4BAAA

Redesign of a phenylalanine aminomutase into a beta-phenylalanine ammonia lyase
Total Genus 245
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
245
sequence length
667
structure length
635
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIYGVTTGFGACSSSRTNRLSELQESLIRCLLAGVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHTLVDRLAEFEKRLSDRLENEMTAVRVLYERIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords PHENYLALANINE AMMONIA-LYASE
publication title Redesign of a Phenylalanine Aminomutase Into a Phenylalanine Ammonia Lyase
rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
total genus 245
structure length 635
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2012-09-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4baaA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4baaA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4baaA02
4EEIA 1HY1A 5HW2A 1J3UA 4APAA 2NYNA 4APBA 4BAAA 1K62A 1C3CA 1YISA 2PTQA 4MX2A 2O7EA 4C5RA 4NLEA 2YIIA 1AUWA 4CQ5A 1TJVA 1T6JA 2O7DA 3GZHA 2RJSA 1U15A 1K7WA 2NYFA 1YFMA 1YFEA 4FLCA 3R6YA 3QBPA 5EYVA 2PTSA 1KQ7A 2QVEA 1GK2A 1Q5NA 1GKMA 3NO9A 2HVGA 1U16A 1DCNA 1RE5A 1HY0A 3RRPA 2VD6A 3R6VA 2O7BA 1I0AA 1W27A 4V2RA 5D6BA 3CZOA 3UNVA 3C8TA 1B8FA 2RJRA 2O78A 4BABA 3OCEA 4HGVA 4C5SA 2J91A 4FFXA 1GKJA 1FUQA 1TJ7A 3R6QA 4NSLA 3E04A 1EB4A 4ADMA 4C5UA 2E9FA 5EYTA 1T6PA 1FURA 3KDYA 1GK3A 2FUSA 1C3UA 1VDKA 3KDZA 1DOFA 5F91A 1FUPA 2PFMA 1Y2MA 4V2QA 1JSWA 2O7FA 3TV2A 3OCFA 3BHGA 1TJUA 2QGAB 2O6YA 2OHYA 2PTRA 3RD8A 4EFCA 4C6GA 1FUOA 3NZ4A 1TJWA 4ADLA 3GTDA 5F92A 2X75A 1XWOA
chains in the Genus database with same CATH superfamily
2A6HD 4EEIA 2FIOA 1HY1A 5HW2A 2NVXA 1ZYMA 1J3UA 2R7ZA 4APAA 1XMDA 2NYNA 2LTHA 4BAAA 4APBA 1YNND 3EZBA 2AQLA 1K62A 1C3CA 3H0GA 2CW0D 2X0OA 3U44A 1YISA 3CQZA 3LR8A 2PTQA 4MX2A 2O7EA 4C5RA 4NLEA 2MP0A 3GTKA 2B63A 2LKMB 2YIIA 4FBSA 1AUWA 4CQ5A 1I6VD 1TJVA 1T6JA 2O7DA 2EZBA 3GZHA 3GTQA 2RJSA 1TWCA 1U15A 1K7WA 1XLYA 2NYFA 1YFMA 2R93A 1YFEA 4FLCA 3R6YA 3QBPA 5EYVA 2PTSA 1KQ7A 2X0QA 2QVEA 