4APAA

Crystal structure of mycobacterium tuberculosis fumarase (rv1098c) s318a in apo form
Total Genus 173
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
173
sequence length
459
structure length
440
Chain Sequence
NYRIEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLLSIEDLDRRLDVLAMAKAE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Conformational Changes Upon Ligand Binding in the Essential Class II Fumarase Rv1098C from Mycobacterium Tuberculosis.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Hydrolase
molecule keywords FUMARATE HYDRATASE CLASS II
total genus 173
structure length 440
sequence length 459
chains with identical sequence B, C, D
ec nomenclature ec 4.2.1.2: Fumarate hydratase.
pdb deposition date 2012-03-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10415 FumaraseC_C Fumarase C C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.40.30 Mainly Alpha Orthogonal Bundle Ribonucleotide Reductase Protein R1; domain 1 Fumarase/aspartase (C-terminal domain) 4apaA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4apaA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4apaA02
1FURA 4APAA 5D6BA 1C3CA 1HY1A 2O7FA 2FUSA 1C3UA 1U15A 1GKJA 3NZ4A 1VDKA 3QBPA 5EYTA 4FFXA 1YFMA 3OCFA 1JSWA 4EFCA 2RJRA 3GZHA 4C5SA 1HY0A 2VD6A 4CQ5A 3CZOA 1AUWA 4EEIA 1RE5A 4MX2A 3BHGA 4V2QA 2PTQA 4BAAA 4FLCA 2OHYA 2O7EA 1GKMA 3E04A 3R6YA 2O78A 1YFEA 2PTRA 1TJUA 2E9FA 4ADMA 1W27A 3TV2A 2O7BA 1KQ7A 1XWOA 3KDZA 3R6QA 4C5UA 1I0AA 1DOFA 3KDYA 3NO9A 3R6VA 1TJ7A 1FUPA 2YIIA 5EYVA 4C5RA 2X75A 1J3UA 3RRPA 3RD8A 1DCNA 4NSLA 1Q5NA 5F92A 2PFMA 2RJSA 4BABA 1B8FA 4HGVA 1TJWA 4ADLA 1U16A 2QGAB 1GK3A 2PTSA 1EB4A 2NYNA 2O7DA 1T6PA 1K62A 4NLEA 1T6JA 1YISA 2J91A 2HVGA 1Y2MA 1K7WA 3GTDA 3C8TA 4APBA 2O6YA 3UNVA 4V2RA 1GK2A 3OCEA 1TJVA 1FUQA 2QVEA 1FUOA 5HW2A 5F91A 4C6GA 2NYFA
chains in the Genus database with same CATH superfamily
1FURA 2YV5A 4APAA 5D6BA 1C3CA 1HY1A 4MUMA 4E88A 1MH9A 2O7FA 2FUSA 1C3UA 1Q91A 1U15A 1GKJA 2JAWA 2JAOA 1Z4MA 3NZ4A 1VDKA 3QBPA 3CRVA 5EYTA 4FFXA 1YFMA 3OCFA 1JSWA 4EFCA 2RJRA 3GZHA 4C5SA 1HY0A 2VD6A 4CQ5A 3CZOA 1AUWA 2D28C 1RE5A 4EEIA 4MX2A 3BHGA 4V2QA 2PTQA 4L6AA 2JARA 4BAAA 4FLCA 2OHYA 2O7EA 4L6CA 3F4RA 3F4SA 1GKMA 3CRW1 1XMDA 3E04A 3R6YA 2O78A 1YFEA 2PTRA 1TJUA 2E9FA 4ADMA 2FELA 5M0IA 1W27A 3TV2A 4YIKA 2O7BA 1KQ7A 1XWOA 3BWVA 3KDZA 3R6QA 4C5UA 1Z4JA 1I0AA 1DOFA 3KDYA 3NO9A 2D27A 1XL8A 5M0JA 3R6VA 1TJ7A 1FUPA 2YIIA 5EYVA 4C5RA 2X75A 1XL7A 1J3UA 3RRPA 3RD8A 1DCNA 4NSLA 1Q5NA 