4C6GA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 252
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
252
sequence length
669
structure length
624
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEACRARVETCSSWVQRKAEDGADIYGLQESLIRCLLAGVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSASGDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVAGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHTDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords PHENYLALANINE AMMONIA-LYASE
publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
total genus 252
structure length 624
sequence length 669
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c6gA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c6gA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c6gA02
1TJWA 3GZHA 2RJRA 1GKJA 3E04A 5F92A 1U15A 1VDKA 2O78A 1JSWA 1B8FA 3UNVA 2O6YA 3R6QA 2VD6A 3BHGA 1GK2A 2HVGA 4C6GA 5D6BA 1EB4A 1W27A 3KDZA 1AUWA 1U16A 2O7EA 3NO9A 3R6VA 4C5RA 4V2RA 2NYNA 5EYTA 4BAAA 2PFMA 1FUPA 4EFCA 1HY1A 5F91A 1YFEA 2RJSA 2QGAB 1YISA 1GK3A 1C3CA 2NYFA 3RRPA 1TJUA 2YIIA 3TV2A 1Y2MA 4BABA 3NZ4A 1YFMA 3OCFA 1J3UA 4C5UA 4ADMA 1HY0A 4C5SA 5EYVA 1GKMA 1FUOA 1DOFA 2OHYA 2PTQA 3R6YA 4FLCA 1T6PA 3C8TA 2E9FA 2O7FA 5HW2A 3GTDA 4V2QA 4CQ5A 1XWOA 4NLEA 4ADLA 2PTSA 3CZOA 1TJVA 4NSLA 4EEIA 1DCNA 3RD8A 4APAA 1T6JA 4MX2A 2O7BA 2PTRA 1C3UA 2FUSA 1FURA 2O7DA 1FUQA 1TJ7A 4FFXA 1RE5A 1K62A 1I0AA 3QBPA 2X75A 1Q5NA 4APBA 4HGVA 1K7WA 3KDYA 1KQ7A 2QVEA 2J91A 3OCEA
chains in the Genus database with same CATH superfamily
4FBSA 4C2MA 1TJWA 1XLYA 4WNLA 2A6HD 2LPIA 3GZHA 2RJRA 2X0OA 1ZYMA 2LKMB 1GKJA 3GTOA 2EZCA 3E04A 5F92A 1U15A 2YU9A 2FENA 2R92A 1TWGA 1VDKA 3GTJA 1JSWA 1B8FA 2O78A 3UNVA 2O6YA 3R6QA 2FIPA 2VD6A 1I6VD 3BHGA 1GK2A 2HVGA 4C6GA 5D6BA 3CQZA 2X0QA 2F5JA 2E2HA 1EB4A 1W27A 2N1DB 5M0IA 3EZEA 1EZAA 2MP0A 3GTKA 3KDZA 1AUWA 1U16A 5IZ2A 2O7EA 3GTQA 2CW0D 3NO9A 3R6VA 2LTHA 1ZYRD 1HQMD 1XMDA 4C5RA 4V2RA 2NYNA 5EYTA 2EZAA 2A68D 2X0PA 2MX8A 3U4QA 1TWFA 2A69D 4BAAA 2JA5A 2PFMA 2VL7A 2FELA 1R9TA 5H8WA 1SFOA 2LYIA 1FUPA 4EFCA 3FKIA 1HY1A 1XL8A 2N3EA 5F91A 2Y0NA 2B63A 4A15A 1YFEA 2RJSA 2QGAB 1YISA 1GK3A 2R93A 2HWGA 2LPJA 2VK9A 1C3CA 3GTPA 2NYFA 3RRPA 1I50A 3LR8A 1TJUA 2YIIA 3TV2A 1Y2MA 4BABA 4CEHA 3NZ4A 2FIOA 2K3OA 4CEJA 1YFMA 3OCFA 1J3UA 4C5UA 4CEIA 4ADMA 1HY0A 4C5SA 5EYVA 1GKMA 1FUOA 2NVXA 1K83A 1DOFA 5M0JA 2E2IA 2OHYA 4QIWA 3CRVA 3U44A 2R7ZA 3EZBA 2PTQA 2MQAA 4FLCA 3R6YA 1T6PA 3C8TA 2VSFA 2E9FA 2O7FA 1Y1VA 2EZBA 5HW2A 3GTDA 3GTLA 4V2QA 4CQ5A 2HROA 2K3NA 1XWOA 4NLEA 1WCMA 4ADLA 1TWCA 2PTSA 1I3QA 1YNND 3CZOA 2JA6A 1TJVA 4NSLA 1XL7A 4EEIA 1TWAA 1DCNA 3RD8A 4APAA 3GTGA 3LRDA 1T6JA 1Y1WA 4MX2A 2O7BA 2JA7A 2PTRA 1C3UA 2FUSA 1FURA 2O7DA 2A6ED 2AQLA 3GTMA 2MX9A 1FUQA 2K3QA 1EZBA 1RE5A 1TJ7A 1K62A 3LR6A 1YNJD 4FFXA 1IW7D 1I0AA 3QBPA 2X75A 3H0GA 2O5JD 1Q5NA 3EZAA 1SMYD 4APBA 2BE5D 1TWHA 2VUMA 4HGVA 1K7WA 1XMCA 3LR2A 3CRW1 3KDYA 2NVYA 1KQ7A 2QVEA 2J91A 3OCEA
