4B2RA

Solution structure of ccp modules 10-11 of complement factor h
Total Genus 17
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
17
sequence length
126
structure length
126
Chain Sequence
EAAGERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTLPVCIVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords COMPLEMENT FACTOR H
publication title Solution Structure of Ccp Modules 10-12 Illuminates Functional Architecture of the Complement Regulator, Factor H.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Immune system
total genus 17
structure length 126
sequence length 126
ec nomenclature
pdb deposition date 2012-07-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00084 Sushi Sushi repeat (SCR repeat)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4b2rA01
2.10.70.10 Mainly Beta Ribbon Complement Module; domain 1 Complement Module, domain 1 4b2rA02
1TPNA 1HCCA 4ONTD 1GHQB 4F4OC 3NFPI 5HYUB 1SRZA 2CG6A 5HYPA 1HFHA 1OK3A 2CKUA 4KKDA 1G4GA 3CALA 2YBYA 4CSYA 3ERBA 1MD7A 1ZJKA 2LOJA 2EHFA 2KMSA 3OEDC 5FO8C 5HYTB 1ELVA 1O9AA 1MD8A 2XRDA 1LY2A 2XWBF 3L89M 4AYIA 1H04P 2W81A 1VVCA 3SW0X 3RJ3D 3KZJA 3OP8A 4DJZA 2MCZA 4IGDA 1NWVA 5I0QB 2XRBA 1C1ZA 2RLQA 3IX0A 4YNXA 2MCYA 3R62A 1OK9A 1FBRA 4JHSA 4ZH1D 2JGWA 1QGBA 1Q3XA 1E88A 2RKYA 3EJHA 1QO6A 1OJYA 1TPGA 2YRAA 2RLPA 4AYMA 2V8EA 2ERJA 3ZD2A 2RL0A 2WIIC 1Z92B 2B5ID 1GKGA 2W80A 2O39C 1OK2A 3T5OA 3INBC 4PZ5A 4FXGG 3O8EB 1HFIA 3IU3I 1UOTP 1CKLA 3GOVA 1OJWA 1QUBA 4AYEA 4LOTA 3OXUD 1H2PP 4B2SA 4C16A 1G4FA 3GXEA 1VVDA 3KXVA 1SS2A 1U5MA 3ZRZA 2IZ3A 4AYDA 4MUCA 2JRAA 1E8BA 1GKNA 2BZMA 5HZPB 3TVJA 1E5GA 2IZ4A 2CG7A 1H2QP 2UWNA 3M7PA 2RKZA 2QY0A 4K12A 1GPZA 1H03P 4B2RA 2A55A 2JGXA 4J38B 4LOSA 2EC3A 3MQLA 5JPMG 3ZD1A 2G7IA 4WJG2 1OJVA 1TPMA 2KRIA 4A5WB 2XQWC 1OK1A 1PPQA 2XWJI
chains in the Genus database with same CATH superfamily
