4BAAA

Redesign of a phenylalanine aminomutase into a beta-phenylalanine ammonia lyase
Total Genus 245
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
245
sequence length
667
structure length
635
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIYGVTTGFGACSSSRTNRLSELQESLIRCLLAGVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHTLVDRLAEFEKRLSDRLENEMTAVRVLYERIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Redesign of a Phenylalanine Aminomutase Into a Phenylalanine Ammonia Lyase
rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
molecule keywords PHENYLALANINE AMMONIA-LYASE
total genus 245
structure length 635
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2012-09-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4baaA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4baaA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4baaA02
2FUSA 1HY0A 2NYNA 4CQ5A 2PFMA 2O7FA 2YIIA 2NYFA 4APBA 4C5RA 3NO9A 3E04A 1K7WA 1GK2A 1GKJA 4ADMA 4BAAA 1GKMA 5F92A 1J3UA 4HGVA 3C8TA 1JSWA 2OHYA 4EEIA 4EFCA 2RJSA 1U15A 1YFEA 1DOFA 4C5UA 3GTDA 5HW2A 1TJ7A 2PTRA 1Q5NA 1EB4A 1U16A 2X75A 1FUPA 2O7EA 3TV2A 1YFMA 1FUQA 3KDYA 1Y2MA 2E9FA 1T6JA 4V2QA 1XWOA 5EYVA 4BABA 1I0AA 3NZ4A 1TJWA 2O7BA 3GZHA 3KDZA 4C5SA 3BHGA 4FFXA 3R6VA 1K62A 1KQ7A 2O7DA 4NSLA 1AUWA 4ADLA 2VD6A 1VDKA 2J91A 1TJVA 1YISA 3RD8A 2PTQA 1HY1A 5F91A 2QVEA 1GK3A 3UNVA 1RE5A 5D6BA 2O78A 1FURA 3OCFA 1W27A 1T6PA 2RJRA 3QBPA 1DCNA 1TJUA 2O6YA 2QGAB 4APAA 1C3CA 4C6GA 3R6QA 2PTSA 1C3UA 3R6YA 4NLEA 1B8FA 3RRPA 3OCEA 5EYTA 3CZOA 4MX2A 1FUOA 4FLCA 2HVGA 4V2RA
chains in the Genus database with same CATH superfamily
1IW7D 2FUSA 2FELA 2NVYA 3GTLA 1HY0A 1I3QA 2NYNA 4CQ5A 1YNND 3LR8A 2VL7A 2PFMA 2O7FA 2X0QA 5IZ2A 1XMCA 2JA5A 2LYIA 2YIIA 2NYFA 4APBA 4C5RA 3NO9A 1I6VD 3E04A 1K7WA 1GK2A 2EZBA 2A68D 2HWGA 2JA7A 1GKJA 4ADMA 4BAAA 1GKMA 5F92A 1I50A 1J3UA 4HGVA 3C8TA 2Y0NA 1TWFA 1JSWA 2MX8A 3GTKA 2OHYA 4CEHA 4EEIA 4EFCA 2RJSA 1U15A 1YFEA 3GTPA 1DOFA 1SFOA 1ZYMA 3EZEA 2R92A 3CRW1 4C5UA 3GTDA 5HW2A 3CRVA 1TJ7A 