4BZBA

Crystal structure of the tetrameric dgtp-bound samhd1 mutant catalytic core
Total Genus 165
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
165
sequence length
487
structure length
481
Chain Sequence
DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Hydrolase
molecule keywords DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1
publication title Mechanism of Allosteric Activation of Samhd1 by Dgtp
pubmed doi rcsb
source organism Homo sapiens
total genus 165
structure length 481
sequence length 487
chains with identical sequence B, C, D
ec nomenclature ec 3.1.5.-:
pdb deposition date 2013-07-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4bzbA01
3HI0A 4QFZA 1VJ7A 4BZCA 2OGIA 4TNXA 4ZWGA 2GZ4A 1YNBA 4TNQA 4QG0A 2DQBA 1VQRA 4RXPA 4TO4A 4TNZA 4RXOA 1U6ZA 3M1TA 3RF0A 5AO0A 5TK7A 4X9EA 3MEMA 4MLMA 4TO1A 2FLOA 4L1JA 4R8ZA 4TNPA 5AO3A 5TK8A 5AO2A 4RXRA 4MCWA 4QFYA 5TKAA 3TM8A 4ME4A 2CQZA 4MLNA 2PQ7A 3I7AA 3BG2A 4TO0A 4RXSA 2PAQA 5AO1A 2O08A 3LJXA 3HC1A 4MZ7A 4L7EA 4XDSA 4QFXA 3CCGA 4BZBA 4RXQA 5AO4A 3IRHA 1XX7A 4QG4A 4DMBA 4N6WA 2PARA 4QG1A 3MZOA 2Q14A 4ZWEA 2O6IA 5TK6A 5TK9A 4QG2A 4N71A 4L1JB 3NQWA 4TO3A 1YOYA 4TO5A 3P3QA 3NR1A 3TMBA 4TO6A 3TMDA 4TNYA 2HEKA 4MDZA 2PAUA 4TNRA 2PGSA 4TO2A 3U1NA 4LRLA 4Q7HA 4L7WA 3KH1A 3TMCA
chains in the Genus database with same CATH superfamily
3HI0A 4QFZA 1VJ7A 4BZCA 2OGIA 4TNXA 3SK9A 4ZWGA 2GZ4A 1YNBA 4TNQA 4QG0A 2DQBA 1VQRA 4RXPA 4TO4A 4TNZA 4RXOA 1U6ZA 3M1TA 3RF0A 3S4LA 5AO0A 5TK7A 4X9EA 3MEMA 4MLMA 4TO1A 2FLOA 3KQ5A 4L1JA 4R8ZA 4TNPA 5AO3A 3SKDA 5TK8A 5AO2A 4RXRA 4MCWA 4QFYA 5TKAA 3TM8A 4ME4A 2CQZA 4MLNA 4QQWA 2PQ7A 3I7AA 3BG2A 4TO0A 4RXSA 2PAQA 5AO1A 2O08A 3LJXA 3HC1A 4MZ7A 4L7EA 4XDSA 4QFXA 3CCGA 4BZBA 4RXQA 5AO4A 3IRHA 1XX7A 4Q2CA 4QG4A 4DMBA 4N6WA 2PARA 4QG1A 3MZOA 2Q14A 3GW7A 4ZWEA 2O6IA 5TK6A 5TK9A 4QQXA 4Q2DA 4QG2A 4N71A 4L1JB 3NQWA 4TO3A 4QQZA 1YOYA 4TO5A 3P3QA 3NR1A 3TMBA 4TO6A 3TMDA 4TNYA 2HEKA 4MDZA 2PAUA 4TNRA 2PGSA 4TO2A 3U1NA 4LRLA 4Q7HA 4L7WA 3KH1A 3TMCA 4QQYA
chains in the Genus database with same CATH topology
3HI0A 4QFZA 1VJ7A 4BZCA 2OGIA 4TNXA 3SK9A 4ZWGA 2GZ4A 1YNBA 4TNQA 4QG0A 2DQBA 1VQRA 4RXPA 4TO4A 4TNZA 4RXOA 1U6ZA 3M1TA 3RF0A 3S4LA 5AO0A 5TK7A 4X9EA 3MEMA 4MLMA 4TO1A 2FLOA 3KQ5A 4L1JA 4R8ZA 4TNPA 5AO3A 3SKDA 5TK8A 5AO2A 4RXRA 4MCWA 4QFYA 5TKAA 3TM8A 4ME4A 2CQZA 4MLNA 4QQWA 2PQ7A 3I7AA 3BG2A 4TO0A 4RXSA 2PAQA 5AO1A 2O08A 3LJXA 3HC1A 4MZ7A 4L7EA 4XDSA 4QFXA 3CCGA 4BZBA 4RXQA 5AO4A 3IRHA 1XX7A 4Q2CA 4QG4A 4DMBA 4N6WA 2PARA 4QG1A 3MZOA 2Q14A 3GW7A 4ZWEA 2O6IA 5TK6A 5TK9A 4QQXA 4Q2DA 4QG2A 4N71A 4L1JB 3NQWA 4TO3A 4QQZA 1YOYA 4TO5A 3P3QA 3NR1A 3TMBA 4TO6A 3TMDA 4TNYA 2HEKA 4MDZA 2PAUA 4TNRA 2PGSA 4TO2A 3U1NA 4LRLA 4Q7HA 4L7WA 3KH1A 3TMCA 4QQYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HI0 A;  4QFZ A;  1VJ7 A;  4BZC A;  2OGI A;  4TNX A;  4ZWG A;  2GZ4 A;  1YNB A;  4TNQ A;  4QG0 A;  2DQB A;  1VQR A;  4RXP A;  4TO4 