4C6GA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 252
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
252
sequence length
669
structure length
624
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEACRARVETCSSWVQRKAEDGADIYGLQESLIRCLLAGVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSASGDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVAGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHTDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
molecule keywords PHENYLALANINE AMMONIA-LYASE
total genus 252
structure length 624
sequence length 669
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c6gA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c6gA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c6gA02
3RD8A 4BABA 1GK3A 2OHYA 2O7DA 1T6PA 1EB4A 1FURA 2PFMA 4C5RA 1FUQA 4HGVA 5D6BA 2RJRA 2QGAB 1K62A 1B8FA 4C5UA 5F92A 2PTSA 4V2RA 2HVGA 4C6GA 4C5SA 1YFEA 3OCEA 1GKJA 1RE5A 4ADMA 5EYTA 2RJSA 2X75A 1DOFA 3TV2A 3OCFA 1GKMA 1GK2A 1FUOA 4NLEA 1YFMA 3NZ4A 2PTRA 1KQ7A 5F91A 3QBPA 3R6YA 2NYFA 1DCNA 4ADLA 2NYNA 3RRPA 1K7WA 1TJVA 1T6JA 3GZHA 2E9FA 1HY0A 2QVEA 2FUSA 3UNVA 3GTDA 1VDKA 1TJWA 2O6YA 3BHGA 1TJUA 3KDZA 1YISA 1Y2MA 2PTQA 3R6VA 1AUWA 4BAAA 2J91A 4CQ5A 4FFXA 5HW2A 1U16A 1C3UA 1I0AA 2YIIA 4EEIA 5EYVA 2VD6A 3KDYA 2O7BA 1JSWA 2O7EA 1HY1A 2O78A 4EFCA 1W27A 4FLCA 3CZOA 4NSLA 1Q5NA 4APAA 4V2QA 1C3CA 3E04A 1J3UA 3NO9A 1XWOA 4MX2A 1FUPA 3R6QA 4APBA 1TJ7A 2O7FA 1U15A 3C8TA
chains in the Genus database with same CATH superfamily
3RD8A 4BABA 1GK3A 2OHYA 2O7DA 1HQMD 2VK9A 3GTGA 1T6PA 3U44A 1EB4A 2K3QA 4C5RA 1FUQA 1FURA 2PFMA 3U4QA 2RJRA 4C2MA 5D6BA 1XMDA 1XLYA 2LTHA 1IW7D 4FBSA 3LR8A 3CRW1 3GTLA 1K62A 2QGAB 2HROA 3EZEA 4C5UA 2E2HA 1B8FA 5F92A 2PTSA 2B63A 2NVYA 4V2RA 3GTPA 5H8WA 2HVGA 1WCMA 4C6GA 4C5SA 1YFEA 3OCEA 1GKJA 2AQLA 1RE5A 4ADMA 3LRDA 5EYTA 2RJSA 2A6HD 2X0QA 2X75A 1EZBA 1XL8A 2LKMB 4QIWA 2O5JD 1DOFA 2K3NA 3TV2A 3OCFA 1GKMA 1GK2A 1FUOA 2YU9A 1SMYD 2MX9A 4NLEA 1EZAA 4CEJA 1SFOA 2CW0D 1YFMA 3NZ4A 1TWHA 1XMCA 2PTRA 1KQ7A 2A68D 2JA6A 1ZYMA 5F91A 3CQZA 1I50A 3QBPA 2R93A 1YNND 1YNJD 3R6YA 2LPJA 2NYFA 1DCNA 1I6VD 2FIOA 4ADLA 2NYNA 3LR2A 2MQAA 4HGVA 2BE5D 3RRPA 2N1DB 1K7WA 1TJVA 1T6JA 4CEIA 3GZHA 2E9FA 1HY0A 2JA7A 2EZBA 2QVEA 2FUSA 3UNVA 3GTDA 1TWAA 1K83A 1Y1VA 1VDKA 1TWCA 1R9TA 2LYIA 2FELA 1TJWA 2O6YA 3BHGA 1TJUA 3GTJA 2R7ZA 3KDZA 1YISA 1Y2MA 4A15A 2FENA 2A69D 2EZCA 2HWGA 2PTQA 1I3QA 2R92A 3R6VA 3GTQA 1AUWA 2K3OA 4BAAA 2J91A 4CQ5A 4FFXA 3H0GA 1XL7A 5HW2A 1C3UA 1U16A 1I0AA 2YIIA 4EEIA 5EYVA 2VD6A 2Y0NA 2O7BA 2EZAA 3GTKA 3KDYA 1JSWA 5M0IA 5M0JA 2O7EA 2VUMA 2E2IA 1HY1A 2O78A 4EFCA 1TWGA 1W27A 4FLCA 2VSFA 4WNLA 1ZYRD 2LPIA 3GTOA 3CZOA 4NSLA 1Q5NA 4APAA 4V2QA 1C3CA 2VL7A 3GTMA 2X0PA 2FIPA 3EZBA 3E04A 1J3UA 3NO9A 1XWOA 4MX2A 3CRVA 2NVXA 2X0OA 2MP0A 3EZAA 3FKIA 3LR6A 1FUPA 3R6QA 4APBA 2N3EA 5IZ2A 2F5JA 2A6ED 1TJ7A 2MX8A 2JA5A 2O7FA 1TWFA 4CEHA 1U15A 3C8TA 1Y1WA
