 2O7EA 4C5RA 1FUOA 1AUWA 1JSWA 4C5UA 1Z4LA 3U13A
chains in the Genus database with same CATH topology
1K62A 3TV2A 3UNVA 1T6JA 2YIIA 4CQ5A 4V2RA 1DOFA 1K7WA 2O6YA 4EEIA 3GTDA 3C8TA 5F91A 1KQ7A 2NYNA 4C5SA 1XWOA 2O7DA 1T6PA 4EFCA 1C3UA 2PTQA 1Y2MA 4NSLA 1GKMA 2RJSA 1J3UA 2O78A 1FUPA 3R6VA 2O7FA 3BHGA 1YFMA 2QGAB 1VDKA 4BAAA 1YISA 3KDYA 3R6QA 4ADMA 1TJWA 3GZHA 5HW2A 3QBPA 2PFMA 4C6GA 1Q5NA 1TJUA 1C3CA 4MX2A 4APBA 1EB4A 1RE5A 3OCFA 2NYFA 2QVEA 4APAA 4BABA 3R6YA 1HY1A 5EYVA 1TJ7A 3CZOA 3RD8A 2HVGA 4HGVA 3OCEA 1TJVA 2J91A 1FUQA 5EYTA 3E04A 2FUSA 4V2QA 4ADLA 2X75A 2PTSA 1B8FA 1U15A 1GK3A 2RJRA 4FLCA 1U16A 1I0AA 2O7BA 2E9FA 1GKJA 3KDZA 3RRPA 1DCNA 5F92A 5D6BA 2VD6A 4FFXA 2OHYA 1FURA 1GK2A 2PTRA 1YFEA 3NZ4A 3NO9A 4NLEA 1W27A 1HY0A 2O7EA 4C5RA 1FUOA 1AUWA 1JSWA 4C5UA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1K62 A;  3TV2 A;  3UNV A;  1T6J A;  2YII A;  4CQ5 A;  4V2R A;  1DOF A;  1K7W A;  2O6Y A;  4EEI A;  3GTD A;  3C8T A;  5F91 A;  1KQ7 A;  2NYN A;  4C5S A;  1XWO A;  2O7D A;  1T6P A;  4EFC A;  1C3U A;  2PTQ A;  1Y2M A;  4NSL A;  1GKM A;  2RJS A;  1J3U A;  2O78 A;  1FUP A;  3R6V A;  2O7F A;  3BHG A;  1YFM A;  2QGA B;  1VDK A;  4BAA A;  1YIS A;  3KDY A;  3R6Q A;  4ADM A;  1TJW A;  3GZH A;  5HW2 A;  3QBP A;  2PFM A;  4C6G A;  1Q5N A;  1TJU A;  1C3C A;  4MX2 A;  4APB A;  1EB4 A;  1RE5 A;  3OCF A;  2NYF A;  2QVE A;  4APA A;  4BAB A;  3R6Y A;  1HY1 A;  5EYV A;  1TJ7 A;  3CZO A;  3RD8 A;  2HVG A;  4HGV A;  3OCE A;  1TJV A;  2J91 A;  1FUQ A;  5EYT A;  3E04 A;  2FUS A;  4V2Q A;  4ADL A;  2X75 A;  2PTS A;  1B8F A;  1U15 A;  1GK3 A;  2RJR A;  4FLC A;  1U16 A;  1I0A A;  2O7B A;  2E9F A;  1GKJ A;  3KDZ A;  3RRP A;  1DCN A;  5F92 A;  5D6B A;  2VD6 A;  4FFX A;  2OHY A;  1FUR A;  1GK2 A;  2PTR A;  1YFE A;  3NZ4 A;  3NO9 A;  4NLE A;  1W27 A;  1HY0 A;  2O7E A;  4C5R A;  1FUO A;  1AUW A;  1JSW A;  4C5U A; 
#chains in the Genus database with same CATH topology
 1K62 A;  3TV2 A;  1XL8 A;  3UNV A;  1T6J A;  2YII A;  4CQ5 A;  4V2R A;  1DOF A;  1K7W A;  3U19 A;  1Z4K A;  4L57 A;  3CRW 1;  2O6Y A;  4EEI A;  3GTD A;  3C8T A;  5F91 A;  1KQ7 A;  2D27 A;  1XLY A;  1Z4J A;  4MWO A;  2NYN A;  2JAO A;  4L6A A;  4C5S A;  2FEL A;  1XWO A;  2YV5 A;  2O7D A;  1Q92 A;  1T6P A;  4EFC A;  1C3U A;  2PTQ A;  1Y2M A;  4NSL A;  1GKM A;  2RJS A;  1J3U A;  2O78 A;  