4BT7A

Acetolactate decarboxylase with a bound phosphate ion
Total Genus 74
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
74
sequence length
236
structure length
236
Chain Sequence
APKNVLFQYSTINALMLGQFEGDLTLKDLKLRGDMGLGTINDLDGEMIQMGTKFYQIDSTGKLSELPESVKTPFAVTTHFEPKEKTTLTNVQDYNQLTKMLEEKFENKNVFYAVKLTGTFKMVKARTVPKQTRPYPQLTEVTKKQSEFEFKNVKGTLIGFYTPNYAAALNVPGFHLHFITEDKTSGGHVLNLQFDNANLEISPIHEFDVQLPHTDDFAHSDLTQVTTSQVHQAESE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords ALPHA-ACETOLACTATE DECARBOXYLASE
publication title Structure and Mechanism of Acetolactate Decarboxylase.
pubmed doi rcsb
source organism Brevibacillus brevis
molecule tags Lyase
total genus 74
structure length 236
sequence length 236
ec nomenclature ec 4.1.1.5: Acetolactate decarboxylase.
pdb deposition date 2013-06-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03306 AAL_decarboxy Alpha-acetolactate decarboxylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1330.80 Alpha Beta 2-Layer Sandwich 60s Ribosomal Protein L30; Chain: A; Hypothetical protein, similar to alpha- acetolactate decarboxylase; domain 2 4bt7A02
3.30.1330.80 Alpha Beta 2-Layer Sandwich 60s Ribosomal Protein L30; Chain: A; Hypothetical protein, similar to alpha- acetolactate decarboxylase; domain 2 4bt7A01
2HX0A 2P6YA 4BT6A 4BT4A 4BT7A 2H6LA 4BT5A 4BT2A 1XV2A 3HWUA 2DT4A 3HTNA 2NMUA 4BT3A
chains in the Genus database with same CATH superfamily
5AVMA 2QTPA 4I50A 3U0OA 5JVDA 5J2TA 4X1KA 3HAXD 1W2BF 5LP6B 3VTIC 5GIPC 1VQ4F 4I4TB 3GHZA 3N2GB 1Z5WA 3V7QA 5KX5B 3M1XA 4G4VA 2PMPA 2KTUA 5LXTA 3MQWA 3WPXA 1W5BA 3CPQA 2N48A 2NMUA 3P10A 1VQ6F 2HRUA 1Q81H 4C81A 2HP3A 5KMGB 1YIJF 1OAPA 3O85A 4M8IA 1JD1A 5LP6A 3S0HA 3HJWC 3I3FA 4I4TA 1X52A 2B33A 3N2GA 3CG6A 5KX5A 4X3LA 3LWQC 2P6YA 1W55A 3JALB 5CA0B 1ODEA 1W5FA 1Q7YH 3J81M 3LWPC 4FFBB 2JNBA 4ZHQB 3ELCA 3TD3A 2Z01A 3CYQA 3S0WA 2KG4A 3I7TA 3K12A 1H48A 3V7EA 3VMFB 1KQSF 1Q82H 1TVKB 5MN5A 2CZWA 4ZOLB 3IR9A 2UYNB 3VYUC 5KMGA 3SIUA 4O2BA 5LOVA 4DRXB 3HKCA 