4CHBA

Crystal structure of the human klhl2 kelch domain in complex with a wnk4 peptide
Total Genus 66
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
66
sequence length
286
structure length
286
Chain Sequence
PKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDVASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural and Biochemical Characterisation of the Klhl3-Wnk Kinase Interaction Important in Blood Pressure Regulation.
pubmed doi rcsb
molecule tags Signaling protein/transferase
source organism Homo sapiens
molecule keywords KELCH-LIKE PROTEIN 2
total genus 66
structure length 286
sequence length 286
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01344 Kelch_1 Kelch motif
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.120.10.80 Mainly Beta 6 Propeller Neuraminidase Kelch-type beta propeller 4chbA00
2VPJA 2ZZKA 2ZW9A 5FZJA 5CGJA 3WDZA 3ZGCA 2WOZA 3VNGA 5FNTA 5FNUA 4L7DA 5FNQA 1X2RA 2FLUX 4IN4A 5FNRA 5FZNA 4CHBA 4CH9A 3ADEA 4N1BA 3WN7A 3II7A 2ZWAA 3ZGDA 2Z32A 4ZGCA 3VNHA 2DYHA 4L7CA 4IQKA 5F72C 4ASCA 4ZY3A 4IFLX 1X2JA 1U6DX 4L7BA 4YY8A 4XMBA 5FNSA 2XN4A 1ZGKA 4IFJA 4IFNX
chains in the Genus database with same CATH superfamily
5EO7A 1MS4A 5D9BA 4C1YB 4YW2A 2QWKA 5HUMA 1NMBN 3SALA 4CSDA 1OFZA 2QWAA 1F8DA 1Z4VA 5GX1A 4KS3A 1E8TA 2F27A 4IMBA 1MWEA 4CHBA 1EUUA 1INHA 3H72A 2CMLA 2HT5A 4FZHA 4FOQA 1RWLA 3LI4A 2QWDA 4WA5A 4L7CA 4MWLA 1W8OA 4QN3A 2W20A 3SANA 1SO7A 2VSMA 2VVZA 2QWJA 1SLLA 2XZJA 2HQSA 4FPOB 3SOVA 2YDPA 2ZZKA 3ZGCA 4K1KA 1IJQA 3K39A 1NSDA 1XOGA 2W8BB 2V91A 2YA7A 4D8SA 4O5TA 1W0OA 4XJ8A 3K36A 4GZXA 4MZEA 1NMAN 2FLUX 4KS4A 1S18A 2HT8A 2IARA 3O9KA 4GDJA 2F11A 1IUCA 4GN9A 3SOQA 1INFA 1IVDA 3B7EA 4XMAA 4DGRA 1X2JA 4MWQA 2F29A 1NSCA 4GDIA 2XZIA 1V2IA 4H52A 6NN9A 1DIMA 3NN9A 1V04A 2F24A 2F13A 4FQ4A 3CYEA 4GZPA 1CVMA 1NCDN 2VK5A 4MWYA 3E5ZA 4GZOA 5FNRA 1V3CA 1IVFA 3WN7A 4ZGCA 4AGIA 1SUUA 3IAXA 1IUBA 4IFLX 3SLIA 1SNTA 3FW0A 1A4QA 4G3NA 2XN4A 3TI5A 1Z4WA 4GNBA 1H6LA 2ZW9A 5F9TA 2YA8A 3O4PA 4XIKA 3CL0A 4HZXA 4XJWA 4B7JA 3H73A 2DG0A 4MJVA 2GVXA 5HUNA 1Z4ZA 1USRA 1WCSA 2HTVA 3V64C 3SREA 1C5KA 1NPEA 5GX2A 4MWVA 3A72A 3ADEA 4NC5A 4D4UA 1PJXA 2B8HA 2HTQA 4FPKA 2SLIA 1S1DA 1E8UA 3WW9A 4DG6A 4FP3A 4MZAA 5FNSA 3HLIA 1N1YA 2X9MA 4D52C 7NN9A 2VPJA 5D9DA 5FZJA 5CGJA 4XMIA 3TIAA 2FHRA 1F8CA 2C4AA 5GX3A 5HUKA 2IAVA 1MS1A 4FPLA 4K1JA 4YW4A 2HTYA 2YA5A 2Z32A 1NCCN 3VNHA 4A0PA 2XZKA 4ASCA 1Z4XA 2QE8A 1V3BA 2HTWA 2HU4A 1V3EA 4HZWA 