4BAAA

Redesign of a phenylalanine aminomutase into a beta-phenylalanine ammonia lyase
Total Genus 245
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
245
sequence length
667
structure length
635
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAEDGADIYGVTTGFGACSSSRTNRLSELQESLIRCLLAGVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHTLVDRLAEFEKRLSDRLENEMTAVRVLYERIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Redesign of a Phenylalanine Aminomutase Into a Phenylalanine Ammonia Lyase
rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
molecule keywords PHENYLALANINE AMMONIA-LYASE
total genus 245
structure length 635
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2012-09-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4baaA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4baaA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4baaA02
2X75A 3CZOA 2J91A 3E04A 1GKJA 3C8TA 2HVGA 1YFEA 1TJ7A 1FUPA 3R6YA 3OCFA 2O7BA 1HY0A 5HW2A 1W27A 1U15A 3NZ4A 4CQ5A 2PTSA 3RRPA 3KDZA 3NO9A 1FURA 2QVEA 5EYTA 4APAA 4APBA 1DOFA 3TV2A 1AUWA 4NSLA 1GK2A 5D6BA 4FLCA 1TJUA 1C3CA 1FUOA 1VDKA 2FUSA 4FFXA 1J3UA 2PFMA 4C6GA 1FUQA 1B8FA 1GK3A 2O7EA 1K62A 1Y2MA 1U16A 3OCEA 5EYVA 3R6VA 4HGVA 1KQ7A 3BHGA 5F92A 5F91A 1EB4A 1HY1A 1JSWA 4ADLA 2OHYA 2E9FA 2YIIA 4C5RA 1GKMA 1RE5A 3UNVA 1TJVA 1XWOA 4V2QA 1T6JA 1DCNA 4C5UA 1YISA 4BAAA 2O6YA 1T6PA 2VD6A 2PTQA 3R6QA 3GTDA 2O7FA 4EEIA 2QGAB 2O7DA 4MX2A 4ADMA 3QBPA 1C3UA 2NYFA 4C5SA 2RJRA 1Q5NA 3KDYA 2NYNA 1TJWA 4NLEA 4EFCA 3RD8A 2RJSA 1K7WA 3GZHA 4BABA 4V2RA 2O78A 2PTRA 1YFMA 1I0AA
chains in the Genus database with same CATH superfamily
4CEJA 1I50A 2X75A 3GTPA 3CZOA 2CW0D 2J91A 3E04A 2X0OA 1GKJA 3C8TA 2EZAA 2HVGA 2O5JD 1YFEA 2K3QA 1TJ7A 1FUPA 3R6YA 1TWAA 3OCFA 2K3NA 2O7BA 1HY0A 5HW2A 1W27A 2VUMA 1U15A 2LTHA 3GTOA 3NZ4A 4CQ5A 2PTSA 3RRPA 3KDZA 3NO9A 2FELA 2F5JA 2R7ZA 1FURA 2QVEA 5EYTA 4APAA 4APBA 3LR2A 4QIWA 2E2HA 2K3OA 3GTGA 1DOFA 3EZBA 1ZYRD 1XMDA 5IZ2A 1HQMD 3U44A 3TV2A 1TWFA 1AUWA 1Y1WA 4NSLA 1GK2A 