4BVVA

Identification of small molecule inhibitors selective for apo(a) kringles kiv-7, kiv-10 and kv.
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
81
structure length
81
Chain Sequence
DCMFGNGKGYRGKKATTVTGTPCQEWAAQEPHRHSTFIPGTNKWAGLEKNYCRNPDGDINGPWCYTMNPRKLFDYCDIPLC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords APOLIPOPROTEIN(A)
publication title Small Molecules Used to Decipher the Pathophysiological Roles of the Kringle Domains Kiv-7, - 10 and Kv of Apolipoprotein(A)
rcsb
source organism Homo sapiens
total genus 18
structure length 81
sequence length 81
ec nomenclature ec 3.4.21.-:
pdb deposition date 2013-06-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 4bvvA00
3E6PL 1A0HA 1URKA 4BVVA 3NXPA 2DOIA 5CT1A 2L0SA 5CT3A 3K65A 4A5TS 4BV5A 4DURA 4IUAA 5CT2A 5HPGA 1KRNA 5CS1A 1NL2A 1HPKA 2SPTA 1I5KA 1JFNA 2I9AA 3BT2A 5CP9A 4BVCA 4BV7A 2HPPP 5CS3A 4BVWA 2DOHX 2I9BA 2K51A 1TPKA 1NL1A 2K4RA 1CEAA 4D3CA 5COEA 1PKRA 4CIKA 1PK2A 1PMLA 1GMNA 3LAQA 5CSQA 1PMKA 1KDUA 2KJ4A 5CS5A 1KI0A 1KIVA 2QJ2A 1I71A 5CS9A 4NZQA 2HPQP 1B2IA 2PF1A 2FD6A 2KNFA 3SP8A 3KIVA 2PF2A 2PK4A 2FEBA 1CEBA 3HN4A 2QJ4A 4BVDA 1GMOA 4HZHA 3MKPA 4KIVA 1GP9A 3BT1A 3U73A 1BHTA 4O03A 1PK4A 1NK1A 1HPJA
chains in the Genus database with same CATH superfamily
3E6PL 1A0HA 1URKA 4BVVA 3NXPA 2DOIA 5CT1A 2L0SA 5CT3A 3K65A 4A5TS 4BV5A 4DURA 4IUAA 5CT2A 5HPGA 1KRNA 5CS1A 1NL2A 1HPKA 2SPTA 1I5KA 1JFNA 2I9AA 3BT2A 5CP9A 4BVCA 4BV7A 2HPPP 5CS3A 4BVWA 2DOHX 2I9BA 2K51A 1TPKA 1NL1A 2K4RA 1CEAA 4D3CA 5COEA 1PKRA 4CIKA 1PK2A 1PMLA 1GMNA 3LAQA 5CSQA 1PMKA 1KDUA 2KJ4A 5CS5A 1KI0A 1KIVA 2QJ2A 1I71A 5CS9A 4NZQA 2HPQP 1B2IA 2PF1A 2FD6A 2KNFA 3SP8A 3KIVA 2PF2A 2PK4A 2FEBA 1CEBA 3HN4A 2QJ4A 4BVDA 1GMOA 4HZHA 3MKPA 4KIVA 1GP9A 3BT1A 3U73A 1BHTA 4O03A 1PK4A 1NK1A 1HPJA
chains in the Genus database with same CATH topology
3E6PL 1A0HA 1URKA 4BVVA 3NXPA 2DOIA 5CT1A 2L0SA 5CT3A 3K65A 4A5TS 4BV5A 4DURA 4IUAA 5CT2A 5HPGA 1KRNA 5CS1A 1NL2A 1HPKA 2SPTA 1I5KA 1JFNA 2I9AA 3BT2A 5CP9A 4BVCA 4BV7A 2HPPP 5CS3A 4BVWA 2DOHX 2I9BA 2K51A 1TPKA 1NL1A 2K4RA 1CEAA 4D3CA 5COEA 1PKRA 4CIKA 1PK2A 1PMLA 1GMNA 3LAQA 5CSQA 1PMKA 1KDUA 2KJ4A 5CS5A 1KI0A 1KIVA 2QJ2A 1I71A 5CS9A 4NZQA 2HPQP 1B2IA 2PF1A 2FD6A 2KNFA 3SP8A 3KIVA 2PF2A 2PK4A 2FEBA 1CEBA 3HN4A 2QJ4A 4BVDA 1GMOA 4HZHA 3MKPA 4KIVA 1GP9A 3BT1A 3U73A 1BHTA 4O03A 1PK4A 1NK1A 1HPJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3E6P L;  1A0H A;  1URK A;  4BVV A;  3NXP A;  2DOI A;  5CT1 A;  2L0S A;  5CT3 A;  