4BT7A

Acetolactate decarboxylase with a bound phosphate ion
Total Genus 74
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
74
sequence length
236
structure length
236
Chain Sequence
APKNVLFQYSTINALMLGQFEGDLTLKDLKLRGDMGLGTINDLDGEMIQMGTKFYQIDSTGKLSELPESVKTPFAVTTHFEPKEKTTLTNVQDYNQLTKMLEEKFENKNVFYAVKLTGTFKMVKARTVPKQTRPYPQLTEVTKKQSEFEFKNVKGTLIGFYTPNYAAALNVPGFHLHFITEDKTSGGHVLNLQFDNANLEISPIHEFDVQLPHTDDFAHSDLTQVTTSQVHQAESE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords ALPHA-ACETOLACTATE DECARBOXYLASE
publication title Structure and Mechanism of Acetolactate Decarboxylase.
pubmed doi rcsb
source organism Brevibacillus brevis
molecule tags Lyase
total genus 74
structure length 236
sequence length 236
ec nomenclature ec 4.1.1.5: Acetolactate decarboxylase.
pdb deposition date 2013-06-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03306 AAL_decarboxy Alpha-acetolactate decarboxylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1330.80 Alpha Beta 2-Layer Sandwich 60s Ribosomal Protein L30; Chain: A; Hypothetical protein, similar to alpha- acetolactate decarboxylase; domain 2 4bt7A02
3.30.1330.80 Alpha Beta 2-Layer Sandwich 60s Ribosomal Protein L30; Chain: A; Hypothetical protein, similar to alpha- acetolactate decarboxylase; domain 2 4bt7A01
2NMUA 4BT3A 2DT4A 2HX0A 3HTNA 4BT4A 4BT2A 2H6LA 4BT6A 1XV2A 3HWUA 4BT5A 4BT7A 2P6YA
chains in the Genus database with same CATH superfamily
3G71F 3CXCF 1CLIA 2UYNA 3LWQC 2H6LA 3CCJF 3S0HA 1RQ7A 1SA0A 4X1KB 3ZOPA 5IJ9B 2LCAA 3I3FA 5CA1B 1W55A 2GLZA 3F0EA 4LNUA 1CN7A 1QAHA 2ZVZA 4BT6A 5J2TB 4X1YB 3RYIB 3CMAF 1FFXB 1JJ2F 3WJPA 5LP6A 1M1KH 3GYQA 4NQ3A 3FFMA 1IV4A 3WXMB 1VQVA 3WGNA 2RHLA 1YIJF 3KJKA 2HVYD 3SIVA 3DDNA 4O2AB 5IJ0A 3JATB 3G4SF 5EWRA 4X1KA 1VQ5F 1KQSF 5HP7A 2CHTA 4O4JA 3VOAA 2GVIA 2ZOVA 3IEQA 4B45A 1YJ9F 1ZWZA 1Q86H 5J2TA 5IT9M 1YGYA 2QTPA 4X1YA 4ZHQB 5KX5A 5JQGB 3HKBB 5HP8A 1QVFF 3N4YA 3IKEA 3CCLF 3MDOA 3C9SA 5HWEA 3HJWC 3JALA 5LYJB 3KE1A 5ITZB 2CVLA 2RHHA 4IIJA 1VH8A 4O2AA 