4BABA

Redesign of a phenylalanine aminomutase into a beta-phenylalanine ammonia lyase
Total Genus 230
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
230
sequence length
667
structure length
611
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEAEQCRARVETCSSWVQRKAESELQESLIRCLLAGVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVNGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHDTLVDRLAEFRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords PHENYLALANINE AMINOMUTASE
publication title Redesign of a Phenylalanine Aminomutase Into a Phenylalanine Ammonia Lyase
rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
total genus 230
structure length 611
sequence length 667
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2012-09-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4babA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4babA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4babA02
1T6JA 1FURA 1YFMA 1GKMA 3TV2A 3QBPA 1TJ7A 1HY1A 1C3CA 1GK2A 2FUSA 3BHGA 1YFEA 4NSLA 2O7EA 1FUOA 1Q5NA 2RJSA 5EYVA 4FFXA 4APBA 2PFMA 1JSWA 4ADLA 4V2QA 5EYTA 1T6PA 2X75A 3OCEA 4C5UA 2RJRA 1K62A 1KQ7A 1EB4A 5D6BA 2NYNA 1YISA 4EFCA 4C5RA 4HGVA 3UNVA 1FUQA 1TJUA 3R6QA 2E9FA 4MX2A 2O7DA 2PTQA 2QVEA 4BAAA 2O6YA 1GKJA 1TJVA 2VD6A 1XWOA 1Y2MA 1J3UA 3CZOA 3R6YA 1VDKA 3NZ4A 2PTSA 4V2RA 1K7WA 3GTDA 3NO9A 1W27A 2J91A 3OCFA 4APAA 1AUWA 1DOFA 1U16A 2YIIA 5F92A 3RD8A 1C3UA 3R6VA 3KDZA 3E04A 2O7FA 2O78A 2NYFA 1B8FA 2QGAB 4EEIA 2HVGA 4C5SA 1HY0A 1I0AA 2PTRA 4BABA 4C6GA 3C8TA 4NLEA 1DCNA 1RE5A 1TJWA 5F91A 2O7BA 1FUPA 1GK3A 1U15A 3KDYA 4FLCA 3RRPA 4CQ5A 2OHYA 3GZHA 4ADMA 5HW2A
chains in the Genus database with same CATH superfamily
3CRVA 1EZAA 3GTKA 1T6JA 1FURA 2A69D 5M0IA 1YFMA 1GKMA 1YNND 2Y0NA 1XL8A 2MX9A 3TV2A 2FELA 3QBPA 1TJ7A 1HY1A 1C3CA 4QIWA 2O5JD 1GK2A 3EZAA 2FUSA 4A15A 2JA7A 3BHGA 1YFEA 4NSLA 2O7EA 3U4QA 1Y1WA 1FUOA 1Q5NA 2F5JA 1XMCA 2RJSA 3FKIA 1XL7A 1I6VD 2OHYA 5EYVA 2X0PA 4FFXA 4APBA 1XMDA 2K3OA 1K83A 1EZBA 2PFMA 2LKMB 1JSWA 1YNJD 1SFOA 2VUMA 4ADLA 2LTHA 