4AYIA

Structure of a complex between ccps 6 and 7 of human complement factor h and neisseria meningitidis fhbp variant 3 wild type
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
120
structure length
120
Chain Sequence
PCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules.
pubmed doi rcsb
molecule tags Immune system
source organism Homo sapiens
molecule keywords COMPLEMENT FACTOR H
total genus 21
structure length 120
sequence length 120
chains with identical sequence E
ec nomenclature
pdb deposition date 2012-06-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4ayiA02
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4ayiA01
2QY0A 3KXVA 4LOTA 1VVCA 1H2QP 2MCYA 2EC3A 1SS2A 2UWNA 1QGBA 3MQLA 2CG7A 3ERBA 1E8BA 3IU3I 2RL0A 1G4GA 1G4FA 1OK3A 2A55A 1HFIA 2XRDA 2YRAA 2EHFA 3OP8A 4C16A 5I0QB 3KZJA 1HFHA 3NFPI 3SW0X 2W81A 2YBYA 4DJZA 1QO6A 3M7PA 1H03P 3OXUD 3TVJA 3GXEA 4AYIA 4AYEA 1LY2A 2RLPA 3T5OA 1OK1A 2KRIA 4WJG2 3INBC 5HZPB 1E88A 5FO8C 4ZH1D 4ONTD 1C1ZA 5JPMG 1Z92B 3CALA 4B2RA 2RLQA 3ZD2A 2XWBF 2RKYA 4B2SA 2JGWA 1TPMA 1GHQB 1H2PP 1O9AA 1OJVA 1GPZA 3L89M 2MCZA 3O8EB 1U5MA 4AYDA 1TPGA 1ELVA 3R62A 4CSYA 3OEDC 4IGDA 1VVDA 2JRAA 2BZMA 2XRBA 2WIIC 4YNXA 2W80A 1HCCA 1MD7A 3RJ3D 1TPNA 1FBRA 4AYMA 1UOTP 2KMSA 3GOVA 1E5GA 2O39C 1CKLA 1Q3XA 4J38B 2JGXA 3ZRZA 4F4OC 1NWVA 5HYUB 4MUCA 4KKDA 3ZD1A 1ZJKA 1GKNA 2ERJA 2CKUA 4LOSA 4PZ5A 4K12A 1OJWA 2G7IA 1MD8A 2B5ID 2RKZA 4JHSA 4A5WB 2LOJA 1QUBA 1SRZA 1OK9A 2XWJI 1OJYA 3EJHA 5HYTB 3IX0A 2IZ4A 1H04P 5HYPA 2CG6A 1GKGA 2V8EA 2XQWC 1OK2A 4FXGG 1PPQA 2IZ3A
chains in the Genus database with same CATH superfamily
2QY0A 3KXVA 4LOTA 2X2ZA 1VVCA 1H2QP 2MCYA 2EC3A 1SS2A 2UWNA 1QGBA 3MQLA 2CG7A 3ERBA 1E8BA 3IU3I 2RL0A 1G4GA 1G4FA 1OK3A 2A55A 1HFIA 2XRDA 2YRAA 2EHFA 3OP8A 5DN5A 4C16A 5I0QB 3KZJA 1HFHA 3NFPI 3SW0X 2Y8TA 2W81A 3ZLDA 3K3TA 2YBYA 2Y8RA 4DJZA 1QO6A 3M7PA 3WSXA 1H03P 3OXUD 3TVJA 3GXEA 4AYIA 3F6KA 4AYEA 1LY2A 2RLPA 3T5OA 1OK1A 2KRIA 4WJG2 3INBC 5HZPB 1E88A 3VWOA 5DN4A 5FO8C 4ZH1D 4ONTD 1C1ZA 3FGTA 5JPMG 1RLHA 