4C6GA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 252
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
252
sequence length
669
structure length
624
Chain Sequence
b'SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEACRARVETCSSWVQRKAEDGADIYGLQESLIRCLLAGVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSASGDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVAGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHTDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords PHENYLALANINE AMMONIA-LYASE
publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
total genus 252
structure length 624
sequence length 669
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c6gA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c6gA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c6gA02
1GKMA 2HVGA 1YFMA 4C6GA 3TV2A 5EYTA 1HY0A 2RJRA 3R6VA 2YIIA 2OHYA 3GZHA 2PTRA 4CQ5A 1DCNA 1XWOA 3GTDA 5F91A 3E04A 3OCEA 4C5SA 2FUSA 2PTSA 4APAA 1TJWA 4BABA 1RE5A 4C5UA 4BAAA 1T6PA 1Q5NA 3KDZA 1FUQA 2PFMA 1U15A 1C3CA 4C5RA 2VD6A 1TJVA 5HW2A 1W27A 1FUPA 5D6BA 1FUOA 2NYFA 1GK2A 4FFXA 2RJSA 3NZ4A 2O78A 2PTQA 1FURA 4EFCA 2O7EA 3CZOA 3KDYA 5EYVA 4V2RA 1TJUA 4HGVA 1VDKA 2E9FA 1DOFA 1KQ7A 2X75A 3UNVA 2J91A 1J3UA 1YISA 1K62A 3R6QA 3BHGA 1EB4A 4NLEA 1AUWA 1TJ7A 2QVEA 1GK3A 4ADLA 5F92A 1JSWA 1C3UA 4V2QA 3OCFA 3NO9A 2O7DA 1U16A 1K7WA 2O7FA 1YFEA 2O7BA 4ADMA 3C8TA 4MX2A 4NSLA 2O6YA 1T6JA 4FLCA 1B8FA 1GKJA 2QGAB 3RD8A 3R6YA 2NYNA 3QBPA 1Y2MA 1HY1A 4APBA 3RRPA 4EEIA 1I0AA
chains in the Genus database with same CATH superfamily
2X0PA 1GKMA 2YU9A 2HVGA 1XL7A 1YFMA 4C6GA 4QIWA 1IW7D 2LPIA 2JA6A 4CEHA 3TV2A 5EYTA 1HY0A 2RJRA 3R6VA 5M0JA 2YIIA 3U4QA 2OHYA 1ZYMA 3GZHA 2PTRA 4CQ5A 1DCNA 1XWOA 3GTDA 5F91A 3GTGA 1TWAA 2VUMA 2JA7A 3E04A 2FENA 3OCEA 1TWGA 2VK9A 2VL7A 4C5SA 3CRW1 2FUSA 2PTSA 4APAA 1EZAA 4BABA 4CEIA 1RE5A 1TJWA 2CW0D 2Y0NA 1Y1WA 1XL8A 4C5UA 3FKIA 4A15A 5M0IA 3EZBA 5IZ2A 2A69D 4BAAA 3GTLA 1T6PA 1Q5NA 3KDZA 1FUQA 2PFMA 1U15A 2HROA 1I3QA 2E2IA 1YNND 2MX8A 3LRDA 2BE5D 2R7ZA 1C3CA 4C5RA 2VD6A 1TJVA 5HW2A 1W27A 1I6VD 1FUPA 5D6BA 1FUOA 2JA5A 1ZYRD 2NVXA 2NYFA 1GK2A 4FFXA 2RJSA 3NZ4A 2HWGA 3EZAA 2O78A 2PTQA 5H8WA 3CQZA 2EZCA 3GTKA 4C2MA 3GTJA 1FURA 4EFCA 4CEJA 2LKMB 1XMCA 1R9TA 2EZAA 2O7EA 2FIPA 2F5JA 3CZOA 3KDYA 1XLYA 2MX9A 1SFOA 3GTMA 5EYVA 3GTQA 3LR6A 1HQMD 2EZBA 4V2RA 2NVYA 3LR2A 3LR8A 1TJUA 2K3QA 1TWCA 4HGVA 1I50A 1K83A 1VDKA 3U44A 2E9FA 1DOFA 2MP0A 1KQ7A 2FIOA 2X75A 3UNVA 2J91A 1J3UA 1YISA 2K3OA 2FELA 2N3EA 4WNLA 2R93A 1K62A 2LYIA 3R6QA 3BHGA 1EB4A 2A6ED 4NLEA 4FBSA 1AUWA 1YNJD 1TJ7A 3H0GA 1WCMA 2QVEA 2AQLA 2N1DB 2O5JD 1GK3A 2B63A 1EZBA 4ADLA 2LTHA 5F92A 1JSWA 2VSFA 2K3NA 2LPJA 1TWHA 1C3UA 4V2QA 3OCFA 3NO9A 2O7DA 3GTOA 2X0OA 2MQAA 1U16A 1K7WA 2O7FA 1XMDA 3EZEA 1TWFA 1YFEA 2O7BA 4ADMA 3C8TA 3CRVA 4MX2A 4NSLA 2A68D 2O6YA 1T6JA 4FLCA 1Y1VA 1B8FA 1GKJA 2QGAB 1SMYD 3RD8A 3R6YA 2NYNA 3QBPA 2A6HD 2X0QA 3GTPA 1Y2MA 1HY1A 4APBA 2E2HA 3RRPA 4EEIA 2R92A 1I0AA
chains in the Genus database with same CATH topology
1GKMA 2HVGA 1YFMA 4C6GA 3TV2A 5EYTA 1HY0A 2RJRA 3R6VA 2YIIA 2OHYA 3GZHA 2PTRA 4CQ5A 1DCNA 1XWOA 3GTDA 5F91A 3E04A 3OCEA 4C5SA 2FUSA 2PTSA 4APAA 1TJWA 4BABA 1RE5A 4C5UA 4BAAA 1T6PA 1Q5NA 3KDZA 1FUQA 2PFMA 1U15A 1C3CA 4C5RA 2VD6A 1TJVA 5HW2A 1W27A 1FUPA 5D6BA 1FUOA 2NYFA 1GK2A 4FFXA 2RJSA 3NZ4A 2O78A 2PTQA 1FURA 4EFCA 2O7EA 3CZOA 3KDYA 5EYVA 4V2RA 1TJUA 4HGVA 1VDKA 2E9FA 1DOFA 1KQ7A 2X75A 3UNVA 2J91A 1J3UA 1YISA 1K62A 3R6QA 3BHGA 1EB4A 4NLEA 1AUWA 1TJ7A 2QVEA 1GK3A 4ADLA 5F92A 1JSWA 1C3UA 4V2QA 3OCFA 3NO9A 2O7DA 1U16A 1K7WA 2O7FA 1YFEA 2O7BA 4ADMA 3C8TA 4MX2A 4NSLA 2O6YA 1T6JA 4FLCA 1B8FA 1GKJA 2QGAB 3RD8A 3R6YA 2NYNA 3QBPA 1Y2MA 1HY1A 4APBA 3RRPA 4EEIA 1I0AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1GKM A;  2HVG A;  1YFM A;  4C6G A;  3TV2 A;  5EYT A;  1HY0 A;  2RJR A;  3R6V A;  2YII A;  2OHY A;  3GZH A;  2PTR A;  4CQ5 A;  1DCN A;  1XWO A;  3GTD A;  5F91 A;  3E04 A;  3OCE A;  4C5S A;  2FUS A;  2PTS A;  4APA A;  1TJW A;  4BAB A;  1RE5 A;  4C5U A;  4BAA A;  1T6P A;  1Q5N A;  3KDZ A;  1FUQ A;  2PFM A;  1U15 A;  1C3C A;  4C5R A;  2VD6 A;  1TJV A;  5HW2 A;  1W27 A;  1FUP A;  5D6B A;  1FUO A;  2NYF A;  1GK2 A;  4FFX A;  2RJS A;  3NZ4 A;  2O78 A;  2PTQ A;  1FUR A;  4EFC A;  2O7E A;  3CZO A;  3KDY A;  5EYV A;  4V2R A;  1TJU A;  4HGV A;  1VDK A;  2E9F A;  1DOF A;  1KQ7 A;  2X75 A;  3UNV A;  2J91 A;  1J3U A;  1YIS A;  1K62 A;  3R6Q A;  3BHG A;  1EB4 A;  4NLE A;  1AUW A;  1TJ7 A;  2QVE A;  1GK3 A;  4ADL A;  5F92 A;  1JSW A;  1C3U A;  4V2Q A;  3OCF A;  3NO9 A;  2O7D A;  1U16 A;  1K7W A;  2O7F A;  1YFE A;  2O7B A;  4ADM A;  3C8T A;  4MX2 A;  4NSL A;  2O6Y A;  1T6J A;  4FLC A;  1B8F A;  1GKJ A;  2QGA B;  3RD8 A;  3R6Y A;  2NYN A;  3QBP A;  1Y2M A;  1HY1 A;  4APB A;  3RRP A;  4EEI A;  1I0A A; 
#chains in the Genus database with same CATH topology
 2X0P A;  1GKM A;  2YU9 A;  2HVG A;  1XL7 A;  1YFM A;  4C6G A;  4QIW A;  1IW7 D;  2LPI A;  2JA6 A;  4CEH A;  3TV2 A;  5EYT A;  1HY0 A;  2RJR A;  3R6V A;  5M0J A;  2YII A;  3U4Q A;  2OHY A;  1ZYM A;  3GZH A;  2PTR A;  4CQ5 A;  1DCN A;  1XWO A;  3GTD A;  5F91 A;  3GTG A;  1TWA A;  2VUM A;  2JA7 A;  3E04 A;  2FEN A;  3OCE A;  1TWG A;  2VK9 A;  2VL7 A;  4C5S A;  3CRW 1;  2FUS A;  2PTS A;  4APA A;  1EZA A;  4BAB A;  4CEI A;  1RE5 A;  1TJW A;  2CW0 D;  2Y0N A;  1Y1W A;  1XL8 A;  4C5U A;  3FKI A;  4A15 A;  5M0I A;  3EZB A;  5IZ2 A;  2A69 D;  4BAA A;  