4G4YA 3D54A 3VIUA 1FFXB 1NJIH 2FGYA 3E20B 3ESJA 5EIBD 3JALA 5CA0A 5HWEA 2QA4F 4LNUA 2UZHA 4ZK7A 4NUTA 1R1MA 2V9YA 1KD1H 3E1YA 3OONA 2Z1TA 4ZHQA 3KJJA 3MCQA 1TVKA 3WGKA 4BT4A 4ZOLA 2DYYA 5LA6B 3NK6A 1VQLF 1K73H 2VAWA 3ZP4A 3I56F 5IJ0B 2ZODA 4DRXA 5A2QM 1W59A 1S72F 1FFXA 2AIFA 3CC2F 3ERNA 5FNVB 1T0KB 4R40B 3S0YA 4E6EA 3Q8HA 3BYQA 3IKFA 2EWCA 4TV8B 3RYCB 2HRYA 1YJNF 2IAFA 2UYKA 3B6NA 3I55F 1GX1A 3WGLA 3HKDB 2R751 4O4JB 2BTQB 4NQ3A 3F0GA 3L7QA 1Q86H 5LA6A 5FJ4C 4RQOA 3JCMM 1TUBB 3V4DA 1CN7A 4B45A 5IJ0A 3CCRF 3RYFA 5B8FA 2UYPA 4C82A 3FD5A 2GVIA 5FNVA 2LBWA 3GTZA 4TV9B 1W3EX 4TV8A 1K8AH 2ZOVA 5IYZB 1KC8H 3HKDA 1VQ9F 3K0TA 4O4JA 3PAFA 4O4HB 3WGJA 5JVDB 3JAKB 4IIJB 1TUBA 5HP8A 1IV4A 1VQVA 4BT6A 3M4SA 5DCVA 3J7AR 3HKEB 2ALEA 4B5CA 4TV9A 3VOAA 3JAMM 4XCQA 1DBFA 5LXTB 5HP7A 4RHAA 5IYZA 1VK3A 1W57A 3MDOA 2Q1XA 4F6RB 5GINC 4O4HA 3WGNA 2W8BC 5GANK 1VQPF 3JAKA 4IIJA 5EIBC 5MN4A 1J7HA 1VQOF 3LYBA 5J2UB 3CCVF 1M1KH 2H6LA 3J80M 5HY4A 3JVHA 3MCAB 3HKEA 1QVFF 4O4LB 1JN1A 5EB1B 3JASB 5MN6A 4ERHA 1JY8A 2I6RA 3KJKA 3ZOPA 4F6RA 4O2AB 5IT9M 3V3TA 2CWJA 1DT9A 4O2BB 4BVSA 3EORA 5J2UA 2FC3A 1FSZA 5LOVB 3LWRC 3QTYA 1W5AA 3HKCB 5JCOC 2VXYA 3LWVC 1UFYA 4O4LA 4LNUB 2OTMA 3K2XA 4ZHWA 3JASA 5G4VC 3WJRA 4TZZA 1VQNF 2OTJF 3TD4A 5JH7A 4O2AA 1VQKF 1RLUA 5G4UC 1SDSA 3FBAA 3IKEA 3IMPA 3RE3A 1ZWZA 4G4WA 4B62A 1KNKA 1K9MH 3TD5A 2CW4A 1ONIA 5JQGB 5HY1A 1W40A 5EB0A 3HTNA 2BTUA 3S03A 2HX0A 3F6MA 3RYHB 3D00A 1YI2F 1YJWF 1QVGF 3AGKA 5HXZA 3CC7F 3WPWA 2Z1FA 5CB4B 1YQNA 3QUWA 3NMUC 1VQ7F 4X20A 1YGYA 3LDTA 2K1SA 1COMA 1T0AA 3QHDA 3RYFB 5JQGA 5LYJB 4ZHVA 4YJ3A 1W5EA 3CPWF 3RYHA 3G4SF 3LWOC 2DT4A 5GONB 5FLXM 1JJ2F 1E7KA 3N4ZA 2RHHA 2RB9A 5CA1B 4EI8A 1SA0B 5CB4A 1YITF 2Q1YA 2RHLA 4C4WC 4EB6B 3C9SA 3CC4F 3G6EF 2LBXA 3CMEF 2CSLA 5LYJA 2L26A 4X1YA 5EZYB 3CYPB 5GAPK 2HS0A 2BTOA 5GONA 1XBIA 3C8LA 3S02A 2HQSC 2IQQA 5CA1A 3IEQA 3OW2F 1SA0A 2OZBA 2QI2A 4B46A 2ZAUA 2GZLA 3S06A 3CXCF 3G71F 3P4EA 5EO3A 4EB6A 3VO8A 2OHWA 4WBNB 3T80A 5GIOC 5EZYA 5C8YB 4NWOB 3UT5A 3NVKE 2GLZA 3ZP7A 2LCAA 1X25A 2HP0B 3VCZA 