3N2KB 3CCSF 4C8EA 3JATA 3LWPC 3JAWB 1RLGA 1JY8A 3HWUA 1IV1A 3T80A 2OZBA 2HRUA 5EZYA 5C8YA 2HX0A 1COMA 3WJRA 2PHNA 5JH7B 2R6R1 3HKEB 1KD1H 1CK2A 3OONA 1H47A 3V3TA 3O85A 3C9TA 3RYFA 4B5CA 3DC2A 4ERHA 3D00A 2CSLA 2AMTA 4I50B 3CPWF 4I55B 1K9MH 1Q7YH 5HY1A 1GX1A 5BMVB 3N2KA 3WGLA 3J81M 2HS4A 4C8IA 1QD9A 4C82A 1R1MA 1RA4A 3JAKB 3WPXA 3F0FA 2OTLF 3HKEA 3E22B 4NUTA 4ZOLB 3S03A 1PXWA 2HP3A 3LWRC 2HQSC 2K1SA 3V4DA 3KIZA 3WJQA 1TVKB 1XRGA 3CG6A 4HNAB 5BMVA 4X3LA 1JN1A 2IAFA 4EB6B 2IG8A 2VGMA 3TD3A 4I4TB 3F0DA 2I6DA 5GONB 3TD4A 4BT7A 1Q82H 1YHQF 4G4ZA 3JAKA 2Q1XA 3KJJA 5GANK 3K12A 1X52A 2RB9A 4ZOLA 3V7EA 4X3MA 2LBWA 5GAPK 3IR9A 3P10A 1NQ3A 4TV9A 2VAMA 5JCOA 1NJIH 2FGYA 4BVSA 3IKFA 3VTIC 2CW4A 5G4UC 1FSZA 5EB1B 2ZVYA 3CCMF 2Z1TA 3BYQA 1K73H 1H7MA 1W41A 2H8EA 4EI9A 4YJ2B 3ELCA 1VHAA 1YJNF 3JVHA 3WGKA 3CMEF 5HXZA 1J7HA 4X1IA 3D01A 2NMUA 1KNJA 3E20B 5FJ4C 3R0PA 5IYZB 5KMGB 3TD5A 2HP0B 4F6RB 2VAWA 2RHJA 4G4VA 2VXYA 5GINC 1QVGF 3HKCB 2QEXF 2KGWA 5MN4A 5EAZA 3JARB 1JFFB 3OBWA 3L7QA 2R751 3OW2F 4C81A 1T0AA 5AVMA 2UYKA 5G4VC 4O4IB 5MN6A 1TUBB 3JASB 2OTJF 2V9YA 3M4SA 3K14A 2H8CA 3N4ZA 1VQ9F 5IJ9A 4ZK7A 5CA1A 1VQ4F 1XBIA 3CB2A 2YXZA 1W5AA 3FD6A 3HTNA 3RYIA 1VQPF 1FFXA 4B62A 3HKCA 2LBXA 3FBAA 2EWCA 2VGNA 3ON1A 1Q81H 1VQOF 3JARA 1W5EA 4X20B 1VQ8F 2GZLA 5LXTB 3WGMA 1VQMF 4BVTA 1QU9A 5CA0B 1GO0A 3RYHB 3CCRF 2Z01A 3C9RA 1FNKA 3MCAB 3MCQA 1YITF 4ZHQA 5JQGA 3HKBA 3RA6A 1W42A 1KC8H 3VYUC 3P0ZA 4C8GA 5JVDB 2CZWA 5LYJA 5ITZA 2BTOA 3RA5A 1PF5A 3SIUA 5GIPC 3JAWA 3K2XA 3RYHA 2AIFA 3VMFB 1XV2A 2HRYA 4U39A 4ZHWA 4RQOA 5JH7A 3VOBA 4G4YA 4R40B 1X25A 2I6RA 3ESJA 1KNKA 3HKDB 3IEWA 3P4EA 3ZO8A 4G4WA 1VQKF 4BT2A 1E7KA 1VK3A 3CCUF 5A2QM 1SDSA 4I50A 4ZHVA 4I55A 4BT3A 3I56F 2YYEA 1U3LA 1VQLF 4O2BB 3ZP7A 1VQNF 3G6EF 3S0YA 3S06A 4U3JB 3UT5B 4RHAA 1GO1A 2OTMA 3VCZA 4O4HB 3WPWA 1YJWF 3RE3A 1W40A 3E22A 1YQNA 3HKDA 5LP6C 4TV8B 3CC7F 4G88A 3M84A 3Q8HA 1ODEA 1IPAA 5FNVB 4EI7A 2PMPA 1K8AH 1TVKA 1T0KB 1U3PA 4HNAA 3HAXD 4EB6A 1Z5WA 5MN5A 3KHNA 4G4XA 2MQEA 4O4LB 3GHZA 4IHJB 4I4TA 5GONA 3PAFA 4B46A 