4C6GA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 252
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
252
sequence length
669
structure length
624
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEACRARVETCSSWVQRKAEDGADIYGLQESLIRCLLAGVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSASGDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVAGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHTDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords PHENYLALANINE AMMONIA-LYASE
publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
total genus 252
structure length 624
sequence length 669
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c6gA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c6gA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c6gA02
2VD6A 2PTQA 1B8FA 2RJSA 4V2QA 1YFEA 3CZOA 3OCEA 1TJ7A 4V2RA 1TJWA 1YFMA 2RJRA 1GK2A 1K7WA 1EB4A 2E9FA 2HVGA 3R6QA 2J91A 2O7DA 4EFCA 1W27A 2YIIA 4C5RA 1GK3A 2O6YA 4ADMA 4EEIA 2O7EA 4FLCA 2O7BA 4MX2A 1U15A 1Y2MA 1GKJA 3KDZA 5F91A 3NO9A 1DCNA 1FUOA 1DOFA 4APBA 1YISA 2FUSA 2QGAB 5D6BA 2NYNA 1T6PA 3GTDA 4NSLA 1C3CA 3RRPA 1KQ7A 2QVEA 1I0AA 1HY1A 3TV2A 3KDYA 4CQ5A 1GKMA 4C5SA 1T6JA 1JSWA 2OHYA 2PFMA 2O7FA 4BAAA 1C3UA 1K62A 5F92A 3OCFA 3E04A 3UNVA 1FUQA 3NZ4A 2NYFA 5HW2A 4BABA 3BHGA 3R6VA 4HGVA 1FUPA 1TJUA 4ADLA 4C5UA 4FFXA 4C6GA 2PTSA 1HY0A 1J3UA 4APAA 3R6YA 1XWOA 1U16A 1Q5NA 3C8TA 1AUWA 4NLEA 2O78A 1RE5A 1TJVA 3GZHA 1FURA 2PTRA 5EYVA 3QBPA 1VDKA 2X75A 3RD8A 5EYTA
chains in the Genus database with same CATH superfamily
2VD6A 2O5JD 2PTQA 1B8FA 2RJSA 2VL7A 2R93A 4V2QA 1YFEA 3CZOA 1Y1VA 3OCEA 3LR8A 2MQAA 1TJ7A 2HROA 4V2RA 1TJWA 1YFMA 2RJRA 2X0PA 1GK2A 2K3QA 1K7WA 5IZ2A 2JA5A 2FIOA 1EB4A 2E9FA 3GTGA 2EZAA 1K83A 3EZAA 1ZYMA 2EZBA 2HVGA 3R6QA 2N3EA 2J91A 2O7DA 4EFCA 1W27A 1TWGA 3GTJA 2EZCA 2YIIA 4C5RA 1GK3A 2O6YA 4ADMA 4EEIA 2O7EA 4FLCA 3LR2A 1WCMA 2O7BA 4MX2A 2NVXA 1Y2MA 1U15A 2LPIA 1GKJA 3KDZA 1XL7A 2Y0NA 2FENA 4WNLA 3GTLA 1XMDA 1I50A 5F91A 4C2MA 3NO9A 1DCNA 1FUOA 1DOFA 2VSFA 4APBA 1YISA 1EZAA 3CRW1 2FUSA 3LR6A 2MX9A 1XMCA 2QGAB 2NYNA 5D6BA 3U44A 1HQMD 1T6PA 2VUMA 3GTDA 1XLYA 1Y1WA 1SMYD 1C3CA 4NSLA 3RRPA 2K3OA 1KQ7A 3EZBA 3LRDA 2A69D 2AQLA 2QVEA 2R7ZA 2A68D 1I0AA 2E2IA 1HY1A 2LTHA 3TV2A 3GTMA 3KDYA 2N1DB 4CQ5A 2A6ED 3H0GA 1YNJD 1GKMA 4C5SA 2JA6A 5M0IA 1T6JA 3CRVA 2LKMB 1JSWA 3EZEA 2OHYA 4CEHA 2PFMA 2FIPA 2A6HD 2BE5D 2X0QA 4BAAA 2B63A 1C3UA 1K62A 2O7FA 1I3QA 5F92A 3OCFA 3E04A 3UNVA 1FUQA 4FBSA 5M0JA 1TWHA 3FKIA 3NZ4A 3RD8A 2NYFA 5HW2A 4BABA 2R92A 1I6VD 1SFOA 3BHGA 2JA7A 3R6VA 3GTKA 4HGVA 1FUPA 1TJUA 4ADLA 4C5UA 4FFXA 4C6GA 1ZYRD 3GTPA 2PTSA 2LYIA 1IW7D 2E2HA 1YNND 2K3NA 1HY0A 1J3UA 4APAA 1TWFA 1TWAA 2MP0A 2CW0D 3R6YA 2HWGA 1XWOA 3GTOA 1U16A 4A15A 4CEIA 1Q5NA 2F5JA 3C8TA 2YU9A 2FELA 1AUWA 4NLEA 4QIWA 2X0OA 2LPJA 2O78A 1RE5A 1TJVA 1R9TA 3GZHA 5H8WA 1EZBA 1FURA 3GTQA 1XL8A 4CEJA 2PTRA 2MX8A 1TWCA 5EYVA 3QBPA 1VDKA 2VK9A 3U4QA 2X75A 2NVYA 5EYTA 3CQZA