3GTL A;  1T6P A;  1Q5N A;  3KDZ A;  1FUQ A;  2PFM A;  1U15 A;  2HRO A;  1I3Q A;  2E2I A;  1YNN D;  2MX8 A;  3LRD A;  2BE5 D;  2R7Z A;  1C3C A;  4C5R A;  2VD6 A;  1TJV A;  5HW2 A;  1W27 A;  1I6V D;  1FUP A;  5D6B A;  1FUO A;  2JA5 A;  1ZYR D;  2NVX A;  2NYF A;  1GK2 A;  4FFX A;  2RJS A;  3NZ4 A;  2HWG A;  3EZA A;  2O78 A;  2PTQ A;  5H8W A;  3CQZ A;  2EZC A;  3GTK A;  4C2M A;  3GTJ A;  1FUR A;  4EFC A;  4CEJ A;  2LKM B;  1XMC A;  1R9T A;  2EZA A;  2O7E A;  2FIP A;  2F5J A;  3CZO A;  3KDY A;  1XLY A;  2MX9 A;  1SFO A;  3GTM A;  5EYV A;  3GTQ A;  3LR6 A;  1HQM D;  2EZB A;  4V2R A;  2NVY A;  3LR2 A;  3LR8 A;  1TJU A;  2K3Q A;  1TWC A;  4HGV A;  1I50 A;  1K83 A;  1VDK A;  3U44 A;  2E9F A;  1DOF A;  2MP0 A;  1KQ7 A;  2FIO A;  2X75 A;  3UNV A;  2J91 A;  1J3U A;  1YIS A;  2K3O A;  2FEL A;  2N3E A;  4WNL A;  2R93 A;  1K62 A;  2LYI A;  3R6Q A;  3BHG A;  1EB4 A;  2A6E D;  4NLE A;  4FBS A;  1AUW A;  1YNJ D;  1TJ7 A;  3H0G A;  1WCM A;  2QVE A;  2AQL A;  2N1D B;  2O5J D;  1GK3 A;  2B63 A;  1EZB A;  4ADL A;  2LTH A;  5F92 A;  1JSW A;  2VSF A;  2K3N A;  2LPJ A;  1TWH A;  1C3U A;  4V2Q A;  3OCF A;  3NO9 A;  2O7D A;  3GTO A;  2X0O A;  2MQA A;  1U16 A;  1K7W A;  2O7F A;  1XMD A;  3EZE A;  1TWF A;  1YFE A;  2O7B A;  4ADM A;  3C8T A;  3CRV A;  4MX2 A;  4NSL A;  2A68 D;  2O6Y A;  1T6J A;  4FLC A;  1Y1V A;  1B8F A;  1GKJ A;  2QGA B;  1SMY D;  3RD8 A;  3R6Y A;  2NYN A;  3QBP A;  2A6H D;  2X0Q A;  3GTP A;  1Y2M A;  1HY1 A;  4APB A;  2E2H A;  3RRP A;  4EEI A;  2R92 A;  1I0A A; 
#chains in the Genus database with same CATH homology
 1GKM A;  2HVG A;  1YFM A;  4C6G A;  3TV2 A;  5EYT A;  1HY0 A;  2RJR A;  3R6V A;  2YII A;  2OHY A;  3GZH A;  2PTR A;  4CQ5 A;  1DCN A;  1XWO A;  3GTD A;  5F91 A;  3E04 A;  3OCE A;  4C5S A;  2FUS A;  2PTS A;  4APA A;  1TJW A;  4BAB A;  1RE5 A;  4C5U A;  4BAA A;  1T6P A;  1Q5N A;  3KDZ A;  1FUQ A;  2PFM A;  1U15 A;  1C3C A;  4C5R A;  2VD6 A;  1TJV A;  5HW2 A;  1W27 A;  1FUP A;  5D6B A;  1FUO A;  2NYF A;  1GK2 A;  4FFX A;  2RJS A;  3NZ4 A;  2O78 A;  2PTQ A;  1FUR A;  4EFC A;  2O7E A;  3CZO A;  3KDY A;  5EYV A;  4V2R A;  1TJU A;  4HGV A;  1VDK A;  2E9F A;  1DOF A;  1KQ7 A;  2X75 A;  3UNV A;  2J91 A;  1J3U A;  1YIS A;  1K62 A;  3R6Q A;  3BHG A;  1EB4 A;  4NLE A;  1AUW A;  1TJ7 A;  2QVE A;  1GK3 A;  4ADL A;  5F92 A;  1JSW A;  1C3U A;  4V2Q A;  3OCF A;  3NO9 A;  2O7D A;  1U16 A;  1K7W A;  2O7F A;  1YFE A;  2O7B A;  4ADM A;  3C8T A;  4MX2 A;  4NSL A;  2O6Y A;  1T6J A;  4FLC A;  1B8F A;  1GKJ A;  2QGA B;  3RD8 A;  3R6Y A;  2NYN A;  3QBP A;  1Y2M A;  1HY1 A;  4APB A;  3RRP A;  4EEI A;  1I0A A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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