2EZCA 1TWAA 3LRDA 4V2QA 2B63A 2AQLA 5EYTA 2X0QA 3GTJA 1T6PA 2MP0A 3U44A 2MQAA 1SMYD 2X75A 3OCEA 4C5UA 1IW7D 2RJRA 1ZYRD 1K62A 1KQ7A 1EB4A 5D6BA 1XLYA 2VK9A 3LR6A 1YISA 2NYNA 4EFCA 4C5RA 4HGVA 5M0JA 4CEJA 3EZBA 1TWHA 2HROA 4C2MA 3UNVA 1I50A 1FUQA 2N3EA 3H0GA 2E2IA 1TWCA 1TJUA 2E9FA 4MX2A 1TWFA 2HWGA 4FBSA 3R6QA 2O7DA 2VL7A 2R7ZA 2EZBA 2PTQA 1HQMD 2A6HD 2QVEA 4BAAA 2JA5A 2LPJA 3CQZA 3GTPA 2O6YA 1GKJA 1TJVA 2VD6A 2E2HA 1XWOA 1Y2MA 1J3UA 3CZOA 3R6YA 1VDKA 3NZ4A 2PTSA 2K3NA 4V2RA 2EZAA 1R9TA 1K7WA 2X0OA 3GTDA 2R93A 3NO9A 4CEIA 2FIPA 2LPIA 2N1DB 2YU9A 1W27A 2J91A 3EZEA 3OCFA 4APAA 1AUWA 1DOFA 1TWGA 1U16A 2YIIA 4WNLA 3GTGA 5F92A 2A6ED 3GTQA 3RD8A 1C3UA 3LR8A 2VSFA 3R6VA 2NVXA 3KDZA 3GTMA 3E04A 2O7FA 2O78A 2NYFA 1B8FA 3GTLA 2QGAB 4EEIA 3GZHA 2HVGA 4C5SA 3LR2A 2MX8A 1I3QA 2FENA 1HY0A 1I0AA 2PTRA 4BABA 2BE5D 1Y1VA 2FIOA 2NVYA 3C8TA 4NLEA 2K3QA 1DCNA 1RE5A 1TJWA 5F91A 2JA6A 3GTOA 2O7BA 1FUPA 1GK3A 2CW0D 1U15A 3CRW1 3KDYA 4FLCA 3RRPA 1ZYMA 2R92A 5H8WA 1WCMA 2A68D 2LYIA 4CQ5A 4C6GA 5IZ2A 4CEHA 4ADMA 5HW2A
chains in the Genus database with same CATH topology
1T6JA 1FURA 1YFMA 1GKMA 3TV2A 3QBPA 1TJ7A 1HY1A 1C3CA 1GK2A 2FUSA 3BHGA 1YFEA 4NSLA 2O7EA 1FUOA 1Q5NA 2RJSA 5EYVA 4FFXA 4APBA 2PFMA 1JSWA 4ADLA 4V2QA 5EYTA 1T6PA 2X75A 3OCEA 4C5UA 2RJRA 1K62A 1KQ7A 1EB4A 5D6BA 2NYNA 1YISA 4EFCA 4C5RA 4HGVA 3UNVA 1FUQA 1TJUA 3R6QA 2E9FA 4MX2A 2O7DA 2PTQA 2QVEA 4BAAA 2O6YA 1GKJA 1TJVA 2VD6A 1XWOA 1Y2MA 1J3UA 3CZOA 3R6YA 1VDKA 3NZ4A 2PTSA 4V2RA 1K7WA 3GTDA 3NO9A 1W27A 2J91A 3OCFA 4APAA 1AUWA 1DOFA 1U16A 2YIIA 5F92A 3RD8A 1C3UA 3R6VA 3KDZA 3E04A 2O7FA 2O78A 2NYFA 1B8FA 2QGAB 4EEIA 2HVGA 4C5SA 1HY0A 1I0AA 2PTRA 4BABA 4C6GA 3C8TA 4NLEA 1DCNA 1RE5A 1TJWA 5F91A 2O7BA 1FUPA 1GK3A 1U15A 3KDYA 4FLCA 3RRPA 4CQ5A 2OHYA 3GZHA 4ADMA 5HW2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1T6J A;  1FUR A;  1YFM A;  1GKM A;  3TV2 A;  3QBP A;  1TJ7 A;  1HY1 A;  1C3C A;  1GK2 A;  2FUS A;  3BHG A;  1YFE A;  4NSL A;  2O7E A;  1FUO A;  1Q5N A;  2RJS A;  5EYV A;  4FFX A;  4APB A;  2PFM A;  1JSW A;  4ADL A;  4V2Q A;  