4U3JA 3CCVF 3ERNA 3UT5A 3MQWA 3CYPB 3E1YA 5EYPB 3CYQA 1IV2A 1Q8RA 3LMEA 4O4HA 3QHDA 1VQ6F 1GZ0A 4TV8A 2W8BC 3S0WA 5EB0A 3CC2F 3VYSC 4FFBB 1OFUA 1SA0B 4YJ3B 2HS0A 2KTUA 4ZI7B 5CB4B 5J2UB 2Z1UA 1YI2F 3IMPA 3VO8A 4IHJA 4LNUB 3F0GA 3CCEF 3FPIA 3MBMA 3OBYA 4EI8A 5LP6B 2KTVA 4YJ2A 1S72F 4TUYB 3N2GB 5IJ0B 4DRXB 1X7OA 5IYZA 4FFBA 5LA6B 1RQ2A 4YJ3A 3C8LA 5KMGA 3NK6A 4ZI7A 5CB4A 5J2UA 4O4JB 2HP0A 4F6RA 4DXDA 5KX5B 2WALA 1W5BA 4C4WC 3LWOC 5EIBD 2BTQB 3RYCB 1UI9A 3B6NA 2CHSA 3JALB 1JFFA 3F6MA 4TUYA 2IQQA 4IIJB 3LFOA 3NMUC 1U43A 3N2GA 4DRXA 4O4IA 3WGJA 4BY9D 1TUBA 2G9IA 3JASA 5LA6A 1IV3A 2AIZP 2B33A 4NWOB 2HS3A 2VAPA 2ZF8A 5EZYB 2ZODA 5C8YB 3LYBA 5DCVA 2F9ZC 4PWTA 4LCKA 1SZQA 2RHOA 3VIUA 2UYJA 3RYFB 3RYCA 3I55F 1RLUA 4X20A 1OAPA 5LXTA 3LWVC 5CA0A 2P6YA 2QI2A 5EO3A 1VQ7F 3I7TA 3D54A 5JCOC 1M90H 4KWEA 2KG4A 2Z1EA 3CC4F 1N8RH 3FD5A 1W57A 3K0TA 2FC3A 2BTUA 3J7AR 2L26A 1Z5VA 5LOVB 5GIOC 2N48A 4BVQA 4BVRA 1ONIA 3PLAC 5HY4A 4BT5A 3QTYA 5JVDA 1W59A 5B8FA 3EORA 1W3EX 3GTZA 4TZZA 3U0OA 5FLXM 3AGKA 2BO1A 3CPQA 1XHOA 3ZP4A 5LOVA 4M8IA 2OHWA 4WBNB 3NK7A 4TV9B 3V7QA 2Q1YA 1U40A 4BW0B 4BT4A 2DYYA 4ZHYB 2JNBA 3NVIB 3M1XA 4O2BA 1FNJA 1X7PA 1UFYA 2CWJA 2ALEA 3S02A 1W581 5HXUA 3JCMM 2LBTA 4E6EA 3LDTA 3C9UA 4X1IB 1DT9A 4WBNA 4XCQA 2Z1FA 3NVKE 5FNVA 2UYNB 3QUWA 3CCQF 1H48A 2UZHA 1W2BF 2ZAUA 4O4LA 3J80M 5EIBC 2DT4A 5HY2A 3JAMM 1JD1A 5EYPA 5HY0A 1DBFA 2UYPA 3CD6F 3VI6A 2QA4F 1NMUB 3VYTC 1W5FA
chains in the Genus database with same CATH topology
2NMUA 4BT3A 2DT4A 2HX0A 3HTNA 4BT4A 4BT2A 2H6LA 4BT6A 1XV2A 3HWUA 4BT5A 4BT7A 2P6YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NMU A;  4BT3 A;  2DT4 A;  2HX0 A;  3HTN A;  4BT4 A;  4BT2 A;  2H6L A;  4BT6 A;  1XV2 A;  3HWU A;  4BT5 A;  4BT7 A;  2P6Y A; 
#chains in the Genus database with same CATH topology