5F92A 2PFMA 2RJSA 3CI0K 4BABA 1B8FA 4HGVA 1TJWA 4ADLA 1U16A 1Z4KA 1IW7D 2QGAB 4L57A 1GK3A 2PTSA 1Q92A 4IQJM 1EB4A 2NYNA 2RCNA 3U13A 4A15A 2O7DA 1Z4PX 1XLYA 4WNLA 2I7DA 1T6PA 1K62A 4MWOA 4NLEA 1T6JA 1YISA 2J91A 2HVGA 1Y2MA 3U19A 1K7WA 2JAUA 3GTDA 3C8TA 2VSFA 4APBA 2O6YA 4YIHA 3UNVA 2FENA 1XMCA 2VL7A 4V2RA 1Z4LA 1Z4IA 1GK2A 3OCEA 1TJVA 3F4TA 5H8WA 1FUQA 1T9HA 2QVEA 1FUOA 5HW2A 5F91A 4C6GA 1U0LA 2NYFA 1Z4QA 4NFLA
chains in the Genus database with same CATH topology
1FURA 4APAA 5D6BA 1C3CA 1HY1A 2O7FA 2FUSA 1C3UA 1U15A 1GKJA 3NZ4A 1VDKA 3QBPA 5EYTA 4FFXA 1YFMA 3OCFA 1JSWA 4EFCA 2RJRA 3GZHA 4C5SA 1HY0A 2VD6A 4CQ5A 3CZOA 1AUWA 4EEIA 1RE5A 4MX2A 3BHGA 4V2QA 2PTQA 4BAAA 4FLCA 2OHYA 2O7EA 1GKMA 3E04A 3R6YA 2O78A 1YFEA 2PTRA 1TJUA 2E9FA 4ADMA 1W27A 3TV2A 2O7BA 1KQ7A 1XWOA 3KDZA 3R6QA 4C5UA 1I0AA 1DOFA 3KDYA 3NO9A 3R6VA 1TJ7A 1FUPA 2YIIA 5EYVA 4C5RA 2X75A 1J3UA 3RRPA 3RD8A 1DCNA 4NSLA 1Q5NA 5F92A 2PFMA 2RJSA 4BABA 1B8FA 4HGVA 1TJWA 4ADLA 1U16A 2QGAB 1GK3A 2PTSA 1EB4A 2NYNA 2O7DA 1T6PA 1K62A 4NLEA 1T6JA 1YISA 2J91A 2HVGA 1Y2MA 1K7WA 3GTDA 3C8TA 4APBA 2O6YA 3UNVA 4V2RA 1GK2A 3OCEA 1TJVA 1FUQA 2QVEA 1FUOA 5HW2A 5F91A 4C6GA 2NYFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FUR A;  4APA A;  5D6B A;  1C3C A;  1HY1 A;  2O7F A;  2FUS A;  1C3U A;  1U15 A;  1GKJ A;  3NZ4 A;  1VDK A;  3QBP A;  5EYT A;  4FFX A;  1YFM A;  3OCF A;  1JSW A;  4EFC A;  2RJR A;  3GZH A;  4C5S A;  1HY0 A;  2VD6 A;  4CQ5 A;  3CZO A;  1AUW A;  4EEI A;  1RE5 A;  4MX2 A;  3BHG A;  4V2Q A;  2PTQ A;  4BAA A;  4FLC A;  2OHY A;  2O7E A;  1GKM A;  3E04 A;  3R6Y A;  2O78 A;  1YFE A;  2PTR A;  1TJU A;  2E9F A;  4ADM A;  1W27 A;  3TV2 A;  2O7B A;  1KQ7 A;  1XWO A;  3KDZ A;  3R6Q A;  4C5U A;  1I0A A;  1DOF A;  3KDY A;  3NO9 A;  3R6V A;  1TJ7 A;  1FUP A;  2YII A;  5EYV A;  4C5R A;  2X75 A;  1J3U A;  3RRP A;  3RD8 A;  1DCN A;  4NSL A;  1Q5N A;  5F92 A;  2PFM A;  2RJS A;  4BAB A;  1B8F A;  4HGV A;  1TJW A;  4ADL A;  1U16 A;  2QGA B;  1GK3 A;  2PTS A;  1EB4 A;  2NYN A;  2O7D A;  1T6P A;  1K62 A;  4NLE A;  1T6J A;  1YIS A;  2J91 A;  2HVG A;  1Y2M A;  1K7W A;  3GTD A;  3C8T A;  4APB A;  2O6Y A;  3UNV A;  4V2R A;  1GK2 A;  3OCE A;  1TJV A;  1FUQ A;  2QVE A;  1FUO A;  5HW2 A;  5F91 A;  4C6G A;  2NYF A; 
#chains in the Genus database with same CATH topology
