4BABA

Redesign of a phenylalanine aminomutase into a beta-phenylalanine ammonia lyase
Total Genus 230
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
230
sequence length
667
structure length
611
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAESELQESLIRCLLAGVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHDTLVDRLAEFRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Redesign of a Phenylalanine Aminomutase Into a Phenylalanine Ammonia Lyase
rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
molecule keywords PHENYLALANINE AMINOMUTASE
total genus 230
structure length 611
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2012-09-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4babA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4babA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4babA02
4EEIA 2NYFA 1XWOA 1Q5NA 1U15A 1GK2A 4NSLA 3R6YA 2NYNA 1TJWA 1EB4A 5HW2A 3GTDA 3OCEA 4ADLA 1GK3A 1FUOA 1U16A 3RD8A 1TJVA 1HY0A 1T6PA 2PTQA 4C5UA 3GZHA 2O7FA 5F91A 3E04A 5D6BA 4C5RA 2OHYA 1RE5A 4BAAA 1FUQA 1DCNA 1GKJA 2O7DA 4V2RA 2E9FA 4APAA 4NLEA 2QVEA 2QGAB 4APBA 1K62A 3C8TA 1AUWA 1YFMA 1K7WA 2J91A 1VDKA 3KDYA 3R6VA 4BABA 1HY1A 2O7BA 1TJ7A 2O6YA 1TJUA 1JSWA 3RRPA 3NO9A 1YISA 5F92A 4ADMA 2YIIA 4V2QA 4FLCA 3NZ4A 3UNVA 3TV2A 4FFXA 2PTRA 2HVGA 4CQ5A 3KDZA 2FUSA 2PFMA 5EYTA 2O78A 1J3UA 4C5SA 2RJRA 1FUPA 1C3CA 3QBPA 2O7EA 1I0AA 2VD6A 4MX2A 2RJSA 4EFCA 4C6GA 1B8FA 3BHGA 5EYVA 2PTSA 3R6QA 1Y2MA 4HGVA 1YFEA 1C3UA 3OCFA 1GKMA 1W27A 1DOFA 1KQ7A 1T6JA 1FURA 3CZOA 2X75A
chains in the Genus database with same CATH superfamily
3LRDA 4EEIA 2NYFA 4A15A 3CQZA 1XWOA 4WNLA 1Q5NA 2E2HA 2N1DB 2A68D 1U15A 3U44A 3EZEA 1GK2A 2HWGA 4NSLA 3R6YA 1K83A 2FIPA 2YU9A 2NYNA 1TJWA 1EB4A 2CW0D 5HW2A 3GTDA 3CRW1 1I3QA 3OCEA 4ADLA 1GK3A 1I50A 1FUOA 1U16A 3RD8A 3GTOA 1TJVA 1HY0A 1T6PA 2PTQA 1TWHA 2AQLA 4C5UA 2R7ZA 2O7FA 3GZHA 5H8WA 5F91A 1TWAA 3U4QA 3E04A 5D6BA 2F5JA 2LTHA 4C5RA 3GTLA 1EZBA 2OHYA 1EZAA 4C2MA 3LR6A 1RE5A 5M0IA 4BAAA 2MX9A 1FUQA 3H0GA 1DCNA 1TWFA 