chains in the Genus database with same CATH topology
2VD6A 2PTQA 1B8FA 2RJSA 4V2QA 1YFEA 3CZOA 3OCEA 1TJ7A 4V2RA 1TJWA 1YFMA 2RJRA 1GK2A 1K7WA 1EB4A 2E9FA 2HVGA 3R6QA 2J91A 2O7DA 4EFCA 1W27A 2YIIA 4C5RA 1GK3A 2O6YA 4ADMA 4EEIA 2O7EA 4FLCA 2O7BA 4MX2A 1U15A 1Y2MA 1GKJA 3KDZA 5F91A 3NO9A 1DCNA 1FUOA 1DOFA 4APBA 1YISA 2FUSA 2QGAB 5D6BA 2NYNA 1T6PA 3GTDA 4NSLA 1C3CA 3RRPA 1KQ7A 2QVEA 1I0AA 1HY1A 3TV2A 3KDYA 4CQ5A 1GKMA 4C5SA 1T6JA 1JSWA 2OHYA 2PFMA 2O7FA 4BAAA 1C3UA 1K62A 5F92A 3OCFA 3E04A 3UNVA 1FUQA 3NZ4A 2NYFA 5HW2A 4BABA 3BHGA 3R6VA 4HGVA 1FUPA 1TJUA 4ADLA 4C5UA 4FFXA 4C6GA 2PTSA 1HY0A 1J3UA 4APAA 3R6YA 1XWOA 1U16A 1Q5NA 3C8TA 1AUWA 4NLEA 2O78A 1RE5A 1TJVA 3GZHA 1FURA 2PTRA 5EYVA 3QBPA 1VDKA 2X75A 3RD8A 5EYTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VD6 A;  2PTQ A;  1B8F A;  2RJS A;  4V2Q A;  1YFE A;  3CZO A;  3OCE A;  1TJ7 A;  4V2R A;  1TJW A;  1YFM A;  2RJR A;  1GK2 A;  1K7W A;  1EB4 A;  2E9F A;  2HVG A;  3R6Q A;  2J91 A;  2O7D A;  4EFC A;  1W27 A;  2YII A;  4C5R A;  1GK3 A;  2O6Y A;  4ADM A;  4EEI A;  2O7E A;  4FLC A;  2O7B A;  4MX2 A;  1U15 A;  1Y2M A;  1GKJ A;  3KDZ A;  5F91 A;  3NO9 A;  1DCN A;  1FUO A;  1DOF A;  4APB A;  1YIS A;  2FUS A;  2QGA B;  5D6B A;  2NYN A;  1T6P A;  3GTD A;  4NSL A;  1C3C A;  3RRP A;  1KQ7 A;  2QVE A;  1I0A A;  1HY1 A;  3TV2 A;  3KDY A;  4CQ5 A;  1GKM A;  4C5S A;  1T6J A;  1JSW A;  2OHY A;  2PFM A;  2O7F A;  4BAA A;  1C3U A;  1K62 A;  5F92 A;  3OCF A;  3E04 A;  3UNV A;  1FUQ A;  3NZ4 A;  2NYF A;  5HW2 A;  4BAB A;  3BHG A;  3R6V A;  4HGV A;  1FUP A;  1TJU A;  4ADL A;  4C5U A;  4FFX A;  4C6G A;  2PTS A;  1HY0 A;  1J3U A;  4APA A;  3R6Y A;  1XWO A;  1U16 A;  1Q5N A;  3C8T A;  1AUW A;  4NLE A;  2O78 A;  1RE5 A;  1TJV A;  3GZH A;  1FUR A;  2PTR A;  5EYV A;  3QBP A;  1VDK A;  2X75 A;  3RD8 A;  5EYT A; 
#chains in the Genus database with same CATH topology
 2VD6 A;  2O5J D;  2PTQ A;  1B8F A;  2RJS A;  2VL7 A;  2R93 A;  4V2Q A;  1YFE A;  3CZO A;  1Y1V A;  3OCE A;  3LR8 A;  2MQA A;  1TJ7 A;  2HRO A;  4V2R A;  1TJW A;  1YFM A;  2RJR A;  2X0P A;  1GK2 A;  2K3Q A;  1K7W A;  5IZ2 A;  2JA5 A;  2FIO A;  1EB4 A;  2E9F A;  3GTG A;  2EZA A;  1K83 A;  3EZA A;  1ZYM A;  2EZB A;  2HVG A;  3R6Q A;  2N3E A;  2J91 A;  2O7D A;  4EFC A;  1W27 A;  1TWG A;  3GTJ A;  2EZC A;  2YII A;  4C5R A;  1GK3 A;  2O6Y A;  4ADM A;  4EEI A;  2O7E A;  4FLC A;  3LR2 A;  1WCM A;  2O7B A;  4MX2 A;  2NVX A;  1Y2M A;  1U15 A;  2LPI A;  1GKJ A;  3KDZ A;  1XL7 A;  2Y0N A;  2FEN A;  4WNL A;  3GTL A;  1XMD A;  1I50 A;  5F91 A;  4C2M A;  3NO9 A;  1DCN A;  1FUO A;  1DOF A;  2VSF A;  4APB A;  1YIS A;  1EZA A;  3CRW 1;  2FUS A;  3LR6 A;  2MX9 A;  1XMC A;  2QGA B;  2NYN A;  5D6B A;  3U44 A;  1HQM D;  1T6P A;  2VUM A;  3GTD A;  1XLY A;  1Y1W A;  1SMY D;  1C3C A;  4NSL A;  3RRP A;  2K3O A;  1KQ7 A;  3EZB A;  3LRD A;  2A69 D;  2AQL A;  2QVE A;  2R7Z A;  2A68 D;  1I0A A;  2E2I A;  1HY1 A;  2LTH A;  3TV2 A;  3GTM A;  3KDY A;  2N1D B;  4CQ5 A;  2A6E D;  3H0G A;  1YNJ D;  1GKM A;  4C5S A;  2JA6 A;  5M0I A;  1T6J A;  3CRV A;  2LKM B;  1JSW A;  3EZE A;  2OHY A;  4CEH A;  2PFM A;  2FIP A;  2A6H D;  2BE5 D;  2X0Q A;  4BAA A;  2B63 A;  1C3U A;  1K62 A;  2O7F A;  1I3Q A;  5F92 A;  3OCF A;  3E04 A;  3UNV A;  1FUQ A;  4FBS A;  5M0J A;  1TWH A;  3FKI A;  3NZ4 A;  3RD8 A;  2NYF A;  5HW2 A;  4BAB A;  2R92 A;  1I6V D;  1SFO A;  3BHG A;  2JA7 A;  3R6V A;  3GTK A;  4HGV A;  1FUP A;  1TJU A;  4ADL A;  4C5U A;  4FFX A;  4C6G A;  1ZYR D;  3GTP A;  2PTS A;  2LYI A;  1IW7 D;  2E2H A;  1YNN D;  2K3N A;  1HY0 A;  1J3U A;  4APA A;  1TWF A;  1TWA A;  2MP0 A;  2CW0 D;  3R6Y A;  2HWG A;  1XWO A;  3GTO A;  1U16 A;  4A15 A;  4CEI A;  1Q5N A;  2F5J A;  3C8T A;  2YU9 A;  2FEL A;  1AUW A;  4NLE A;  4QIW A;  2X0O A;  2LPJ A;  2O78 A;  1RE5 A;  1TJV A;  1R9T A;  3GZH A;  5H8W A;  1EZB A;  1FUR A;  3GTQ A;  1XL8 A;  4CEJ A;  2PTR A;  2MX8 A;  1TWC A;  5EYV A;  3QBP A;  1VDK A;  2VK9 A;  3U4Q A;  2X75 A;  2NVY A;  5EYT A;  3CQZ A; 
#chains in the Genus database with same CATH homology
 2VD6 A;  2PTQ A;  1B8F A;  2RJS A;  4V2Q A;  1YFE A;  3CZO A;  3OCE A;  1TJ7 A;  4V2R A;  1TJW A;  1YFM A;  2RJR A;  1GK2 A;  1K7W A;  1EB4 A;  2E9F A;  2HVG A;  3R6Q A;  2J91 A;  2O7D A;  4EFC A;  1W27 A;  2YII A;  4C5R A;  1GK3 A;  2O6Y A;  4ADM A;  4EEI A;  2O7E A;  4FLC A;  2O7B A;  4MX2 A;  1U15 A;  1Y2M A;  1GKJ A;  3KDZ A;  5F91 A;  3NO9 A;  1DCN A;  1FUO A;  1DOF A;  4APB A;  1YIS A;  2FUS A;  2QGA B;  5D6B A;  2NYN A;  1T6P A;  3GTD A;  4NSL A;  1C3C A;  3RRP A;  1KQ7 A;  2QVE A;  1I0A A;  1HY1 A;  3TV2 A;  3KDY A;  4CQ5 A;  1GKM A;  4C5S A;  1T6J A;  1JSW A;  2OHY A;  2PFM A;  2O7F A;  4BAA A;  1C3U A;  1K62 A;  5F92 A;  3OCF A;  3E04 A;  3UNV A;  1FUQ A;  3NZ4 A;  2NYF A;  5HW2 A;  4BAB A;  3BHG A;  3R6V A;  4HGV A;  1FUP A;  1TJU A;  4ADL A;  4C5U A;  4FFX A;  4C6G A;  2PTS A;  1HY0 A;  1J3U A;  4APA A;  3R6Y A;  1XWO A;  1U16 A;  1Q5N A;  3C8T A;  1AUW A;  4NLE A;  2O78 A;  1RE5 A;  1TJV A;  3GZH A;  1FUR A;  2PTR A;  5EYV A;  3QBP A;  1VDK A;  2X75 A;  3RD8 A;  5EYT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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