4APAA

Crystal structure of mycobacterium tuberculosis fumarase (rv1098c) s318a in apo form
Total Genus 173
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
173
sequence length
459
structure length
440
Chain Sequence
b'NYRIEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLLSIEDLDRRLDVLAMAKAE'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords FUMARATE HYDRATASE CLASS II
publication title Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Hydrolase
total genus 173
structure length 440
sequence length 459
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2012-03-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4apaA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4apaA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4apaA02
3UNVA 2O6YA 2RJRA 1GK2A 1GKJA 1XWOA 1RE5A 1I0AA 1J3UA 1T6PA 1TJVA 2O78A 1DOFA 1U15A 2PTRA 3R6VA 4C6GA 1K7WA 4EEIA 2RJSA 4C5RA 4NSLA 1FUOA 1C3CA 4V2RA 1FUPA 3GTDA 4C5UA 1YISA 2OHYA 4ADMA 5F92A 4V2QA 2YIIA 1JSWA 3E04A 1VDKA 1C3UA 2NYNA 1TJ7A 2O7BA 1GKMA 1TJUA 4APBA 4BAAA 1HY0A 1GK3A 1K62A 3C8TA 1FURA 3R6YA 4HGVA 1W27A 4C5SA 2HVGA 1B8FA 1KQ7A 2PFMA 1DCNA 3OCEA 3NO9A 1U16A 3BHGA 4MX2A 1AUWA 3GZHA 3RD8A 2PTQA 2O7FA 1FUQA 3R6QA 5EYVA 3CZOA 1TJWA 3NZ4A 3OCFA 2PTSA 3TV2A 4FFXA 1EB4A 4ADLA 2J91A 1HY1A 2VD6A 2O7EA 3RRPA 3KDZA 1YFEA 2O7DA 1Q5NA 3QBPA 5EYTA 2E9FA 1Y2MA 2QGAB 4BABA 3KDYA 1YFMA 1T6JA 2QVEA 4FLCA 5F91A 2FUSA 4NLEA 2NYFA 5D6BA 4APAA 4CQ5A 2X75A 4EFCA 5HW2A
chains in the Genus database with same CATH superfamily
1T9HA 2JARA 4L6AA 2O6YA 3UNVA 2RJRA 1GK2A 1GKJA 1XWOA 1RE5A 1I0AA 2RCNA 5H8WA 1J3UA 1T6PA 1TJVA 2O78A 1DOFA 1U15A 4A15A 2PTRA 3R6VA 4C6GA 1K7WA 3CRW1 4L57A 1Z4IA 4EEIA 1XL7A 3F4TA 2RJSA 4C5RA 4NSLA 3F4RA 1FUOA 1C3CA 4V2RA 2VL7A 1FUPA 3GTDA 1Z4MA 1YISA 4C5UA 2OHYA 4ADMA 4YIKA 5F92A 4V2QA 4L6CA 2YIIA 1JSWA 2FENA 3E04A 1VDKA 1C3UA 2NYNA 1TJ7A 1Z4KA 2O7BA 1GKMA 1TJUA 1Z4QA 4APBA 4BAAA 1HY0A 1GK3A 1XMDA 1K62A 3C8TA 1FURA 1Z4LA 3R6YA 4HGVA 1W27A 4C5SA 2HVGA 1B8FA 1KQ7A 1Z4PX 4EFCA 5M0IA 2PFMA 1DCNA 3OCEA 3NO9A 1U16A 2VSFA 2YV5A 3BHGA 4MX2A 4YIHA 1AUWA 3GZHA 3CI0K 3RD8A 2PTQA 2D27A 2O7FA 1FUQA 1Z4JA 3R6QA 4NFLA 5EYVA 3CZOA 1TJWA 4IQJM 3NZ4A 3OCFA 2FELA 2PTSA 3TV2A 4FFXA 3BWVA 1EB4A 3U13A 4ADLA 2J91A 1HY1A 1XL8A 2VD6A 2O7EA 3RRPA 3KDZA 2JAOA 3F4SA 1YFEA 2O7DA 1Q5NA 3QBPA 5M0JA 2JAWA 5EYTA 4MWOA 2E9FA 1U0LA 4MUMA 1Q92A 1MH9A 1Y2MA 4WNLA 2JAUA 2QGAB 1IW7D 4BABA 3KDYA 1YFMA 1T6JA 2D28C 2QVEA 4FLCA 3U19A 1Q91A 3CRVA 1XLYA 5F91A 1XMCA 2FUSA 4NLEA 2NYFA 5D6BA 4APAA 2I7DA 4CQ5A 2X75A 4E88A 5HW2A