3EZBA 1GKJA 2O5JD 2O7DA 4V2RA 2E9FA 4APAA 4NLEA 5IZ2A 2QVEA 2QGAB 4APBA 1K62A 3C8TA 1AUWA 2K3QA 1YFMA 2FENA 1K7WA 2J91A 1VDKA 1XMCA 2X0PA 2HROA 3GTPA 3KDYA 2LPJA 1XLYA 1XL7A 2MX8A 1IW7D 3R6VA 2EZBA 2BE5D 2X0QA 4BABA 2JA7A 1HY1A 2O7BA 4QIWA 2JA5A 1TJ7A 3CRVA 2O6YA 1TJUA 1JSWA 1R9TA 3LR8A 3RRPA 1Y1VA 2NVYA 2Y0NA 3EZAA 3NO9A 1YISA 5F92A 4ADMA 2A69D 1SFOA 2YIIA 1HQMD 2A6HD 2N3EA 2E2IA 4V2QA 2EZCA 4FLCA 3NZ4A 3UNVA 3LR2A 3TV2A 2K3NA 3FKIA 1SMYD 5M0JA 4FFXA 2X0OA 2HVGA 1YNND 2PTRA 4CQ5A 3GTJA 2R92A 2VL7A 3KDZA 2FUSA 2PFMA 5EYTA 2JA6A 2O78A 1J3UA 4C5SA 2RJRA 1WCMA 2FELA 2LKMB 2MQAA 4CEJA 2EZAA 3GTGA 4CEHA 3GTQA 1FUPA 2VK9A 1C3CA 3QBPA 4CEIA 2NVXA 2O7EA 1ZYRD 1I0AA 2VD6A 4FBSA 2MP0A 2K3OA 4MX2A 2RJSA 2LYIA 1I6VD 2VUMA 4EFCA 4C6GA 2A6ED 1B8FA 1Y1WA 3BHGA 2X75A 2VSFA 1ZYMA 2B63A 2R93A 3GTKA 2PTSA 5EYVA 3R6QA 1Y2MA 1TWCA 1TWGA 4HGVA 1XL8A 1YFEA 2LPIA 1C3UA 3OCFA 1GKMA 1W27A 1DOFA 1KQ7A 1XMDA 1T6JA 1FURA 3CZOA 2FIOA 3GTMA 1YNJD
chains in the Genus database with same CATH topology
4EEIA 2NYFA 1XWOA 1Q5NA 1U15A 1GK2A 4NSLA 3R6YA 2NYNA 1TJWA 1EB4A 5HW2A 3GTDA 3OCEA 4ADLA 1GK3A 1FUOA 1U16A 3RD8A 1TJVA 1HY0A 1T6PA 2PTQA 4C5UA 3GZHA 2O7FA 5F91A 3E04A 5D6BA 4C5RA 2OHYA 1RE5A 4BAAA 1FUQA 1DCNA 1GKJA 2O7DA 4V2RA 2E9FA 4APAA 4NLEA 2QVEA 2QGAB 4APBA 1K62A 3C8TA 1AUWA 1YFMA 1K7WA 2J91A 1VDKA 3KDYA 3R6VA 4BABA 1HY1A 2O7BA 1TJ7A 2O6YA 1TJUA 1JSWA 3RRPA 3NO9A 1YISA 5F92A 4ADMA 2YIIA 4V2QA 4FLCA 3NZ4A 3UNVA 3TV2A 4FFXA 2PTRA 2HVGA 4CQ5A 3KDZA 2FUSA 2PFMA 5EYTA 2O78A 1J3UA 4C5SA 2RJRA 1FUPA 1C3CA 3QBPA 2O7EA 1I0AA 2VD6A 4MX2A 2RJSA 4EFCA 4C6GA 1B8FA 3BHGA 5EYVA 2PTSA 3R6QA 1Y2MA 4HGVA 1YFEA 1C3UA 3OCFA 1GKMA 1W27A 1DOFA 1KQ7A 1T6JA 1FURA 3CZOA 2X75A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EEI A;  2NYF A;  1XWO A;  1Q5N A;  1U15 A;  1GK2 A;  4NSL A;  3R6Y A;  2NYN A;  1TJW A;  1EB4 A;  5HW2 A;  3GTD A;  3OCE A;  4ADL A;  1GK3 A;  1FUO A;  1U16 A;  3RD8 A;  1TJV A;  1HY0 A;  1T6P A;  2PTQ A;  4C5U A;  3GZH A;  2O7F A;  5F91 A;  3E04 A;  5D6B A;  4C5R A;  2OHY