2BE5D 2PTRA 4WNLA 2K3NA 2VK9A 1SMYD 1Q5NA 1EB4A 2AQLA 3GTOA 1U16A 2X75A 5H8WA 1FUPA 2O7EA 2B63A 3TV2A 1YFMA 1FUQA 3KDYA 1Y2MA 2MP0A 2MX9A 2X0PA 2LTHA 3LR2A 3GTMA 1Y1VA 3GTGA 2E9FA 1XLYA 1T6JA 1ZYRD 2FENA 1XMDA 4V2QA 2NVXA 1TWHA 1XL8A 2F5JA 1XWOA 1EZBA 3CQZA 2O5JD 2E2HA 5M0JA 1R9TA 5EYVA 4C2MA 1TWGA 1K83A 4BABA 1XL7A 2LPJA 1I0AA 3NZ4A 3EZAA 2FIPA 2A6ED 1TJWA 2O7BA 3GZHA 3KDZA 1TWCA 4C5SA 2MQAA 2E2IA 3BHGA 4FFXA 3R6VA 2EZAA 4FBSA 1K62A 1KQ7A 4CEJA 2O7DA 4NSLA 1AUWA 4ADLA 2VD6A 1VDKA 2J91A 1TJVA 1TWAA 2LKMB 1YISA 3RD8A 3LR6A 2FIOA 2PTQA 1HY1A 5F91A 3FKIA 2A69D 2QVEA 1GK3A 3UNVA 4QIWA 2K3OA 2VSFA 2A6HD 2HROA 2JA6A 1RE5A 5D6BA 2O78A 1FURA 3GTJA 3GTQA 1Y1WA 1W27A 1T6PA 3OCFA 2RJRA 1YNJD 4A15A 3U4QA 3QBPA 2R93A 2K3QA 2N1DB 1DCNA 3LRDA 3H0GA 1TJUA 2O6YA 1C3CA 2QGAB 4APAA 4C6GA 3R6QA 1HQMD 2PTSA 1C3UA 2X0OA 2YU9A 1WCMA 3R6YA 1EZAA 4NLEA 1B8FA 3RRPA 3OCEA 2VUMA 5EYTA 2N3EA 4CEIA 3U44A 3CZOA 4MX2A 2CW0D 5M0IA 2EZCA 2R7ZA 1FUOA 3EZBA 4FLCA 2HVGA 4V2RA 2LPIA
chains in the Genus database with same CATH topology
2FUSA 1HY0A 2NYNA 4CQ5A 2PFMA 2O7FA 2YIIA 2NYFA 4APBA 4C5RA 3NO9A 3E04A 1K7WA 1GK2A 1GKJA 4ADMA 4BAAA 1GKMA 5F92A 1J3UA 4HGVA 3C8TA 1JSWA 2OHYA 4EEIA 4EFCA 2RJSA 1U15A 1YFEA 1DOFA 4C5UA 3GTDA 5HW2A 1TJ7A 2PTRA 1Q5NA 1EB4A 1U16A 2X75A 1FUPA 2O7EA 3TV2A 1YFMA 1FUQA 3KDYA 1Y2MA 2E9FA 1T6JA 4V2QA 1XWOA 5EYVA 4BABA 1I0AA 3NZ4A 1TJWA 2O7BA 3GZHA 3KDZA 4C5SA 3BHGA 4FFXA 3R6VA 1K62A 1KQ7A 2O7DA 4NSLA 1AUWA 4ADLA 2VD6A 1VDKA 2J91A 1TJVA 1YISA 3RD8A 2PTQA 1HY1A 5F91A 2QVEA 1GK3A 3UNVA 1RE5A 5D6BA 2O78A 1FURA 3OCFA 1W27A 1T6PA 2RJRA 3QBPA 1DCNA 1TJUA 2O6YA 2QGAB 4APAA 1C3CA 4C6GA 3R6QA 2PTSA 1C3UA 3R6YA 4NLEA 1B8FA 3RRPA 3OCEA 5EYTA 3CZOA 4MX2A 1FUOA 4FLCA 2HVGA 4V2RA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FUS A;  1HY0 A;  2NYN A;  4CQ5 A;  2PFM A;  2O7F A;  2YII A;  2NYF A;  4APB A;  4C5R A;  3NO9 A;  3E04 A;  1K7W A;  1GK2 A;  1GKJ A;  4ADM A;  4BAA A;  1GKM A;  5F92 A;  1J3U A;  4HGV A;  3C8T A;  1JSW A;  2OHY A;  4EEI A;  4EFC A;  2RJS A;  1U15 A;  1YFE