5EYT A;  1T6P A;  2X75 A;  3OCE A;  4C5U A;  2RJR A;  1K62 A;  1KQ7 A;  1EB4 A;  5D6B A;  2NYN A;  1YIS A;  4EFC A;  4C5R A;  4HGV A;  3UNV A;  1FUQ A;  1TJU A;  3R6Q A;  2E9F A;  4MX2 A;  2O7D A;  2PTQ A;  2QVE A;  4BAA A;  2O6Y A;  1GKJ A;  1TJV A;  2VD6 A;  1XWO A;  1Y2M A;  1J3U A;  3CZO A;  3R6Y A;  1VDK A;  3NZ4 A;  2PTS A;  4V2R A;  1K7W A;  3GTD A;  3NO9 A;  1W27 A;  2J91 A;  3OCF A;  4APA A;  1AUW A;  1DOF A;  1U16 A;  2YII A;  5F92 A;  3RD8 A;  1C3U A;  3R6V A;  3KDZ A;  3E04 A;  2O7F A;  2O78 A;  2NYF A;  1B8F A;  2QGA B;  4EEI A;  2HVG A;  4C5S A;  1HY0 A;  1I0A A;  2PTR A;  4BAB A;  4C6G A;  3C8T A;  4NLE A;  1DCN A;  1RE5 A;  1TJW A;  5F91 A;  2O7B A;  1FUP A;  1GK3 A;  1U15 A;  3KDY A;  4FLC A;  3RRP A;  4CQ5 A;  2OHY A;  3GZH A;  4ADM A;  5HW2 A; 
#chains in the Genus database with same CATH topology
 3CRV A;  1EZA A;  3GTK A;  1T6J A;  1FUR A;  2A69 D;  5M0I A;  1YFM A;  1GKM A;  1YNN D;  2Y0N A;  1XL8 A;  2MX9 A;  3TV2 A;  2FEL A;  3QBP A;  1TJ7 A;  1HY1 A;  1C3C A;  4QIW A;  2O5J D;  1GK2 A;  3EZA A;  2FUS A;  4A15 A;  2JA7 A;  3BHG A;  1YFE A;  4NSL A;  2O7E A;  3U4Q A;  1Y1W A;  1FUO A;  1Q5N A;  2F5J A;  1XMC A;  2RJS A;  3FKI A;  1XL7 A;  1I6V D;  2OHY A;  5EYV A;  2X0P A;  4FFX A;  4APB A;  1XMD A;  2K3O A;  1K83 A;  1EZB A;  2PFM A;  2LKM B;  1JSW A;  1YNJ D;  1SFO A;  2VUM A;  4ADL A;  2LTH A;  2EZC A;  1TWA A;  3LRD A;  4V2Q A;  2B63 A;  2AQL A;  5EYT A;  2X0Q A;  3GTJ A;  1T6P A;  2MP0 A;  3U44 A;  2MQA A;  1SMY D;  2X75 A;  3OCE A;  4C5U A;  1IW7 D;  2RJR A;  1ZYR D;  1K62 A;  1KQ7 A;  1EB4 A;  5D6B A;  1XLY A;  2VK9 A;  3LR6 A;  1YIS A;  2NYN A;  4EFC A;  4C5R A;  4HGV A;  5M0J A;  4CEJ A;  3EZB A;  1TWH A;  2HRO A;  4C2M A;  3UNV A;  1I50 A;  1FUQ A;  2N3E A;  3H0G A;  2E2I A;  1TWC A;  1TJU A;  2E9F A;  4MX2 A;  1TWF A;  2HWG A;  4FBS A;  3R6Q A;  2O7D A;  2VL7 A;  2R7Z A;  2EZB A;  2PTQ A;  1HQM D;  2A6H D;  2QVE A;  4BAA A;  2JA5 A;  2LPJ A;  3CQZ A;  3GTP A;  2O6Y A;  1GKJ A;  1TJV A;  2VD6 A;  2E2H A;  1XWO A;  1Y2M A;  1J3U A;  3CZO