1SFOA 2X0PA 5D6BA 2LKMB 4FLCA 3H0GA 4FBSA 4CEHA 1I6VD 3U4QA 2R93A 1TJUA 2MX8A 1C3CA 1TWGA 5M0JA 1FUOA 1VDKA 2FUSA 3CRVA 4FFXA 1J3UA 2PFMA 1TWCA 2A68D 4C6GA 2R92A 1FUQA 1B8FA 2E2IA 1GK3A 2O7EA 1K62A 1Y2MA 1U16A 3GTKA 2N1DB 1XMCA 2A6HD 3OCEA 5EYVA 1I3QA 3R6VA 5M0IA 4HGVA 2LPIA 1KQ7A 3BHGA 5F92A 5F91A 3EZEA 1EB4A 1HY1A 2FENA 1JSWA 2YU9A 1EZAA 2NVXA 2FIOA 4ADLA 2A6ED 4CEIA 2E9FA 2OHYA 3LRDA 2JA6A 2YIIA 4C2MA 2HROA 4C5RA 2X0QA 1GKMA 1RE5A 3UNVA 1TJVA 1XWOA 1EZBA 4V2QA 2HWGA 1ZYMA 3CQZA 1T6JA 2MQAA 1DCNA 4C5UA 2VSFA 1YISA 2MP0A 4BAAA 2JA7A 2O6YA 1T6PA 2NVYA 2VD6A 1Y1VA 2PTQA 3R6QA 2LYIA 3GTDA 2O7FA 2B63A 4EEIA 2QGAB 3GTQA 3FKIA 2O7DA 3GTLA 4A15A 4MX2A 1TWHA 4WNLA 1WCMA 2EZBA 4ADMA 3QBPA 1YNJD 2EZCA 1YNND 1C3UA 2BE5D 4C5SA 2NYFA 2RJRA 2VK9A 1Q5NA 3KDYA 3EZAA 2NYNA 1TJWA 3CRW1 4NLEA 4EFCA 3RD8A 1IW7D 3GTJA 2RJSA 1K7WA 2AQLA 2JA5A 3GZHA 1XL8A 2VL7A 2A69D 1XL7A 5H8WA 4BABA 1XLYA 4V2RA 2O78A 1K83A 2PTRA 3GTMA 3LR8A 1YFMA 2N3EA 3LR6A 2Y0NA 1I0AA 2FIPA 1SMYD 2MX9A 2LPJA 1R9TA
chains in the Genus database with same CATH topology
2X75A 3CZOA 2J91A 3E04A 1GKJA 3C8TA 2HVGA 1YFEA 1TJ7A 1FUPA 3R6YA 3OCFA 2O7BA 1HY0A 5HW2A 1W27A 1U15A 3NZ4A 4CQ5A 2PTSA 3RRPA 3KDZA 3NO9A 1FURA 2QVEA 5EYTA 4APAA 4APBA 1DOFA 3TV2A 1AUWA 4NSLA 1GK2A 5D6BA 4FLCA 1TJUA 1C3CA 1FUOA 1VDKA 2FUSA 4FFXA 1J3UA 2PFMA 4C6GA 1FUQA 1B8FA 1GK3A 2O7EA 1K62A 1Y2MA 1U16A 3OCEA 5EYVA 3R6VA 4HGVA 1KQ7A 3BHGA 5F92A 5F91A 1EB4A 1HY1A 1JSWA 4ADLA 2OHYA 2E9FA 2YIIA 4C5RA 1GKMA 1RE5A 3UNVA 1TJVA 1XWOA 4V2QA 1T6JA 1DCNA 4C5UA 1YISA 4BAAA 2O6YA 1T6PA 2VD6A 2PTQA 3R6QA 3GTDA 2O7FA 4EEIA 2QGAB 2O7DA 4MX2A 4ADMA 3QBPA 1C3UA 2NYFA 4C5SA 2RJRA 1Q5NA 3KDYA 2NYNA 1TJWA 4NLEA 4EFCA 3RD8A 2RJSA 1K7WA 3GZHA 4BABA 4V2RA 2O78A 2PTRA 1YFMA 1I0AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2X75 A;  3CZO A;  2J91 A;  3E04 A;  1GKJ A;  3C8T A;  2HVG A;  1YFE A;  1TJ7 A;  1FUP A;  3R6Y A;  3OCF A;  2O7B A;  1HY0 A;  5HW2 A;  1W27 A;  1U15 A;  3NZ4 A;  4CQ5 A;  2PTS A;  3RRP A;  3KDZ A;  3NO9 A;  1FUR A;  2QVE A;  5EYT