4BABA

Redesign of a phenylalanine aminomutase into a beta-phenylalanine ammonia lyase
Total Genus 230
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
230
sequence length
667
structure length
611
Chain Sequence
b'SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAESELQESLIRCLLAGVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHDTLVDRLAEFRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords PHENYLALANINE AMINOMUTASE
publication title Redesign of a Phenylalanine Aminomutase Into a Phenylalanine Ammonia Lyase
rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
total genus 230
structure length 611
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2012-09-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4babA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4babA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4babA02
1YFMA 2NYFA 1K62A 1FUOA 2FUSA 2QVEA 4ADLA 2PTSA 1RE5A 5EYTA 1GKMA 1Y2MA 1FUPA 1HY0A 3OCEA 1T6JA 3GZHA 3UNVA 1YFEA 3QBPA 4NSLA 1C3CA 1DOFA 4C5UA 2O7EA 1XWOA 2O78A 2O7BA 2O7FA 5D6BA 4V2QA 1EB4A 3KDZA 1U15A 4C5SA 1GK2A 1B8FA 2RJSA 1T6PA 2PTQA 4BAAA 2PTRA 4EEIA 3BHGA 2RJRA 1JSWA 3E04A 4APAA 1TJ7A 1YISA 4MX2A 2E9FA 3NO9A 3GTDA 1J3UA 1Q5NA 5EYVA 2J91A 3KDYA 1TJUA 3R6QA 4FFXA 4FLCA 2YIIA 4V2RA 1FUQA 1GKJA 1K7WA 4NLEA 3RD8A 3R6YA 5F92A 3R6VA 3TV2A 4C6GA 1TJWA 4CQ5A 1VDKA 2VD6A 2O6YA 3C8TA 1TJVA 4BABA 2HVGA 2NYNA 3OCFA 2PFMA 2O7DA 4APBA 5F91A 2X75A 1KQ7A 1W27A 1HY1A 3CZOA 1I0AA 4ADMA 1U16A 1AUWA 4C5RA 3RRPA 2OHYA 4EFCA 3NZ4A 5HW2A 1DCNA 2QGAB 4HGVA 1C3UA 1FURA 1GK3A
chains in the Genus database with same CATH superfamily
1YFMA 2NYFA 1K62A 1FUOA 2LYIA 1YNJD 4CEJA 2FUSA 2QVEA 4ADLA 2PTSA 1WCMA 1RE5A 2FELA 2E2IA 2R7ZA 5EYTA 1GKMA 1XLYA 1Y2MA 1FUPA 1EZBA 1HY0A 2HWGA 1T6JA 2BE5D 3GZHA 2MQAA 1YFEA 3OCEA 2R93A 3QBPA 4NSLA 3UNVA 2JA6A 1C3CA 3EZEA 1ZYRD 3GTGA 1DOFA 5M0IA 4C5UA 1Y1WA 1XMDA 2K3OA 2O7EA 2MX9A 1XWOA 2A6HD 3H0GA 2O7BA 2O78A 2O7FA 3LR8A 1XL8A 5D6BA 1Y1VA 4V2QA 1EB4A 1XL7A 3GTLA 1K83A 1XMCA 2FIPA 3CRVA 3KDZA 1I6VD 