4APAA

Crystal structure of mycobacterium tuberculosis fumarase (rv1098c) s318a in apo form
Total Genus 173
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
173
sequence length
459
structure length
440
Chain Sequence
NYRIEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLLSIEDLDRRLDVLAMAKAE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Hydrolase
molecule keywords FUMARATE HYDRATASE CLASS II
total genus 173
structure length 440
sequence length 459
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2012-03-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4apaA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4apaA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4apaA02
2PTQA 1JSWA 3BHGA 3TV2A 3GTDA 1Q5NA 4C5UA 1YFMA 2QGAB 1TJWA 2RJSA 4BAAA 1C3UA 4FFXA 2YIIA 1XWOA 2O7EA 4C5SA 3OCEA 2J91A 1FUPA 1AUWA 3UNVA 1GKMA 2O7DA 4ADMA 1KQ7A 2O78A 1T6JA 3CZOA 4EEIA 1J3UA 1TJ7A 4BABA 1W27A 2OHYA 1C3CA 1FUQA 2X75A 2FUSA 4EFCA 5HW2A 1GKJA 1B8FA 5EYVA 4CQ5A 1VDKA 1FUOA 3KDZA 4MX2A 1U16A 3C8TA 2HVGA 1GK3A 3NO9A 5D6BA 1HY0A 4HGVA 3QBPA 4APBA 4APAA 1HY1A 3OCFA 3R6YA 1K7WA 2RJRA 4C6GA 2O6YA 5F92A 1TJUA 1YISA 2PTRA 1DCNA 2QVEA 3R6VA 3GZHA 2PTSA 5F91A 4V2QA 4ADLA 2VD6A 4C5RA 4FLCA 1DOFA 3KDYA 3RRPA 1T6PA 1K62A 5EYTA 1I0AA 1U15A 1FURA 2PFMA 3NZ4A 1RE5A 4NLEA 1EB4A 1TJVA 3E04A 2E9FA 3RD8A 4NSLA 1GK2A 2NYFA 2O7FA 1Y2MA 3R6QA 2O7BA 1YFEA 4V2RA 2NYNA
chains in the Genus database with same CATH superfamily
2PTQA 1JSWA 4IQJM 3BHGA 1Z4IA 3TV2A 3GTDA 1Q5NA 4C5UA 1MH9A 1YFMA 2QGAB 3U13A 1TJWA 2RJSA 4BAAA 1C3UA 4FFXA 2YIIA 1XLYA 1Q91A 4NFLA 1XWOA 1IW7D 2O7EA 3OCEA 4C5SA 4L57A 2J91A 2YV5A 1FUPA 1Z4MA 1Z4KA 1AUWA 3UNVA 2I7DA 1GKMA 4YIKA 2O7DA 4ADMA 1KQ7A 2RCNA 1T6JA 2O78A 3CZOA 4EEIA 1J3UA 1TJ7A 1U0LA 4A15A 2D27A 5M0IA 5M0JA 4BABA 1W27A 2OHYA 1C3CA 3BWVA 1FUQA 2X75A 2FUSA 2JAUA 1Z4QA 3F4RA 4EFCA 2FENA 2JAOA 3F4TA 5HW2A 1GKJA 1Z4LA 1B8FA 5EYVA 4CQ5A 1VDKA 1FUOA 2JARA 3KDZA 4MX2A 3F4SA 1Z4PX 2VL7A 1U16A 3C8TA 2HVGA 1GK3A 4L6CA 3NO9A 4MUMA 5D6BA 2JAWA 2VSFA 1HY0A 4HGVA 4YIHA 3QBPA 4APBA 4APAA 1HY1A 3OCFA 4MWOA 1Z4JA 3R6YA 1K7WA 2RJRA 1XL7A 4C6GA 2O6YA 5F92A 1T9HA 3CI0K 2FELA 1XMCA 1TJUA 1Q92A 1YISA 4WNLA 2D28C 1DCNA 2PTRA 2QVEA 3R6VA 3GZHA 2PTSA 5F91A 4V2QA 4ADLA 2VD6A 4C5RA 4FLCA 1DOFA 3KDYA 3U19A 3RRPA 1T6PA 1K62A 1XL8A 3CRVA 1I0AA 5EYTA 1U15A 1FURA 2PFMA 4E88A 3NZ4A 1RE5A 4NLEA 1EB4A 1TJVA 3E04A 2E9FA 3RD8A 4NSLA 1GK2A 2NYFA 1XMDA 3CRW1 2O7FA 1Y2MA 5H8WA 3R6QA 4L6AA 2O7BA 1YFEA 4V2RA 2NYNA