1TPNA 4BWCA 3ZLDA 4N7EA 1HCCA 4ONTD 1GHQB 4F4OC 3NFPI 5HYUB 1SRZA 2CG6A 5HYPA 1HFHA 1OK3A 2CKUA 4KKDA 1G4GA 3CALA 2YBYA 4CSYA 3ERBA 1MD7A 1ZJKA 2LOJA 2EHFA 2KMSA 2Y8SA 3OEDC 5FO8C 5HYTB 1ELVA 1O9AA 1MD8A 2XRDA 1LY2A 5DN4A 2XWBF 3L89M 4AYIA 1H04P 2W81A 1VVCA 3SW0X 3RJ3D 3KZJA 3OP8A 4DJZA 2MCZA 4IGDA 1NWVA 2I2LA 5DN5A 5I0QB 2XRBA 1C1ZA 2RLQA 3IX0A 4YNXA 2MCYA 3FGTA 3R62A 3VWOA 1OK9A 1FBRA 4JHSA 4ZH1D 2JGWA 1QGBA 1Q3XA 1E88A 2RKYA 3EJHA 1QO6A 1OJYA 2Y8TA 1TPGA 2YRAA 2RLPA 2Y8RA 4AYMA 3CI0J 2V8EA 2ERJA 3F6KA 2RL0A 2WIIC 3ZD2A 1Z92B 2B5ID 3ZLEA 1GKGA 2W80A 2O39C 1RLHA 1OK2A 3T5OA 3INBC 4PZ5A 4FXGG 3O8EB 1HFIA 3IU3I 1UOTP 1CKLA 3GOVA 1OJWA 1QUBA 4AYEA 4LOTA 3OXUD 1H2PP 4B2SA 4C16A 1G4FA 3GXEA 1VVDA 3KXVA 1SS2A 1U5MA 3ZRZA 2IZ3A 4AYDA 4YIZA 4MUCA 2JRAA 1E8BA 1GKNA 2BZMA 2ZYCA 5HZPB 3TVJA 1E5GA 2IZ4A 2CG7A 1H2QP 2UWNA 3M7PA 2RKZA 2QY0A 4K12A 1GPZA 3WSYA 3WSXA 1H03P 3FGRA 4B2RA 2A55A 2JGXA 4J38B 4LOSA 2EC3A 3MQLA 5JPMG 3ZD1A 4APLA 2G7IA 4WJG2 4MSLA 4PO7A 1OJVA 1TPMA 2KRIA 4A5WB 2XQWC 2X2ZA 1OK1A 1PPQA 2XWJI 3K3TA 3NJAA
chains in the Genus database with same CATH topology
1TPNA 1HCCA 4ONTD 1GHQB 4F4OC 3NFPI 5HYUB 1SRZA 2CG6A 5HYPA 1HFHA 1OK3A 2CKUA 4KKDA 1G4GA 3CALA 2YBYA 4CSYA 3ERBA 1MD7A 1ZJKA 2LOJA 2EHFA 2KMSA 3OEDC 5FO8C 5HYTB 1ELVA 1O9AA 1MD8A 2XRDA 1LY2A 2XWBF 3L89M 4AYIA 1H04P 2W81A 1VVCA 3SW0X 3RJ3D 3KZJA 3OP8A 4DJZA 2MCZA 4IGDA 1NWVA 5I0QB 2XRBA 1C1ZA 2RLQA 3IX0A 4YNXA 2MCYA 3R62A 1OK9A 1FBRA 4JHSA 4ZH1D 2JGWA 1QGBA 1Q3XA 1E88A 2RKYA 3EJHA 1QO6A 1OJYA 1TPGA 2YRAA 2RLPA 4AYMA 2V8EA 2ERJA 3ZD2A 2RL0A 2WIIC 1Z92B 2B5ID 1GKGA 2W80A 2O39C 1OK2A 3T5OA 3INBC 4PZ5A 4FXGG 3O8EB 1HFIA 3IU3I 1UOTP 1CKLA 3GOVA 1OJWA 1QUBA 4AYEA 4LOTA 3OXUD 1H2PP 4B2SA 4C16A 1G4FA 3GXEA 1VVDA 3KXVA 1SS2A 1U5MA 3ZRZA 2IZ3A 4AYDA 4MUCA 2JRAA 1E8BA 1GKNA 2BZMA 5HZPB 3TVJA 1E5GA 2IZ4A 2CG7A 1H2QP 2UWNA 3M7PA 2RKZA 2QY0A 4K12A 1GPZA 1H03P 4B2RA 2A55A 2JGXA 4J38B 4LOSA 2EC3A 3MQLA 5JPMG 3ZD1A 2G7IA 4WJG2 1OJVA 1TPMA 2KRIA 4A5WB 2XQWC 1OK1A 1PPQA 2XWJI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TPN A;  1HCC A;  4ONT D;  1GHQ B;  4F4O C;  3NFP I;  5HYU B;  1SRZ A;  2CG6 A;  5HYP A;  1HFH A;  1OK3 A;  2CKU A;  4KKD A;  1G4G A;  3CAL A;  2YBY A;  4CSY A;  3ERB A;  1MD7 A;  1ZJK A;  2LOJ A;  2EHF A;  2KMS A;  3OED C;  5FO8 C;  5HYT B;  1ELV A;  1O9A A;  1MD8 A;  2XRD