4BVDA

Identification of small molecule inhibitors selective for apo(a) kringles kiv-7, kiv-10 and kv.
Total Genus 20
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
20
sequence length
78
structure length
78
Chain Sequence
CYHGNGQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPENYPNDGLTMNYCRNPDADTGPWCFTMDPSIRWEYCALTRC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords APOLIPOPROTEIN(A)
publication title Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
rcsb
source organism Homo sapiens
total genus 20
structure length 78
sequence length 78
ec nomenclature ec 3.4.21.-:
pdb deposition date 2013-06-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 4bvdA00
5CS5A 5COEA 3BT1A 2PF2A 1A0HA 2HPQP 2HPPP 2PF1A 3MKPA 2I9BA 2DOHX 2L0SA 4A5TS 1KRNA 5CSQA 4DURA 3K65A 1NL2A 2FEBA 3E6PL 2KNFA 1HPKA 2QJ4A 4HZHA 5CP9A 4D3CA 1PK2A 3BT2A 4CIKA 1URKA 2I9AA 1JFNA 5CT3A 5CS3A 2PK4A 2K4RA 1CEAA 2QJ2A 4BV7A 1BHTA 1PMLA 1NL1A 2K51A 1PMKA 1KDUA 5CT1A 1NK1A 4NZQA 3LAQA 1HPJA 3SP8A 3KIVA 1CEBA 5CS1A 1GP9A 4BVVA 4O03A 1KI0A 5CS9A 1GMNA 1I5KA 1KIVA 5HPGA 1GMOA 2FD6A 5CT2A 3U73A 4BV5A 2SPTA 4IUAA 1PK4A 1TPKA 3HN4A 4BVWA 4KIVA 4BVDA 1I71A 2KJ4A 3NXPA 1B2IA 1PKRA 4BVCA 2DOIA
chains in the Genus database with same CATH superfamily
5CS5A 5COEA 3BT1A 2PF2A 1A0HA 2HPQP 2HPPP 2PF1A 3MKPA 2I9BA 2DOHX 2L0SA 4A5TS 1KRNA 5CSQA 4DURA 3K65A 1NL2A 2FEBA 3E6PL 2KNFA 1HPKA 2QJ4A 4HZHA 5CP9A 4D3CA 1PK2A 3BT2A 4CIKA 1URKA 2I9AA 1JFNA 5CT3A 5CS3A 2PK4A 2K4RA 1CEAA 2QJ2A 4BV7A 1BHTA 1PMLA 1NL1A 2K51A 1PMKA 1KDUA 5CT1A 1NK1A 4NZQA 3LAQA 1HPJA 3SP8A 3KIVA 1CEBA 5CS1A 1GP9A 4BVVA 4O03A 1KI0A 5CS9A 1GMNA 1I5KA 1KIVA 5HPGA 1GMOA 2FD6A 5CT2A 3U73A 4BV5A 2SPTA 4IUAA 1PK4A 1TPKA 3HN4A 4BVWA 4KIVA 4BVDA 1I71A 2KJ4A 3NXPA 1B2IA 1PKRA 4BVCA 2DOIA
chains in the Genus database with same CATH topology
5CS5A 5COEA 3BT1A 2PF2A 1A0HA 2HPQP 2HPPP 2PF1A 3MKPA 2I9BA 2DOHX 2L0SA 4A5TS 1KRNA 5CSQA 4DURA 3K65A 1NL2A 2FEBA 3E6PL 2KNFA 1HPKA 2QJ4A 4HZHA 5CP9A 4D3CA 1PK2A 3BT2A 4CIKA 1URKA 2I9AA 1JFNA 5CT3A 5CS3A 2PK4A 2K4RA 1CEAA 2QJ2A 4BV7A 1BHTA 1PMLA 1NL1A 2K51A 1PMKA 1KDUA 5CT1A 1NK1A 4NZQA 3LAQA 1HPJA 3SP8A 3KIVA 1CEBA 5CS1A 1GP9A 4BVVA 4O03A 1KI0A 5CS9A 1GMNA 1I5KA 1KIVA 5HPGA 1GMOA 2FD6A 5CT2A 3U73A 4BV5A 2SPTA 4IUAA 1PK4A 1TPKA 3HN4A 4BVWA 4KIVA 4BVDA 1I71A 2KJ4A 3NXPA 1B2IA 1PKRA 4BVCA 2DOIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5CS5 A;  5COE A;  3BT1 A;  2PF2 A;  1A0H A;  2HPQ P;  2HPP P;  2PF1 A;  3MKP A;  2I9B