4BPXB

Crystal structure of human primase in complex with the primase- binding motif of dna polymerase alpha
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
217
structure length
181
Chain Sequence
ISLIEFENLAIDRVKLLKSVENLSKLESELRKLRRDHISHFILRLAYCQSEELRRWFIQQEMDLLRFRFSILPKDKIQDFLKDSQLQFEAISDEEKTLREQEIVASSPSLLGFESIYKIPFADALDLFRGRKVYLEDGFAYVPLKDIVAIILNEFRAKLSKALALTARSLDERLQPLLNHL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of Human Primase Reveal Design of Nucleotide Elongation Site and Mode of Pol Alpha Tethering
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords DNA PRIMASE SMALL SUBUNIT
total genus 50
structure length 181
sequence length 217
chains with identical sequence D
ec nomenclature ec 2.7.7.-:
pdb deposition date 2013-05-28
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.930.80 Mainly Alpha Up-down Bundle Transcription Elongation Factor S-II; Chain A Transcription Elongation Factor S-II; Chain A 4bpxB00
4BPXB 4BPUB 4RR2B 4BPWB
chains in the Genus database with same CATH superfamily
3SJFA 2C6GA 1YVHA 1Z8LA 3SJEA 4NGQA 4BPUB 3D7FA 4A4CA 3HPHE 5ELYA 2PVWA 3BUOB 3VROA 3HPGG 3OB2B 5HKZA 4P4IA 4MCRA 3ZNIA 4W9YA 2Y1NA 3BI0A 4P4DA 5BY0A 2Y1MA 3BUMB 1EO0A 2XEGA 5F09A 2OOTA 2VKZG 1FBVA 2XEFA 3D7DA 4OMEA 4OC5A 2XPNA 2PVVA 3D7GA 4OC3A 3PLFB 2C6CA 1CX8A 1B47A 3FEDA 2OR4A 1Z9EA 4BPWB 2CIJA 3OP0A 3VGOA 3RBUA 3PFVA 3HMJG 2C6PA 5AXIA 4OC2A 3SJGA 2XPLA 4A4BA 4BPXB 5J3XA 3KASA 5HKWA 3O8ZA 3PT1A 4GPLB 4OC0A 3SJXA 3VRNA 4P44A 3BUXB 2XEIA 3OAKA 4RR2B 4LQGA 2XPPA 4OC4A 4MCPA 4P4FA 3S9LA 3FECA 5D29A 4P4BA 3BHXA 4X3RA 3VRQA 3D7HA 3OB1B 4P4JA 3FF3A 4P4EA 3IWWA 2UV8G 5F13A 3FEEA 2N3AB 4JZ0A 4P45A 4NGRA 3F9KC 2XPOA 4BTFA 3BI1A 4OC1A 3VRRA 4NGPA 2DLAA 4MCSA 3BXMA 1DE4C 2CBLA 4NGSA 3S9NA 3VRPA 4NGTA 3BUNB 4JYWA 4NGMA 3NFQA 3U88C 4NGNA 1WJTA 3BUWB 2XEJA 4MCQA 2B4JC 3S9MA 5HKYA 2JBKA 2JBJA
chains in the Genus database with same CATH topology
2DLAA 4BPUB 4RR2B 4BPWB 3HMJG 2UV8G 5F13A 3PT1A 4BPXB 2VKZG 5BY0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4BPX B;  4BPU B;  4RR2 B;  4BPW B; 
#chains in the Genus database with same CATH topology
 3SJF A;  2C6G A;  1YVH A;  1Z8L A;  3SJE A;  4NGQ A;  4BPU B;  3D7F A;  4A4C A;  3HPH E;  5ELY A;  2PVW A;  3BUO B;  3VRO A;  3HPG G;  3OB2 B;  5HKZ A;  4P4I A;  4MCR A;  3ZNI A;  4W9Y A;  2Y1N A;  3BI0 A;  4P4D A;  5BY0 A;  2Y1M A;  3BUM B;  1EO0 A;  2XEG A;  5F09 A;  2OOT A;  2VKZ G;  1FBV A;  2XEF A;  3D7D A;  4OME A;  4OC5 A;  2XPN A;  2PVV A;  3D7G A;  4OC3 A;  3PLF B;  2C6C A;  1CX8 A;  1B47 A;  3FED A;  2OR4 A;  1Z9E A;  4BPW B;  2CIJ A;  3OP0 A;  3VGO A;  3RBU A;  3PFV A;  3HMJ G;  2C6P A;  5AXI A;  4OC2 A;  3SJG A;  2XPL A;  4A4B A;  4BPX B;  5J3X A;  3KAS A;  5HKW A;  3O8Z A;  3PT1 A;  4GPL B;  4OC0 A;  3SJX A;  3VRN A;  4P44 A;  3BUX B;  2XEI A;  3OAK A;  4RR2 B;  4LQG A;  2XPP A;  4OC4 A;  4MCP A;  4P4F A;  3S9L A;  3FEC A;  5D29 A;  4P4B A;  3BHX A;  4X3R A;  3VRQ A;  3D7H A;  3OB1 B;  4P4J A;  3FF3 A;  4P4E A;  3IWW A;  2UV8 G;  5F13 A;  3FEE A;  2N3A B;  4JZ0 A;  4P45 A;  4NGR A;  3F9K C;  2XPO A;  4BTF A;  3BI1 A;  4OC1 A;  3VRR A;  4NGP A;  2DLA A;  4MCS A;  3BXM A;  1DE4 C;  2CBL A;  4NGS A;  3S9N A;  3VRP A;  4NGT A;  3BUN B;  4JYW A;  4NGM A;  3NFQ A;  3U88 C;  4NGN A;  1WJT A;  3BUW B;  2XEJ A;  4MCQ A;  2B4J C;  3S9M A;  5HKY A;  2JBK A;  2JBJ A; 
#chains in the Genus database with same CATH homology
 2DLA A;  4BPU B;  4RR2 B;  4BPW B;  3HMJ G;  2UV8 G;  5F13 A;  3PT1 A;  4BPX B;  2VKZ G;  5BY0 A; 
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similar chains in the Genus database (?% sequence similarity)
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#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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