1SMYD 4CEHA 2FENA 1GK2A 3GTOA 2MX9A 1Q5NA 1K83A 1GKMA 2X0PA 2N3EA 3NO9A 4A15A 2HVGA 1I3QA 1R9TA 1U16A 1DCNA 2MQAA 2HWGA 2FIPA 2VUMA 1RE5A 2A68D 1HY0A 4CEJA 4QIWA 1HQMD 2VD6A 3RRPA 3GTMA 2LPJA 1XL7A 3R6VA 1IW7D 1Y1VA 2JA6A 2O7BA 5M0JA 2K3QA 1I0AA 1W27A 2BE5D 1TWFA 4V2RA 1I50A 1XMCA 5D6BA 3CZOA 3GTJA 3UNVA 3C8TA 1B8FA 5H8WA 2K3OA 2O78A 2RJRA 2E2HA 3LR6A 2F5JA 2NVYA 2JA5A 3CRW1 5IZ2A 3GTPA 2VK9A 4BABA 3OCEA 4HGVA 4WNLA 2JA7A 4C5SA 3LRDA 2J91A 4FFXA 1GKJA 3FKIA 1ZYRD 1FUQA 1TJ7A 4NSLA 3R6QA 2LPIA 1EZAA 3E04A 1EB4A 4ADMA 4C5UA 2E2IA 3GTLA 2E9FA 5EYTA 3EZAA 4CEIA 1T6PA 2A69D 1EZBA 1FURA 3KDYA 1GK3A 2FUSA 3GTGA 1C3UA 2Y0NA 1VDKA 3KDZA 1DOFA 5F91A 1FUPA 2PFMA 2N1DB 2YU9A 1Y2MA 3EZEA 4V2QA 1SFOA 1JSWA 2O7FA 3TV2A 3OCFA 3BHGA 1TJUA 2O5JD 1Y1WA 2QGAB 4C2MA 2HROA 2O6YA 1XL8A 2MX8A 3LR2A 2OHYA 2FELA 2PTRA 2A6ED 3RD8A 4EFCA 4C6GA 1TWAA 2R92A 1FUOA 1YNJD 2EZAA 2K3NA 3NZ4A 1TJWA 2VSFA 3U4QA 3CRVA 1TWHA 4ADLA 3GTDA 2LYIA 2VL7A 1TWGA 5F92A 2EZCA 1WCMA 5M0IA 2X75A 1XWOA
chains in the Genus database with same CATH topology
4EEIA 1HY1A 5HW2A 1J3UA 4APAA 2NYNA 4APBA 4BAAA 1K62A 1C3CA 1YISA 2PTQA 4MX2A 2O7EA 4C5RA 4NLEA 2YIIA 1AUWA 4CQ5A 1TJVA 1T6JA 2O7DA 3GZHA 2RJSA 1U15A 1K7WA 2NYFA 1YFMA 1YFEA 4FLCA 3R6YA 3QBPA 5EYVA 2PTSA 1KQ7A 2QVEA 1GK2A 1Q5NA 1GKMA 3NO9A 2HVGA 1U16A 1DCNA 1RE5A 1HY0A 3RRPA 2VD6A 3R6VA 2O7BA 1I0AA 1W27A 4V2RA 5D6BA 3CZOA 3UNVA 3C8TA 1B8FA 2RJRA 2O78A 4BABA 3OCEA 4HGVA 4C5SA 2J91A 4FFXA 1GKJA 1FUQA 1TJ7A 3R6QA 4NSLA 3E04A 1EB4A 4ADMA 4C5UA 2E9FA 5EYTA 1T6PA 1FURA 3KDYA 1GK3A 2FUSA 1C3UA 1VDKA 3KDZA 1DOFA 5F91A 1FUPA 2PFMA 1Y2MA 4V2QA 1JSWA 2O7FA 3TV2A 3OCFA 3BHGA 1TJUA 2QGAB 2O6YA 2OHYA 2PTRA 3RD8A 4EFCA 4C6GA 1FUOA 3NZ4A 1TJWA 4ADLA 3GTDA 5F92A 2X75A 1XWOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EEI A;  1HY1 A;  5HW2 A;  1J3U A;  4APA A;  2NYN A;  4APB A;  4BAA A;  1K62 A;  1C3C A;  1YIS A;  2PTQ A;  4MX2 A;  2O7E A;  4C5R A;  4NLE A;  2YII A;  1AUW A;  4CQ5 A;  1TJV A;  1T6J A;  2O7D A;  3GZH A;  2RJS A;  1U15 A;  1K7W A;  2NYF A;  1YFM A;  1YFE