A;  2DOH X;  2L0S A;  4A5T S;  1KRN A;  5CSQ A;  4DUR A;  3K65 A;  1NL2 A;  2FEB A;  3E6P L;  2KNF A;  1HPK A;  2QJ4 A;  4HZH A;  5CP9 A;  4D3C A;  1PK2 A;  3BT2 A;  4CIK A;  1URK A;  2I9A A;  1JFN A;  5CT3 A;  5CS3 A;  2PK4 A;  2K4R A;  1CEA A;  2QJ2 A;  4BV7 A;  1BHT A;  1PML A;  1NL1 A;  2K51 A;  1PMK A;  1KDU A;  5CT1 A;  1NK1 A;  4NZQ A;  3LAQ A;  1HPJ A;  3SP8 A;  3KIV A;  1CEB A;  5CS1 A;  1GP9 A;  4BVV A;  4O03 A;  1KI0 A;  5CS9 A;  1GMN A;  1I5K A;  1KIV A;  5HPG A;  1GMO A;  2FD6 A;  5CT2 A;  3U73 A;  4BV5 A;  2SPT A;  4IUA A;  1PK4 A;  1TPK A;  3HN4 A;  4BVW A;  4KIV A;  4BVD A;  1I71 A;  2KJ4 A;  3NXP A;  1B2I A;  1PKR A;  4BVC A;  2DOI A; 
#chains in the Genus database with same CATH topology
 5CS5 A;  5COE A;  3BT1 A;  2PF2 A;  1A0H A;  2HPQ P;  2HPP P;  2PF1 A;  3MKP A;  2I9B A;  2DOH X;  2L0S A;  4A5T S;  1KRN A;  5CSQ A;  4DUR A;  3K65 A;  1NL2 A;  2FEB A;  3E6P L;  2KNF A;  1HPK A;  2QJ4 A;  4HZH A;  5CP9 A;  4D3C A;  1PK2 A;  3BT2 A;  4CIK A;  1URK A;  2I9A A;  1JFN A;  5CT3 A;  5CS3 A;  2PK4 A;  2K4R A;  1CEA A;  2QJ2 A;  4BV7 A;  1BHT A;  1PML A;  1NL1 A;  2K51 A;  1PMK A;  1KDU A;  5CT1 A;  1NK1 A;  4NZQ A;  3LAQ A;  1HPJ A;  3SP8 A;  3KIV A;  1CEB A;  5CS1 A;  1GP9 A;  4BVV A;  4O03 A;  1KI0 A;  5CS9 A;  1GMN A;  1I5K A;  1KIV A;  5HPG A;  1GMO A;  2FD6 A;  5CT2 A;  3U73 A;  4BV5 A;  2SPT A;  4IUA A;  1PK4 A;  1TPK A;  3HN4 A;  4BVW A;  4KIV A;  4BVD A;  1I71 A;  2KJ4 A;  3NXP A;  1B2I A;  1PKR A;  4BVC A;  2DOI A; 
#chains in the Genus database with same CATH homology
 5CS5 A;  5COE A;  3BT1 A;  2PF2 A;  1A0H A;  2HPQ P;  2HPP P;  2PF1 A;  3MKP A;  2I9B A;  2DOH X;  2L0S A;  4A5T S;  1KRN A;  5CSQ A;  4DUR A;  3K65 A;  1NL2 A;  2FEB A;  3E6P L;  2KNF A;  1HPK A;  2QJ4 A;  4HZH A;  5CP9 A;  4D3C A;  1PK2 A;  3BT2 A;  4CIK A;  1URK A;  2I9A A;  1JFN A;  5CT3 A;  5CS3 A;  2PK4 A;  2K4R A;  1CEA A;  2QJ2 A;  4BV7 A;  1BHT A;  1PML A;  1NL1 A;  2K51 A;  1PMK A;  1KDU A;  5CT1 A;  1NK1 A;  4NZQ A;  3LAQ A;  1HPJ A;  3SP8 A;  3KIV A;  1CEB A;  5CS1 A;  1GP9 A;  4BVV A;  4O03 A;  1KI0 A;  5CS9 A;  1GMN A;  1I5K A;  1KIV A;  5HPG A;  1GMO A;  2FD6 A;  5CT2 A;  3U73 A;  4BV5 A;  2SPT A;  4IUA A;  1PK4 A;  1TPK A;  3HN4 A;  4BVW A;  4KIV A;  4BVD A;  1I71 A;  2KJ4 A;  3NXP A;  1B2I A;  1PKR A;  4BVC A;  2DOI A; 
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similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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