chains in the Genus database with same CATH topology
3RD8A 4BABA 1GK3A 2OHYA 2O7DA 1T6PA 1EB4A 1FURA 2PFMA 4C5RA 1FUQA 4HGVA 5D6BA 2RJRA 2QGAB 1K62A 1B8FA 4C5UA 5F92A 2PTSA 4V2RA 2HVGA 4C6GA 4C5SA 1YFEA 3OCEA 1GKJA 1RE5A 4ADMA 5EYTA 2RJSA 2X75A 1DOFA 3TV2A 3OCFA 1GKMA 1GK2A 1FUOA 4NLEA 1YFMA 3NZ4A 2PTRA 1KQ7A 5F91A 3QBPA 3R6YA 2NYFA 1DCNA 4ADLA 2NYNA 3RRPA 1K7WA 1TJVA 1T6JA 3GZHA 2E9FA 1HY0A 2QVEA 2FUSA 3UNVA 3GTDA 1VDKA 1TJWA 2O6YA 3BHGA 1TJUA 3KDZA 1YISA 1Y2MA 2PTQA 3R6VA 1AUWA 4BAAA 2J91A 4CQ5A 4FFXA 5HW2A 1U16A 1C3UA 1I0AA 2YIIA 4EEIA 5EYVA 2VD6A 3KDYA 2O7BA 1JSWA 2O7EA 1HY1A 2O78A 4EFCA 1W27A 4FLCA 3CZOA 4NSLA 1Q5NA 4APAA 4V2QA 1C3CA 3E04A 1J3UA 3NO9A 1XWOA 4MX2A 1FUPA 3R6QA 4APBA 1TJ7A 2O7FA 1U15A 3C8TA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3RD8 A;  4BAB A;  1GK3 A;  2OHY A;  2O7D A;  1T6P A;  1EB4 A;  1FUR A;  2PFM A;  4C5R A;  1FUQ A;  4HGV A;  5D6B A;  2RJR A;  2QGA B;  1K62 A;  1B8F A;  4C5U A;  5F92 A;  2PTS A;  4V2R A;  2HVG A;  4C6G A;  4C5S A;  1YFE A;  3OCE A;  1GKJ A;  1RE5 A;  4ADM A;  5EYT A;  2RJS A;  2X75 A;  1DOF A;  3TV2 A;  3OCF A;  1GKM A;  1GK2 A;  1FUO A;  4NLE A;  1YFM A;  3NZ4 A;  2PTR A;  1KQ7 A;  5F91 A;  3QBP A;  3R6Y A;  2NYF A;  1DCN A;  4ADL A;  2NYN A;  3RRP A;  1K7W A;  1TJV A;  1T6J A;  3GZH A;  2E9F A;  1HY0 A;  2QVE A;  2FUS A;  3UNV A;  3GTD A;  1VDK A;  1TJW A;  2O6Y A;  3BHG A;  1TJU A;  3KDZ A;  1YIS A;  1Y2M A;  2PTQ A;  3R6V A;  1AUW A;  4BAA A;  2J91 A;  4CQ5 A;  4FFX A;  5HW2 A;  1U16 A;  1C3U A;  1I0A A;  2YII A;  4EEI A;  5EYV A;  2VD6 A;  3KDY A;  2O7B A;  1JSW A;  2O7E A;  1HY1 A;  2O78 A;  4EFC A;  1W27 A;  4FLC A;  3CZO A;  4NSL A;  1Q5N A;  4APA A;  4V2Q A;  1C3C A;  3E04 A;  1J3U A;  3NO9 A;  1XWO A;  4MX2 A;  1FUP A;  3R6Q A;  4APB A;  1TJ7 A;  2O7F A;  1U15 A;  3C8T A; 
#chains in the Genus database with same CATH topology
 3RD8 A;  4BAB A;  1GK3 A;  2OHY A;  2O7D A;  1HQM D;  2VK9 A;  3GTG A;  1T6P A;  3U44 A;  1EB4 A;  2K3Q A;  4C5R A;  1FUQ A;  1FUR A;  2PFM A;  3U4Q A;  2RJR A;  4C2M A;  5D6B A;  1XMD A;  1XLY A;  2LTH A;  1IW7 D;  4FBS A;  3LR8 A;  3CRW 1;  3GTL A;  1K62 A;  2QGA B;  2HRO A;  3EZE A;  4C5U A;  2E2H A;  1B8F A;  5F92 A;  2PTS A;  2B63 A;  2NVY A;  4V2R A;  3GTP A;  5H8W A;  2HVG A;  1WCM A;  4C6G A;  4C5S A;  1YFE A;  3OCE A;  1GKJ A;  2AQL A;  1RE5 A;  4ADM A;  3LRD A;  5EYT A;  2RJS A;  2A6H D;  2X0Q A;  2X75 A;  1EZB A;  1XL8 A;  2LKM B;  4QIW A;  2O5J D;  1DOF