chains in the Genus database with same CATH topology
3UNVA 2O6YA 2RJRA 1GK2A 1GKJA 1XWOA 1RE5A 1I0AA 1J3UA 1T6PA 1TJVA 2O78A 1DOFA 1U15A 2PTRA 3R6VA 4C6GA 1K7WA 4EEIA 2RJSA 4C5RA 4NSLA 1FUOA 1C3CA 4V2RA 1FUPA 3GTDA 4C5UA 1YISA 2OHYA 4ADMA 5F92A 4V2QA 2YIIA 1JSWA 3E04A 1VDKA 1C3UA 2NYNA 1TJ7A 2O7BA 1GKMA 1TJUA 4APBA 4BAAA 1HY0A 1GK3A 1K62A 3C8TA 1FURA 3R6YA 4HGVA 1W27A 4C5SA 2HVGA 1B8FA 1KQ7A 2PFMA 1DCNA 3OCEA 3NO9A 1U16A 3BHGA 4MX2A 1AUWA 3GZHA 3RD8A 2PTQA 2O7FA 1FUQA 3R6QA 5EYVA 3CZOA 1TJWA 3NZ4A 3OCFA 2PTSA 3TV2A 4FFXA 1EB4A 4ADLA 2J91A 1HY1A 2VD6A 2O7EA 3RRPA 3KDZA 1YFEA 2O7DA 1Q5NA 3QBPA 5EYTA 2E9FA 1Y2MA 2QGAB 4BABA 3KDYA 1YFMA 1T6JA 2QVEA 4FLCA 5F91A 2FUSA 4NLEA 2NYFA 5D6BA 4APAA 4CQ5A 2X75A 4EFCA 5HW2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3UNV A;  2O6Y A;  2RJR A;  1GK2 A;  1GKJ A;  1XWO A;  1RE5 A;  1I0A A;  1J3U A;  1T6P A;  1TJV A;  2O78 A;  1DOF A;  1U15 A;  2PTR A;  3R6V A;  4C6G A;  1K7W A;  4EEI A;  2RJS A;  4C5R A;  4NSL A;  1FUO A;  1C3C A;  4V2R A;  1FUP A;  3GTD A;  4C5U A;  1YIS A;  2OHY A;  4ADM A;  5F92 A;  4V2Q A;  2YII A;  1JSW A;  3E04 A;  1VDK A;  1C3U A;  2NYN A;  1TJ7 A;  2O7B A;  1GKM A;  1TJU A;  4APB A;  4BAA A;  1HY0 A;  1GK3 A;  1K62 A;  3C8T A;  1FUR A;  3R6Y A;  4HGV A;  1W27 A;  4C5S A;  2HVG A;  1B8F A;  1KQ7 A;  2PFM A;  1DCN A;  3OCE A;  3NO9 A;  1U16 A;  3BHG A;  4MX2 A;  1AUW A;  3GZH A;  3RD8 A;  2PTQ A;  2O7F A;  1FUQ A;  3R6Q A;  5EYV A;  3CZO A;  1TJW A;  3NZ4 A;  3OCF A;  2PTS A;  3TV2 A;  4FFX A;  1EB4 A;  4ADL A;  2J91 A;  1HY1 A;  2VD6 A;  2O7E A;  3RRP A;  3KDZ A;  1YFE A;  2O7D A;  1Q5N A;  3QBP A;  5EYT A;  2E9F A;  1Y2M A;  2QGA B;  4BAB A;  3KDY A;  1YFM A;  1T6J A;  2QVE A;  4FLC A;  5F91 A;  2FUS A;  4NLE A;  2NYF A;  5D6B A;  4APA A;  4CQ5 A;  2X75 A;  4EFC A;  5HW2 A; 
#chains in the Genus database with same CATH topology