1H7MA 1CK2A 1UI9A 4G4ZA 1GO1A 3OBWA 4TUYB 1XHOA 1FNKA 4O4IB 1SZQA 1QAHA 2YXZA 1U43A 1X7OA 3RA5A 3DC2A 3F0EA 4C8GA 2AMTA 1RLGA 5LP6C 1PF5A 4WBNA 1GO0A 3JATB 5C8YA 2G9IA 2HVYD 2Z1UA 1IV2A 2UYJA 2HP0A 1XRGA 3IEWA 2WALA 4TUYA 1VQ8F 3C9RA 5JH7B 4O4IA 4BT3A 3CCUF 4BY9D 1RQ7A 4X3MA 3CCEF 1NQ3A 2CHSA 4KWEA 4U39A 3N4YA 4X1IB 4LCKA 5HXUA 4BVQA 3JATA 2LBTA 1PXWA 2VGNA 3FFMA 2HS4A 1IPAA 1YJ9F 1IV1A 1X7PA 1FNJA 2CVLA 3ZO8A 3CD6F 2RHOA 3LMEA 1VQ5F 3VI6A 1QU9A 4G88A 1H47A 2F9ZC 2IG8A 2KGWA 3NK7A 4HNAB 3CCSF 4X20B 3KE1A 4X1IA 3HKBB 1U3LA 3RA6A 2RHJA 2QEXF 4PWTA 1QD9A 4YJ3B 1VQMF 2R6R1 3PLAC 1GZ0A 1YHQF 3KIZA 2HS3A 3C9TA 3M84A 5EYPB 2H8CA 3GYQA 1N8RH 1M90H 1IV3A 3WXMB 4HNAA 4EI7A 5HY2A 3DDNA 2CHTA 4ZI7B 1Q8RA 2KTVA 2VAMA 4EI9A 2VGMA 5JCOA 1XV2A 3HKBA 3R0PA 5IJ9B 3WJPA 2H8EA 2ZVYA 3LFOA 4X1YB 5BMVB 3SIVA 5EAZA 4BT5A 5ITZB 4FFBA 1NMUB 3VYTC 4G4XA 4C8IA 5EYPA 3NVIB 3JARB 3RYIB 4ZHYB 1U40A 3CCMF 2UYNA 4ZI7A 2I6DA 4IHJB 5IJ9A 4C8EA 1RA4A 3FD6A 2VAPA 5BMVA 3WJQA 5ITZA 3UT5B 4DXDA 3WGMA 4BVRA 1W42A 4YJ2B 4U3JB 3JARA 3RYIA 3MBMA 3E22B 1U3PA 3F0DA 3JAWB 3VYSC 3K14A 4IHJA 1OFUA 1W41A 1JFFB 1Z5VA 3CB2A 5HY0A 4I55B 3P0ZA 2YYEA 3CMAF 3VOBA 3RYCA 3C9UA 1VHAA 4YJ2A 3OBYA 3KHNA 1VH8A 4U3JA 3N2KB 5EWRA 1KNJA 2OTLF 4BVTA 4I50B 2Z1EA 3D01A 5J2TB 4X1KB 3E22A 3JAWA 3CCQF 2BO1A 3FPIA 2ZF8A 3F0FA 3CCLF 1JFFA 1CLIA 2PHNA 2AIZP 2ZVZA 4BW0B 4I55A 3HWUA 3ON1A 4BT7A 1RQ2A 1W581 4BT2A 3CCJF 3N2KA 2MQEA
chains in the Genus database with same CATH topology
2HX0A 2P6YA 4BT6A 4BT4A 4BT7A 2H6LA 4BT5A 4BT2A 1XV2A 3HWUA 2DT4A 3HTNA 2NMUA 4BT3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2HX0 A;  2P6Y A;  4BT6 A;  4BT4 A;  4BT7 A;  2H6L A;  4BT5 A;  4BT2 A;  1XV2 A;  3HWU A;  2DT4 A;  3HTN A;  2NMU A;  4BT3 A; 
#chains in the Genus database with same CATH topology