A;  2K3N A;  3TV2 A;  3OCF A;  1GKM A;  1GK2 A;  1FUO A;  2YU9 A;  1SMY D;  2MX9 A;  4NLE A;  1EZA A;  4CEJ A;  1SFO A;  2CW0 D;  1YFM A;  3NZ4 A;  1TWH A;  1XMC A;  2PTR A;  1KQ7 A;  2A68 D;  2JA6 A;  1ZYM A;  5F91 A;  3CQZ A;  1I50 A;  3QBP A;  2R93 A;  1YNN D;  1YNJ D;  3R6Y A;  2LPJ A;  2NYF A;  1DCN A;  1I6V D;  2FIO A;  4ADL A;  2NYN A;  3LR2 A;  2MQA A;  4HGV A;  2BE5 D;  3RRP A;  2N1D B;  1K7W A;  1TJV A;  1T6J A;  4CEI A;  3GZH A;  2E9F A;  1HY0 A;  2JA7 A;  2EZB A;  2QVE A;  2FUS A;  3UNV A;  3GTD A;  1TWA A;  1K83 A;  1Y1V A;  1VDK A;  1TWC A;  1R9T A;  2LYI A;  2FEL A;  1TJW A;  2O6Y A;  3BHG A;  1TJU A;  3GTJ A;  2R7Z A;  3KDZ A;  1YIS A;  1Y2M A;  4A15 A;  2FEN A;  2A69 D;  2EZC A;  2HWG A;  2PTQ A;  1I3Q A;  2R92 A;  3R6V A;  3GTQ A;  1AUW A;  2K3O A;  4BAA A;  2J91 A;  4CQ5 A;  4FFX A;  3H0G A;  1XL7 A;  5HW2 A;  1C3U A;  1U16 A;  1I0A A;  2YII A;  4EEI A;  5EYV A;  2VD6 A;  2Y0N A;  2O7B A;  2EZA A;  3GTK A;  3KDY A;  1JSW A;  5M0I A;  5M0J A;  2O7E A;  2VUM A;  2E2I A;  1HY1 A;  2O78 A;  4EFC A;  1TWG A;  1W27 A;  4FLC A;  2VSF A;  4WNL A;  1ZYR D;  2LPI A;  3GTO A;  3CZO A;  4NSL A;  1Q5N A;  4APA A;  4V2Q A;  1C3C A;  2VL7 A;  3GTM A;  2X0P A;  2FIP A;  3EZB A;  3E04 A;  1J3U A;  3NO9 A;  1XWO A;  4MX2 A;  3CRV A;  2NVX A;  2X0O A;  2MP0 A;  3EZA A;  3FKI A;  3LR6 A;  1FUP A;  3R6Q A;  4APB A;  2N3E A;  5IZ2 A;  2F5J A;  2A6E D;  1TJ7 A;  2MX8 A;  2JA5 A;  2O7F A;  1TWF A;  4CEH A;  1U15 A;  3C8T A;  1Y1W A; 
#chains in the Genus database with same CATH homology
 3RD8 A;  4BAB A;  1GK3 A;  2OHY A;  2O7D A;  1T6P A;  1EB4 A;  1FUR A;  2PFM A;  4C5R A;  1FUQ A;  4HGV A;  5D6B A;  2RJR A;  2QGA B;  1K62 A;  1B8F A;  4C5U A;  5F92 A;  2PTS A;  4V2R A;  2HVG A;  4C6G A;  4C5S A;  1YFE A;  3OCE A;  1GKJ A;  1RE5 A;  4ADM A;  5EYT A;  2RJS A;  2X75 A;  1DOF A;  3TV2 A;  3OCF A;  1GKM A;  1GK2 A;  1FUO A;  4NLE A;  1YFM A;  3NZ4 A;  2PTR A;  1KQ7 A;  5F91 A;  3QBP A;  3R6Y A;  2NYF A;  1DCN A;  4ADL A;  2NYN A;  3RRP A;  1K7W A;  1TJV A;  1T6J A;  3GZH A;  2E9F A;  1HY0 A;  2QVE A;  2FUS A;  3UNV A;  3GTD A;  1VDK A;  1TJW A;  2O6Y A;  3BHG A;  1TJU A;  3KDZ A;  1YIS A;  1Y2M A;  2PTQ A;  3R6V A;  1AUW A;  4BAA A;  2J91 A;  4CQ5 A;  4FFX A;  5HW2 A;  1U16 A;  1C3U A;  1I0A A;  2YII A;  4EEI A;  5EYV A;  2VD6 A;  3KDY A;  2O7B A;  1JSW A;  2O7E A;  1HY1 A;  2O78 A;  4EFC A;  1W27 A;  4FLC A;  3CZO A;  4NSL A;  1Q5N A;  4APA A;  4V2Q A;  1C3C A;  3E04 A;  1J3U A;  3NO9 A;  1XWO A;  4MX2 A;  1FUP A;  3R6Q A;  4APB A;  1TJ7 A;  2O7F A;  1U15 A;  3C8T A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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