4BVCA

Identification of small molecule inhibitors selective for apo(a) kringles kiv-7, kiv-10 and kv.
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
79
structure length
79
Chain Sequence
QCYHGNGQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPENYPNDGLTMNYCRNPDADTGPWCFTMDPSIRWEYCALTRC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
rcsb
molecule keywords APOLIPOPROTEIN(A)
molecule tags Hydrolase
source organism Homo sapiens
total genus 21
structure length 79
sequence length 79
ec nomenclature ec 3.4.21.-:
pdb deposition date 2013-06-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 4bvcA00
1KI0A 1GP9A 2KJ4A 1KRNA 1NL2A 2I9AA 5CT2A 1A0HA 1CEBA 2QJ2A 3E6PL 2HPPP 5CSQA 2K4RA 2PF2A 5CS3A 3LAQA 2FEBA 1URKA 4O03A 1HPJA 4A5TS 2PF1A 2FD6A 4BVCA 4BVDA 2SPTA 1GMOA 1PMKA 1PK2A 1CEAA 1KDUA 3U73A 4NZQA 3BT2A 2DOHX 5CS5A 4DURA 1TPKA 1I5KA 3NXPA 2I9BA 4HZHA 3KIVA 1NL1A 4BVVA 1PKRA 2KNFA 4D3CA 3K65A 3MKPA 5CS1A 1NK1A 1PMLA 2DOIA 2L0SA 5CP9A 2K51A 4BV7A 3BT1A 4CIKA 4IUAA 4KIVA 1B2IA 5CS9A 5COEA 1KIVA 3SP8A 3HN4A 1JFNA 4BV5A 2HPQP 2QJ4A 1I71A 1GMNA 1HPKA 4BVWA 5CT1A 5HPGA 5CT3A 1PK4A 2PK4A 1BHTA
chains in the Genus database with same CATH superfamily
1KI0A 1GP9A 2KJ4A 1KRNA 1NL2A 2I9AA 5CT2A 1A0HA 1CEBA 2QJ2A 3E6PL 2HPPP 5CSQA 2K4RA 2PF2A 5CS3A 3LAQA 2FEBA 1URKA 4O03A 1HPJA 4A5TS 2PF1A 2FD6A 4BVCA 4BVDA 2SPTA 1GMOA 1PMKA 1PK2A 1CEAA 1KDUA 3U73A 4NZQA 3BT2A 2DOHX 5CS5A 4DURA 1TPKA 1I5KA 3NXPA 2I9BA 4HZHA 3KIVA 1NL1A 4BVVA 1PKRA 2KNFA 4D3CA 3K65A 3MKPA 5CS1A 1NK1A 1PMLA 2DOIA 2L0SA 5CP9A 2K51A 4BV7A 3BT1A 4CIKA 4IUAA 4KIVA 1B2IA 5CS9A 5COEA 1KIVA 3SP8A 3HN4A 1JFNA 4BV5A 2HPQP 2QJ4A 1I71A 1GMNA 1HPKA 4BVWA 5CT1A 5HPGA 5CT3A 1PK4A 2PK4A 1BHTA
chains in the Genus database with same CATH topology
1KI0A 1GP9A 2KJ4A 1KRNA 1NL2A 2I9AA 5CT2A 1A0HA 1CEBA 2QJ2A 3E6PL 2HPPP 5CSQA 2K4RA 2PF2A 5CS3A 3LAQA 2FEBA 1URKA 4O03A 1HPJA 4A5TS 2PF1A 2FD6A 4BVCA 4BVDA 2SPTA 1GMOA 1PMKA 1PK2A 1CEAA 1KDUA 3U73A 4NZQA 3BT2A 2DOHX 5CS5A 4DURA 1TPKA 1I5KA 3NXPA 2I9BA 4HZHA 3KIVA 1NL1A 4BVVA 1PKRA 2KNFA 4D3CA 3K65A 3MKPA 5CS1A 1NK1A 1PMLA 2DOIA 2L0SA 5CP9A 2K51A 4BV7A 3BT1A 4CIKA 4IUAA 4KIVA 1B2IA 5CS9A 5COEA 1KIVA 3SP8A 3HN4A 1JFNA 4BV5A 2HPQP 2QJ4A 1I71A 1GMNA 1HPKA 4BVWA 5CT1A 5HPGA 5CT3A 1PK4A 2PK4A 1BHTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KI0 A;  1GP9 A;  2KJ4 A;  1KRN A;  1NL2 A;  2I9A A;  5CT2 A;  1A0H A;  1CEB A;  2QJ2 A;  