4C6GA

Structural investigations into the stereochemistry and activity of a phenylalanine-2,3-aminomutase from taxus chinensis
Total Genus 252
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
252
sequence length
669
structure length
624
Chain Sequence
SHVKDILGLINAFNEVKKITVDGTTPITVAHVAALARRHDVKVALEACRARVETCSSWVQRKAEDGADIYGLQESLIRCLLAGVFTDELPATATRSAMLLRLNSFTYGCSGIRWEVMEALEKLLNSNVSPKVPLRGSVSASGDLIPLAYIAGLLIGKPSVIARIGDDVEVPAPEALSRVGLRPFKLQAKEGLALVAGTSFATAVASTVMYDANVLLLLVETLCGMFCEVIFGREEFAHPLIHKVKPHPGQIESAELLEWLLRSSPFQELSREYYSIDKLKKPKQDRYALRSSPQWLAPLVQTIRDATTTVETEVNSANDNPIIDHANDRALHGANFQGSAVGFYMDYVRIAVAGLGKLLFAQFTELMIEYYSNGLPGNLSLGPDLSVDYGLKGLDIAMAAYSSELQYLANPVTTHVHSAEQHNQDINSLALISARKTEEALDILKLMIASHLTAMCQAVDLRQLEEALVKVVENVVSTLADECGLPNDTKARLLYVAKAVPVYTYLESPCDPTLPLLLGLKQSCFDTILALHTDTLVDRLAEFEKRLSDRLENEMTAVRVLYEKVRIQGSKFLPFYRFVREELDTGVMSARREQTPQEDVQKVFDAIADGRITVPLLHCLQGFL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Investigations Into the Stereochemistry and Activity of a Phenylalanine-2,3-Aminomutase from Taxus Chinensis.
pubmed doi rcsb
source organism Taxus wallichiana var. chinensis
molecule tags Lyase
molecule keywords PHENYLALANINE AMMONIA-LYASE
total genus 252
structure length 624
sequence length 669
chains with identical sequence B, C, D
ec nomenclature ec 4.3.1.24: Phenylalanine ammonia-lyase.
pdb deposition date 2013-09-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00221 Lyase_aromatic Aromatic amino acid lyase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.274.20 Mainly Alpha Orthogonal Bundle Enzyme I; Chain A, domain 2 Phenylalanine ammonia-lyase 1; domain 3 4c6gA03
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4c6gA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4c6gA02
1HY1A 1TJ7A 4NLEA 4C5SA 1TJWA 3KDYA 1YFMA 4APBA 3GTDA 1GKJA 1EB4A 2NYNA 4BABA 2O7FA 2RJRA 1HY0A 2E9FA 2RJSA 2X75A 4BAAA 5F91A 2O7DA 3RRPA 1U16A 4C5RA 2PFMA 2O7BA 1XWOA 1K62A 2YIIA 4NSLA 1KQ7A 1FUPA 1FURA 2PTSA 3CZOA 2O78A 1DCNA 1U15A 4ADLA 1B8FA 3NZ4A 4V2RA 4ADMA 3UNVA 1T6JA 4FLCA 4C6GA 2VD6A 5D6BA 1FUOA 3R6YA 1W27A 1GKMA 3R6QA 2QGAB 4V2QA 4C5UA 1AUWA 3BHGA 5EYTA 3GZHA 4CQ5A 3OCEA 3R6VA 1FUQA 3KDZA 2PTQA 1C3CA 1RE5A 2NYFA 1K7WA 4EFCA 1GK3A 1DOFA 3TV2A 2OHYA 4FFXA 3E04A 1YFEA 2PTRA 1I0AA 2HVGA 1T6PA 3RD8A 3OCFA 5F92A 5HW2A 3NO9A 2O6YA 3QBPA 5EYVA 1YISA 3C8TA 4MX2A 1TJUA 1C3UA 2QVEA 1Y2MA 2FUSA 1TJVA 2J91A 1Q5NA 1J3UA 4EEIA 2O7EA 1VDKA 4HGVA 4APAA 1JSWA 1GK2A
