4BEX1

Structure of human cofilin1
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
166
structure length
166
Chain Sequence
MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDVGQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKLTGIKHELQANCYEEVKDRATLAEKLGGSAVISLEGKPL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Analysis of the Human Cofilin1 Structure Reveals Conformational Changes Required for Actin-Binding
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords COFILIN-1
total genus 46
structure length 166
sequence length 166
ec nomenclature
pdb deposition date 2013-03-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
1 PF00241 Cofilin_ADF Cofilin/tropomyosin-type actin-binding protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 4bex100
5DD2A 5KYUB 1CNUA 1EQYS 3EGXA 1Q8XA 2LXXA 2FF3A 1PD0A 2FH3A 1DEJS 1T3XA 3FG7A 3EGDA 1SVRA 1RGIG 3A5LS 1M2VB 4KEFA 5KYYB 1YVNG 3CI5G 1AHQA 2I2QA 1P8XA 3CIPG 1AK7A 1JHWA 3EG9B 1WM4A 5KYWA 1J72A 3L50A 5A1MA 1WFSA 1QPVA 2FH1A 3EFOB 2FF6G 2W0IA 5KYXA 4KEDA 2FH4A 5FAEA 1C0GS 1P8ZG 1VFQA 2KVKA 2FGHA 1PCXA 2FH2A 2NUPB 1ESVS 1VKKA 4CBWG 2NUTB 1C0FS 1M2OA 3EFOA 4JD2H 3DAWB 5KYNA 2HD7A 1TVJA 5KYUA 1SVQA 1D0NA 3EH1A 1WNJA 5FAFA 1NMDG 1V6FA 1X67A 4CBXG 2XFAA 1HQZ1 1M2VA 5KYYA 3CJCG 3A5OS 1F7SA 2LJ8A 1AK6A 4BEX1 2MP4A 4PKHB 1T3YA 1CFYA 3EG9A 4PKGG 1KCQA 3Q2BA 3FFKA 3A5NS 3FFNA 1SVYA 1M4JA 1YAGG 3EGXB 2MV2A 1NLVG 3FG6A 4Z94G 5HVKB 1COFA 4S10C 1UDMA 2NUPA 3EGDB 1PD1A 1MDUA 3A5MS 4KEEA 2NUTA 3CJBG 5HVKD 2VACA 1H1VG 1T44G 2XF1A 5IVUA 4CBUG 1D4XG 2LLFA 4PKIG 2D8BA 1NM1G 1T2LA 2MOTA 5L6WC 5KYWB 2VILA 1Q8GA 2QTVA 2L72A 5KYXB 4LIZA 1NPHA 1TMWA 2VIKA 3TU5B 3EH2A
chains in the Genus database with same CATH superfamily
5DD2A 5KYUB 1CNUA 1EQYS 3EGXA 1Q8XA 2LXXA 2FF3A 1PD0A 2FH3A 1DEJS 1T3XA 3FG7A 3EGDA 1SVRA 1RGIG 3A5LS 1M2VB 4KEFA 5KYYB 1YVNG 3CI5G 1AHQA 2I2QA 1P8XA 3CIPG 1AK7A 1JHWA 3DA7A 3EG9B 1WM4A 5KYWA 1J72A 3L50A 5A1MA 1WFSA 1QPVA 2FH1A 3EFOB 2FF6G 2W0IA 5KYXA 4KEDA 2FH4A 5FAEA 1C0GS 1P8ZG 1VFQA 2KVKA 2FGHA 1PCXA 2FH2A 2NUPB 1ESVS 1VKKA 4CBWG 2NUTB 1C0FS 1M2OA 3EFOA 4JD2H 3DAWB 5KYNA 2HD7A 1TVJA 5KYUA 1SVQA 1D0NA 3EH1A 1WNJA 5FAFA 1NMDG 1V6FA 1X67A 4CBXG 2XFAA 1HQZ1 1M2VA 5KYYA 3CJCG 3A5OS 1F7SA 2LJ8A 1AK6A 4BEX1 2MP4A 4PKHB 1T3YA 1CFYA 3EG9A 4PKGG 1KCQA 3Q2BA 3FFKA 3A5NS 3FFNA 1SVYA 1M4JA 1YAGG 3EGXB 2MV2A 1NLVG 3FG6A 4Z94G 5HVKB 1COFA 4S10C 1UDMA 2NUPA 3EGDB 1PD1A 1MDUA 3A5MS 4KEEA 2NUTA 3CJBG 5HVKD 2VACA 1H1VG 1T44G 2XF1A 5IVUA 4CBUG 1D4XG 2LLFA 4PKIG 2D8BA 1NM1G 1T2LA 2MOTA 5L6WC 5KYWB 2VILA 1Q8GA 2QTVA 2L72A 5KYXB 4LIZA 1NPHA 1TMWA 2VIKA 3TU5B 3EH2A