A;  3R6Y A;  1VDK A;  3NZ4 A;  2PTS A;  2K3N A;  4V2R A;  2EZA A;  1R9T A;  1K7W A;  2X0O A;  3GTD A;  2R93 A;  3NO9 A;  4CEI A;  2FIP A;  2LPI A;  2N1D B;  2YU9 A;  1W27 A;  2J91 A;  3EZE A;  3OCF A;  4APA A;  1AUW A;  1DOF A;  1TWG A;  1U16 A;  2YII A;  4WNL A;  3GTG A;  5F92 A;  2A6E D;  3GTQ A;  3RD8 A;  1C3U A;  3LR8 A;  2VSF A;  3R6V A;  2NVX A;  3KDZ A;  3GTM A;  3E04 A;  2O7F A;  2O78 A;  2NYF A;  1B8F A;  3GTL A;  2QGA B;  4EEI A;  3GZH A;  2HVG A;  4C5S A;  3LR2 A;  2MX8 A;  1I3Q A;  2FEN A;  1HY0 A;  1I0A A;  2PTR A;  4BAB A;  2BE5 D;  1Y1V A;  2FIO A;  2NVY A;  3C8T A;  4NLE A;  2K3Q A;  1DCN A;  1RE5 A;  1TJW A;  5F91 A;  2JA6 A;  3GTO A;  2O7B A;  1FUP A;  1GK3 A;  2CW0 D;  1U15 A;  3CRW 1;  3KDY A;  4FLC A;  3RRP A;  1ZYM A;  2R92 A;  5H8W A;  1WCM A;  2A68 D;  2LYI A;  4CQ5 A;  4C6G A;  5IZ2 A;  4CEH A;  4ADM A;  5HW2 A; 
#chains in the Genus database with same CATH homology
 1T6J A;  1FUR A;  1YFM A;  1GKM A;  3TV2 A;  3QBP A;  1TJ7 A;  1HY1 A;  1C3C A;  1GK2 A;  2FUS A;  3BHG A;  1YFE A;  4NSL A;  2O7E A;  1FUO A;  1Q5N A;  2RJS A;  5EYV A;  4FFX A;  4APB A;  2PFM A;  1JSW A;  4ADL A;  4V2Q A;  5EYT A;  1T6P A;  2X75 A;  3OCE A;  4C5U A;  2RJR A;  1K62 A;  1KQ7 A;  1EB4 A;  5D6B A;  2NYN A;  1YIS A;  4EFC A;  4C5R A;  4HGV A;  3UNV A;  1FUQ A;  1TJU A;  3R6Q A;  2E9F A;  4MX2 A;  2O7D A;  2PTQ A;  2QVE A;  4BAA A;  2O6Y A;  1GKJ A;  1TJV A;  2VD6 A;  1XWO A;  1Y2M A;  1J3U A;  3CZO A;  3R6Y A;  1VDK A;  3NZ4 A;  2PTS A;  4V2R A;  1K7W A;  3GTD A;  3NO9 A;  1W27 A;  2J91 A;  3OCF A;  4APA A;  1AUW A;  1DOF A;  1U16 A;  2YII A;  5F92 A;  3RD8 A;  1C3U A;  3R6V A;  3KDZ A;  3E04 A;  2O7F A;  2O78 A;  2NYF A;  1B8F A;  2QGA B;  4EEI A;  2HVG A;  4C5S A;  1HY0 A;  1I0A A;  2PTR A;  4BAB A;  4C6G A;  3C8T A;  4NLE A;  1DCN A;  1RE5 A;  1TJW A;  5F91 A;  2O7B A;  1FUP A;  1GK3 A;  1U15 A;  3KDY A;  4FLC A;  3RRP A;  4CQ5 A;  2OHY A;  3GZH A;  4ADM A;  5HW2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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