A;  4TNZ A;  4RXO A;  1U6Z A;  3M1T A;  3RF0 A;  5AO0 A;  5TK7 A;  4X9E A;  3MEM A;  4MLM A;  4TO1 A;  2FLO A;  4L1J A;  4R8Z A;  4TNP A;  5AO3 A;  5TK8 A;  5AO2 A;  4RXR A;  4MCW A;  4QFY A;  5TKA A;  3TM8 A;  4ME4 A;  2CQZ A;  4MLN A;  2PQ7 A;  3I7A A;  3BG2 A;  4TO0 A;  4RXS A;  2PAQ A;  5AO1 A;  2O08 A;  3LJX A;  3HC1 A;  4MZ7 A;  4L7E A;  4XDS A;  4QFX A;  3CCG A;  4BZB A;  4RXQ A;  5AO4 A;  3IRH A;  1XX7 A;  4QG4 A;  4DMB A;  4N6W A;  2PAR A;  4QG1 A;  3MZO A;  2Q14 A;  4ZWE A;  2O6I A;  5TK6 A;  5TK9 A;  4QG2 A;  4N71 A;  4L1J B;  3NQW A;  4TO3 A;  1YOY A;  4TO5 A;  3P3Q A;  3NR1 A;  3TMB A;  4TO6 A;  3TMD A;  4TNY A;  2HEK A;  4MDZ A;  2PAU A;  4TNR A;  2PGS A;  4TO2 A;  3U1N A;  4LRL A;  4Q7H A;  4L7W A;  3KH1 A;  3TMC A; 
#chains in the Genus database with same CATH topology
 3HI0 A;  4QFZ A;  1VJ7 A;  4BZC A;  2OGI A;  4TNX A;  3SK9 A;  4ZWG A;  2GZ4 A;  1YNB A;  4TNQ A;  4QG0 A;  2DQB A;  1VQR A;  4RXP A;  4TO4 A;  4TNZ A;  4RXO A;  1U6Z A;  3M1T A;  3RF0 A;  3S4L A;  5AO0 A;  5TK7 A;  4X9E A;  3MEM A;  4MLM A;  4TO1 A;  2FLO A;  3KQ5 A;  4L1J A;  4R8Z A;  4TNP A;  5AO3 A;  3SKD A;  5TK8 A;  5AO2 A;  4RXR A;  4MCW A;  4QFY A;  5TKA A;  3TM8 A;  4ME4 A;  2CQZ A;  4MLN A;  4QQW A;  2PQ7 A;  3I7A A;  3BG2 A;  4TO0 A;  4RXS A;  2PAQ A;  5AO1 A;  2O08 A;  3LJX A;  3HC1 A;  4MZ7 A;  4L7E A;  4XDS A;  4QFX A;  3CCG A;  4BZB A;  4RXQ A;  5AO4 A;  3IRH A;  1XX7 A;  4Q2C A;  4QG4 A;  4DMB A;  4N6W A;  2PAR A;  4QG1 A;  3MZO A;  2Q14 A;  3GW7 A;  4ZWE A;  2O6I A;  5TK6 A;  5TK9 A;  4QQX A;  4Q2D A;  4QG2 A;  4N71 A;  4L1J B;  3NQW A;  4TO3 A;  4QQZ A;  1YOY A;  4TO5 A;  3P3Q A;  3NR1 A;  3TMB A;  4TO6 A;  3TMD A;  4TNY A;  2HEK A;  4MDZ A;  2PAU A;  4TNR A;  2PGS A;  4TO2 A;  3U1N A;  4LRL A;  4Q7H A;  4L7W A;  3KH1 A;  3TMC A;  4QQY A; 
#chains in the Genus database with same CATH homology
 3HI0 A;  4QFZ A;  1VJ7 A;  4BZC A;  2OGI A;  4TNX A;  3SK9 A;  4ZWG A;  2GZ4 A;  1YNB A;  4TNQ A;  4QG0 A;  2DQB A;  1VQR A;  4RXP A;  4TO4 A;  4TNZ A;  4RXO A;  1U6Z A;  3M1T A;  3RF0 A;  3S4L A;  5AO0 A;  5TK7 A;  4X9E A;  3MEM A;  4MLM A;  4TO1 A;  2FLO A;  3KQ5 A;  4L1J A;  4R8Z A;  4TNP A;  5AO3 A;  3SKD A;  5TK8 A;  5AO2 A;  4RXR A;  4MCW A;  4QFY A;  5TKA A;  3TM8 A;  4ME4 A;  2CQZ A;  4MLN A;  4QQW A;  2PQ7 A;  3I7A A;  3BG2 A;  4TO0 A;  4RXS A;  2PAQ A;  5AO1 A;  2O08 A;  3LJX A;  3HC1 A;  4MZ7 A;  4L7E A;  4XDS A;  4QFX A;  3CCG A;  4BZB A;  4RXQ A;  5AO4 A;  3IRH A;  1XX7 A;  4Q2C A;  4QG4 A;  4DMB A;  4N6W A;  2PAR A;  4QG1 A;  3MZO A;  2Q14 A;  3GW7 A;  4ZWE A;  2O6I A;  5TK6 A;  5TK9 A;  4QQX A;  4Q2D A;  4QG2 A;  4N71 A;  4L1J B;  3NQW A;  4TO3 A;  4QQZ A;  1YOY A;  4TO5 A;  3P3Q A;  3NR1 A;  3TMB A;  4TO6 A;  3TMD A;  4TNY A;  2HEK A;  4MDZ A;  2PAU A;  4TNR A;  2PGS A;  4TO2 A;  3U1N A;  4LRL A;  4Q7H A;  4L7W A;  3KH1 A;  3TMC A;  4QQY A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...