1WCQA 1F8EA 4X49A 1E1AA 3A71A 3VNGA 3ALWA 2F10A 1N7DA 3NO0A 4O5SA 5EO8A 2GVWA 4QN7A 5M1ZA 4ZLRA 4L7BA 1MS0A 4YZ4A 1VCUA 1ZGKA 4GZSA 1W8NA 4HW6A 3V1SA 1NNCA 1N6EA 3CKZA 4CPYA 4GZQA 4AHAA 4MWJA 4JMLA 1S0IA 2WOZA 5GX4A 1C9UA 4GB1A 4MWWA 2SIMA 1QLGA 4FPHA 3I1CA 1SLIA 5B2DA 5JYYA 5FWWA 4HZVA 4NCSA 4R40A 4YZ2A 3TI4A 3GVLA 4GN8A 1N1TA 3TICA 2OJHA 4GNAA 2VW2A 3JU4A 4FPJA 5GTQA 4YW5A 4JF7A 4FPEA 1USXA 4AH4A 1CRUA 4Q6KA 2FPBA 3K3AA 1EUSA 4YW1A 4QNPA 1X2RA 5HUGA 4CH9A 2BF6A 4N1BA 4SLIA 4K3YA 2F26A 4UF7A 3ZGDA 3G4HA 1V3DA 4CPMA 1A4GA 4XHXA 1NCAN 1B9SA 3B69A 1L7FA 3D12A 1ZI0A 2ZB6A 3FVZA 4XJAA 2W5OA 1KITA 2SILA 3P5BL 4B7QA 2XCYA 3DASA 2W38A 2QWCA 5FNTA 5FNUA 5D9CA 1QBIA 3Q6TA 4FPCA 2VAQA 2VW0A 1B9TA 5NN9A 3G4EA 3II7A 2ZWAA 3GVJA 4Q1UA 2IVZA 3TI3A 4IQKA 1INVA 2QWFA 1NCBN 4XJUA 4YY8A 4NN9A 4XOGA 1L7GA 3W09A 5HX0A 1RWIA 1W1XA 2IAXA 2VK7A 2JKBA 3KYAA 1IVCA 1L7HA 3DR2A 2QWEA 4XJQA 2QWHA 4FPFA 3WDZA 1IVGA 2IATA 3HRPA 4B7MA 1A14N 2IAPA 5B2CA 1Q7FA 1MR5A 4KS1A 1N6FA 4D52A 1WP5A 1E8VA 1MS9A 4MWUA 4XJZA 3S8ZA 2VSKA 1EUTA 3U0SA 1DILA 2VWDA 1MS8A 4XHBA 4HZZA 1U6DX 1NSBA 4YZ5A 5H47A 3TC9A 2IASA 4FOWA 5EX7A 4J9TA 4HHOA 4IFNX 2FP8A 4FJ6A 1MS3A 3SILA 2H2UA 2F25A 3NSSA 2H2NA 3Q6KA 1CRZA 4HHQA 4HZYA 2HT7A 2W8BA 4MJUA 4M4NA 3SRGA 4L7DA 3INBA 4CPNA 1Z50A 1F8BA 3CL2A 4GNCA 2VW1A 4UOUA 1BJIA 4QN6A 2DG1A 4ZY3A 3ALXA 2W5NA 4YZ3A 1NMCA 2QWIA 1N1SA 2P4OA 4XJRA 1VCJA 4PWZA 4X47A 1V0EA 1Z4YA 2A75A 2ISMA 4XE9A 4M3MA 3H6JA 4D52B 1B9VA 4YW3A 3OPZA 1MS5A 3TI8A 2QWGA 2IAWA 2F12A 4WEFA 2IAOA 5F72C 3LI5A 4XJ9A 3S2KA 4GJTA 2GVUA 1W21A 4YZ1A 4IFJA 3A9GA 4B7RA 1N1VA 4AGTA 1V0FA 2ZB5A 4FVKA 4FP2A 3S8VA 4XYXA 4GZWA 4XILA 2AH2A 3AMRA 2DSOA 2F0ZA 4IN4A 2AEPA 2YA6A 4MWRA 3SOBB 1POOA 2G8SA 2YDTA 1MZ6A 4FPGA 2DYHA 3BEQA 4FPYA 2POOA 4B7NA 2C4LA 4XIOA 3HLHA 3GVKA 4QN4A 3PJQA 4WEGA 3H71A 1NNAA 2HTRA 1V0ZA 4FOYA 3KGGA 3V65B 4GN7A 2YA4A 3TI6A 3UC1A 4H53A 4IYGA 2HTUA 4GZTA 4KS2A 2QWBA 3WWAA 4MC7A 5GX5A 2VK6A 2GHSA 4XMBA 4BBWA 1INWA 1NN2A 3AMSA 3S94A 4MWXA 4MX0A 1IVEA 1W0PA 4C1YA 4KS5A 3LI3A 4K1IA 4WA4A 2RKCA 5FNQA 1CQ1A 5FZNA 3L6VA 3K38A 2AGSA 4X6KA 3A9HA 1S0JA 3BYCA 2BERA 2BATA 4CPLA 1EURA 3O9JA 1W20A 4M4VA 2IAUA 2IAQA 1INYA 4WA3A 4I00A 2BZDA 3K37A 4X4AA 2AEQA 1INGA 4M4UA 4GEZA 4CPOA 1MZ5A 1NNBA 1K32A 4HIZA 1N6DA 3D11A 2F28A 3T1EA 3TIBA 4CPZA 4QN5A 3Q6PA 4K1HA 2GVVA 1INXA 2FPCA 4FOVA 1IVBA 2FP9A 1XOEA 2HU0A
chains in the Genus database with same CATH topology