A;  4FLC A;  3R6Y A;  3QBP A;  5EYV A;  2PTS A;  1KQ7 A;  2QVE A;  1GK2 A;  1Q5N A;  1GKM A;  3NO9 A;  2HVG A;  1U16 A;  1DCN A;  1RE5 A;  1HY0 A;  3RRP A;  2VD6 A;  3R6V A;  2O7B A;  1I0A A;  1W27 A;  4V2R A;  5D6B A;  3CZO A;  3UNV A;  3C8T A;  1B8F A;  2RJR A;  2O78 A;  4BAB A;  3OCE A;  4HGV A;  4C5S A;  2J91 A;  4FFX A;  1GKJ A;  1FUQ A;  1TJ7 A;  3R6Q A;  4NSL A;  3E04 A;  1EB4 A;  4ADM A;  4C5U A;  2E9F A;  5EYT A;  1T6P A;  1FUR A;  3KDY A;  1GK3 A;  2FUS A;  1C3U A;  1VDK A;  3KDZ A;  1DOF A;  5F91 A;  1FUP A;  2PFM A;  1Y2M A;  4V2Q A;  1JSW A;  2O7F A;  3TV2 A;  3OCF A;  3BHG A;  1TJU A;  2QGA B;  2O6Y A;  2OHY A;  2PTR A;  3RD8 A;  4EFC A;  4C6G A;  1FUO A;  3NZ4 A;  1TJW A;  4ADL A;  3GTD A;  5F92 A;  2X75 A;  1XWO A; 
#chains in the Genus database with same CATH topology
 2A6H D;  4EEI A;  2FIO A;  1HY1 A;  5HW2 A;  2NVX A;  1ZYM A;  1J3U A;  2R7Z A;  4APA A;  1XMD A;  2NYN A;  2LTH A;  4BAA A;  4APB A;  1YNN D;  3EZB A;  2AQL A;  1K62 A;  1C3C A;  3H0G A;  2CW0 D;  2X0O A;  3U44 A;  1YIS A;  3CQZ A;  3LR8 A;  2PTQ A;  4MX2 A;  2O7E A;  4C5R A;  4NLE A;  2MP0 A;  3GTK A;  2B63 A;  2LKM B;  2YII A;  4FBS A;  1AUW A;  4CQ5 A;  1I6V D;  1TJV A;  1T6J A;  2O7D A;  2EZB A;  3GZH A;  3GTQ A;  2RJS A;  1TWC A;  1U15 A;  1K7W A;  1XLY A;  2NYF A;  1YFM A;  2R93 A;  1YFE A;  4FLC A;  3R6Y A;  3QBP A;  5EYV A;  2PTS A;  1KQ7 A;  2X0Q A;  2QVE A;  1SMY D;  4CEH A;  2FEN A;  1GK2 A;  3GTO A;  2MX9 A;  1Q5N A;  1K83 A;  1GKM A;  2X0P A;  2N3E A;  3NO9 A;  4A15 A;  2HVG A;  1I3Q A;  1R9T A;  1U16 A;  1DCN A;  2MQA A;  2HWG A;  2FIP A;  2VUM A;  1RE5 A;  2A68 D;  1HY0 A;  4CEJ A;  4QIW A;  1HQM D;  2VD6 A;  3RRP A;  3GTM A;  2LPJ A;  1XL7 A;  3R6V A;  1IW7 D;  1Y1V A;  2JA6 A;  2O7B A;  5M0J A;  2K3Q A;  1I0A A;  1W27 A;  2BE5 D;  1TWF A;  4V2R A;  1I50 A;  1XMC A;  5D6B A;  3CZO A;  3GTJ A;  3UNV A;  3C8T A;  1B8F A;  5H8W A;  2K3O A;  2O78 A;  2RJR A;  2E2H A;  3LR6 A;  2F5J A;  2NVY A;  2JA5 A;  3CRW 1;  5IZ2 A;  3GTP A;  2VK9 A;  4BAB A;  3OCE A;  