1Z92B 3CALA 4MSLA 4B2RA 2RLQA 3FGRA 3ZD2A 2XWBF 2RKYA 4B2SA 2JGWA 4BWCA 1TPMA 1GHQB 1H2PP 1O9AA 1OJVA 1GPZA 3L89M 2MCZA 3O8EB 1U5MA 4AYDA 4PO7A 1TPGA 1ELVA 3R62A 4CSYA 3OEDC 2ZYCA 4IGDA 1VVDA 2JRAA 2BZMA 2XRBA 2WIIC 3NJAA 2W80A 1HCCA 4YNXA 1MD7A 3RJ3D 1TPNA 1FBRA 4AYMA 1UOTP 2KMSA 3GOVA 1E5GA 2O39C 1CKLA 1Q3XA 4J38B 2JGXA 3ZRZA 4F4OC 1NWVA 5HYUB 4MUCA 4KKDA 3ZD1A 1ZJKA 1GKNA 2ERJA 2Y8SA 2CKUA 4LOSA 4APLA 4PZ5A 4K12A 2I2LA 1OJWA 2G7IA 1MD8A 2B5ID 2RKZA 4JHSA 4A5WB 2LOJA 1QUBA 1SRZA 1OK9A 3WSYA 3ZLEA 2XWJI 1OJYA 3EJHA 5HYTB 4N7EA 3IX0A 2IZ4A 1H04P 3CI0J 5HYPA 2CG6A 4YIZA 1GKGA 2V8EA 2XQWC 1OK2A 4FXGG 1PPQA 2IZ3A
chains in the Genus database with same CATH topology
2QY0A 3KXVA 4LOTA 1VVCA 1H2QP 2MCYA 2EC3A 1SS2A 2UWNA 1QGBA 3MQLA 2CG7A 3ERBA 1E8BA 3IU3I 2RL0A 1G4GA 1G4FA 1OK3A 2A55A 1HFIA 2XRDA 2YRAA 2EHFA 3OP8A 4C16A 5I0QB 3KZJA 1HFHA 3NFPI 3SW0X 2W81A 2YBYA 4DJZA 1QO6A 3M7PA 1H03P 3OXUD 3TVJA 3GXEA 4AYIA 4AYEA 1LY2A 2RLPA 3T5OA 1OK1A 2KRIA 4WJG2 3INBC 5HZPB 1E88A 5FO8C 4ZH1D 4ONTD 1C1ZA 5JPMG 1Z92B 3CALA 4B2RA 2RLQA 3ZD2A 2XWBF 2RKYA 4B2SA 2JGWA 1TPMA 1GHQB 1H2PP 1O9AA 1OJVA 1GPZA 3L89M 2MCZA 3O8EB 1U5MA 4AYDA 1TPGA 1ELVA 3R62A 4CSYA 3OEDC 4IGDA 1VVDA 2JRAA 2BZMA 2XRBA 2WIIC 4YNXA 2W80A 1HCCA 1MD7A 3RJ3D 1TPNA 1FBRA 4AYMA 1UOTP 2KMSA 3GOVA 1E5GA 2O39C 1CKLA 1Q3XA 4J38B 2JGXA 3ZRZA 4F4OC 1NWVA 5HYUB 4MUCA 4KKDA 3ZD1A 1ZJKA 1GKNA 2ERJA 2CKUA 4LOSA 4PZ5A 4K12A 1OJWA 2G7IA 1MD8A 2B5ID 2RKZA 4JHSA 4A5WB 2LOJA 1QUBA 1SRZA 1OK9A 2XWJI 1OJYA 3EJHA 5HYTB 3IX0A 2IZ4A 1H04P 5HYPA 2CG6A 1GKGA 2V8EA 2XQWC 1OK2A 4FXGG 1PPQA 2IZ3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2QY0 A;  3KXV A;  4LOT A;  1VVC A;  1H2Q P;  2MCY A;  2EC3 A;  1SS2 A;  2UWN A;  1QGB A;  3MQL A;  2CG7 A;  3ERB A;  1E8B A;  3IU3 I;  2RL0 A;  1G4G A;  1G4F A;  1OK3 A;  2A55 A;  1HFI A;  2XRD A;  2YRA A;  2EHF A;  3OP8 A;  4C16 A;  5I0Q B;  3KZJ A;  1HFH A;  3NFP I;  3SW0 X;  2W81 A;  2YBY A;  4DJZ A;  1QO6 A;  3M7P A;  1H03 P;  3OXU D;  3TVJ A;  3GXE A;  4AYI A;  4AYE A;  1LY2 A;  2RLP