4BABA

Redesign of a phenylalanine aminomutase into a beta-phenylalanine ammonia lyase
Total Genus 230
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
230
sequence length
667
structure length
611
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAESELQESLIRCLLAGVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHDTLVDRLAEFRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Redesign of a Phenylalanine Aminomutase Into a Phenylalanine Ammonia Lyase
rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
molecule keywords PHENYLALANINE AMINOMUTASE
total genus 230
structure length 611
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2012-09-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4babA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4babA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4babA02
2HVGA 2NYFA 1FUQA 1YISA 3QBPA 4C5UA 1YFMA 2FUSA 2O7DA 3RRPA 5HW2A 3UNVA 4HGVA 3NO9A 4APBA 2PTQA 1GK3A 3C8TA 1K62A 1Q5NA 1XWOA 3NZ4A 4FFXA 1C3UA 1B8FA 1HY0A 1FURA 2VD6A 1K7WA 5EYVA 4C5RA 1C3CA 3GZHA 2O7EA 1VDKA 2O7BA 5F92A 2E9FA 4C6GA 2J91A 4NLEA 3R6VA 2YIIA 1TJUA 1GKMA 2PTRA 3R6YA 4V2QA 4V2RA 4EEIA 1FUOA 2RJRA 4C5SA 3E04A 2O78A 1AUWA 3CZOA 1KQ7A 4MX2A 3BHGA 1T6PA 4BAAA 1TJWA 1I0AA 1Y2MA 1YFEA 1J3UA 1TJ7A 1JSWA 1DCNA 4BABA 2QGAB 3KDYA 5F91A 1RE5A 2O6YA 2X75A 4NSLA 3OCFA 2OHYA 5EYTA 5D6BA 2PTSA 4ADMA 3KDZA 1DOFA 1FUPA 1GKJA 3TV2A 4EFCA 1W27A 1EB4A 4FLCA 3GTDA 3R6QA 3RD8A 4APAA 2QVEA 3OCEA 2O7FA 1U16A 2PFMA 2RJSA 2NYNA 4CQ5A 4ADLA 1T6JA 1GK2A 1TJVA 1HY1A 1U15A
chains in the Genus database with same CATH superfamily
3CQZA 1Y1VA 3U44A 3EZAA 2HVGA 1K83A 3CRVA 2NYFA 1FUQA 1YISA 2VUMA 3QBPA 4C5UA 1YFMA 2FUSA 2O7DA 3RRPA 5HW2A 1I50A 3UNVA 2K3NA 2EZBA 2CW0D 4HGVA 3NO9A 1I3QA 1ZYRD 4APBA 2PTQA 1GK3A 3H0GA 1K62A 3C8TA 1Q5NA 1XWOA 2R92A 3NZ4A 4FFXA 1C3UA 1ZYMA 2FIOA 2EZAA 1B8FA 1HY0A 4C2MA 1FURA 2K3OA 4CEHA 2JA5A 4QIWA 4A15A 5M0JA 2VD6A 2LKMB 1K7WA 5EYVA 1XL8A 4CEIA 2MP0A 2LYIA 4C5RA 2A6ED 3U4QA 2E2HA 1C3CA 2O7EA 3GZHA 1VDKA 2O7BA 3GTMA 