3E6P L;  2HPP P;  5CSQ A;  2K4R A;  2PF2 A;  5CS3 A;  3LAQ A;  2FEB A;  1URK A;  4O03 A;  1HPJ A;  4A5T S;  2PF1 A;  2FD6 A;  4BVC A;  4BVD A;  2SPT A;  1GMO A;  1PMK A;  1PK2 A;  1CEA A;  1KDU A;  3U73 A;  4NZQ A;  3BT2 A;  2DOH X;  5CS5 A;  4DUR A;  1TPK A;  1I5K A;  3NXP A;  2I9B A;  4HZH A;  3KIV A;  1NL1 A;  4BVV A;  1PKR A;  2KNF A;  4D3C A;  3K65 A;  3MKP A;  5CS1 A;  1NK1 A;  1PML A;  2DOI A;  2L0S A;  5CP9 A;  2K51 A;  4BV7 A;  3BT1 A;  4CIK A;  4IUA A;  4KIV A;  1B2I A;  5CS9 A;  5COE A;  1KIV A;  3SP8 A;  3HN4 A;  1JFN A;  4BV5 A;  2HPQ P;  2QJ4 A;  1I71 A;  1GMN A;  1HPK A;  4BVW A;  5CT1 A;  5HPG A;  5CT3 A;  1PK4 A;  2PK4 A;  1BHT A; 
#chains in the Genus database with same CATH topology
 1KI0 A;  1GP9 A;  2KJ4 A;  1KRN A;  1NL2 A;  2I9A A;  5CT2 A;  1A0H A;  1CEB A;  2QJ2 A;  3E6P L;  2HPP P;  5CSQ A;  2K4R A;  2PF2 A;  5CS3 A;  3LAQ A;  2FEB A;  1URK A;  4O03 A;  1HPJ A;  4A5T S;  2PF1 A;  2FD6 A;  4BVC A;  4BVD A;  2SPT A;  1GMO A;  1PMK A;  1PK2 A;  1CEA A;  1KDU A;  3U73 A;  4NZQ A;  3BT2 A;  2DOH X;  5CS5 A;  4DUR A;  1TPK A;  1I5K A;  3NXP A;  2I9B A;  4HZH A;  3KIV A;  1NL1 A;  4BVV A;  1PKR A;  2KNF A;  4D3C A;  3K65 A;  3MKP A;  5CS1 A;  1NK1 A;  1PML A;  2DOI A;  2L0S A;  5CP9 A;  2K51 A;  4BV7 A;  3BT1 A;  4CIK A;  4IUA A;  4KIV A;  1B2I A;  5CS9 A;  5COE A;  1KIV A;  3SP8 A;  3HN4 A;  1JFN A;  4BV5 A;  2HPQ P;  2QJ4 A;  1I71 A;  1GMN A;  1HPK A;  4BVW A;  5CT1 A;  5HPG A;  5CT3 A;  1PK4 A;  2PK4 A;  1BHT A; 
#chains in the Genus database with same CATH homology
 1KI0 A;  1GP9 A;  2KJ4 A;  1KRN A;  1NL2 A;  2I9A A;  5CT2 A;  1A0H A;  1CEB A;  2QJ2 A;  3E6P L;  2HPP P;  5CSQ A;  2K4R A;  2PF2 A;  5CS3 A;  3LAQ A;  2FEB A;  1URK A;  4O03 A;  1HPJ A;  4A5T S;  2PF1 A;  2FD6 A;  4BVC A;  4BVD A;  2SPT A;  1GMO A;  1PMK A;  1PK2 A;  1CEA A;  1KDU A;  3U73 A;  4NZQ A;  3BT2 A;  2DOH X;  5CS5 A;  4DUR A;  1TPK A;  1I5K A;  3NXP A;  2I9B A;  4HZH A;  3KIV A;  1NL1 A;  4BVV A;  1PKR A;  2KNF A;  4D3C A;  3K65 A;  3MKP A;  5CS1 A;  1NK1 A;  1PML A;  2DOI A;  2L0S A;  5CP9 A;  2K51 A;  4BV7 A;  3BT1 A;  4CIK A;  4IUA A;  4KIV A;  1B2I A;  5CS9 A;  5COE A;  1KIV A;  3SP8 A;  3HN4 A;  1JFN A;  4BV5 A;  2HPQ P;  2QJ4 A;  1I71 A;  1GMN A;  1HPK A;  4BVW A;  5CT1 A;  5HPG A;  5CT3 A;  1PK4 A;  2PK4 A;  1BHT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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