A;  1LY2 A;  2XWB F;  3L89 M;  4AYI A;  1H04 P;  2W81 A;  1VVC A;  3SW0 X;  3RJ3 D;  3KZJ A;  3OP8 A;  4DJZ A;  2MCZ A;  4IGD A;  1NWV A;  5I0Q B;  2XRB A;  1C1Z A;  2RLQ A;  3IX0 A;  4YNX A;  2MCY A;  3R62 A;  1OK9 A;  1FBR A;  4JHS A;  4ZH1 D;  2JGW A;  1QGB A;  1Q3X A;  1E88 A;  2RKY A;  3EJH A;  1QO6 A;  1OJY A;  1TPG A;  2YRA A;  2RLP A;  4AYM A;  2V8E A;  2ERJ A;  3ZD2 A;  2RL0 A;  2WII C;  1Z92 B;  2B5I D;  1GKG A;  2W80 A;  2O39 C;  1OK2 A;  3T5O A;  3INB C;  4PZ5 A;  4FXG G;  3O8E B;  1HFI A;  3IU3 I;  1UOT P;  1CKL A;  3GOV A;  1OJW A;  1QUB A;  4AYE A;  4LOT A;  3OXU D;  1H2P P;  4B2S A;  4C16 A;  1G4F A;  3GXE A;  1VVD A;  3KXV A;  1SS2 A;  1U5M A;  3ZRZ A;  2IZ3 A;  4AYD A;  4MUC A;  2JRA A;  1E8B A;  1GKN A;  2BZM A;  5HZP B;  3TVJ A;  1E5G A;  2IZ4 A;  2CG7 A;  1H2Q P;  2UWN A;  3M7P A;  2RKZ A;  2QY0 A;  4K12 A;  1GPZ A;  1H03 P;  4B2R A;  2A55 A;  2JGX A;  4J38 B;  4LOS A;  2EC3 A;  3MQL A;  5JPM G;  3ZD1 A;  2G7I A;  4WJG 2;  1OJV A;  1TPM A;  2KRI A;  4A5W B;  2XQW C;  1OK1 A;  1PPQ A;  2XWJ I; 
#chains in the Genus database with same CATH topology
 1TPN A;  4BWC A;  3ZLD A;  4N7E A;  1HCC A;  4ONT D;  1GHQ B;  4F4O C;  3NFP I;  5HYU B;  1SRZ A;  2CG6 A;  5HYP A;  1HFH A;  1OK3 A;  2CKU A;  4KKD A;  1G4G A;  3CAL A;  2YBY A;  4CSY A;  3ERB A;  1MD7 A;  1ZJK A;  2LOJ A;  2EHF A;  2KMS A;  2Y8S A;  3OED C;  5FO8 C;  5HYT B;  1ELV A;  1O9A A;  1MD8 A;  2XRD A;  1LY2 A;  5DN4 A;  2XWB F;  3L89 M;  4AYI A;  1H04 P;  2W81 A;  1VVC A;  3SW0 X;  3RJ3 D;  3KZJ A;  3OP8 A;  4DJZ A;  2MCZ A;  4IGD A;  1NWV A;  2I2L A;  5DN5 A;  5I0Q B;  2XRB A;  1C1Z A;  2RLQ A;  3IX0 A;  4YNX A;  2MCY A;  3FGT A;  3R62 A;  3VWO A;  1OK9 A;  1FBR A;  4JHS A;  4ZH1 D;  2JGW A;  1QGB A;  1Q3X A;  1E88 A;  2RKY A;  3EJH A;  1QO6 A;  1OJY A;  2Y8T A;  1TPG A;  2YRA A;  2RLP A;  2Y8R A;  4AYM A;  3CI0 J;  2V8E A;  2ERJ A;  3F6K A;  2RL0 A;  2WII C;  3ZD2 A;  1Z92 B;  2B5I D;  3ZLE A;  1GKG A;  2W80 A;  2O39 C;  1RLH A;  1OK2 A;  3T5O A;  3INB C;  4PZ5 A;  4FXG G;  3O8E B;  1HFI A;  3IU3 I;  1UOT P;  1CKL A;  3GOV A;  1OJW