5F92A 2E9FA 2HROA 4C6GA 2Y0NA 2JA7A 2J91A 4NLEA 3R6VA 2YIIA 1SFOA 3GTKA 2B63A 2A68D 2VSFA 2FENA 1TJUA 1GKMA 2PTRA 3R6YA 2JA6A 1EZAA 3LRDA 2F5JA 2E2IA 4V2QA 4V2RA 2YU9A 4EEIA 2MQAA 2VK9A 1FUOA 1XMCA 2RJRA 2X0OA 2MX9A 4C5SA 2R93A 1I6VD 3E04A 1TWCA 2O78A 1AUWA 3CZOA 1KQ7A 2X0PA 3GTJA 4MX2A 3BHGA 1T6PA 3FKIA 4BAAA 3LR2A 1TJWA 1WCMA 2MX8A 2A6HD 1I0AA 1SMYD 3GTLA 5IZ2A 3GTOA 2EZCA 1Y2MA 1YFEA 1TWHA 1J3UA 2LPIA 1XMDA 3GTGA 1TJ7A 1JSWA 2NVYA 1DCNA 4BABA 1Y1WA 2QGAB 3KDYA 1XL7A 5M0IA 4CEJA 5F91A 1IW7D 4FBSA 1XLYA 4WNLA 1RE5A 1HQMD 2O6YA 2X75A 4NSLA 2AQLA 3LR6A 2NVXA 2OHYA 3OCFA 5EYTA 5D6BA 2PTSA 4ADMA 3KDZA 1DOFA 5H8WA 1FUPA 3LR8A 3CRW1 1GKJA 2VL7A 3TV2A 4EFCA 1TWAA 3EZBA 1YNJD 1W27A 3GTPA 2BE5D 2R7ZA 1EB4A 2O5JD 4FLCA 3GTDA 3R6QA 3RD8A 4APAA 1TWGA 2QVEA 3OCEA 2O7FA 1U16A 2PFMA 2RJSA 2NYNA 2FIPA 4CQ5A 4ADLA 3GTQA 1T6JA 1EZBA 2N3EA 3EZEA 1GK2A 1TJVA 2N1DB 2X0QA 1HY1A 1U15A 2FELA 2K3QA 2LPJA 1TWFA 1R9TA 2A69D 1YNND 2HWGA 2LTHA
chains in the Genus database with same CATH topology
2HVGA 2NYFA 1FUQA 1YISA 3QBPA 4C5UA 1YFMA 2FUSA 2O7DA 3RRPA 5HW2A 3UNVA 4HGVA 3NO9A 4APBA 2PTQA 1GK3A 3C8TA 1K62A 1Q5NA 1XWOA 3NZ4A 4FFXA 1C3UA 1B8FA 1HY0A 1FURA 2VD6A 1K7WA 5EYVA 4C5RA 1C3CA 3GZHA 2O7EA 1VDKA 2O7BA 5F92A 2E9FA 4C6GA 2J91A 4NLEA 3R6VA 2YIIA 1TJUA 1GKMA 2PTRA 3R6YA 4V2QA 4V2RA 4EEIA 1FUOA 2RJRA 4C5SA 3E04A 2O78A 1AUWA 3CZOA 1KQ7A 4MX2A 3BHGA 1T6PA 4BAAA 1TJWA 1I0AA 1Y2MA 1YFEA 1J3UA 1TJ7A 1JSWA 1DCNA 4BABA 2QGAB 3KDYA 5F91A 1RE5A 2O6YA 2X75A 4NSLA 3OCFA 2OHYA 5EYTA 5D6BA 2PTSA 4ADMA 3KDZA 1DOFA 1FUPA 1GKJA 3TV2A 4EFCA 1W27A 1EB4A 4FLCA 3GTDA 3R6QA 3RD8A 4APAA 2QVEA 3OCEA 2O7FA 1U16A 2PFMA 2RJSA 2NYNA 4CQ5A 4ADLA 1T6JA 1GK2A 1TJVA 1HY1A 1U15A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2HVG A;  2NYF A;  1FUQ A;  1YIS A;  3QBP A;  4C5U A;  1YFM A;  2FUS A;  2O7D A;  3RRP A;  5HW2 A;  3UNV A;  4HGV A;  3NO9 A;  4APB A;  2PTQ A;  1GK3 A;  3C8T A;  1K62 A;  1Q5N A;  1XWO A;  3NZ4 A;  4FFX A;  1C3U A;  1B8F A;  1HY0 A;  1FUR A;  2VD6 A;  1K7W A;  5EYV A;  4C5R