2X0OA 4C5SA 2AQLA 1HQMD 1U15A 1GK2A 1B8FA 2YU9A 2RJSA 1SMYD 4CEIA 2B63A 1T6PA 2PTQA 2MX8A 3GTMA 2MP0A 4BAAA 2PTRA 1ZYMA 3FKIA 3U4QA 4CEHA 3GTPA 3BHGA 4EEIA 2RJRA 1JSWA 3E04A 4APAA 2LKMB 1TJ7A 1YISA 4MX2A 2E9FA 3NO9A 3GTDA 4QIWA 3GTJA 2R92A 1J3UA 2O5JD 2NVXA 2CW0D 2A6ED 1Q5NA 1YNND 3EZBA 2J91A 3KDYA 5EYVA 1TJUA 3GTKA 2F5JA 1R9TA 3R6QA 2LTHA 4FFXA 4FLCA 2YIIA 4V2RA 1FUQA 1GKJA 3CQZA 2X0PA 2VK9A 1K7WA 4NLEA 3RD8A 1IW7D 3R6YA 5F92A 3R6VA 3TV2A 2K3NA 2K3QA 3GTQA 4C6GA 1TJWA 4CQ5A 1VDKA 2VD6A 1EZAA 2O6YA 3GTOA 3C8TA 4A15A 1TJVA 2VSFA 4BABA 2VUMA 4WNLA 2HROA 2E2HA 4FBSA 2HVGA 2EZAA 1I3QA 2NYNA 3EZAA 3OCFA 2LPIA 5IZ2A 2PFMA 2JA7A 1TWCA 2O7DA 2X0QA 4APBA 2JA5A 5F91A 1SFOA 1TWAA 4C2MA 2X75A 3LR2A 5M0JA 2NVYA 1KQ7A 1TWHA 1W27A 1HY1A 3CZOA 1TWGA 2FENA 1I0AA 4ADMA 2EZCA 2Y0NA 1U16A 1AUWA 3U44A 4C5RA 3RRPA 1TWFA 2OHYA 2N3EA 3CRW1 5H8WA 4EFCA 2EZBA 2VL7A 3NZ4A 5HW2A 2A68D 2A69D 3LR6A 1DCNA 2FIOA 2N1DB 2QGAB 4HGVA 1C3UA 1FURA 1GK3A 1I50A 2LPJA 3LRDA
chains in the Genus database with same CATH topology
1YFMA 2NYFA 1K62A 1FUOA 2FUSA 2QVEA 4ADLA 2PTSA 1RE5A 5EYTA 1GKMA 1Y2MA 1FUPA 1HY0A 3OCEA 1T6JA 3GZHA 3UNVA 1YFEA 3QBPA 4NSLA 1C3CA 1DOFA 4C5UA 2O7EA 1XWOA 2O78A 2O7BA 2O7FA 5D6BA 4V2QA 1EB4A 3KDZA 1U15A 4C5SA 1GK2A 1B8FA 2RJSA 1T6PA 2PTQA 4BAAA 2PTRA 4EEIA 3BHGA 2RJRA 1JSWA 3E04A 4APAA 1TJ7A 1YISA 4MX2A 2E9FA 3NO9A 3GTDA 1J3UA 1Q5NA 5EYVA 2J91A 3KDYA 1TJUA 3R6QA 4FFXA 4FLCA 2YIIA 4V2RA 1FUQA 1GKJA 1K7WA 4NLEA 3RD8A 3R6YA 5F92A 3R6VA 3TV2A 4C6GA 1TJWA 4CQ5A 1VDKA 2VD6A 2O6YA 3C8TA 1TJVA 4BABA 2HVGA 2NYNA 3OCFA 2PFMA 2O7DA 4APBA 5F91A 2X75A 1KQ7A 1W27A 1HY1A 3CZOA 1I0AA 4ADMA 1U16A 1AUWA 4C5RA 3RRPA 2OHYA 4EFCA 3NZ4A 5HW2A 1DCNA 2QGAB 4HGVA 1C3UA 1FURA 1GK3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YFM A;  2NYF A;  1K62 A;  1FUO A;  2FUS A;  2QVE A;  4ADL A;  2PTS A;  1RE5 A;  5EYT A;  1GKM A;  1Y2M A;  1FUP A;  1HY0 A;  3OCE A;  1T6J A;  3GZH A;  3UNV A;  1YFE A;  3QBP A;  4NSL A;  1C3C A;  1DOF A;  4C5U A;  2O7E A;  1XWO A;  2O78 A;  2O7B A;  2O7F A;  5D6B