 3G71 F;  3CXC F;  1CLI A;  2UYN A;  3LWQ C;  2H6L A;  3CCJ F;  3S0H A;  1RQ7 A;  1SA0 A;  4X1K B;  3ZOP A;  5IJ9 B;  2LCA A;  3I3F A;  5CA1 B;  1W55 A;  2GLZ A;  3F0E A;  4LNU A;  1CN7 A;  1QAH A;  2ZVZ A;  4BT6 A;  5J2T B;  4X1Y B;  3RYI B;  3CMA F;  1FFX B;  1JJ2 F;  3WJP A;  5LP6 A;  1M1K H;  3GYQ A;  4NQ3 A;  3FFM A;  1IV4 A;  3WXM B;  1VQV A;  3WGN A;  2RHL A;  1YIJ F;  3KJK A;  2HVY D;  3SIV A;  3DDN A;  4O2A B;  5IJ0 A;  3JAT B;  3G4S F;  5EWR A;  4X1K A;  1VQ5 F;  1KQS F;  5HP7 A;  2CHT A;  4O4J A;  3VOA A;  2GVI A;  2ZOV A;  3IEQ A;  4B45 A;  1YJ9 F;  1ZWZ A;  1Q86 H;  5J2T A;  5IT9 M;  1YGY A;  2QTP A;  4X1Y A;  4ZHQ B;  5KX5 A;  5JQG B;  3HKB B;  5HP8 A;  1QVF F;  3N4Y A;  3IKE A;  3CCL F;  3MDO A;  3C9S A;  5HWE A;  3HJW C;  3JAL A;  5LYJ B;  3KE1 A;  5ITZ B;  2CVL A;  2RHH A;  4IIJ A;  1VH8 A;  4O2A A;  3N2K B;  3CCS F;  4C8E A;  3JAT A;  3LWP C;  3JAW B;  1RLG A;  1JY8 A;  3HWU A;  1IV1 A;  3T80 A;  2OZB A;  2HRU A;  5EZY A;  5C8Y A;  2HX0 A;  1COM A;  3WJR A;  2PHN A;  5JH7 B;  2R6R 1;  3HKE B;  1KD1 H;  1CK2 A;  3OON A;  1H47 A;  3V3T A;  3O85 A;  3C9T A;  3RYF A;  4B5C A;  3DC2 A;  4ERH A;  3D00 A;  2CSL A;  2AMT A;  4I50 B;  3CPW F;  4I55 B;  1K9M H;  1Q7Y H;  5HY1 A;  1GX1 A;  5BMV B;  3N2K A;  3WGL A;  3J81 M;  2HS4 A;  4C8I A;  1QD9 A;  4C82 A;  1R1M A;  1RA4 A;  3JAK B;  3WPX A;  3F0F A;  2OTL F;  3HKE A;  3E22 B;  4NUT A;  4ZOL B;  3S03 A;  1PXW A;  2HP3 A;  3LWR C;  2HQS C;  2K1S A;  3V4D A;  3KIZ A;  3WJQ A;  1TVK B;  1XRG A;  3CG6 A;  4HNA B;  5BMV A;  4X3L A;  1JN1 A;  2IAF A;  4EB6 B;  2IG8 A;  2VGM A;  3TD3 A;  4I4T B;  3F0D A;  2I6D A;  5GON B;  3TD4 A;  4BT7 A;  1Q82 H;  1YHQ F;  4G4Z A;  3JAK A;  2Q1X A;  3KJJ A;  5GAN K;  3K12 A;  1X52 A;  2RB9 A;  4ZOL A;  3V7E A;  4X3M A;  2LBW A;  5GAP K;  3IR9 A;  3P10 A;  1NQ3 A;  4TV9 A;  2VAM A;  5JCO A;  1NJI H;  2FGY A;  4BVS A;  3IKF A;  3VTI C;  2CW4 A;  5G4U C;  1FSZ A;  5EB1 B;  2ZVY A;  3CCM F;  2Z1T A;  3BYQ A;  1K73 H;  1H7M A;  1W41 A;  2H8E A;  4EI9 A;  4YJ2 B;  3ELC A;  1VHA A;  1YJN F;  3JVH A;  3WGK A;  3CME F;  5HXZ A;  1J7H A;  4X1I A;  3D01 A;  2NMU A;  1KNJ A;  3E20 B;  5FJ4 C;  3R0P A;  5IYZ B;  5KMG B;  3TD5 A;  2HP0 B;  4F6R B;  2VAW A;  2RHJ A;  4G4V A;  2VXY A;  