A;  1C3C A;  3GZH A;  2O7E A;  1VDK A;  2O7B A;  5F92 A;  2E9F A;  4C6G A;  2J91 A;  4NLE A;  3R6V A;  2YII A;  1TJU A;  1GKM A;  2PTR A;  3R6Y A;  4V2Q A;  4V2R A;  4EEI A;  1FUO A;  2RJR A;  4C5S A;  3E04 A;  2O78 A;  1AUW A;  3CZO A;  1KQ7 A;  4MX2 A;  3BHG A;  1T6P A;  4BAA A;  1TJW A;  1I0A A;  1Y2M A;  1YFE A;  1J3U A;  1TJ7 A;  1JSW A;  1DCN A;  4BAB A;  2QGA B;  3KDY A;  5F91 A;  1RE5 A;  2O6Y A;  2X75 A;  4NSL A;  3OCF A;  2OHY A;  5EYT A;  5D6B A;  2PTS A;  4ADM A;  3KDZ A;  1DOF A;  1FUP A;  1GKJ A;  3TV2 A;  4EFC A;  1W27 A;  1EB4 A;  4FLC A;  3GTD A;  3R6Q A;  3RD8 A;  4APA A;  2QVE A;  3OCE A;  2O7F A;  1U16 A;  2PFM A;  2RJS A;  2NYN A;  4CQ5 A;  4ADL A;  1T6J A;  1GK2 A;  1TJV A;  1HY1 A;  1U15 A; 
#chains in the Genus database with same CATH topology
 3CQZ A;  1Y1V A;  3U44 A;  3EZA A;  2HVG A;  1K83 A;  3CRV A;  2NYF A;  1FUQ A;  1YIS A;  2VUM A;  3QBP A;  4C5U A;  1YFM A;  2FUS A;  2O7D A;  3RRP A;  5HW2 A;  1I50 A;  3UNV A;  2K3N A;  2EZB A;  2CW0 D;  4HGV A;  3NO9 A;  1I3Q A;  1ZYR D;  4APB A;  2PTQ A;  1GK3 A;  3H0G A;  1K62 A;  3C8T A;  1Q5N A;  1XWO A;  2R92 A;  3NZ4 A;  4FFX A;  1C3U A;  1ZYM A;  2FIO A;  2EZA A;  1B8F A;  1HY0 A;  4C2M A;  1FUR A;  2K3O A;  4CEH A;  2JA5 A;  4QIW A;  4A15 A;  5M0J A;  2VD6 A;  2LKM B;  1K7W A;  5EYV A;  1XL8 A;  4CEI A;  2MP0 A;  2LYI A;  4C5R A;  2A6E D;  3U4Q A;  2E2H A;  1C3C A;  2O7E A;  3GZH A;  1VDK A;  2O7B A;  3GTM A;  5F92 A;  2E9F A;  2HRO A;  4C6G A;  2Y0N A;  2JA7 A;  2J91 A;  4NLE A;  3R6V A;  2YII A;  1SFO A;  3GTK A;  2B63 A;  2A68 D;  2VSF A;  2FEN A;  1TJU A;  1GKM A;  2PTR A;  3R6Y A;  2JA6 A;  1EZA A;  3LRD A;  2F5J A;  2E2I A;  4V2Q A;  4V2R A;  2YU9 A;  4EEI A;  2MQA A;  2VK9 A;  1FUO A;  1XMC A;  2RJR A;  2X0O A;  2MX9 A;  4C5S A;  2R93 A;  1I6V D;  3E04 A;  1TWC A;  2O78 A;  1AUW A;  3CZO A;  1KQ7 A;  2X0P A;  3GTJ A;  4MX2 A;  3BHG A;  1T6P A;  3FKI A;  4BAA A;  3LR2 A;  1TJW A;  1WCM A;  2MX8 A;  2A6H D;  1I0A A;  1SMY D;  3GTL A;  5IZ2 A;  3GTO A;  2EZC A;  1Y2M