 1T9H A;  2JAR A;  4L6A A;  2O6Y A;  3UNV A;  2RJR A;  1GK2 A;  1GKJ A;  1XWO A;  1RE5 A;  1I0A A;  2RCN A;  5H8W A;  1J3U A;  1T6P A;  1TJV A;  2O78 A;  1DOF A;  1U15 A;  4A15 A;  2PTR A;  3R6V A;  4C6G A;  1K7W A;  3CRW 1;  4L57 A;  1Z4I A;  4EEI A;  1XL7 A;  3F4T A;  2RJS A;  4C5R A;  4NSL A;  3F4R A;  1FUO A;  1C3C A;  4V2R A;  2VL7 A;  1FUP A;  3GTD A;  1Z4M A;  1YIS A;  4C5U A;  2OHY A;  4ADM A;  4YIK A;  5F92 A;  4V2Q A;  4L6C A;  2YII A;  1JSW A;  2FEN A;  3E04 A;  1VDK A;  1C3U A;  2NYN A;  1TJ7 A;  1Z4K A;  2O7B A;  1GKM A;  1TJU A;  1Z4Q A;  4APB A;  4BAA A;  1HY0 A;  1GK3 A;  1XMD A;  1K62 A;  3C8T A;  1FUR A;  1Z4L A;  3R6Y A;  4HGV A;  1W27 A;  4C5S A;  2HVG A;  1B8F A;  1KQ7 A;  1Z4P X;  4EFC A;  5M0I A;  2PFM A;  1DCN A;  3OCE A;  3NO9 A;  1U16 A;  2VSF A;  2YV5 A;  3BHG A;  4MX2 A;  4YIH A;  1AUW A;  3GZH A;  3CI0 K;  3RD8 A;  2PTQ A;  2D27 A;  2O7F A;  1FUQ A;  1Z4J A;  3R6Q A;  4NFL A;  5EYV A;  3CZO A;  1TJW A;  4IQJ M;  3NZ4 A;  3OCF A;  2FEL A;  2PTS A;  3TV2 A;  4FFX A;  3BWV A;  1EB4 A;  3U13 A;  4ADL A;  2J91 A;  1HY1 A;  1XL8 A;  2VD6 A;  2O7E A;  3RRP A;  3KDZ A;  2JAO A;  3F4S A;  1YFE A;  2O7D A;  1Q5N A;  3QBP A;  5M0J A;  2JAW A;  5EYT A;  4MWO A;  2E9F A;  1U0L A;  4MUM A;  1Q92 A;  1MH9 A;  1Y2M A;  4WNL A;  2JAU A;  2QGA B;  1IW7 D;  4BAB A;  3KDY A;  1YFM A;  1T6J A;  2D28 C;  2QVE A;  4FLC A;  3U19 A;  1Q91 A;  3CRV A;  1XLY A;  5F91 A;  1XMC A;  2FUS A;  4NLE A;  2NYF A;  5D6B A;  4APA A;  2I7D A;  4CQ5 A;  2X75 A;  4E88 A;  5HW2 A; 
#chains in the Genus database with same CATH homology
 3UNV A;  2O6Y A;  2RJR A;  1GK2 A;  1GKJ A;  1XWO A;  1RE5 A;  1I0A A;  1J3U A;  1T6P A;  1TJV A;  2O78 A;  1DOF A;  1U15 A;  2PTR A;  3R6V A;  4C6G A;  1K7W A;  4EEI A;  2RJS A;  4C5R A;  4NSL A;  1FUO A;  1C3C A;  4V2R A;  1FUP A;  3GTD A;  4C5U A;  1YIS A;  2OHY A;  4ADM A;  5F92 A;  4V2Q A;  2YII A;  1JSW A;  3E04 A;  1VDK A;  1C3U A;  2NYN A;  1TJ7 A;  2O7B A;  1GKM A;  1TJU A;  4APB A;  4BAA A;  1HY0 A;  1GK3 A;  1K62 A;  3C8T A;  1FUR A;  3R6Y A;  4HGV A;  1W27 A;  4C5S A;  2HVG A;  1B8F A;  1KQ7 A;  2PFM A;  1DCN A;  3OCE A;  3NO9 A;  1U16 A;  3BHG A;  4MX2 A;  1AUW A;  3GZH A;  3RD8 A;  2PTQ A;  2O7F A;  1FUQ A;  3R6Q A;  5EYV A;  3CZO A;  1TJW A;  3NZ4 A;  3OCF A;  2PTS A;  3TV2 A;  4FFX A;  1EB4 A;  4ADL A;  2J91 A;  1HY1 A;  2VD6 A;  2O7E A;  3RRP A;  3KDZ A;  1YFE A;  2O7D A;  1Q5N A;  3QBP A;  5EYT A;  2E9F A;  1Y2M A;  2QGA B;  4BAB A;  3KDY A;  1YFM A;  1T6J A;  2QVE A;  4FLC A;  5F91 A;  2FUS A;  4NLE A;  2NYF A;  5D6B A;  4APA A;  4CQ5 A;  2X75 A;  4EFC A;  5HW2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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