A;  1QUB A;  4AYE A;  4LOT A;  3OXU D;  1H2P P;  4B2S A;  4C16 A;  1G4F A;  3GXE A;  1VVD A;  3KXV A;  1SS2 A;  1U5M A;  3ZRZ A;  2IZ3 A;  4AYD A;  4YIZ A;  4MUC A;  2JRA A;  1E8B A;  1GKN A;  2BZM A;  2ZYC A;  5HZP B;  3TVJ A;  1E5G A;  2IZ4 A;  2CG7 A;  1H2Q P;  2UWN A;  3M7P A;  2RKZ A;  2QY0 A;  4K12 A;  1GPZ A;  3WSY A;  3WSX A;  1H03 P;  3FGR A;  4B2R A;  2A55 A;  2JGX A;  4J38 B;  4LOS A;  2EC3 A;  3MQL A;  5JPM G;  3ZD1 A;  4APL A;  2G7I A;  4WJG 2;  4MSL A;  4PO7 A;  1OJV A;  1TPM A;  2KRI A;  4A5W B;  2XQW C;  2X2Z A;  1OK1 A;  1PPQ A;  2XWJ I;  3K3T A;  3NJA A; 
#chains in the Genus database with same CATH homology
 1TPN A;  1HCC A;  4ONT D;  1GHQ B;  4F4O C;  3NFP I;  5HYU B;  1SRZ A;  2CG6 A;  5HYP A;  1HFH A;  1OK3 A;  2CKU A;  4KKD A;  1G4G A;  3CAL A;  2YBY A;  4CSY A;  3ERB A;  1MD7 A;  1ZJK A;  2LOJ A;  2EHF A;  2KMS A;  3OED C;  5FO8 C;  5HYT B;  1ELV A;  1O9A A;  1MD8 A;  2XRD A;  1LY2 A;  2XWB F;  3L89 M;  4AYI A;  1H04 P;  2W81 A;  1VVC A;  3SW0 X;  3RJ3 D;  3KZJ A;  3OP8 A;  4DJZ A;  2MCZ A;  4IGD A;  1NWV A;  5I0Q B;  2XRB A;  1C1Z A;  2RLQ A;  3IX0 A;  4YNX A;  2MCY A;  3R62 A;  1OK9 A;  1FBR A;  4JHS A;  4ZH1 D;  2JGW A;  1QGB A;  1Q3X A;  1E88 A;  2RKY A;  3EJH A;  1QO6 A;  1OJY A;  1TPG A;  2YRA A;  2RLP A;  4AYM A;  2V8E A;  2ERJ A;  3ZD2 A;  2RL0 A;  2WII C;  1Z92 B;  2B5I D;  1GKG A;  2W80 A;  2O39 C;  1OK2 A;  3T5O A;  3INB C;  4PZ5 A;  4FXG G;  3O8E B;  1HFI A;  3IU3 I;  1UOT P;  1CKL A;  3GOV A;  1OJW A;  1QUB A;  4AYE A;  4LOT A;  3OXU D;  1H2P P;  4B2S A;  4C16 A;  1G4F A;  3GXE A;  1VVD A;  3KXV A;  1SS2 A;  1U5M A;  3ZRZ A;  2IZ3 A;  4AYD A;  4MUC A;  2JRA A;  1E8B A;  1GKN A;  2BZM A;  5HZP B;  3TVJ A;  1E5G A;  2IZ4 A;  2CG7 A;  1H2Q P;  2UWN A;  3M7P A;  2RKZ A;  2QY0 A;  4K12 A;  1GPZ A;  1H03 P;  4B2R A;  2A55 A;  2JGX A;  4J38 B;  4LOS A;  2EC3 A;  3MQL A;  5JPM G;  3ZD1 A;  2G7I A;  4WJG 2;  1OJV A;  1TPM A;  2KRI A;  4A5W B;  2XQW C;  1OK1 A;  1PPQ A;  2XWJ I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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