5GIN C;  1QVG F;  3HKC B;  2QEX F;  2KGW A;  5MN4 A;  5EAZ A;  3JAR B;  1JFF B;  3OBW A;  3L7Q A;  2R75 1;  3OW2 F;  4C81 A;  1T0A A;  5AVM A;  2UYK A;  5G4V C;  4O4I B;  5MN6 A;  1TUB B;  3JAS B;  2OTJ F;  2V9Y A;  3M4S A;  3K14 A;  2H8C A;  3N4Z A;  1VQ9 F;  5IJ9 A;  4ZK7 A;  5CA1 A;  1VQ4 F;  1XBI A;  3CB2 A;  2YXZ A;  1W5A A;  3FD6 A;  3HTN A;  3RYI A;  1VQP F;  1FFX A;  4B62 A;  3HKC A;  2LBX A;  3FBA A;  2EWC A;  2VGN A;  3ON1 A;  1Q81 H;  1VQO F;  3JAR A;  1W5E A;  4X20 B;  1VQ8 F;  2GZL A;  5LXT B;  3WGM A;  1VQM F;  4BVT A;  1QU9 A;  5CA0 B;  1GO0 A;  3RYH B;  3CCR F;  2Z01 A;  3C9R A;  1FNK A;  3MCA B;  3MCQ A;  1YIT F;  4ZHQ A;  5JQG A;  3HKB A;  3RA6 A;  1W42 A;  1KC8 H;  3VYU C;  3P0Z A;  4C8G A;  5JVD B;  2CZW A;  5LYJ A;  5ITZ A;  2BTO A;  3RA5 A;  1PF5 A;  3SIU A;  5GIP C;  3JAW A;  3K2X A;  3RYH A;  2AIF A;  3VMF B;  1XV2 A;  2HRY A;  4U39 A;  4ZHW A;  4RQO A;  5JH7 A;  3VOB A;  4G4Y A;  4R40 B;  1X25 A;  2I6R A;  3ESJ A;  1KNK A;  3HKD B;  3IEW A;  3P4E A;  3ZO8 A;  4G4W A;  1VQK F;  4BT2 A;  1E7K A;  1VK3 A;  3CCU F;  5A2Q M;  1SDS A;  4I50 A;  4ZHV A;  4I55 A;  4BT3 A;  3I56 F;  2YYE A;  1U3L A;  1VQL F;  4O2B B;  3ZP7 A;  1VQN F;  3G6E F;  3S0Y A;  3S06 A;  4U3J B;  3UT5 B;  4RHA A;  1GO1 A;  2OTM A;  3VCZ A;  4O4H B;  3WPW A;  1YJW F;  3RE3 A;  1W40 A;  3E22 A;  1YQN A;  3HKD A;  5LP6 C;  4TV8 B;  3CC7 F;  4G88 A;  3M84 A;  3Q8H A;  1ODE A;  1IPA A;  5FNV B;  4EI7 A;  2PMP A;  1K8A H;  1TVK A;  1T0K B;  1U3P A;  4HNA A;  3HAX D;  4EB6 A;  1Z5W A;  5MN5 A;  3KHN A;  4G4X A;  2MQE A;  4O4L B;  3GHZ A;  4IHJ B;  4I4T A;  5GON A;  3PAF A;  4B46 A;  4U3J A;  3CCV F;  3ERN A;  3UT5 A;  3MQW A;  3CYP B;  3E1Y A;  5EYP B;  3CYQ A;  1IV2 A;  1Q8R A;  3LME A;  4O4H A;  3QHD A;  1VQ6 F;  1GZ0 A;  4TV8 A;  2W8B C;  3S0W A;  5EB0 A;  3CC2 F;  3VYS C;  4FFB B;  1OFU A;  1SA0 B;  4YJ3 B;  2HS0 A;  2KTU A;  4ZI7 B;  5CB4 B;  5J2U B;  2Z1U A;  1YI2 F;  3IMP A;  3VO8 A;  4IHJ A;  4LNU B;  3F0G A;  3CCE F;  3FPI A;  3MBM A;  3OBY A;  