chains in the Genus database with same CATH topology
1TJWA 3GZHA 2RJRA 1GKJA 3E04A 5F92A 1U15A 1VDKA 2O78A 1JSWA 1B8FA 3UNVA 2O6YA 3R6QA 2VD6A 3BHGA 1GK2A 2HVGA 4C6GA 5D6BA 1EB4A 1W27A 3KDZA 1AUWA 1U16A 2O7EA 3NO9A 3R6VA 4C5RA 4V2RA 2NYNA 5EYTA 4BAAA 2PFMA 1FUPA 4EFCA 1HY1A 5F91A 1YFEA 2RJSA 2QGAB 1YISA 1GK3A 1C3CA 2NYFA 3RRPA 1TJUA 2YIIA 3TV2A 1Y2MA 4BABA 3NZ4A 1YFMA 3OCFA 1J3UA 4C5UA 4ADMA 1HY0A 4C5SA 5EYVA 1GKMA 1FUOA 1DOFA 2OHYA 2PTQA 3R6YA 4FLCA 1T6PA 3C8TA 2E9FA 2O7FA 5HW2A 3GTDA 4V2QA 4CQ5A 1XWOA 4NLEA 4ADLA 2PTSA 3CZOA 1TJVA 4NSLA 4EEIA 1DCNA 3RD8A 4APAA 1T6JA 4MX2A 2O7BA 2PTRA 1C3UA 2FUSA 1FURA 2O7DA 1FUQA 1TJ7A 4FFXA 1RE5A 1K62A 1I0AA 3QBPA 2X75A 1Q5NA 4APBA 4HGVA 1K7WA 3KDYA 1KQ7A 2QVEA 2J91A 3OCEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TJW A;  3GZH A;  2RJR A;  1GKJ A;  3E04 A;  5F92 A;  1U15 A;  1VDK A;  2O78 A;  1JSW A;  1B8F A;  3UNV A;  2O6Y A;  3R6Q A;  2VD6 A;  3BHG A;  1GK2 A;  2HVG A;  4C6G A;  5D6B A;  1EB4 A;  1W27 A;  3KDZ A;  1AUW A;  1U16 A;  2O7E A;  3NO9 A;  3R6V A;  4C5R A;  4V2R A;  2NYN A;  5EYT A;  4BAA A;  2PFM A;  1FUP A;  4EFC A;  1HY1 A;  5F91 A;  1YFE A;  2RJS A;  2QGA B;  1YIS A;  1GK3 A;  1C3C A;  2NYF A;  3RRP A;  1TJU A;  2YII A;  3TV2 A;  1Y2M A;  4BAB A;  3NZ4 A;  1YFM A;  3OCF A;  1J3U A;  4C5U A;  4ADM A;  1HY0 A;  4C5S A;  5EYV A;  1GKM A;  1FUO A;  1DOF A;  2OHY A;  2PTQ A;  3R6Y A;  4FLC A;  1T6P A;  3C8T A;  2E9F A;  2O7F A;  5HW2 A;  3GTD A;  4V2Q A;  4CQ5 A;  1XWO A;  4NLE A;  4ADL A;  2PTS A;  3CZO A;  1TJV A;  4NSL A;  4EEI A;  1DCN A;  3RD8 A;  4APA A;  1T6J A;  4MX2 A;  2O7B A;  2PTR A;  1C3U A;  2FUS A;  1FUR A;  2O7D A;  1FUQ A;  1TJ7 A;  4FFX A;  1RE5 A;  1K62 A;  1I0A A;  3QBP A;  2X75 A;  1Q5N A;  4APB A;  4HGV A;  1K7W A;  3KDY A;  1KQ7 A;  2QVE A;  2J91 A;  3OCE A; 
#chains in the Genus database with same CATH topology
 4FBS A;  4C2M A;  1TJW A;  1XLY A;  4WNL A;  2A6H D;  2LPI A;  3GZH A;  2RJR A;  2X0O A;  1ZYM A;  2LKM B;  1GKJ A;  3GTO A;  2EZC A;  3E04 A;  5F92 A;  1U15 A;  2YU9 A;  2FEN A;  2R92 A;  1TWG A;  1VDK A;  3GTJ A;  1JSW A;  1B8F A;  2O78 A;  3UNV A;  2O6Y A;  3R6Q A;  2FIP A;  2VD6 A;  1I6V D;  3BHG A;  1GK2 A;  2HVG A;  4C6G A;  5D6B A;  3CQZ A;  2X0Q A;  2F5J A;  2E2H A;  1EB4 A;  1W27 A;  2N1D B;  5M0I A;  3EZE A;  1EZA A;  2MP0 A;  3GTK A;  3KDZ A;  1AUW A;  1U16 A;  5IZ2 A;  2O7E A;  3GTQ A;  2CW0 D;  3NO9 A;  3R6V A;  2LTH A;  1ZYR D;  1HQM