A;  1RE5 A;  4BAA A;  1FUQ A;  1DCN A;  1GKJ A;  2O7D A;  4V2R A;  2E9F A;  4APA A;  4NLE A;  2QVE A;  2QGA B;  4APB A;  1K62 A;  3C8T A;  1AUW A;  1YFM A;  1K7W A;  2J91 A;  1VDK A;  3KDY A;  3R6V A;  4BAB A;  1HY1 A;  2O7B A;  1TJ7 A;  2O6Y A;  1TJU A;  1JSW A;  3RRP A;  3NO9 A;  1YIS A;  5F92 A;  4ADM A;  2YII A;  4V2Q A;  4FLC A;  3NZ4 A;  3UNV A;  3TV2 A;  4FFX A;  2PTR A;  2HVG A;  4CQ5 A;  3KDZ A;  2FUS A;  2PFM A;  5EYT A;  2O78 A;  1J3U A;  4C5S A;  2RJR A;  1FUP A;  1C3C A;  3QBP A;  2O7E A;  1I0A A;  2VD6 A;  4MX2 A;  2RJS A;  4EFC A;  4C6G A;  1B8F A;  3BHG A;  5EYV A;  2PTS A;  3R6Q A;  1Y2M A;  4HGV A;  1YFE A;  1C3U A;  3OCF A;  1GKM A;  1W27 A;  1DOF A;  1KQ7 A;  1T6J A;  1FUR A;  3CZO A;  2X75 A; 
#chains in the Genus database with same CATH topology
 3LRD A;  4EEI A;  2NYF A;  4A15 A;  3CQZ A;  1XWO A;  4WNL A;  1Q5N A;  2E2H A;  2N1D B;  2A68 D;  1U15 A;  3U44 A;  3EZE A;  1GK2 A;  2HWG A;  4NSL A;  3R6Y A;  1K83 A;  2FIP A;  2YU9 A;  2NYN A;  1TJW A;  1EB4 A;  2CW0 D;  5HW2 A;  3GTD A;  3CRW 1;  1I3Q A;  3OCE A;  4ADL A;  1GK3 A;  1I50 A;  1FUO A;  1U16 A;  3RD8 A;  3GTO A;  1TJV A;  1HY0 A;  1T6P A;  2PTQ A;  1TWH A;  2AQL A;  4C5U A;  2R7Z A;  2O7F A;  3GZH A;  5H8W A;  5F91 A;  1TWA A;  3U4Q A;  3E04 A;  5D6B A;  2F5J A;  2LTH A;  4C5R A;  3GTL A;  1EZB A;  2OHY A;  1EZA A;  4C2M A;  3LR6 A;  1RE5 A;  5M0I A;  4BAA A;  2MX9 A;  1FUQ A;  3H0G A;  1DCN A;  1TWF A;  3EZB A;  1GKJ A;  2O5J D;  2O7D A;  4V2R A;  2E9F A;  4APA A;  4NLE A;  5IZ2 A;  2QVE A;  2QGA B;  4APB A;  1K62 A;  3C8T A;  1AUW A;  2K3Q A;  1YFM A;  2FEN A;  1K7W A;  2J91 A;  1VDK A;  1XMC A;  2X0P A;  2HRO A;  3GTP A;  3KDY A;  2LPJ A;  1XLY A;  1XL7 A;  2MX8 A;  1IW7 D;  3R6V A;  2EZB A;  2BE5 D;  2X0Q A;  4BAB A;  2JA7 A;  1HY1 A;  2O7B A;  4QIW A;  2JA5 A;  1TJ7 A;  3CRV A;  2O6Y A;  1TJU A;  1JSW A;  1R9T A;  3LR8 A;  3RRP A;  1Y1V A;  2NVY A;  2Y0N A;  3EZA A;  3NO9 A;  1YIS A;  5F92 A;  4ADM A;  2A69 D;  1SFO A;  2YII A;  1HQM D;  2A6H D;  2N3E A;  2E2I