chains in the Genus database with same CATH topology
5DD2A 5KYUB 1CNUA 1EQYS 3EGXA 1Q8XA 2LXXA 2FF3A 1PD0A 2FH3A 1DEJS 1T3XA 3FG7A 3EGDA 1SVRA 1RGIG 3A5LS 1M2VB 4KEFA 5KYYB 1YVNG 3CI5G 1AHQA 2I2QA 1P8XA 3CIPG 1AK7A 1JHWA 3DA7A 3EG9B 1WM4A 5KYWA 1J72A 3L50A 5A1MA 1WFSA 1QPVA 2FH1A 3EFOB 2FF6G 2W0IA 5KYXA 4KEDA 2FH4A 5FAEA 1C0GS 1P8ZG 1VFQA 2KVKA 2FGHA 1PCXA 2FH2A 2NUPB 1ESVS 1VKKA 4CBWG 2NUTB 1C0FS 1M2OA 3EFOA 4JD2H 3DAWB 5KYNA 2HD7A 1TVJA 5KYUA 1SVQA 1D0NA 3EH1A 1WNJA 5FAFA 1NMDG 1V6FA 1X67A 4CBXG 2XFAA 1HQZ1 1M2VA 5KYYA 3CJCG 3A5OS 1F7SA 2LJ8A 1AK6A 4BEX1 2MP4A 4PKHB 1T3YA 1CFYA 3EG9A 4PKGG 1KCQA 3Q2BA 3FFKA 3A5NS 3FFNA 1SVYA 1M4JA 1YAGG 3EGXB 2MV2A 1NLVG 3FG6A 4Z94G 5HVKB 1COFA 4S10C 1UDMA 2NUPA 3EGDB 1PD1A 1MDUA 3A5MS 4KEEA 2NUTA 3CJBG 5HVKD 2VACA 1H1VG 1T44G 2XF1A 5IVUA 4CBUG 1D4XG 2LLFA 4PKIG 2D8BA 1NM1G 1T2LA 2MOTA 5L6WC 5KYWB 2VILA 1Q8GA 2QTVA 2L72A 5KYXB 4LIZA 1NPHA 1TMWA 2VIKA 3TU5B 3EH2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5DD2 A;  5KYU B;  1CNU A;  1EQY S;  3EGX A;  1Q8X A;  2LXX A;  2FF3 A;  1PD0 A;  2FH3 A;  1DEJ S;  1T3X A;  3FG7 A;  3EGD A;  1SVR A;  1RGI G;  3A5L S;  1M2V B;  4KEF A;  5KYY B;  1YVN G;  3CI5 G;  1AHQ A;  2I2Q A;  1P8X A;  3CIP G;  1AK7 A;  1JHW A;  3EG9 B;  1WM4 A;  5KYW A;  1J72 A;  3L50 A;  5A1M A;  1WFS A;  1QPV A;  2FH1 A;  3EFO B;  2FF6 G;  2W0I A;  5KYX A;  4KED A;  2FH4 A;  5FAE A;  1C0G S;  1P8Z G;  1VFQ A;  2KVK A;  2FGH A;  1PCX A;  2FH2 A;  2NUP B;  1ESV S;  1VKK A;  4CBW G;  2NUT B;  1C0F S;  1M2O A;  3EFO A;  4JD2 H;  3DAW B;  5KYN A;  2HD7 A;  1TVJ A;  5KYU A;  1SVQ A;  1D0N A;  3EH1 A;  1WNJ A;  5FAF A;  1NMD G;  1V6F A;  1X67 A;  4CBX G;  2XFA A;  1HQZ 1;  1M2V A;  5KYY A;  3CJC G;  3A5O S;  1F7S A;  2LJ8 A;  1AK6 A;  4BEX 1;  2MP4 A;  4PKH B;  1T3Y A;  1CFY A;  3EG9 A;  4PKG G;  1KCQ A;  3Q2B A;  3FFK A;  3A5N S;  3FFN A;  1SVY A;  1M4J A;  1YAG G;  3EGX B;  2MV2 A;  1NLV G;  3FG6 A;  4Z94 G;  5HVK B;  1COF A;  4S10 C;  1UDM A;  2NUP A;  3EGD B;  1PD1 A;  1MDU A;  3A5M S;  4KEE A;  2NUT A;  3CJB G;  5HVK D;  2VAC A;  1H1V G;  1T44 G;  2XF1 A;  5IVU A;  4CBU G;  1D4X G;  2LLF A;  4PKI G;  2D8B A;  1NM1 G;  1T2L A;  2MOT A;  5L6W C;  5KYW B;  2VIL A;  1Q8G A;  2QTV A;  2L72 A;  5KYX B;  4LIZ A;  1NPH A;  1TMW A;  2VIK A;  3TU5 B;  3EH2 A; 
#chains in the Genus database with same CATH topology