A;  1YFE A;  1TWH A;  1J3U A;  2LPI A;  1XMD A;  3GTG A;  1TJ7 A;  1JSW A;  2NVY A;  1DCN A;  4BAB A;  1Y1W A;  2QGA B;  3KDY A;  1XL7 A;  5M0I A;  4CEJ A;  5F91 A;  1IW7 D;  4FBS A;  1XLY A;  4WNL A;  1RE5 A;  1HQM D;  2O6Y A;  2X75 A;  4NSL A;  2AQL A;  3LR6 A;  2NVX A;  2OHY A;  3OCF A;  5EYT A;  5D6B A;  2PTS A;  4ADM A;  3KDZ A;  1DOF A;  5H8W A;  1FUP A;  3LR8 A;  3CRW 1;  1GKJ A;  2VL7 A;  3TV2 A;  4EFC A;  1TWA A;  3EZB A;  1YNJ D;  1W27 A;  3GTP A;  2BE5 D;  2R7Z A;  1EB4 A;  2O5J D;  4FLC A;  3GTD A;  3R6Q A;  3RD8 A;  4APA A;  1TWG A;  2QVE A;  3OCE A;  2O7F A;  1U16 A;  2PFM A;  2RJS A;  2NYN A;  2FIP A;  4CQ5 A;  4ADL A;  3GTQ A;  1T6J A;  1EZB A;  2N3E A;  3EZE A;  1GK2 A;  1TJV A;  2N1D B;  2X0Q A;  1HY1 A;  1U15 A;  2FEL A;  2K3Q A;  2LPJ A;  1TWF A;  1R9T A;  2A69 D;  1YNN D;  2HWG A;  2LTH A; 
#chains in the Genus database with same CATH homology
 2HVG A;  2NYF A;  1FUQ A;  1YIS A;  3QBP A;  4C5U A;  1YFM A;  2FUS A;  2O7D A;  3RRP A;  5HW2 A;  3UNV A;  4HGV A;  3NO9 A;  4APB A;  2PTQ A;  1GK3 A;  3C8T A;  1K62 A;  1Q5N A;  1XWO A;  3NZ4 A;  4FFX A;  1C3U A;  1B8F A;  1HY0 A;  1FUR A;  2VD6 A;  1K7W A;  5EYV A;  4C5R A;  1C3C A;  3GZH A;  2O7E A;  1VDK A;  2O7B A;  5F92 A;  2E9F A;  4C6G A;  2J91 A;  4NLE A;  3R6V A;  2YII A;  1TJU A;  1GKM A;  2PTR A;  3R6Y A;  4V2Q A;  4V2R A;  4EEI A;  1FUO A;  2RJR A;  4C5S A;  3E04 A;  2O78 A;  1AUW A;  3CZO A;  1KQ7 A;  4MX2 A;  3BHG A;  1T6P A;  4BAA A;  1TJW A;  1I0A A;  1Y2M A;  1YFE A;  1J3U A;  1TJ7 A;  1JSW A;  1DCN A;  4BAB A;  2QGA B;  3KDY A;  5F91 A;  1RE5 A;  2O6Y A;  2X75 A;  4NSL A;  3OCF A;  2OHY A;  5EYT A;  5D6B A;  2PTS A;  4ADM A;  3KDZ A;  1DOF A;  1FUP A;  1GKJ A;  3TV2 A;  4EFC A;  1W27 A;  1EB4 A;  4FLC A;  3GTD A;  3R6Q A;  3RD8 A;  4APA A;  2QVE A;  3OCE A;  2O7F A;  1U16 A;  2PFM A;  2RJS A;  2NYN A;  4CQ5 A;  4ADL A;  1T6J A;  1GK2 A;  1TJV A;  1HY1 A;  1U15 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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