D;  1XMD A;  4C5R A;  4V2R A;  2NYN A;  5EYT A;  2EZA A;  2A68 D;  2X0P A;  2MX8 A;  3U4Q A;  1TWF A;  2A69 D;  4BAA A;  2JA5 A;  2PFM A;  2VL7 A;  2FEL A;  1R9T A;  5H8W A;  1SFO A;  2LYI A;  1FUP A;  4EFC A;  3FKI A;  1HY1 A;  1XL8 A;  2N3E A;  5F91 A;  2Y0N A;  2B63 A;  4A15 A;  1YFE A;  2RJS A;  2QGA B;  1YIS A;  1GK3 A;  2R93 A;  2HWG A;  2LPJ A;  2VK9 A;  1C3C A;  3GTP A;  2NYF A;  3RRP A;  1I50 A;  3LR8 A;  1TJU A;  2YII A;  3TV2 A;  1Y2M A;  4BAB A;  4CEH A;  3NZ4 A;  2FIO A;  2K3O A;  4CEJ A;  1YFM A;  3OCF A;  1J3U A;  4C5U A;  4CEI A;  4ADM A;  1HY0 A;  4C5S A;  5EYV A;  1GKM A;  1FUO A;  2NVX A;  1K83 A;  1DOF A;  5M0J A;  2E2I A;  2OHY A;  4QIW A;  3CRV A;  3U44 A;  2R7Z A;  3EZB A;  2PTQ A;  2MQA A;  4FLC A;  3R6Y A;  1T6P A;  3C8T A;  2VSF A;  2E9F A;  2O7F A;  1Y1V A;  2EZB A;  5HW2 A;  3GTD A;  3GTL A;  4V2Q A;  4CQ5 A;  2HRO A;  2K3N A;  1XWO A;  4NLE A;  1WCM A;  4ADL A;  1TWC A;  2PTS A;  1I3Q A;  1YNN D;  3CZO A;  2JA6 A;  1TJV A;  4NSL A;  1XL7 A;  4EEI A;  1TWA A;  1DCN A;  3RD8 A;  4APA A;  3GTG A;  3LRD A;  1T6J A;  1Y1W A;  4MX2 A;  2O7B A;  2JA7 A;  2PTR A;  1C3U A;  2FUS A;  1FUR A;  2O7D A;  2A6E D;  2AQL A;  3GTM A;  2MX9 A;  1FUQ A;  2K3Q A;  1EZB A;  1RE5 A;  1TJ7 A;  1K62 A;  3LR6 A;  1YNJ D;  4FFX A;  1IW7 D;  1I0A A;  3QBP A;  2X75 A;  3H0G A;  2O5J D;  1Q5N A;  3EZA A;  1SMY D;  4APB A;  2BE5 D;  1TWH A;  2VUM A;  4HGV A;  1K7W A;  1XMC A;  3LR2 A;  3CRW 1;  3KDY A;  2NVY A;  1KQ7 A;  2QVE A;  2J91 A;  3OCE A; 
#chains in the Genus database with same CATH homology
 1TJW A;  3GZH A;  2RJR A;  1GKJ A;  3E04 A;  5F92 A;  1U15 A;  1VDK A;  2O78 A;  1JSW A;  1B8F A;  3UNV A;  2O6Y A;  3R6Q A;  2VD6 A;  3BHG A;  1GK2 A;  2HVG A;  4C6G A;  5D6B A;  1EB4 A;  1W27 A;  3KDZ A;  1AUW A;  1U16 A;  2O7E A;  3NO9 A;  3R6V A;  4C5R A;  4V2R A;  2NYN A;  5EYT A;  4BAA A;  2PFM A;  1FUP A;  4EFC A;  1HY1 A;  5F91 A;  1YFE A;  2RJS A;  2QGA B;  1YIS A;  1GK3 A;  1C3C A;  2NYF A;  3RRP A;  1TJU A;  2YII A;  3TV2 A;  1Y2M A;  4BAB A;  3NZ4 A;  1YFM A;  3OCF A;  1J3U A;  4C5U A;  4ADM A;  1HY0 A;  4C5S A;  5EYV A;  1GKM A;  1FUO A;  1DOF A;  2OHY A;  2PTQ A;  3R6Y A;  4FLC A;  1T6P A;  3C8T A;  2E9F A;  2O7F A;  5HW2 A;  3GTD A;  4V2Q A;  4CQ5 A;  1XWO A;  4NLE A;  4ADL A;  2PTS A;  3CZO A;  1TJV A;  4NSL A;  4EEI A;  1DCN A;  3RD8 A;  4APA A;  1T6J A;  4MX2 A;  2O7B A;  2PTR A;  1C3U A;  2FUS A;  1FUR A;  2O7D A;  1FUQ A;  1TJ7 A;  4FFX A;  1RE5 A;  1K62 A;  1I0A A;  3QBP A;  2X75 A;  1Q5N A;  4APB A;  4HGV A;  1K7W A;  3KDY A;  1KQ7 A;  2QVE A;  2J91 A;  3OCE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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