4BPXA

Crystal structure of human primase in complex with the primase- binding motif of dna polymerase alpha
Total Genus 121
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
121
sequence length
406
structure length
381
Chain Sequence
TFDPTELPELLKLYYRRLFPYSQYYRWLNYGGVIKNYFQHREFSFTLKDDIYIRYQSFNNQSDLEKEMQAANPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIDMTDYDDVRRCCSSADICPKCWTLMTMAIRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSAVRSGIVEYLSLVKGGQDVKKKVHLSEKIHPFIRKSINIIKKYFEEYALVNQDILENKESWDKILALVPETIHDELQQSFQKSHNSLQRWEHLKKVASRYQNNPWLEWEIMLQYCFPRLDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELDAIRTRDYKKTSLAPYVKVFEHFLENLDKSRKG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase
molecule keywords DNA PRIMASE SMALL SUBUNIT
publication title Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering
pubmed doi rcsb
source organism Homo sapiens
total genus 121
structure length 381
sequence length 406
chains with identical sequence C
ec nomenclature ec 2.7.7.-:
pdb deposition date 2013-05-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01896 DNA_primase_S DNA primase small subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.920.30 Alpha Beta Alpha-Beta Complex DNA primase, PRIM domain DNA primase, PRIM domain 4bpxA00
4MHQA 4LIKA 4MM2A 5EXRA 4BPXA 1ZT2A 2FAOA 2FARA 4LIMA 4BPUA 4LILA 4RR2A 2FAQA 4BPWA
chains in the Genus database with same CATH superfamily
4MHQA 4LIKA 4MM2A 5EXRA 1V34A 4BPXA 2FAQA 1ZT2A 1V33A 2FAOA 2FARA 4LIMA 4BPUA 2ATZA 4LILA 4RR2A 1G71A 4BPWA
chains in the Genus database with same CATH topology
4MHQA 4LIKA 4MM2A 5EXRA 1V34A 4BPXA 2FAQA 1ZT2A 1V33A 2FAOA 2FARA 4LIMA 4BPUA 4LILA 4RR2A 1G71A 4BPWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MHQ A;  4LIK A;  4MM2 A;  5EXR A;  4BPX A;  1ZT2 A;  2FAO A;  2FAR A;  4LIM A;  4BPU A;  4LIL A;  4RR2 A;  2FAQ A;  4BPW A; 
#chains in the Genus database with same CATH topology
 4MHQ A;  4LIK A;  4MM2 A;  5EXR A;  1V34 A;  4BPX A;  2FAQ A;  1ZT2 A;  1V33 A;  2FAO A;  2FAR A;  4LIM A;  4BPU A;  2ATZ A;  4LIL A;  4RR2 A;  1G71 A;  4BPW A; 
#chains in the Genus database with same CATH homology
 4MHQ A;  4LIK A;  4MM2 A;  5EXR A;  1V34 A;  4BPX A;  2FAQ A;  1ZT2 A;  1V33 A;  2FAO A;  2FAR A;  4LIM A;  4BPU A;  4LIL A;  4RR2 A;  1G71 A;  4BPW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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