 5AVM A;  2QTP A;  4I50 A;  3U0O A;  5JVD A;  5J2T A;  4X1K A;  3HAX D;  1W2B F;  5LP6 B;  3VTI C;  5GIP C;  1VQ4 F;  4I4T B;  3GHZ A;  3N2G B;  1Z5W A;  3V7Q A;  5KX5 B;  3M1X A;  4G4V A;  2PMP A;  2KTU A;  5LXT A;  3MQW A;  3WPX A;  1W5B A;  3CPQ A;  2N48 A;  2NMU A;  3P10 A;  1VQ6 F;  2HRU A;  1Q81 H;  4C81 A;  2HP3 A;  5KMG B;  1YIJ F;  1OAP A;  3O85 A;  4M8I A;  1JD1 A;  5LP6 A;  3S0H A;  3HJW C;  3I3F A;  4I4T A;  1X52 A;  2B33 A;  3N2G A;  3CG6 A;  5KX5 A;  4X3L A;  3LWQ C;  2P6Y A;  1W55 A;  3JAL B;  5CA0 B;  1ODE A;  1W5F A;  1Q7Y H;  3J81 M;  3LWP C;  4FFB B;  2JNB A;  4ZHQ B;  3ELC A;  3TD3 A;  2Z01 A;  3CYQ A;  3S0W A;  2KG4 A;  3I7T A;  3K12 A;  1H48 A;  3V7E A;  3VMF B;  1KQS F;  1Q82 H;  1TVK B;  5MN5 A;  2CZW A;  4ZOL B;  3IR9 A;  2UYN B;  3VYU C;  5KMG A;  3SIU A;  4O2B A;  5LOV A;  4DRX B;  3HKC A;  4G4Y A;  3D54 A;  3VIU A;  1FFX B;  1NJI H;  2FGY A;  3E20 B;  3ESJ A;  5EIB D;  3JAL A;  5CA0 A;  5HWE A;  2QA4 F;  4LNU A;  2UZH A;  4ZK7 A;  4NUT A;  1R1M A;  2V9Y A;  1KD1 H;  3E1Y A;  3OON A;  2Z1T A;  4ZHQ A;  3KJJ A;  3MCQ A;  1TVK A;  3WGK A;  4BT4 A;  4ZOL A;  2DYY A;  5LA6 B;  3NK6 A;  1VQL F;  1K73 H;  2VAW A;  3ZP4 A;  3I56 F;  5IJ0 B;  2ZOD A;  4DRX A;  5A2Q M;  1W59 A;  1S72 F;  1FFX A;  2AIF A;  3CC2 F;  3ERN A;  5FNV B;  1T0K B;  4R40 B;  3S0Y A;  4E6E A;  3Q8H A;  3BYQ A;  3IKF A;  2EWC A;  4TV8 B;  3RYC B;  2HRY A;  1YJN F;  2IAF A;  2UYK A;  3B6N A;  3I55 F;  1GX1 A;  3WGL A;  3HKD B;  2R75 1;  4O4J B;  2BTQ B;  4NQ3 A;  3F0G A;  3L7Q A;  1Q86 H;  5LA6 A;  5FJ4 C;  4RQO A;  3JCM M;  1TUB B;  3V4D A;  1CN7 A;  4B45 A;  5IJ0 A;  3CCR F;  3RYF A;  5B8F A;  2UYP A;  4C82 A;  3FD5 A;  2GVI A;  5FNV A;  2LBW A;  3GTZ A;  4TV9 B;  1W3E X;  4TV8 A;  1K8A H;  2ZOV A;  5IYZ B;  1KC8 H;  3HKD A;  1VQ9 F;  3K0T A;  4O4J A;  3PAF A;  4O4H B;  3WGJ A;  5JVD B;  3JAK B;  4IIJ B;  1TUB A;  5HP8 A;  1IV4 A;  1VQV A;  4BT6 A;  3M4S A;  5DCV A;  3J7A R;  3HKE B;  2ALE A;  4B5C A;  4TV9 A;  3VOA A;  3JAM M;  4XCQ A;  1DBF A;  5LXT B;  5HP7 A;  4RHA A;  5IYZ A;  1VK3 A;  1W57 A;  3MDO A;  2Q1X A;  4F6R B;  5GIN C;  4O4H A;  3WGN A;  2W8B C;  5GAN K;  1VQP F;  3JAK A;  4IIJ A;  5EIB C;  5MN4 A;  1J7H A;  1VQO F;  3LYB A;  5J2U B;  3CCV F;  1M1K H;  