A;  4V2Q A;  1EB4 A;  3KDZ A;  1U15 A;  4C5S A;  1GK2 A;  1B8F A;  2RJS A;  1T6P A;  2PTQ A;  4BAA A;  2PTR A;  4EEI A;  3BHG A;  2RJR A;  1JSW A;  3E04 A;  4APA A;  1TJ7 A;  1YIS A;  4MX2 A;  2E9F A;  3NO9 A;  3GTD A;  1J3U A;  1Q5N A;  5EYV A;  2J91 A;  3KDY A;  1TJU A;  3R6Q A;  4FFX A;  4FLC A;  2YII A;  4V2R A;  1FUQ A;  1GKJ A;  1K7W A;  4NLE A;  3RD8 A;  3R6Y A;  5F92 A;  3R6V A;  3TV2 A;  4C6G A;  1TJW A;  4CQ5 A;  1VDK A;  2VD6 A;  2O6Y A;  3C8T A;  1TJV A;  4BAB A;  2HVG A;  2NYN A;  3OCF A;  2PFM A;  2O7D A;  4APB A;  5F91 A;  2X75 A;  1KQ7 A;  1W27 A;  1HY1 A;  3CZO A;  1I0A A;  4ADM A;  1U16 A;  1AUW A;  4C5R A;  3RRP A;  2OHY A;  4EFC A;  3NZ4 A;  5HW2 A;  1DCN A;  2QGA B;  4HGV A;  1C3U A;  1FUR A;  1GK3 A; 
#chains in the Genus database with same CATH topology
 1YFM A;  2NYF A;  1K62 A;  1FUO A;  2LYI A;  1YNJ D;  4CEJ A;  2FUS A;  2QVE A;  4ADL A;  2PTS A;  1WCM A;  1RE5 A;  2FEL A;  2E2I A;  2R7Z A;  5EYT A;  1GKM A;  1XLY A;  1Y2M A;  1FUP A;  1EZB A;  1HY0 A;  2HWG A;  1T6J A;  2BE5 D;  3GZH A;  2MQA A;  1YFE A;  3OCE A;  2R93 A;  3QBP A;  4NSL A;  3UNV A;  2JA6 A;  1C3C A;  3EZE A;  1ZYR D;  3GTG A;  1DOF A;  5M0I A;  4C5U A;  1Y1W A;  1XMD A;  2K3O A;  2O7E A;  2MX9 A;  1XWO A;  2A6H D;  3H0G A;  2O7B A;  2O78 A;  2O7F A;  3LR8 A;  1XL8 A;  5D6B A;  1Y1V A;  4V2Q A;  1EB4 A;  1XL7 A;  3GTL A;  1K83 A;  1XMC A;  2FIP A;  3CRV A;  3KDZ A;  1I6V D;  2X0O A;  4C5S A;  2AQL A;  1HQM D;  1U15 A;  1GK2 A;  1B8F A;  2YU9 A;  2RJS A;  1SMY D;  4CEI A;  2B63 A;  1T6P A;  2PTQ A;  2MX8 A;  3GTM A;  2MP0 A;  4BAA A;  2PTR A;  1ZYM A;  3FKI A;  3U4Q A;  4CEH A;  3GTP A;  3BHG A;  4EEI A;  2RJR A;  1JSW A;  3E04 A;  4APA A;  2LKM B;  1TJ7 A;  1YIS A;  4MX2 A;  2E9F A;  3NO9 A;  3GTD A;  4QIW A;  3GTJ A;  2R92 A;  1J3U A;  2O5J D;  2NVX A;  2CW0 D;  2A6E D;  1Q5N A;  1YNN D;  3EZB A;  2J91 A;  3KDY A;  5EYV A;  1TJU A;  3GTK A;  2F5J A;  1R9T A;  3R6Q A;  2LTH A;  4FFX A;  4FLC A;  2YII A;  4V2R A;  1FUQ A;  1GKJ A;  3CQZ A;  2X0P A;  2VK9 A;  