3K65 A;  4A5T S;  4BV5 A;  4DUR A;  4IUA A;  5CT2 A;  5HPG A;  1KRN A;  5CS1 A;  1NL2 A;  1HPK A;  2SPT A;  1I5K A;  1JFN A;  2I9A A;  3BT2 A;  5CP9 A;  4BVC A;  4BV7 A;  2HPP P;  5CS3 A;  4BVW A;  2DOH X;  2I9B A;  2K51 A;  1TPK A;  1NL1 A;  2K4R A;  1CEA A;  4D3C A;  5COE A;  1PKR A;  4CIK A;  1PK2 A;  1PML A;  1GMN A;  3LAQ A;  5CSQ A;  1PMK A;  1KDU A;  2KJ4 A;  5CS5 A;  1KI0 A;  1KIV A;  2QJ2 A;  1I71 A;  5CS9 A;  4NZQ A;  2HPQ P;  1B2I A;  2PF1 A;  2FD6 A;  2KNF A;  3SP8 A;  3KIV A;  2PF2 A;  2PK4 A;  2FEB A;  1CEB A;  3HN4 A;  2QJ4 A;  4BVD A;  1GMO A;  4HZH A;  3MKP A;  4KIV A;  1GP9 A;  3BT1 A;  3U73 A;  1BHT A;  4O03 A;  1PK4 A;  1NK1 A;  1HPJ A; 
#chains in the Genus database with same CATH topology
 3E6P L;  1A0H A;  1URK A;  4BVV A;  3NXP A;  2DOI A;  5CT1 A;  2L0S A;  5CT3 A;  3K65 A;  4A5T S;  4BV5 A;  4DUR A;  4IUA A;  5CT2 A;  5HPG A;  1KRN A;  5CS1 A;  1NL2 A;  1HPK A;  2SPT A;  1I5K A;  1JFN A;  2I9A A;  3BT2 A;  5CP9 A;  4BVC A;  4BV7 A;  2HPP P;  5CS3 A;  4BVW A;  2DOH X;  2I9B A;  2K51 A;  1TPK A;  1NL1 A;  2K4R A;  1CEA A;  4D3C A;  5COE A;  1PKR A;  4CIK A;  1PK2 A;  1PML A;  1GMN A;  3LAQ A;  5CSQ A;  1PMK A;  1KDU A;  2KJ4 A;  5CS5 A;  1KI0 A;  1KIV A;  2QJ2 A;  1I71 A;  5CS9 A;  4NZQ A;  2HPQ P;  1B2I A;  2PF1 A;  2FD6 A;  2KNF A;  3SP8 A;  3KIV A;  2PF2 A;  2PK4 A;  2FEB A;  1CEB A;  3HN4 A;  2QJ4 A;  4BVD A;  1GMO A;  4HZH A;  3MKP A;  4KIV A;  1GP9 A;  3BT1 A;  3U73 A;  1BHT A;  4O03 A;  1PK4 A;  1NK1 A;  1HPJ A; 
#chains in the Genus database with same CATH homology
 3E6P L;  1A0H A;  1URK A;  4BVV A;  3NXP A;  2DOI A;  5CT1 A;  2L0S A;  5CT3 A;  3K65 A;  4A5T S;  4BV5 A;  4DUR A;  4IUA A;  5CT2 A;  5HPG A;  1KRN A;  5CS1 A;  1NL2 A;  1HPK A;  2SPT A;  1I5K A;  1JFN A;  2I9A A;  3BT2 A;  5CP9 A;  4BVC A;  4BV7 A;  2HPP P;  5CS3 A;  4BVW A;  2DOH X;  2I9B A;  2K51 A;  1TPK A;  1NL1 A;  2K4R A;  1CEA A;  4D3C A;  5COE A;  1PKR A;  4CIK A;  1PK2 A;  1PML A;  1GMN A;  3LAQ A;  5CSQ A;  1PMK A;  1KDU A;  2KJ4 A;  5CS5 A;  1KI0 A;  1KIV A;  2QJ2 A;  1I71 A;  5CS9 A;  4NZQ A;  2HPQ P;  1B2I A;  2PF1 A;  2FD6 A;  2KNF A;  3SP8 A;  3KIV A;  2PF2 A;  2PK4 A;  2FEB A;  1CEB A;  3HN4 A;  2QJ4 A;  4BVD A;  1GMO A;  4HZH A;  3MKP A;  4KIV A;  1GP9 A;  3BT1 A;  3U73 A;  1BHT A;  4O03 A;  1PK4 A;  1NK1 A;  1HPJ A; 
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similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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