4HGV A;  4WNL A;  2JA7 A;  4C5S A;  3LRD A;  2J91 A;  4FFX A;  1GKJ A;  3FKI A;  1ZYR D;  1FUQ A;  1TJ7 A;  4NSL A;  3R6Q A;  2LPI A;  1EZA A;  3E04 A;  1EB4 A;  4ADM A;  4C5U A;  2E2I A;  3GTL A;  2E9F A;  5EYT A;  3EZA A;  4CEI A;  1T6P A;  2A69 D;  1EZB A;  1FUR A;  3KDY A;  1GK3 A;  2FUS A;  3GTG A;  1C3U A;  2Y0N A;  1VDK A;  3KDZ A;  1DOF A;  5F91 A;  1FUP A;  2PFM A;  2N1D B;  2YU9 A;  1Y2M A;  3EZE A;  4V2Q A;  1SFO A;  1JSW A;  2O7F A;  3TV2 A;  3OCF A;  3BHG A;  1TJU A;  2O5J D;  1Y1W A;  2QGA B;  4C2M A;  2HRO A;  2O6Y A;  1XL8 A;  2MX8 A;  3LR2 A;  2OHY A;  2FEL A;  2PTR A;  2A6E D;  3RD8 A;  4EFC A;  4C6G A;  1TWA A;  2R92 A;  1FUO A;  1YNJ D;  2EZA A;  2K3N A;  3NZ4 A;  1TJW A;  2VSF A;  3U4Q A;  3CRV A;  1TWH A;  4ADL A;  3GTD A;  2LYI A;  2VL7 A;  1TWG A;  5F92 A;  2EZC A;  1WCM A;  5M0I A;  2X75 A;  1XWO A; 
#chains in the Genus database with same CATH homology
 4EEI A;  1HY1 A;  5HW2 A;  1J3U A;  4APA A;  2NYN A;  4APB A;  4BAA A;  1K62 A;  1C3C A;  1YIS A;  2PTQ A;  4MX2 A;  2O7E A;  4C5R A;  4NLE A;  2YII A;  1AUW A;  4CQ5 A;  1TJV A;  1T6J A;  2O7D A;  3GZH A;  2RJS A;  1U15 A;  1K7W A;  2NYF A;  1YFM A;  1YFE A;  4FLC A;  3R6Y A;  3QBP A;  5EYV A;  2PTS A;  1KQ7 A;  2QVE A;  1GK2 A;  1Q5N A;  1GKM A;  3NO9 A;  2HVG A;  1U16 A;  1DCN A;  1RE5 A;  1HY0 A;  3RRP A;  2VD6 A;  3R6V A;  2O7B A;  1I0A A;  1W27 A;  4V2R A;  5D6B A;  3CZO A;  3UNV A;  3C8T A;  1B8F A;  2RJR A;  2O78 A;  4BAB A;  3OCE A;  4HGV A;  4C5S A;  2J91 A;  4FFX A;  1GKJ A;  1FUQ A;  1TJ7 A;  3R6Q A;  4NSL A;  3E04 A;  1EB4 A;  4ADM A;  4C5U A;  2E9F A;  5EYT A;  1T6P A;  1FUR A;  3KDY A;  1GK3 A;  2FUS A;  1C3U A;  1VDK A;  3KDZ A;  1DOF A;  5F91 A;  1FUP A;  2PFM A;  1Y2M A;  4V2Q A;  1JSW A;  2O7F A;  3TV2 A;  3OCF A;  3BHG A;  1TJU A;  2QGA B;  2O6Y A;  2OHY A;  2PTR A;  3RD8 A;  4EFC A;  4C6G A;  1FUO A;  3NZ4 A;  1TJW A;  4ADL A;  3GTD A;  5F92 A;  2X75 A;  1XWO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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