chains in the Genus database with same CATH superfamily
2VK9A 1HY1A 1TJ7A 4NLEA 2MP0A 2N3EA 4C5SA 1I50A 2X0OA 1TJWA 3KDYA 1YFMA 4APBA 1YNJD 3GTDA 1GKJA 1EB4A 1ZYRD 2VUMA 2NYNA 1I3QA 4BABA 1TWCA 2JA7A 1XL7A 3LR8A 2O7FA 2E2IA 2RJRA 2VSFA 1HY0A 3CQZA 2HWGA 2E9FA 4WNLA 2K3OA 2LPIA 2RJSA 2HROA 2R7ZA 2X75A 5M0IA 3FKIA 5H8WA 1YNND 1TWFA 4BAAA 2A6ED 5F91A 2O7DA 2X0PA 3RRPA 1U16A 4C5RA 2A68D 2PFMA 2O7BA 1XWOA 1Y1VA 1K62A 2YIIA 1EZAA 4C2MA 4NSLA 1KQ7A 2EZCA 3GTPA 1FUPA 1FURA 2A69D 3EZAA 2BE5D 3U4QA 2PTSA 4A15A 3CZOA 1IW7D 2O78A 4FBSA 1DCNA 1U15A 1WCMA 2A6HD 4ADLA 3GTGA 2NVYA 3LR2A 2B63A 2FIPA 4CEIA 1B8FA 3NZ4A 2E2HA 2FENA 2EZAA 4V2RA 4ADMA 1Y1WA 1T6JA 2JA6A 4FLCA 3UNVA 2NVXA 2K3QA 4C6GA 1TWAA 2VD6A 5D6BA 1FUOA 2LYIA 3R6YA 1EZBA 1W27A 1SMYD 1GKMA 3R6QA 2VL7A 2QGAB 4V2QA 4C5UA 3GTKA 2EZBA 5M0JA 1AUWA 5IZ2A 1XMCA 3BHGA 3GTQA 5EYTA 3GZHA 4QIWA 2LKMB 4CQ5A 1TWGA 1HQMD 3OCEA 3R6VA 2FELA 4CEHA 4CEJA 2MX8A 2FIOA 1FUQA 3KDZA 2CW0D 2R93A 2PTQA 3GTOA 1C3CA 1RE5A 2NYFA 1XLYA 1K7WA 4EFCA 1GK3A 3LRDA 2LTHA 1DOFA 3TV2A 2AQLA 2O5JD 2OHYA 4FFXA 3E04A 2MQAA 1YFEA 2PTRA 3EZBA 1I0AA 1T6PA 2HVGA 3RD8A 1XMDA 3OCFA 2K3NA 5F92A 5HW2A 1XL8A 3NO9A 1SFOA 1TWHA 3EZEA 2JA5A 2O6YA 3QBPA 1ZYMA 2Y0NA 3GTJA 3CRW1 3LR6A 2MX9A 5EYVA 1YISA 3C8TA 4MX2A 3GTMA 1TJUA 1K83A 1C3UA 3CRVA 2QVEA 1JSWA 2LPJA 2YU9A 1Y2MA 2FUSA 1TJVA 2J91A 3H0GA 2R92A 2F5JA 1Q5NA 1J3UA 2X0QA 4EEIA 1R9TA 3GTLA 1VDKA 2O7EA 4HGVA 4APAA 2N1DB 3U44A 1I6VD 1GK2A
chains in the Genus database with same CATH topology
1HY1A 1TJ7A 4NLEA 4C5SA 1TJWA 3KDYA 1YFMA 4APBA 3GTDA 1GKJA 1EB4A 2NYNA 4BABA 2O7FA 2RJRA 1HY0A 2E9FA 2RJSA 2X75A 4BAAA 5F91A 2O7DA 3RRPA 1U16A 4C5RA 2PFMA 2O7BA 1XWOA 1K62A 2YIIA 4NSLA 1KQ7A 1FUPA 1FURA 2PTSA 3CZOA 2O78A 1DCNA 1U15A 4ADLA 1B8FA 3NZ4A 4V2RA 4ADMA 3UNVA 1T6JA 4FLCA 4C6GA 2VD6A 5D6BA 1FUOA 3R6YA 1W27A 1GKMA 3R6QA 2QGAB 4V2QA 4C5UA 1AUWA 3BHGA 5EYTA 3GZHA 4CQ5A 3OCEA 3R6VA 1FUQA 3KDZA 2PTQA 1C3CA 1RE5A 2NYFA 1K7WA 4EFCA 1GK3A 1DOFA 3TV2A 2OHYA 4FFXA 3E04A 1YFEA 2PTRA 1I0AA 2HVGA 1T6PA 3RD8A 3OCFA 5F92A 5HW2A 3NO9A 2O6YA 