 1FUR A;  2YV5 A;  4APA A;  5D6B A;  1C3C A;  1HY1 A;  4MUM A;  4E88 A;  1MH9 A;  2O7F A;  2FUS A;  1C3U A;  1Q91 A;  1U15 A;  1GKJ A;  2JAW A;  2JAO A;  1Z4M A;  3NZ4 A;  1VDK A;  3QBP A;  3CRV A;  5EYT A;  4FFX A;  1YFM A;  3OCF A;  1JSW A;  4EFC A;  2RJR A;  3GZH A;  4C5S A;  1HY0 A;  2VD6 A;  4CQ5 A;  3CZO A;  1AUW A;  2D28 C;  1RE5 A;  4EEI A;  4MX2 A;  3BHG A;  4V2Q A;  2PTQ A;  4L6A A;  2JAR A;  4BAA A;  4FLC A;  2OHY A;  2O7E A;  4L6C A;  3F4R A;  3F4S A;  1GKM A;  3CRW 1;  1XMD A;  3E04 A;  3R6Y A;  2O78 A;  1YFE A;  2PTR A;  1TJU A;  2E9F A;  4ADM A;  2FEL A;  5M0I A;  1W27 A;  3TV2 A;  4YIK A;  2O7B A;  1KQ7 A;  1XWO A;  3BWV A;  3KDZ A;  3R6Q A;  4C5U A;  1Z4J A;  1I0A A;  1DOF A;  3KDY A;  3NO9 A;  2D27 A;  1XL8 A;  5M0J A;  3R6V A;  1TJ7 A;  1FUP A;  2YII A;  5EYV A;  4C5R A;  2X75 A;  1XL7 A;  1J3U A;  3RRP A;  3RD8 A;  1DCN A;  4NSL A;  1Q5N A;  5F92 A;  2PFM A;  2RJS A;  3CI0 K;  4BAB A;  1B8F A;  4HGV A;  1TJW A;  4ADL A;  1U16 A;  1Z4K A;  1IW7 D;  2QGA B;  4L57 A;  1GK3 A;  2PTS A;  1Q92 A;  4IQJ M;  1EB4 A;  2NYN A;  2RCN A;  3U13 A;  4A15 A;  2O7D A;  1Z4P X;  1XLY A;  4WNL A;  2I7D A;  1T6P A;  1K62 A;  4MWO A;  4NLE A;  1T6J A;  1YIS A;  2J91 A;  2HVG A;  1Y2M A;  3U19 A;  1K7W A;  2JAU A;  3GTD A;  3C8T A;  2VSF A;  4APB A;  2O6Y A;  4YIH A;  3UNV A;  2FEN A;  1XMC A;  2VL7 A;  4V2R A;  1Z4L A;  1Z4I A;  1GK2 A;  3OCE A;  1TJV A;  3F4T A;  5H8W A;  1FUQ A;  1T9H A;  2QVE A;  1FUO A;  5HW2 A;  5F91 A;  4C6G A;  1U0L A;  2NYF A;  1Z4Q A;  4NFL A; 
#chains in the Genus database with same CATH homology
 1FUR A;  4APA A;  5D6B A;  1C3C A;  1HY1 A;  2O7F A;  2FUS A;  1C3U A;  1U15 A;  1GKJ A;  3NZ4 A;  1VDK A;  3QBP A;  5EYT A;  4FFX A;  1YFM A;  3OCF A;  1JSW A;  4EFC A;  2RJR A;  3GZH A;  4C5S A;  1HY0 A;  2VD6 A;  4CQ5 A;  3CZO A;  1AUW A;  4EEI A;  1RE5 A;  4MX2 A;  3BHG A;  4V2Q A;  2PTQ A;  4BAA A;  4FLC A;  2OHY A;  2O7E A;  1GKM A;  3E04 A;  3R6Y A;  2O78 A;  1YFE A;  2PTR A;  1TJU A;  2E9F A;  4ADM A;  1W27 A;  3TV2 A;  2O7B A;  1KQ7 A;  1XWO A;  3KDZ A;  3R6Q A;  4C5U A;  1I0A A;  1DOF A;  3KDY A;  3NO9 A;  3R6V A;  1TJ7 A;  1FUP A;  2YII A;  5EYV A;  4C5R A;  2X75 A;  1J3U A;  3RRP A;  3RD8 A;  1DCN A;  4NSL A;  1Q5N A;  5F92 A;  2PFM A;  2RJS A;  4BAB A;  1B8F A;  4HGV A;  1TJW A;  4ADL A;  1U16 A;  2QGA B;  1GK3 A;  2PTS A;  1EB4 A;  2NYN A;  2O7D A;  1T6P A;  1K62 A;  4NLE A;  1T6J A;  1YIS A;  2J91 A;  2HVG A;  1Y2M A;  1K7W A;  3GTD A;  3C8T A;  4APB A;  2O6Y A;  3UNV A;  4V2R A;  1GK2 A;  3OCE A;  1TJV A;  1FUQ A;  2QVE A;  1FUO A;  5HW2 A;  5F91 A;  4C6G A;  2NYF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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