2H6L A;  3J80 M;  5HY4 A;  3JVH A;  3MCA B;  3HKE A;  1QVF F;  4O4L B;  1JN1 A;  5EB1 B;  3JAS B;  5MN6 A;  4ERH A;  1JY8 A;  2I6R A;  3KJK A;  3ZOP A;  4F6R A;  4O2A B;  5IT9 M;  3V3T A;  2CWJ A;  1DT9 A;  4O2B B;  4BVS A;  3EOR A;  5J2U A;  2FC3 A;  1FSZ A;  5LOV B;  3LWR C;  3QTY A;  1W5A A;  3HKC B;  5JCO C;  2VXY A;  3LWV C;  1UFY A;  4O4L A;  4LNU B;  2OTM A;  3K2X A;  4ZHW A;  3JAS A;  5G4V C;  3WJR A;  4TZZ A;  1VQN F;  2OTJ F;  3TD4 A;  5JH7 A;  4O2A A;  1VQK F;  1RLU A;  5G4U C;  1SDS A;  3FBA A;  3IKE A;  3IMP A;  3RE3 A;  1ZWZ A;  4G4W A;  4B62 A;  1KNK A;  1K9M H;  3TD5 A;  2CW4 A;  1ONI A;  5JQG B;  5HY1 A;  1W40 A;  5EB0 A;  3HTN A;  2BTU A;  3S03 A;  2HX0 A;  3F6M A;  3RYH B;  3D00 A;  1YI2 F;  1YJW F;  1QVG F;  3AGK A;  5HXZ A;  3CC7 F;  3WPW A;  2Z1F A;  5CB4 B;  1YQN A;  3QUW A;  3NMU C;  1VQ7 F;  4X20 A;  1YGY A;  3LDT A;  2K1S A;  1COM A;  1T0A A;  3QHD A;  3RYF B;  5JQG A;  5LYJ B;  4ZHV A;  4YJ3 A;  1W5E A;  3CPW F;  3RYH A;  3G4S F;  3LWO C;  2DT4 A;  5GON B;  5FLX M;  1JJ2 F;  1E7K A;  3N4Z A;  2RHH A;  2RB9 A;  5CA1 B;  4EI8 A;  1SA0 B;  5CB4 A;  1YIT F;  2Q1Y A;  2RHL A;  4C4W C;  4EB6 B;  3C9S A;  3CC4 F;  3G6E F;  2LBX A;  3CME F;  2CSL A;  5LYJ A;  2L26 A;  4X1Y A;  5EZY B;  3CYP B;  5GAP K;  2HS0 A;  2BTO A;  5GON A;  1XBI A;  3C8L A;  3S02 A;  2HQS C;  2IQQ A;  5CA1 A;  3IEQ A;  3OW2 F;  1SA0 A;  2OZB A;  2QI2 A;  4B46 A;  2ZAU A;  2GZL A;  3S06 A;  3CXC F;  3G71 F;  3P4E A;  5EO3 A;  4EB6 A;  3VO8 A;  2OHW A;  4WBN B;  3T80 A;  5GIO C;  5EZY A;  5C8Y B;  4NWO B;  3UT5 A;  3NVK E;  2GLZ A;  3ZP7 A;  2LCA A;  1X25 A;  2HP0 B;  3VCZ A;  1H7M A;  1CK2 A;  1UI9 A;  4G4Z A;  1GO1 A;  3OBW A;  4TUY B;  1XHO A;  1FNK A;  4O4I B;  1SZQ A;  1QAH A;  2YXZ A;  1U43 A;  1X7O A;  3RA5 A;  3DC2 A;  3F0E A;  4C8G A;  2AMT A;  1RLG A;  5LP6 C;  1PF5 A;  4WBN A;  1GO0 A;  3JAT B;  5C8Y A;  2G9I A;  2HVY D;  2Z1U A;  1IV2 A;  2UYJ A;  2HP0 A;  1XRG A;  3IEW A;  2WAL A;  4TUY A;  1VQ8 F;  3C9R A;  5JH7 B;  4O4I A;  4BT3 A;  