4EI8 A;  5LP6 B;  2KTV A;  4YJ2 A;  1S72 F;  4TUY B;  3N2G B;  5IJ0 B;  4DRX B;  1X7O A;  5IYZ A;  4FFB A;  5LA6 B;  1RQ2 A;  4YJ3 A;  3C8L A;  5KMG A;  3NK6 A;  4ZI7 A;  5CB4 A;  5J2U A;  4O4J B;  2HP0 A;  4F6R A;  4DXD A;  5KX5 B;  2WAL A;  1W5B A;  4C4W C;  3LWO C;  5EIB D;  2BTQ B;  3RYC B;  1UI9 A;  3B6N A;  2CHS A;  3JAL B;  1JFF A;  3F6M A;  4TUY A;  2IQQ A;  4IIJ B;  3LFO A;  3NMU C;  1U43 A;  3N2G A;  4DRX A;  4O4I A;  3WGJ A;  4BY9 D;  1TUB A;  2G9I A;  3JAS A;  5LA6 A;  1IV3 A;  2AIZ P;  2B33 A;  4NWO B;  2HS3 A;  2VAP A;  2ZF8 A;  5EZY B;  2ZOD A;  5C8Y B;  3LYB A;  5DCV A;  2F9Z C;  4PWT A;  4LCK A;  1SZQ A;  2RHO A;  3VIU A;  2UYJ A;  3RYF B;  3RYC A;  3I55 F;  1RLU A;  4X20 A;  1OAP A;  5LXT A;  3LWV C;  5CA0 A;  2P6Y A;  2QI2 A;  5EO3 A;  1VQ7 F;  3I7T A;  3D54 A;  5JCO C;  1M90 H;  4KWE A;  2KG4 A;  2Z1E A;  3CC4 F;  1N8R H;  3FD5 A;  1W57 A;  3K0T A;  2FC3 A;  2BTU A;  3J7A R;  2L26 A;  1Z5V A;  5LOV B;  5GIO C;  2N48 A;  4BVQ A;  4BVR A;  1ONI A;  3PLA C;  5HY4 A;  4BT5 A;  3QTY A;  5JVD A;  1W59 A;  5B8F A;  3EOR A;  1W3E X;  3GTZ A;  4TZZ A;  3U0O A;  5FLX M;  3AGK A;  2BO1 A;  3CPQ A;  1XHO A;  3ZP4 A;  5LOV A;  4M8I A;  2OHW A;  4WBN B;  3NK7 A;  4TV9 B;  3V7Q A;  2Q1Y A;  1U40 A;  4BW0 B;  4BT4 A;  2DYY A;  4ZHY B;  2JNB A;  3NVI B;  3M1X A;  4O2B A;  1FNJ A;  1X7P A;  1UFY A;  2CWJ A;  2ALE A;  3S02 A;  1W58 1;  5HXU A;  3JCM M;  2LBT A;  4E6E A;  3LDT A;  3C9U A;  4X1I B;  1DT9 A;  4WBN A;  4XCQ A;  2Z1F A;  3NVK E;  5FNV A;  2UYN B;  3QUW A;  3CCQ F;  1H48 A;  2UZH A;  1W2B F;  2ZAU A;  4O4L A;  3J80 M;  5EIB C;  2DT4 A;  5HY2 A;  3JAM M;  1JD1 A;  5EYP A;  5HY0 A;  1DBF A;  2UYP A;  3CD6 F;  3VI6 A;  2QA4 F;  1NMU B;  3VYT C;  1W5F A; 
#chains in the Genus database with same CATH homology
 2NMU A;  4BT3 A;  2DT4 A;  2HX0 A;  3HTN A;  4BT4 A;  4BT2 A;  2H6L A;  4BT6 A;  1XV2 A;  3HWU A;  4BT5 A;  4BT7 A;  2P6Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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