A;  1DOF A;  4C5U A;  3GTD A;  5HW2 A;  1TJ7 A;  2PTR A;  1Q5N A;  1EB4 A;  1U16 A;  2X75 A;  1FUP A;  2O7E A;  3TV2 A;  1YFM A;  1FUQ A;  3KDY A;  1Y2M A;  2E9F A;  1T6J A;  4V2Q A;  1XWO A;  5EYV A;  4BAB A;  1I0A A;  3NZ4 A;  1TJW A;  2O7B A;  3GZH A;  3KDZ A;  4C5S A;  3BHG A;  4FFX A;  3R6V A;  1K62 A;  1KQ7 A;  2O7D A;  4NSL A;  1AUW A;  4ADL A;  2VD6 A;  1VDK A;  2J91 A;  1TJV A;  1YIS A;  3RD8 A;  2PTQ A;  1HY1 A;  5F91 A;  2QVE A;  1GK3 A;  3UNV A;  1RE5 A;  5D6B A;  2O78 A;  1FUR A;  3OCF A;  1W27 A;  1T6P A;  2RJR A;  3QBP A;  1DCN A;  1TJU A;  2O6Y A;  2QGA B;  4APA A;  1C3C A;  4C6G A;  3R6Q A;  2PTS A;  1C3U A;  3R6Y A;  4NLE A;  1B8F A;  3RRP A;  3OCE A;  5EYT A;  3CZO A;  4MX2 A;  1FUO A;  4FLC A;  2HVG A;  4V2R A; 
#chains in the Genus database with same CATH topology
 1IW7 D;  2FUS A;  2FEL A;  2NVY A;  3GTL A;  1HY0 A;  1I3Q A;  2NYN A;  4CQ5 A;  1YNN D;  3LR8 A;  2VL7 A;  2PFM A;  2O7F A;  2X0Q A;  5IZ2 A;  1XMC A;  2JA5 A;  2LYI A;  2YII A;  2NYF A;  4APB A;  4C5R A;  3NO9 A;  1I6V D;  3E04 A;  1K7W A;  1GK2 A;  2EZB A;  2A68 D;  2HWG A;  2JA7 A;  1GKJ A;  4ADM A;  4BAA A;  1GKM A;  5F92 A;  1I50 A;  1J3U A;  4HGV A;  3C8T A;  2Y0N A;  1TWF A;  1JSW A;  2MX8 A;  3GTK A;  2OHY A;  4CEH A;  4EEI A;  4EFC A;  2RJS A;  1U15 A;  1YFE A;  3GTP A;  1DOF A;  1SFO A;  1ZYM A;  3EZE A;  2R92 A;  3CRW 1;  4C5U A;  3GTD A;  5HW2 A;  3CRV A;  1TJ7 A;  2BE5 D;  2PTR A;  4WNL A;  2K3N A;  2VK9 A;  1SMY D;  1Q5N A;  1EB4 A;  2AQL A;  3GTO A;  1U16 A;  2X75 A;  5H8W A;  1FUP A;  2O7E A;  2B63 A;  3TV2 A;  1YFM A;  1FUQ A;  3KDY A;  1Y2M A;  2MP0 A;  2MX9 A;  2X0P A;  2LTH A;  3LR2 A;  3GTM A;  1Y1V A;  3GTG A;  2E9F A;  1XLY A;  1T6J A;  1ZYR D;  2FEN A;  1XMD A;  4V2Q A;  2NVX A;  1TWH A;  1XL8 A;  2F5J A;  1XWO A;  1EZB A;  3CQZ A;  2O5J D;  2E2H A;  5M0J A;  1R9T A;  5EYV A;  4C2M A;  1TWG A;  1K83 A;  4BAB A;  1XL7 A;  2LPJ A;  1I0A A;  3NZ4 A;  3EZA A;  2FIP A;  2A6E D;  1TJW A;  2O7B A;  3GZH A;  3KDZ A;  1TWC A;  4C5S A;  2MQA A;  2E2I A;  3BHG