 5DD2 A;  5KYU B;  1CNU A;  1EQY S;  3EGX A;  1Q8X A;  2LXX A;  2FF3 A;  1PD0 A;  2FH3 A;  1DEJ S;  1T3X A;  3FG7 A;  3EGD A;  1SVR A;  1RGI G;  3A5L S;  1M2V B;  4KEF A;  5KYY B;  1YVN G;  3CI5 G;  1AHQ A;  2I2Q A;  1P8X A;  3CIP G;  1AK7 A;  1JHW A;  3DA7 A;  3EG9 B;  1WM4 A;  5KYW A;  1J72 A;  3L50 A;  5A1M A;  1WFS A;  1QPV A;  2FH1 A;  3EFO B;  2FF6 G;  2W0I A;  5KYX A;  4KED A;  2FH4 A;  5FAE A;  1C0G S;  1P8Z G;  1VFQ A;  2KVK A;  2FGH A;  1PCX A;  2FH2 A;  2NUP B;  1ESV S;  1VKK A;  4CBW G;  2NUT B;  1C0F S;  1M2O A;  3EFO A;  4JD2 H;  3DAW B;  5KYN A;  2HD7 A;  1TVJ A;  5KYU A;  1SVQ A;  1D0N A;  3EH1 A;  1WNJ A;  5FAF A;  1NMD G;  1V6F A;  1X67 A;  4CBX G;  2XFA A;  1HQZ 1;  1M2V A;  5KYY A;  3CJC G;  3A5O S;  1F7S A;  2LJ8 A;  1AK6 A;  4BEX 1;  2MP4 A;  4PKH B;  1T3Y A;  1CFY A;  3EG9 A;  4PKG G;  1KCQ A;  3Q2B A;  3FFK A;  3A5N S;  3FFN A;  1SVY A;  1M4J A;  1YAG G;  3EGX B;  2MV2 A;  1NLV G;  3FG6 A;  4Z94 G;  5HVK B;  1COF A;  4S10 C;  1UDM A;  2NUP A;  3EGD B;  1PD1 A;  1MDU A;  3A5M S;  4KEE A;  2NUT A;  3CJB G;  5HVK D;  2VAC A;  1H1V G;  1T44 G;  2XF1 A;  5IVU A;  4CBU G;  1D4X G;  2LLF A;  4PKI G;  2D8B A;  1NM1 G;  1T2L A;  2MOT A;  5L6W C;  5KYW B;  2VIL A;  1Q8G A;  2QTV A;  2L72 A;  5KYX B;  4LIZ A;  1NPH A;  1TMW A;  2VIK A;  3TU5 B;  3EH2 A; 
#chains in the Genus database with same CATH homology
 5DD2 A;  5KYU B;  1CNU A;  1EQY S;  3EGX A;  1Q8X A;  2LXX A;  2FF3 A;  1PD0 A;  2FH3 A;  1DEJ S;  1T3X A;  3FG7 A;  3EGD A;  1SVR A;  1RGI G;  3A5L S;  1M2V B;  4KEF A;  5KYY B;  1YVN G;  3CI5 G;  1AHQ A;  2I2Q A;  1P8X A;  3CIP G;  1AK7 A;  1JHW A;  3DA7 A;  3EG9 B;  1WM4 A;  5KYW A;  1J72 A;  3L50 A;  5A1M A;  1WFS A;  1QPV A;  2FH1 A;  3EFO B;  2FF6 G;  2W0I A;  5KYX A;  4KED A;  2FH4 A;  5FAE A;  1C0G S;  1P8Z G;  1VFQ A;  2KVK A;  2FGH A;  1PCX A;  2FH2 A;  2NUP B;  1ESV S;  1VKK A;  4CBW G;  2NUT B;  1C0F S;  1M2O A;  3EFO A;  4JD2 H;  3DAW B;  5KYN A;  2HD7 A;  1TVJ A;  5KYU A;  1SVQ A;  1D0N A;  3EH1 A;  1WNJ A;  5FAF A;  1NMD G;  1V6F A;  1X67 A;  4CBX G;  2XFA A;  1HQZ 1;  1M2V A;  5KYY A;  3CJC G;  3A5O S;  1F7S A;  2LJ8 A;  1AK6 A;  4BEX 1;  2MP4 A;  4PKH B;  1T3Y A;  1CFY A;  3EG9 A;  4PKG G;  1KCQ A;  3Q2B A;  3FFK A;  3A5N S;  3FFN A;  1SVY A;  1M4J A;  1YAG G;  3EGX B;  2MV2 A;  1NLV G;  3FG6 A;  4Z94 G;  5HVK B;  1COF A;  4S10 C;  1UDM A;  2NUP A;  3EGD B;  1PD1 A;  1MDU A;  3A5M S;  4KEE A;  2NUT A;  3CJB G;  5HVK D;  2VAC A;  1H1V G;  1T44 G;  2XF1 A;  5IVU A;  4CBU G;  1D4X G;  2LLF A;  4PKI G;  2D8B A;  1NM1 G;  1T2L A;  2MOT A;  5L6W C;  5KYW B;  2VIL A;  1Q8G A;  2QTV A;  2L72 A;  5KYX B;  4LIZ A;  1NPH A;  1TMW A;  2VIK A;  3TU5 B;  3EH2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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