4BTHA

The leua146trp,pheb24tyr double mutant of the quorum quenching n-acyl homoserine lactone acylase pvdq has an altered substrate specificity towards small acyl chains
Total Genus 53
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
53
sequence length
164
structure length
164
Chain Sequence
TGLAADIRWTAYGVPHIRAKDERGLGYGIGYAYARDNACLLAEEIVTARGERARYFGSEGKSSAELDNLPSDIFYAWLNQPEALQAFWQAQTPAVRQLLEGYAAGFNRFLREADGKTTSCLGQPWLRAIATDDLLRLTRRWLVEGGVGQFADALVAAAPPGAEK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords ACYL-HOMOSERINE LACTONE ACYLASE PVDQ SUBUNIT ALPHA
publication title Reducing Virulence of the Human Pathogen Burkholderia by Altering the Substrate Specificity of the Quorum-Quenching Acylase Pvdq
pubmed doi rcsb
source organism Pseudomonas aeruginosa
total genus 53
structure length 164
sequence length 164
ec nomenclature ec 3.5.1.97: Acyl-homoserine-lactone acylase.
pdb deposition date 2013-06-18
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.439.10 Mainly Alpha Orthogonal Bundle Penicillin Amidohydrolase; domain 1 Penicillin Amidohydrolase, domain 1 4bthA00
1GM8A 1K5QA 4K2GA 4YFBA 1AI5A 3L94A 1PNMA 1KECA 1GKFA 1JW0A 1PNKA 2WYCA 4HSTA 4E56A 1GK1A 1KEHA 2WYBA 4WKTA 1GM7A 4M1JA 2WYDA 4WKSA 4BTHA 1OR0A 1PNLA 3SRBA 3JTRA 1FXVA 2ADVA 4HSRA 4PEMA 3SRAA 3ML0A 4E57A 3K3WA 3L91A 1GK9A 4YF9A 3JTQA 3S8RA 2WYEA 1FM2A 1AJQA 1JX9A 4WKVA 2AE4A 2AE3A 1AI4A 1E3AA 1GK0A 4PELA 1K5SA 1AI7A 2AE5A 3SRCA 1FXHA 1AJNA 1CP9A 1AI6A 1GM9A 4WKUA 1AJPA 1H2GA 1GHDA 4E55A 1JVZA 4K2FA 4YFAA 1K7DA
chains in the Genus database with same CATH superfamily
1GM8A 1K5QA 4K2GA 4YFBA 1AI5A 3L94A 1PNMA 1KECA 1GKFA 1JW0A 1PNKA 2WYCA 4HSTA 4E56A 1GK1A 1KEHA 2WYBA 4WKTA 1GM7A 4M1JA 2WYDA 4WKSA 4BTHA 1OR0A 1PNLA 3SRBA 3JTRA 1FXVA 2ADVA 4HSRA 4PEMA 3SRAA 3ML0A 4E57A 3K3WA 3L91A 1GK9A 3FGRA 4YF9A 3JTQA 3S8RA 2WYEA 1FM2A 1AJQA 1JX9A 4WKVA 2AE4A 2AE3A 1AI4A 1E3AA 4BWCA 1GK0A 4PELA 1K5SA 1AI7A 2AE5A 3SRCA 1FXHA 1AJNA 1CP9A 1AI6A 1GM9A 3FGTA 1AJPA 1H2GA 1GHDA 4WKUA 4E55A 1JVZA 4K2FA 4YFAA 1K7DA
chains in the Genus database with same CATH topology