A;  3T5O A;  1OK1 A;  2KRI A;  4WJG 2;  3INB C;  5HZP B;  1E88 A;  5FO8 C;  4ZH1 D;  4ONT D;  1C1Z A;  5JPM G;  1Z92 B;  3CAL A;  4B2R A;  2RLQ A;  3ZD2 A;  2XWB F;  2RKY A;  4B2S A;  2JGW A;  1TPM A;  1GHQ B;  1H2P P;  1O9A A;  1OJV A;  1GPZ A;  3L89 M;  2MCZ A;  3O8E B;  1U5M A;  4AYD A;  1TPG A;  1ELV A;  3R62 A;  4CSY A;  3OED C;  4IGD A;  1VVD A;  2JRA A;  2BZM A;  2XRB A;  2WII C;  4YNX A;  2W80 A;  1HCC A;  1MD7 A;  3RJ3 D;  1TPN A;  1FBR A;  4AYM A;  1UOT P;  2KMS A;  3GOV A;  1E5G A;  2O39 C;  1CKL A;  1Q3X A;  4J38 B;  2JGX A;  3ZRZ A;  4F4O C;  1NWV A;  5HYU B;  4MUC A;  4KKD A;  3ZD1 A;  1ZJK A;  1GKN A;  2ERJ A;  2CKU A;  4LOS A;  4PZ5 A;  4K12 A;  1OJW A;  2G7I A;  1MD8 A;  2B5I D;  2RKZ A;  4JHS A;  4A5W B;  2LOJ A;  1QUB A;  1SRZ A;  1OK9 A;  2XWJ I;  1OJY A;  3EJH A;  5HYT B;  3IX0 A;  2IZ4 A;  1H04 P;  5HYP A;  2CG6 A;  1GKG A;  2V8E A;  2XQW C;  1OK2 A;  4FXG G;  1PPQ A;  2IZ3 A; 
#chains in the Genus database with same CATH topology
 2QY0 A;  3KXV A;  4LOT A;  2X2Z A;  1VVC A;  1H2Q P;  2MCY A;  2EC3 A;  1SS2 A;  2UWN A;  1QGB A;  3MQL A;  2CG7 A;  3ERB A;  1E8B A;  3IU3 I;  2RL0 A;  1G4G A;  1G4F A;  1OK3 A;  2A55 A;  1HFI A;  2XRD A;  2YRA A;  2EHF A;  3OP8 A;  5DN5 A;  4C16 A;  5I0Q B;  3KZJ A;  1HFH A;  3NFP I;  3SW0 X;  2Y8T A;  2W81 A;  3ZLD A;  3K3T A;  2YBY A;  2Y8R A;  4DJZ A;  1QO6 A;  3M7P A;  3WSX A;  1H03 P;  3OXU D;  3TVJ A;  3GXE A;  4AYI A;  3F6K A;  4AYE A;  1LY2 A;  2RLP A;  3T5O A;  1OK1 A;  2KRI A;  4WJG 2;  3INB C;  5HZP B;  1E88 A;  3VWO A;  5DN4 A;  5FO8 C;  4ZH1 D;  4ONT D;  1C1Z A;  3FGT A;  5JPM G;  1RLH A;  1Z92 B;  3CAL A;  4MSL A;  4B2R A;  2RLQ A;  3FGR A;  3ZD2 A;  2XWB F;  2RKY A;  4B2S A;  2JGW A;  4BWC A;  1TPM A;  1GHQ B;  1H2P P;  1O9A A;  1OJV A;  1GPZ A;  3L89 M;  2MCZ A;  3O8E B;  1U5M A;  4AYD A;  4PO7 A;  1TPG A;  1ELV A;  3R62 A;  4CSY A;  3OED C;  2ZYC A;  4IGD A;  1VVD A;  2JRA A;  2BZM A;  2XRB A;  2WII C;  3NJA A;  2W80 A;  1HCC A;  4YNX A;  1MD7 A;  3RJ3 D;  1TPN A;  1FBR A;  4AYM A;  