1K7W A;  4NLE A;  3RD8 A;  1IW7 D;  3R6Y A;  5F92 A;  3R6V A;  3TV2 A;  2K3N A;  2K3Q A;  3GTQ A;  4C6G A;  1TJW A;  4CQ5 A;  1VDK A;  2VD6 A;  1EZA A;  2O6Y A;  3GTO A;  3C8T A;  4A15 A;  1TJV A;  2VSF A;  4BAB A;  2VUM A;  4WNL A;  2HRO A;  2E2H A;  4FBS A;  2HVG A;  2EZA A;  1I3Q A;  2NYN A;  3EZA A;  3OCF A;  2LPI A;  5IZ2 A;  2PFM A;  2JA7 A;  1TWC A;  2O7D A;  2X0Q A;  4APB A;  2JA5 A;  5F91 A;  1SFO A;  1TWA A;  4C2M A;  2X75 A;  3LR2 A;  5M0J A;  2NVY A;  1KQ7 A;  1TWH A;  1W27 A;  1HY1 A;  3CZO A;  1TWG A;  2FEN A;  1I0A A;  4ADM A;  2EZC A;  2Y0N A;  1U16 A;  1AUW A;  3U44 A;  4C5R A;  3RRP A;  1TWF A;  2OHY A;  2N3E A;  3CRW 1;  5H8W A;  4EFC A;  2EZB A;  2VL7 A;  3NZ4 A;  5HW2 A;  2A68 D;  2A69 D;  3LR6 A;  1DCN A;  2FIO A;  2N1D B;  2QGA B;  4HGV A;  1C3U A;  1FUR A;  1GK3 A;  1I50 A;  2LPJ A;  3LRD A; 
#chains in the Genus database with same CATH homology
 1YFM A;  2NYF A;  1K62 A;  1FUO A;  2FUS A;  2QVE A;  4ADL A;  2PTS A;  1RE5 A;  5EYT A;  1GKM A;  1Y2M A;  1FUP A;  1HY0 A;  3OCE A;  1T6J A;  3GZH A;  3UNV A;  1YFE A;  3QBP A;  4NSL A;  1C3C A;  1DOF A;  4C5U A;  2O7E A;  1XWO A;  2O78 A;  2O7B A;  2O7F A;  5D6B A;  4V2Q A;  1EB4 A;  3KDZ A;  1U15 A;  4C5S A;  1GK2 A;  1B8F A;  2RJS A;  1T6P A;  2PTQ A;  4BAA A;  2PTR A;  4EEI A;  3BHG A;  2RJR A;  1JSW A;  3E04 A;  4APA A;  1TJ7 A;  1YIS A;  4MX2 A;  2E9F A;  3NO9 A;  3GTD A;  1J3U A;  1Q5N A;  5EYV A;  2J91 A;  3KDY A;  1TJU A;  3R6Q A;  4FFX A;  4FLC A;  2YII A;  4V2R A;  1FUQ A;  1GKJ A;  1K7W A;  4NLE A;  3RD8 A;  3R6Y A;  5F92 A;  3R6V A;  3TV2 A;  4C6G A;  1TJW A;  4CQ5 A;  1VDK A;  2VD6 A;  2O6Y A;  3C8T A;  1TJV A;  4BAB A;  2HVG A;  2NYN A;  3OCF A;  2PFM A;  2O7D A;  4APB A;  5F91 A;  2X75 A;  1KQ7 A;  1W27 A;  1HY1 A;  3CZO A;  1I0A A;  4ADM A;  1U16 A;  1AUW A;  4C5R A;  3RRP A;  2OHY A;  4EFC A;  3NZ4 A;  5HW2 A;  1DCN A;  2QGA B;  4HGV A;  1C3U A;  1FUR A;  1GK3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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