3QBPA 5EYVA 1YISA 3C8TA 4MX2A 1TJUA 1C3UA 2QVEA 1Y2MA 2FUSA 1TJVA 2J91A 1Q5NA 1J3UA 4EEIA 2O7EA 1VDKA 4HGVA 4APAA 1JSWA 1GK2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HY1 A;  1TJ7 A;  4NLE A;  4C5S A;  1TJW A;  3KDY A;  1YFM A;  4APB A;  3GTD A;  1GKJ A;  1EB4 A;  2NYN A;  4BAB A;  2O7F A;  2RJR A;  1HY0 A;  2E9F A;  2RJS A;  2X75 A;  4BAA A;  5F91 A;  2O7D A;  3RRP A;  1U16 A;  4C5R A;  2PFM A;  2O7B A;  1XWO A;  1K62 A;  2YII A;  4NSL A;  1KQ7 A;  1FUP A;  1FUR A;  2PTS A;  3CZO A;  2O78 A;  1DCN A;  1U15 A;  4ADL A;  1B8F A;  3NZ4 A;  4V2R A;  4ADM A;  3UNV A;  1T6J A;  4FLC A;  4C6G A;  2VD6 A;  5D6B A;  1FUO A;  3R6Y A;  1W27 A;  1GKM A;  3R6Q A;  2QGA B;  4V2Q A;  4C5U A;  1AUW A;  3BHG A;  5EYT A;  3GZH A;  4CQ5 A;  3OCE A;  3R6V A;  1FUQ A;  3KDZ A;  2PTQ A;  1C3C A;  1RE5 A;  2NYF A;  1K7W A;  4EFC A;  1GK3 A;  1DOF A;  3TV2 A;  2OHY A;  4FFX A;  3E04 A;  1YFE A;  2PTR A;  1I0A A;  2HVG A;  1T6P A;  3RD8 A;  3OCF A;  5F92 A;  5HW2 A;  3NO9 A;  2O6Y A;  3QBP A;  5EYV A;  1YIS A;  3C8T A;  4MX2 A;  1TJU A;  1C3U A;  2QVE A;  1Y2M A;  2FUS A;  1TJV A;  2J91 A;  1Q5N A;  1J3U A;  4EEI A;  2O7E A;  1VDK A;  4HGV A;  4APA A;  1JSW A;  1GK2 A; 
#chains in the Genus database with same CATH topology
 2VK9 A;  1HY1 A;  1TJ7 A;  4NLE A;  2MP0 A;  2N3E A;  4C5S A;  1I50 A;  2X0O A;  1TJW A;  3KDY A;  1YFM A;  4APB A;  1YNJ D;  3GTD A;  1GKJ A;  1EB4 A;  1ZYR D;  2VUM A;  2NYN A;  1I3Q A;  4BAB A;  1TWC A;  2JA7 A;  1XL7 A;  3LR8 A;  2O7F A;  2E2I A;  2RJR A;  2VSF A;  1HY0 A;  3CQZ A;  2HWG A;  2E9F A;  4WNL A;  2K3O A;  2LPI A;  2RJS A;  2HRO A;  2R7Z A;  2X75 A;  5M0I A;  3FKI A;  5H8W A;  1YNN D;  1TWF A;  4BAA A;  2A6E D;  5F91 A;  2O7D A;  2X0P A;  3RRP A;  1U16 A;  4C5R A;  2A68 D;  2PFM A;  2O7B A;  1XWO A;  1Y1V A;  1K62 A;  2YII A;  1EZA A;  4C2M A;  4NSL A;  1KQ7 A;  2EZC A;  3GTP A;  1FUP A;  1FUR A;  2A69 D;  3EZA A;  2BE5 D;  3U4Q A;  2PTS A;  4A15 A;  3CZO A;  1IW7 D;  2O78 A;  4FBS A;  1DCN A;  1U15 A;  1WCM A;  2A6H D;  4ADL A;  3GTG A;  2NVY A;  3LR2 A;  2B63 A;  2FIP A;  4CEI A;  1B8F A;  3NZ4 A;  2E2H A;  2FEN A;  2EZA A;  4V2R A;  4ADM A;  1Y1W A;  1T6J A;  2JA6 A;  4FLC A;  3UNV A;  2NVX A;  2K3Q A;  4C6G A;  1TWA A;  2VD6 A;  5D6B A;  1FUO