1FUP A;  3R6V A;  2VSF A;  2O7F A;  4E88 A;  3F4S A;  3BHG A;  1YFM A;  2I7D A;  2QGA B;  1VDK A;  5M0J A;  4MUM A;  3CI0 K;  4BAA A;  4NFL A;  2FEN A;  1YIS A;  3KDY A;  3R6Q A;  4ADM A;  1TJW A;  4IQJ M;  2JAW A;  3GZH A;  2JAR A;  3BWV A;  5HW2 A;  1XL7 A;  3QBP A;  2PFM A;  4C6G A;  5M0I A;  1Q5N A;  1TJU A;  1C3C A;  1IW7 D;  4MX2 A;  4APB A;  1EB4 A;  3CRV A;  1RE5 A;  3OCF A;  4YIH A;  2NYF A;  2QVE A;  4APA A;  4BAB A;  3R6Y A;  1HY1 A;  3F4T A;  5EYV A;  1TJ7 A;  3CZO A;  2JAU A;  3F4R A;  1Z4P X;  3RD8 A;  2HVG A;  1Z4I A;  2VL7 A;  5H8W A;  4HGV A;  3OCE A;  4WNL A;  1U0L A;  1TJV A;  1Q91 A;  2RCN A;  1MH9 A;  2J91 A;  1FUQ A;  5EYT A;  3E04 A;  2FUS A;  4L6C A;  4ADL A;  2X75 A;  2PTS A;  4V2Q A;  1B8F A;  1XMD A;  1U15 A;  1GK3 A;  2RJR A;  1T9H A;  4FLC A;  1U16 A;  1I0A A;  1Z4Q A;  1Z4M A;  2O7B A;  2E9F A;  1GKJ A;  3KDZ A;  2D28 C;  3RRP A;  1DCN A;  5F92 A;  5D6B A;  2VD6 A;  4A15 A;  4FFX A;  2OHY A;  1FUR A;  1GK2 A;  1XMC A;  2PTR A;  4YIK A;  1YFE A;  3NZ4 A;  3NO9 A;  4NLE A;  1W27 A;  1HY0 A;  2O7E A;  4C5R A;  1FUO A;  1AUW A;  1JSW A;  4C5U A;  1Z4L A;  3U13 A; 
#chains in the Genus database with same CATH homology
 1K62 A;  3TV2 A;  3UNV A;  1T6J A;  2YII A;  4CQ5 A;  4V2R A;  1DOF A;  1K7W A;  2O6Y A;  4EEI A;  3GTD A;  3C8T A;  5F91 A;  1KQ7 A;  2NYN A;  4C5S A;  1XWO A;  2O7D A;  1T6P A;  4EFC A;  1C3U A;  2PTQ A;  1Y2M A;  4NSL A;  1GKM A;  2RJS A;  1J3U A;  2O78 A;  1FUP A;  3R6V A;  2O7F A;  3BHG A;  1YFM A;  2QGA B;  1VDK A;  4BAA A;  1YIS A;  3KDY A;  3R6Q A;  4ADM A;  1TJW A;  3GZH A;  5HW2 A;  3QBP A;  2PFM A;  4C6G A;  1Q5N A;  1TJU A;  1C3C A;  4MX2 A;  4APB A;  1EB4 A;  1RE5 A;  3OCF A;  2NYF A;  2QVE A;  4APA A;  4BAB A;  3R6Y A;  1HY1 A;  5EYV A;  1TJ7 A;  3CZO A;  3RD8 A;  2HVG A;  4HGV A;  3OCE A;  1TJV A;  2J91 A;  1FUQ A;  5EYT A;  3E04 A;  2FUS A;  4V2Q A;  4ADL A;  2X75 A;  2PTS A;  1B8F A;  1U15 A;  1GK3 A;  2RJR A;  4FLC A;  1U16 A;  1I0A A;  2O7B A;  2E9F A;  1GKJ A;  3KDZ A;  3RRP A;  1DCN A;  5F92 A;  5D6B A;  2VD6 A;  4FFX A;  2OHY A;  1FUR A;  1GK2 A;  2PTR A;  1YFE A;  3NZ4 A;  3NO9 A;  4NLE A;  1W27 A;  1HY0 A;  2O7E A;  4C5R A;  1FUO A;  1AUW A;  1JSW A;  4C5U A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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