chains in the Genus database with same CATH topology
2PTQA 1JSWA 3BHGA 3TV2A 3GTDA 1Q5NA 4C5UA 1YFMA 2QGAB 1TJWA 2RJSA 4BAAA 1C3UA 4FFXA 2YIIA 1XWOA 2O7EA 4C5SA 3OCEA 2J91A 1FUPA 1AUWA 3UNVA 1GKMA 2O7DA 4ADMA 1KQ7A 2O78A 1T6JA 3CZOA 4EEIA 1J3UA 1TJ7A 4BABA 1W27A 2OHYA 1C3CA 1FUQA 2X75A 2FUSA 4EFCA 5HW2A 1GKJA 1B8FA 5EYVA 4CQ5A 1VDKA 1FUOA 3KDZA 4MX2A 1U16A 3C8TA 2HVGA 1GK3A 3NO9A 5D6BA 1HY0A 4HGVA 3QBPA 4APBA 4APAA 1HY1A 3OCFA 3R6YA 1K7WA 2RJRA 4C6GA 2O6YA 5F92A 1TJUA 1YISA 2PTRA 1DCNA 2QVEA 3R6VA 3GZHA 2PTSA 5F91A 4V2QA 4ADLA 2VD6A 4C5RA 4FLCA 1DOFA 3KDYA 3RRPA 1T6PA 1K62A 5EYTA 1I0AA 1U15A 1FURA 2PFMA 3NZ4A 1RE5A 4NLEA 1EB4A 1TJVA 3E04A 2E9FA 3RD8A 4NSLA 1GK2A 2NYFA 2O7FA 1Y2MA 3R6QA 2O7BA 1YFEA 4V2RA 2NYNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PTQ A;  1JSW A;  3BHG A;  3TV2 A;  3GTD A;  1Q5N A;  4C5U A;  1YFM A;  2QGA B;  1TJW A;  2RJS A;  4BAA A;  1C3U A;  4FFX A;  2YII A;  1XWO A;  2O7E A;  4C5S A;  3OCE A;  2J91 A;  1FUP A;  1AUW A;  3UNV A;  1GKM A;  2O7D A;  4ADM A;  1KQ7 A;  2O78 A;  1T6J A;  3CZO A;  4EEI A;  1J3U A;  1TJ7 A;  4BAB A;  1W27 A;  2OHY A;  1C3C A;  1FUQ A;  2X75 A;  2FUS A;  4EFC A;  5HW2 A;  1GKJ A;  1B8F A;  5EYV A;  4CQ5 A;  1VDK A;  1FUO A;  3KDZ A;  4MX2 A;  1U16 A;  3C8T A;  2HVG A;  1GK3 A;  3NO9 A;  5D6B A;  1HY0 A;  4HGV A;  3QBP A;  4APB A;  4APA A;  1HY1 A;  3OCF A;  3R6Y A;  1K7W A;  2RJR A;  4C6G A;  2O6Y A;  5F92 A;  1TJU A;  1YIS A;  2PTR A;  1DCN A;  2QVE A;  3R6V A;  3GZH A;  2PTS A;  5F91 A;  4V2Q A;  4ADL A;  2VD6 A;  4C5R A;  4FLC A;  1DOF A;  3KDY A;  3RRP A;  1T6P A;  1K62 A;  5EYT A;  1I0A A;  1U15 A;  1FUR A;  2PFM A;  3NZ4 A;  1RE5 A;  4NLE A;  1EB4 A;  1TJV A;  3E04 A;  2E9F A;  3RD8 A;  4NSL A;  1GK2 A;  2NYF A;  2O7F A;  1Y2M A;  3R6Q A;  2O7B A;  1YFE A;  4V2R A;  2NYN A; 
#chains in the Genus database with same CATH topology