1UOT P;  2KMS A;  3GOV A;  1E5G A;  2O39 C;  1CKL A;  1Q3X A;  4J38 B;  2JGX A;  3ZRZ A;  4F4O C;  1NWV A;  5HYU B;  4MUC A;  4KKD A;  3ZD1 A;  1ZJK A;  1GKN A;  2ERJ A;  2Y8S A;  2CKU A;  4LOS A;  4APL A;  4PZ5 A;  4K12 A;  2I2L A;  1OJW A;  2G7I A;  1MD8 A;  2B5I D;  2RKZ A;  4JHS A;  4A5W B;  2LOJ A;  1QUB A;  1SRZ A;  1OK9 A;  3WSY A;  3ZLE A;  2XWJ I;  1OJY A;  3EJH A;  5HYT B;  4N7E A;  3IX0 A;  2IZ4 A;  1H04 P;  3CI0 J;  5HYP A;  2CG6 A;  4YIZ A;  1GKG A;  2V8E A;  2XQW C;  1OK2 A;  4FXG G;  1PPQ A;  2IZ3 A; 
#chains in the Genus database with same CATH homology
 2QY0 A;  3KXV A;  4LOT A;  1VVC A;  1H2Q P;  2MCY A;  2EC3 A;  1SS2 A;  2UWN A;  1QGB A;  3MQL A;  2CG7 A;  3ERB A;  1E8B A;  3IU3 I;  2RL0 A;  1G4G A;  1G4F A;  1OK3 A;  2A55 A;  1HFI A;  2XRD A;  2YRA A;  2EHF A;  3OP8 A;  4C16 A;  5I0Q B;  3KZJ A;  1HFH A;  3NFP I;  3SW0 X;  2W81 A;  2YBY A;  4DJZ A;  1QO6 A;  3M7P A;  1H03 P;  3OXU D;  3TVJ A;  3GXE A;  4AYI A;  4AYE A;  1LY2 A;  2RLP A;  3T5O A;  1OK1 A;  2KRI A;  4WJG 2;  3INB C;  5HZP B;  1E88 A;  5FO8 C;  4ZH1 D;  4ONT D;  1C1Z A;  5JPM G;  1Z92 B;  3CAL A;  4B2R A;  2RLQ A;  3ZD2 A;  2XWB F;  2RKY A;  4B2S A;  2JGW A;  1TPM A;  1GHQ B;  1H2P P;  1O9A A;  1OJV A;  1GPZ A;  3L89 M;  2MCZ A;  3O8E B;  1U5M A;  4AYD A;  1TPG A;  1ELV A;  3R62 A;  4CSY A;  3OED C;  4IGD A;  1VVD A;  2JRA A;  2BZM A;  2XRB A;  2WII C;  4YNX A;  2W80 A;  1HCC A;  1MD7 A;  3RJ3 D;  1TPN A;  1FBR A;  4AYM A;  1UOT P;  2KMS A;  3GOV A;  1E5G A;  2O39 C;  1CKL A;  1Q3X A;  4J38 B;  2JGX A;  3ZRZ A;  4F4O C;  1NWV A;  5HYU B;  4MUC A;  4KKD A;  3ZD1 A;  1ZJK A;  1GKN A;  2ERJ A;  2CKU A;  4LOS A;  4PZ5 A;  4K12 A;  1OJW A;  2G7I A;  1MD8 A;  2B5I D;  2RKZ A;  4JHS A;  4A5W B;  2LOJ A;  1QUB A;  1SRZ A;  1OK9 A;  2XWJ I;  1OJY A;  3EJH A;  5HYT B;  3IX0 A;  2IZ4 A;  1H04 P;  5HYP A;  2CG6 A;  1GKG A;  2V8E A;  2XQW C;  1OK2 A;  4FXG G;  1PPQ A;  2IZ3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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