A;  4APA A;  4APB A;  1DOF A;  3TV2 A;  1AUW A;  4NSL A;  1GK2 A;  5D6B A;  4FLC A;  1TJU A;  1C3C A;  1FUO A;  1VDK A;  2FUS A;  4FFX A;  1J3U A;  2PFM A;  4C6G A;  1FUQ A;  1B8F A;  1GK3 A;  2O7E A;  1K62 A;  1Y2M A;  1U16 A;  3OCE A;  5EYV A;  3R6V A;  4HGV A;  1KQ7 A;  3BHG A;  5F92 A;  5F91 A;  1EB4 A;  1HY1 A;  1JSW A;  4ADL A;  2OHY A;  2E9F A;  2YII A;  4C5R A;  1GKM A;  1RE5 A;  3UNV A;  1TJV A;  1XWO A;  4V2Q A;  1T6J A;  1DCN A;  4C5U A;  1YIS A;  4BAA A;  2O6Y A;  1T6P A;  2VD6 A;  2PTQ A;  3R6Q A;  3GTD A;  2O7F A;  4EEI A;  2QGA B;  2O7D A;  4MX2 A;  4ADM A;  3QBP A;  1C3U A;  2NYF A;  4C5S A;  2RJR A;  1Q5N A;  3KDY A;  2NYN A;  1TJW A;  4NLE A;  4EFC A;  3RD8 A;  2RJS A;  1K7W A;  3GZH A;  4BAB A;  4V2R A;  2O78 A;  2PTR A;  1YFM A;  1I0A A; 
#chains in the Genus database with same CATH topology
 4CEJ A;  1I50 A;  2X75 A;  3GTP A;  3CZO A;  2CW0 D;  2J91 A;  3E04 A;  2X0O A;  1GKJ A;  3C8T A;  2EZA A;  2HVG A;  2O5J D;  1YFE A;  2K3Q A;  1TJ7 A;  1FUP A;  3R6Y A;  1TWA A;  3OCF A;  2K3N A;  2O7B A;  1HY0 A;  5HW2 A;  1W27 A;  2VUM A;  1U15 A;  2LTH A;  3GTO A;  3NZ4 A;  4CQ5 A;  2PTS A;  3RRP A;  3KDZ A;  3NO9 A;  2FEL A;  2F5J A;  2R7Z A;  1FUR A;  2QVE A;  5EYT A;  4APA A;  4APB A;  3LR2 A;  4QIW A;  2E2H A;  2K3O A;  3GTG A;  1DOF A;  3EZB A;  1ZYR D;  1XMD A;  5IZ2 A;  1HQM D;  3U44 A;  3TV2 A;  1TWF A;  1AUW A;  1Y1W A;  4NSL A;  1GK2 A;  1SFO A;  2X0P A;  5D6B A;  2LKM B;  4FLC A;  3H0G A;  4FBS A;  4CEH A;  1I6V D;  3U4Q A;  2R93 A;  1TJU A;  2MX8 A;  1C3C A;  1TWG A;  5M0J A;  1FUO A;  1VDK A;  2FUS A;  3CRV A;  4FFX A;  1J3U A;  2PFM A;  1TWC A;  2A68 D;  4C6G A;  2R92 A;  1FUQ A;  1B8F A;  2E2I A;  1GK3 A;  2O7E A;  1K62 A;  1Y2M A;  1U16 A;  3GTK A;  2N1D B;  1XMC A;  2A6H D;  3OCE A;  5EYV A;  1I3Q A;  3R6V A;  5M0I A;  4HGV A;  2LPI A;  1KQ7 A;  3BHG A;  5F92 A;  5F91 A;  3EZE A;  1EB4 A;  1HY1 A;  2FEN A;  1JSW A;  2YU9 A;  1EZA A;  2NVX A;  2FIO A;  4ADL A;  2A6E D;  4CEI A;  2E9F A;  2OHY A;  3LRD A;  2JA6 A;  