3CCU F;  4BY9 D;  1RQ7 A;  4X3M A;  3CCE F;  1NQ3 A;  2CHS A;  4KWE A;  4U39 A;  3N4Y A;  4X1I B;  4LCK A;  5HXU A;  4BVQ A;  3JAT A;  2LBT A;  1PXW A;  2VGN A;  3FFM A;  2HS4 A;  1IPA A;  1YJ9 F;  1IV1 A;  1X7P A;  1FNJ A;  2CVL A;  3ZO8 A;  3CD6 F;  2RHO A;  3LME A;  1VQ5 F;  3VI6 A;  1QU9 A;  4G88 A;  1H47 A;  2F9Z C;  2IG8 A;  2KGW A;  3NK7 A;  4HNA B;  3CCS F;  4X20 B;  3KE1 A;  4X1I A;  3HKB B;  1U3L A;  3RA6 A;  2RHJ A;  2QEX F;  4PWT A;  1QD9 A;  4YJ3 B;  1VQM F;  2R6R 1;  3PLA C;  1GZ0 A;  1YHQ F;  3KIZ A;  2HS3 A;  3C9T A;  3M84 A;  5EYP B;  2H8C A;  3GYQ A;  1N8R H;  1M90 H;  1IV3 A;  3WXM B;  4HNA A;  4EI7 A;  5HY2 A;  3DDN A;  2CHT A;  4ZI7 B;  1Q8R A;  2KTV A;  2VAM A;  4EI9 A;  2VGM A;  5JCO A;  1XV2 A;  3HKB A;  3R0P A;  5IJ9 B;  3WJP A;  2H8E A;  2ZVY A;  3LFO A;  4X1Y B;  5BMV B;  3SIV A;  5EAZ A;  4BT5 A;  5ITZ B;  4FFB A;  1NMU B;  3VYT C;  4G4X A;  4C8I A;  5EYP A;  3NVI B;  3JAR B;  3RYI B;  4ZHY B;  1U40 A;  3CCM F;  2UYN A;  4ZI7 A;  2I6D A;  4IHJ B;  5IJ9 A;  4C8E A;  1RA4 A;  3FD6 A;  2VAP A;  5BMV A;  3WJQ A;  5ITZ A;  3UT5 B;  4DXD A;  3WGM A;  4BVR A;  1W42 A;  4YJ2 B;  4U3J B;  3JAR A;  3RYI A;  3MBM A;  3E22 B;  1U3P A;  3F0D A;  3JAW B;  3VYS C;  3K14 A;  4IHJ A;  1OFU A;  1W41 A;  1JFF B;  1Z5V A;  3CB2 A;  5HY0 A;  4I55 B;  3P0Z A;  2YYE A;  3CMA F;  3VOB A;  3RYC A;  3C9U A;  1VHA A;  4YJ2 A;  3OBY A;  3KHN A;  1VH8 A;  4U3J A;  3N2K B;  5EWR A;  1KNJ A;  2OTL F;  4BVT A;  4I50 B;  2Z1E A;  3D01 A;  5J2T B;  4X1K B;  3E22 A;  3JAW A;  3CCQ F;  2BO1 A;  3FPI A;  2ZF8 A;  3F0F A;  3CCL F;  1JFF A;  1CLI A;  2PHN A;  2AIZ P;  2ZVZ A;  4BW0 B;  4I55 A;  3HWU A;  3ON1 A;  4BT7 A;  1RQ2 A;  1W58 1;  4BT2 A;  3CCJ F;  3N2K A;  2MQE A; 
#chains in the Genus database with same CATH homology
 2HX0 A;  2P6Y A;  4BT6 A;  4BT4 A;  4BT7 A;  2H6L A;  4BT5 A;  4BT2 A;  1XV2 A;  3HWU A;  2DT4 A;  3HTN A;  2NMU A;  4BT3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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