A;  2LYI A;  3R6Y A;  1EZB A;  1W27 A;  1SMY D;  1GKM A;  3R6Q A;  2VL7 A;  2QGA B;  4V2Q A;  4C5U A;  3GTK A;  2EZB A;  5M0J A;  1AUW A;  5IZ2 A;  1XMC A;  3BHG A;  3GTQ A;  5EYT A;  3GZH A;  4QIW A;  2LKM B;  4CQ5 A;  1TWG A;  1HQM D;  3OCE A;  3R6V A;  2FEL A;  4CEH A;  4CEJ A;  2MX8 A;  2FIO A;  1FUQ A;  3KDZ A;  2CW0 D;  2R93 A;  2PTQ A;  3GTO A;  1C3C A;  1RE5 A;  2NYF A;  1XLY A;  1K7W A;  4EFC A;  1GK3 A;  3LRD A;  2LTH A;  1DOF A;  3TV2 A;  2AQL A;  2O5J D;  2OHY A;  4FFX A;  3E04 A;  2MQA A;  1YFE A;  2PTR A;  3EZB A;  1I0A A;  1T6P A;  2HVG A;  3RD8 A;  1XMD A;  3OCF A;  2K3N A;  5F92 A;  5HW2 A;  1XL8 A;  3NO9 A;  1SFO A;  1TWH A;  3EZE A;  2JA5 A;  2O6Y A;  3QBP A;  1ZYM A;  2Y0N A;  3GTJ A;  3CRW 1;  3LR6 A;  2MX9 A;  5EYV A;  1YIS A;  3C8T A;  4MX2 A;  3GTM A;  1TJU A;  1K83 A;  1C3U A;  3CRV A;  2QVE A;  1JSW A;  2LPJ A;  2YU9 A;  1Y2M A;  2FUS A;  1TJV A;  2J91 A;  3H0G A;  2R92 A;  2F5J A;  1Q5N A;  1J3U A;  2X0Q A;  4EEI A;  1R9T A;  3GTL A;  1VDK A;  2O7E A;  4HGV A;  4APA A;  2N1D B;  3U44 A;  1I6V D;  1GK2 A; 
#chains in the Genus database with same CATH homology
 1HY1 A;  1TJ7 A;  4NLE A;  4C5S A;  1TJW A;  3KDY A;  1YFM A;  4APB A;  3GTD A;  1GKJ A;  1EB4 A;  2NYN A;  4BAB A;  2O7F A;  2RJR A;  1HY0 A;  2E9F A;  2RJS A;  2X75 A;  4BAA A;  5F91 A;  2O7D A;  3RRP A;  1U16 A;  4C5R A;  2PFM A;  2O7B A;  1XWO A;  1K62 A;  2YII A;  4NSL A;  1KQ7 A;  1FUP A;  1FUR A;  2PTS A;  3CZO A;  2O78 A;  1DCN A;  1U15 A;  4ADL A;  1B8F A;  3NZ4 A;  4V2R A;  4ADM A;  3UNV A;  1T6J A;  4FLC A;  4C6G A;  2VD6 A;  5D6B A;  1FUO A;  3R6Y A;  1W27 A;  1GKM A;  3R6Q A;  2QGA B;  4V2Q A;  4C5U A;  1AUW A;  3BHG A;  5EYT A;  3GZH A;  4CQ5 A;  3OCE A;  3R6V A;  1FUQ A;  3KDZ A;  2PTQ A;  1C3C A;  1RE5 A;  2NYF A;  1K7W A;  4EFC A;  1GK3 A;  1DOF A;  3TV2 A;  2OHY A;  4FFX A;  3E04 A;  1YFE A;  2PTR A;  1I0A A;  2HVG A;  1T6P A;  3RD8 A;  3OCF A;  5F92 A;  5HW2 A;  3NO9 A;  2O6Y A;  3QBP A;  5EYV A;  1YIS A;  3C8T A;  4MX2 A;  1TJU A;  1C3U A;  2QVE A;  1Y2M A;  2FUS A;  1TJV A;  2J91 A;  1Q5N A;  1J3U A;  4EEI A;  2O7E A;  1VDK A;  4HGV A;  4APA A;  1JSW A;  1GK2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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