1GM8A 1K5QA 4K2GA 4YFBA 1AI5A 3L94A 1PNMA 1KECA 1GKFA 1JW0A 1PNKA 2WYCA 4HSTA 4E56A 1GK1A 1KEHA 2WYBA 4WKTA 1GM7A 4M1JA 2WYDA 4WKSA 4BTHA 1OR0A 1PNLA 3SRBA 3JTRA 1FXVA 2ADVA 4HSRA 4PEMA 3SRAA 3ML0A 4E57A 3K3WA 3L91A 1GK9A 4YF9A 3JTQA 3S8RA 2WYEA 1FM2A 1AJQA 1JX9A 4WKVA 2AE4A 2AE3A 1AI4A 1E3AA 1GK0A 4PELA 1K5SA 1AI7A 2AE5A 3SRCA 1FXHA 1AJNA 1CP9A 1AI6A 1GM9A 4WKUA 1AJPA 1H2GA 1GHDA 4E55A 1JVZA 4K2FA 4YFAA 1K7DA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1GM8 A;  1K5Q A;  4K2G A;  4YFB A;  1AI5 A;  3L94 A;  1PNM A;  1KEC A;  1GKF A;  1JW0 A;  1PNK A;  2WYC A;  4HST A;  4E56 A;  1GK1 A;  1KEH A;  2WYB A;  4WKT A;  1GM7 A;  4M1J A;  2WYD A;  4WKS A;  4BTH A;  1OR0 A;  1PNL A;  3SRB A;  3JTR A;  1FXV A;  2ADV A;  4HSR A;  4PEM A;  3SRA A;  3ML0 A;  4E57 A;  3K3W A;  3L91 A;  1GK9 A;  4YF9 A;  3JTQ A;  3S8R A;  2WYE A;  1FM2 A;  1AJQ A;  1JX9 A;  4WKV A;  2AE4 A;  2AE3 A;  1AI4 A;  1E3A A;  1GK0 A;  4PEL A;  1K5S A;  1AI7 A;  2AE5 A;  3SRC A;  1FXH A;  1AJN A;  1CP9 A;  1AI6 A;  1GM9 A;  4WKU A;  1AJP A;  1H2G A;  1GHD A;  4E55 A;  1JVZ A;  4K2F A;  4YFA A;  1K7D A; 
#chains in the Genus database with same CATH topology
 1GM8 A;  1K5Q A;  4K2G A;  4YFB A;  1AI5 A;  3L94 A;  1PNM A;  1KEC A;  1GKF A;  1JW0 A;  1PNK A;  2WYC A;  4HST A;  4E56 A;  1GK1 A;  1KEH A;  2WYB A;  4WKT A;  1GM7 A;  4M1J A;  2WYD A;  4WKS A;  4BTH A;  1OR0 A;  1PNL A;  3SRB A;  3JTR A;  1FXV A;  2ADV A;  4HSR A;  4PEM A;  3SRA A;  3ML0 A;  4E57 A;  3K3W A;  3L91 A;  1GK9 A;  3FGR A;  4YF9 A;  3JTQ A;  3S8R A;  2WYE A;  1FM2 A;  1AJQ A;  1JX9 A;  4WKV A;  2AE4 A;  2AE3 A;  1AI4 A;  1E3A A;  4BWC A;  1GK0 A;  4PEL A;  1K5S A;  1AI7 A;  2AE5 A;  3SRC A;  1FXH A;  1AJN A;  1CP9 A;  1AI6 A;  1GM9 A;  3FGT A;  1AJP A;  1H2G A;  1GHD A;  4WKU A;  4E55 A;  1JVZ A;  4K2F A;  4YFA A;  1K7D A; 
#chains in the Genus database with same CATH homology
 1GM8 A;  1K5Q A;  4K2G A;  4YFB A;  1AI5 A;  3L94 A;  1PNM A;  1KEC A;  1GKF A;  1JW0 A;  1PNK A;  2WYC A;  4HST A;  4E56 A;  1GK1 A;  1KEH A;  2WYB A;  4WKT A;  1GM7 A;  4M1J A;  2WYD A;  4WKS A;  4BTH A;  1OR0 A;  1PNL A;  3SRB A;  3JTR A;  1FXV A;  2ADV A;  4HSR A;  4PEM A;  3SRA A;  3ML0 A;  4E57 A;  3K3W A;  3L91 A;  1GK9 A;  4YF9 A;  3JTQ A;  3S8R A;  2WYE A;  1FM2 A;  1AJQ A;  1JX9 A;  4WKV A;  2AE4 A;  2AE3 A;  1AI4 A;  1E3A A;  1GK0 A;  4PEL A;  1K5S A;  1AI7 A;  2AE5 A;  3SRC A;  1FXH A;  1AJN A;  1CP9 A;  1AI6 A;  1GM9 A;  4WKU A;  1AJP A;  1H2G A;  1GHD A;  4E55 A;  1JVZ A;  4K2F A;  4YFA A;  1K7D A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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