A;  4FFX A;  3R6V A;  2EZA A;  4FBS A;  1K62 A;  1KQ7 A;  4CEJ A;  2O7D A;  4NSL A;  1AUW A;  4ADL A;  2VD6 A;  1VDK A;  2J91 A;  1TJV A;  1TWA A;  2LKM B;  1YIS A;  3RD8 A;  3LR6 A;  2FIO A;  2PTQ A;  1HY1 A;  5F91 A;  3FKI A;  2A69 D;  2QVE A;  1GK3 A;  3UNV A;  4QIW A;  2K3O A;  2VSF A;  2A6H D;  2HRO A;  2JA6 A;  1RE5 A;  5D6B A;  2O78 A;  1FUR A;  3GTJ A;  3GTQ A;  1Y1W A;  1W27 A;  1T6P A;  3OCF A;  2RJR A;  1YNJ D;  4A15 A;  3U4Q A;  3QBP A;  2R93 A;  2K3Q A;  2N1D B;  1DCN A;  3LRD A;  3H0G A;  1TJU A;  2O6Y A;  1C3C A;  2QGA B;  4APA A;  4C6G A;  3R6Q A;  1HQM D;  2PTS A;  1C3U A;  2X0O A;  2YU9 A;  1WCM A;  3R6Y A;  1EZA A;  4NLE A;  1B8F A;  3RRP A;  3OCE A;  2VUM A;  5EYT A;  2N3E A;  4CEI A;  3U44 A;  3CZO A;  4MX2 A;  2CW0 D;  5M0I A;  2EZC A;  2R7Z A;  1FUO A;  3EZB A;  4FLC A;  2HVG A;  4V2R A;  2LPI A; 
#chains in the Genus database with same CATH homology
 2FUS A;  1HY0 A;  2NYN A;  4CQ5 A;  2PFM A;  2O7F A;  2YII A;  2NYF A;  4APB A;  4C5R A;  3NO9 A;  3E04 A;  1K7W A;  1GK2 A;  1GKJ A;  4ADM A;  4BAA A;  1GKM A;  5F92 A;  1J3U A;  4HGV A;  3C8T A;  1JSW A;  2OHY A;  4EEI A;  4EFC A;  2RJS A;  1U15 A;  1YFE A;  1DOF A;  4C5U A;  3GTD A;  5HW2 A;  1TJ7 A;  2PTR A;  1Q5N A;  1EB4 A;  1U16 A;  2X75 A;  1FUP A;  2O7E A;  3TV2 A;  1YFM A;  1FUQ A;  3KDY A;  1Y2M A;  2E9F A;  1T6J A;  4V2Q A;  1XWO A;  5EYV A;  4BAB A;  1I0A A;  3NZ4 A;  1TJW A;  2O7B A;  3GZH A;  3KDZ A;  4C5S A;  3BHG A;  4FFX A;  3R6V A;  1K62 A;  1KQ7 A;  2O7D A;  4NSL A;  1AUW A;  4ADL A;  2VD6 A;  1VDK A;  2J91 A;  1TJV A;  1YIS A;  3RD8 A;  2PTQ A;  1HY1 A;  5F91 A;  2QVE A;  1GK3 A;  3UNV A;  1RE5 A;  5D6B A;  2O78 A;  1FUR A;  3OCF A;  1W27 A;  1T6P A;  2RJR A;  3QBP A;  1DCN A;  1TJU A;  2O6Y A;  2QGA B;  4APA A;  1C3C A;  4C6G A;  3R6Q A;  2PTS A;  1C3U A;  3R6Y A;  4NLE A;  1B8F A;  3RRP A;  3OCE A;  5EYT A;  3CZO A;  4MX2 A;  1FUO A;  4FLC A;  2HVG A;  4V2R A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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