 2PTQ A;  1JSW A;  4IQJ M;  3BHG A;  1Z4I A;  3TV2 A;  3GTD A;  1Q5N A;  4C5U A;  1MH9 A;  1YFM A;  2QGA B;  3U13 A;  1TJW A;  2RJS A;  4BAA A;  1C3U A;  4FFX A;  2YII A;  1XLY A;  1Q91 A;  4NFL A;  1XWO A;  1IW7 D;  2O7E A;  3OCE A;  4C5S A;  4L57 A;  2J91 A;  2YV5 A;  1FUP A;  1Z4M A;  1Z4K A;  1AUW A;  3UNV A;  2I7D A;  1GKM A;  4YIK A;  2O7D A;  4ADM A;  1KQ7 A;  2RCN A;  1T6J A;  2O78 A;  3CZO A;  4EEI A;  1J3U A;  1TJ7 A;  1U0L A;  4A15 A;  2D27 A;  5M0I A;  5M0J A;  4BAB A;  1W27 A;  2OHY A;  1C3C A;  3BWV A;  1FUQ A;  2X75 A;  2FUS A;  2JAU A;  1Z4Q A;  3F4R A;  4EFC A;  2FEN A;  2JAO A;  3F4T A;  5HW2 A;  1GKJ A;  1Z4L A;  1B8F A;  5EYV A;  4CQ5 A;  1VDK A;  1FUO A;  2JAR A;  3KDZ A;  4MX2 A;  3F4S A;  1Z4P X;  2VL7 A;  1U16 A;  3C8T A;  2HVG A;  1GK3 A;  4L6C A;  3NO9 A;  4MUM A;  5D6B A;  2JAW A;  2VSF A;  1HY0 A;  4HGV A;  4YIH A;  3QBP A;  4APB A;  4APA A;  1HY1 A;  3OCF A;  4MWO A;  1Z4J A;  3R6Y A;  1K7W A;  2RJR A;  1XL7 A;  4C6G A;  2O6Y A;  5F92 A;  1T9H A;  3CI0 K;  2FEL A;  1XMC A;  1TJU A;  1Q92 A;  1YIS A;  4WNL A;  2D28 C;  1DCN A;  2PTR A;  2QVE A;  3R6V A;  3GZH A;  2PTS A;  5F91 A;  4V2Q A;  4ADL A;  2VD6 A;  4C5R A;  4FLC A;  1DOF A;  3KDY A;  3U19 A;  3RRP A;  1T6P A;  1K62 A;  1XL8 A;  3CRV A;  1I0A A;  5EYT A;  1U15 A;  1FUR A;  2PFM A;  4E88 A;  3NZ4 A;  1RE5 A;  4NLE A;  1EB4 A;  1TJV A;  3E04 A;  2E9F A;  3RD8 A;  4NSL A;  1GK2 A;  2NYF A;  1XMD A;  3CRW 1;  2O7F A;  1Y2M A;  5H8W A;  3R6Q A;  4L6A A;  2O7B A;  1YFE A;  4V2R A;  2NYN A; 
#chains in the Genus database with same CATH homology
 2PTQ A;  1JSW A;  3BHG A;  3TV2 A;  3GTD A;  1Q5N A;  4C5U A;  1YFM A;  2QGA B;  1TJW A;  2RJS A;  4BAA A;  1C3U A;  4FFX A;  2YII A;  1XWO A;  2O7E A;  4C5S A;  3OCE A;  2J91 A;  1FUP A;  1AUW A;  3UNV A;  1GKM A;  2O7D A;  4ADM A;  1KQ7 A;  2O78 A;  1T6J A;  3CZO A;  4EEI A;  1J3U A;  1TJ7 A;  4BAB A;  1W27 A;  2OHY A;  1C3C A;  1FUQ A;  2X75 A;  2FUS A;  4EFC A;  5HW2 A;  1GKJ A;  1B8F A;  5EYV A;  4CQ5 A;  1VDK A;  1FUO A;  3KDZ A;  4MX2 A;  1U16 A;  3C8T A;  2HVG A;  1GK3 A;  3NO9 A;  5D6B A;  1HY0 A;  4HGV A;  3QBP A;  4APB A;  4APA A;  1HY1 A;  3OCF A;  3R6Y A;  1K7W A;  2RJR A;  4C6G A;  2O6Y A;  5F92 A;  1TJU A;  1YIS A;  2PTR A;  1DCN A;  2QVE A;  3R6V A;  3GZH A;  2PTS A;  5F91 A;  4V2Q A;  4ADL A;  2VD6 A;  4C5R A;  4FLC A;  1DOF A;  3KDY A;  3RRP A;  1T6P A;  1K62 A;  5EYT A;  1I0A A;  1U15 A;  1FUR A;  2PFM A;  3NZ4 A;  1RE5 A;  4NLE A;  1EB4 A;  1TJV A;  3E04 A;  2E9F A;  3RD8 A;  4NSL A;  1GK2 A;  2NYF A;  2O7F A;  1Y2M A;  3R6Q A;  2O7B A;  1YFE A;  4V2R A;  2NYN A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...