A;  4V2Q A;  2EZC A;  4FLC A;  3NZ4 A;  3UNV A;  3LR2 A;  3TV2 A;  2K3N A;  3FKI A;  1SMY D;  5M0J A;  4FFX A;  2X0O A;  2HVG A;  1YNN D;  2PTR A;  4CQ5 A;  3GTJ A;  2R92 A;  2VL7 A;  3KDZ A;  2FUS A;  2PFM A;  5EYT A;  2JA6 A;  2O78 A;  1J3U A;  4C5S A;  2RJR A;  1WCM A;  2FEL A;  2LKM B;  2MQA A;  4CEJ A;  2EZA A;  3GTG A;  4CEH A;  3GTQ A;  1FUP A;  2VK9 A;  1C3C A;  3QBP A;  4CEI A;  2NVX A;  2O7E A;  1ZYR D;  1I0A A;  2VD6 A;  4FBS A;  2MP0 A;  2K3O A;  4MX2 A;  2RJS A;  2LYI A;  1I6V D;  2VUM A;  4EFC A;  4C6G A;  2A6E D;  1B8F A;  1Y1W A;  3BHG A;  2X75 A;  2VSF A;  1ZYM A;  2B63 A;  2R93 A;  3GTK A;  2PTS A;  5EYV A;  3R6Q A;  1Y2M A;  1TWC A;  1TWG A;  4HGV A;  1XL8 A;  1YFE A;  2LPI A;  1C3U A;  3OCF A;  1GKM A;  1W27 A;  1DOF A;  1KQ7 A;  1XMD A;  1T6J A;  1FUR A;  3CZO A;  2FIO A;  3GTM A;  1YNJ D; 
#chains in the Genus database with same CATH homology
 4EEI A;  2NYF A;  1XWO A;  1Q5N A;  1U15 A;  1GK2 A;  4NSL A;  3R6Y A;  2NYN A;  1TJW A;  1EB4 A;  5HW2 A;  3GTD A;  3OCE A;  4ADL A;  1GK3 A;  1FUO A;  1U16 A;  3RD8 A;  1TJV A;  1HY0 A;  1T6P A;  2PTQ A;  4C5U A;  3GZH A;  2O7F A;  5F91 A;  3E04 A;  5D6B A;  4C5R A;  2OHY A;  1RE5 A;  4BAA A;  1FUQ A;  1DCN A;  1GKJ A;  2O7D A;  4V2R A;  2E9F A;  4APA A;  4NLE A;  2QVE A;  2QGA B;  4APB A;  1K62 A;  3C8T A;  1AUW A;  1YFM A;  1K7W A;  2J91 A;  1VDK A;  3KDY A;  3R6V A;  4BAB A;  1HY1 A;  2O7B A;  1TJ7 A;  2O6Y A;  1TJU A;  1JSW A;  3RRP A;  3NO9 A;  1YIS A;  5F92 A;  4ADM A;  2YII A;  4V2Q A;  4FLC A;  3NZ4 A;  3UNV A;  3TV2 A;  4FFX A;  2PTR A;  2HVG A;  4CQ5 A;  3KDZ A;  2FUS A;  2PFM A;  5EYT A;  2O78 A;  1J3U A;  4C5S A;  2RJR A;  1FUP A;  1C3C A;  3QBP A;  2O7E A;  1I0A A;  2VD6 A;  4MX2 A;  2RJS A;  4EFC A;  4C6G A;  1B8F A;  3BHG A;  5EYV A;  2PTS A;  3R6Q A;  1Y2M A;  4HGV A;  1YFE A;  1C3U A;  3OCF A;  1GKM A;  1W27 A;  1DOF A;  1KQ7 A;  1T6J A;  1FUR A;  3CZO A;  2X75 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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