2YII A;  4C2M A;  2HRO A;  4C5R A;  2X0Q A;  1GKM A;  1RE5 A;  3UNV A;  1TJV A;  1XWO A;  1EZB A;  4V2Q A;  2HWG A;  1ZYM A;  3CQZ A;  1T6J A;  2MQA A;  1DCN A;  4C5U A;  2VSF A;  1YIS A;  2MP0 A;  4BAA A;  2JA7 A;  2O6Y A;  1T6P A;  2NVY A;  2VD6 A;  1Y1V A;  2PTQ A;  3R6Q A;  2LYI A;  3GTD A;  2O7F A;  2B63 A;  4EEI A;  2QGA B;  3GTQ A;  3FKI A;  2O7D A;  3GTL A;  4A15 A;  4MX2 A;  1TWH A;  4WNL A;  1WCM A;  2EZB A;  4ADM A;  3QBP A;  1YNJ D;  2EZC A;  1YNN D;  1C3U A;  2BE5 D;  4C5S A;  2NYF A;  2RJR A;  2VK9 A;  1Q5N A;  3KDY A;  3EZA A;  2NYN A;  1TJW A;  3CRW 1;  4NLE A;  4EFC A;  3RD8 A;  1IW7 D;  3GTJ A;  2RJS A;  1K7W A;  2AQL A;  2JA5 A;  3GZH A;  1XL8 A;  2VL7 A;  2A69 D;  1XL7 A;  5H8W A;  4BAB A;  1XLY A;  4V2R A;  2O78 A;  1K83 A;  2PTR A;  3GTM A;  3LR8 A;  1YFM A;  2N3E A;  3LR6 A;  2Y0N A;  1I0A A;  2FIP A;  1SMY D;  2MX9 A;  2LPJ A;  1R9T A; 
#chains in the Genus database with same CATH homology
 2X75 A;  3CZO A;  2J91 A;  3E04 A;  1GKJ A;  3C8T A;  2HVG A;  1YFE A;  1TJ7 A;  1FUP A;  3R6Y A;  3OCF A;  2O7B A;  1HY0 A;  5HW2 A;  1W27 A;  1U15 A;  3NZ4 A;  4CQ5 A;  2PTS A;  3RRP A;  3KDZ A;  3NO9 A;  1FUR A;  2QVE A;  5EYT A;  4APA A;  4APB A;  1DOF A;  3TV2 A;  1AUW A;  4NSL A;  1GK2 A;  5D6B A;  4FLC A;  1TJU A;  1C3C A;  1FUO A;  1VDK A;  2FUS A;  4FFX A;  1J3U A;  2PFM A;  4C6G A;  1FUQ A;  1B8F A;  1GK3 A;  2O7E A;  1K62 A;  1Y2M A;  1U16 A;  3OCE A;  5EYV A;  3R6V A;  4HGV A;  1KQ7 A;  3BHG A;  5F92 A;  5F91 A;  1EB4 A;  1HY1 A;  1JSW A;  4ADL A;  2OHY A;  2E9F A;  2YII A;  4C5R A;  1GKM A;  1RE5 A;  3UNV A;  1TJV A;  1XWO A;  4V2Q A;  1T6J A;  1DCN A;  4C5U A;  1YIS A;  4BAA A;  2O6Y A;  1T6P A;  2VD6 A;  2PTQ A;  3R6Q A;  3GTD A;  2O7F A;  4EEI A;  2QGA B;  2O7D A;  4MX2 A;  4ADM A;  3QBP A;  1C3U A;  2NYF A;  4C5S A;  2RJR A;  1Q5N A;  3KDY A;  2NYN A;  1TJW A;  4NLE A;  4EFC A;  3RD8 A;  2RJS A;  1K7W A;  3GZH A;  4BAB A;  4V2R A;  2O78 A;  2PTR A;  1YFM A;  1I0A A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...