2VPJA 2ZZKA 2ZW9A 5FZJA 5CGJA 3WDZA 3ZGCA 2WOZA 3VNGA 5FNTA 5FNUA 4L7DA 5FNQA 1X2RA 2FLUX 4IN4A 5FNRA 5FZNA 4CHBA 4CH9A 3ADEA 4N1BA 3WN7A 3II7A 2ZWAA 3ZGDA 2Z32A 4ZGCA 3VNHA 2DYHA 4L7CA 4IQKA 5F72C 4ASCA 4ZY3A 4IFLX 1X2JA 1U6DX 4L7BA 4YY8A 4XMBA 5FNSA 2XN4A 1ZGKA 4IFJA 4IFNX
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VPJ A;  2ZZK A;  2ZW9 A;  5FZJ A;  5CGJ A;  3WDZ A;  3ZGC A;  2WOZ A;  3VNG A;  5FNT A;  5FNU A;  4L7D A;  5FNQ A;  1X2R A;  2FLU X;  4IN4 A;  5FNR A;  5FZN A;  4CHB A;  4CH9 A;  3ADE A;  4N1B A;  3WN7 A;  3II7 A;  2ZWA A;  3ZGD A;  2Z32 A;  4ZGC A;  3VNH A;  2DYH A;  4L7C A;  4IQK A;  5F72 C;  4ASC A;  4ZY3 A;  4IFL X;  1X2J A;  1U6D X;  4L7B A;  4YY8 A;  4XMB A;  5FNS A;  2XN4 A;  1ZGK A;  4IFJ A;  4IFN X; 
#chains in the Genus database with same CATH topology
 5EO7 A;  1MS4 A;  5D9B A;  4C1Y B;  4YW2 A;  2QWK A;  5HUM A;  1NMB N;  3SAL A;  4CSD A;  1OFZ A;  2QWA A;  1F8D A;  1Z4V A;  5GX1 A;  4KS3 A;  1E8T A;  2F27 A;  4IMB A;  1MWE A;  4CHB A;  1EUU A;  1INH A;  3H72 A;  2CML A;  2HT5 A;  4FZH A;  4FOQ A;  1RWL A;  3LI4 A;  2QWD A;  4WA5 A;  4L7C A;  4MWL A;  1W8O A;  4QN3 A;  2W20 A;  3SAN A;  1SO7 A;  2VSM A;  2VVZ A;  2QWJ A;  1SLL A;  2XZJ A;  2HQS A;  4FPO B;  3SOV A;  2YDP A;  2ZZK A;  3ZGC A;  4K1K A;  1IJQ A;  3K39 A;  1NSD A;  1XOG A;  2W8B B;  2V91 A;  2YA7 A;  4D8S A;  4O5T A;  1W0O A;  4XJ8 A;  3K36 A;  4GZX A;  4MZE A;  1NMA N;  2FLU X;  4KS4 A;  1S18 A;  2HT8 A;  2IAR A;  3O9K A;  4GDJ A;  2F11 A;  1IUC A;  4GN9 A;  3SOQ A;  1INF A;  1IVD A;  3B7E A;  4XMA A;  4DGR A;  1X2J A;  4MWQ A;  2F29 A;  1NSC A;  4GDI A;  2XZI A;  1V2I A;  4H52 A;  6NN9 A;  1DIM A;  3NN9 A;  1V04 A;  2F24 A;  2F13 A;  4FQ4 A;  3CYE A;  4GZP A;  1CVM A;  1NCD N;  2VK5 A;  4MWY A;  3E5Z A;  4GZO A;  5FNR A;  1V3C A;  1IVF A;  3WN7 A;  4ZGC A;  4AGI A;  1SUU A;  3IAX A;  1IUB A;  4IFL X;  3SLI A;  1SNT A;  3FW0 A;  1A4Q A;  4G3N A;  2XN4 A;  3TI5 A;  1Z4W A;  4GNB A;  1H6L A;  2ZW9 A;  5F9T A;  2YA8 A;  3O4P A;  4XIK A;  3CL0 A;  4HZX A;  4XJW A;  4B7J A;  3H73 A;  2DG0 A;  4MJV A;  2GVX A;  5HUN A;  1Z4Z A;  1USR A;  1WCS A;  2HTV A;  3V64 C;  3SRE A;  1C5K A;  1NPE A;  5GX2 A;  4MWV A;  3A72 A;  3ADE A;  4NC5 A;  4D4U A;  1PJX A;  2B8H A;  2HTQ A;  4FPK A;  2SLI A;  1S1D A;  1E8U A;  3WW9 A;  4DG6 A;  4FP3 A;  4MZA A;  5FNS A;  3HLI A;  1N1Y A;  2X9M A;  4D52 C;  7NN9 A;  2VPJ A;  5D9D A;  5FZJ A;  5CGJ A;  4XMI A;  3TIA A;  2FHR A;  1F8C A;  2C4A A;  5GX3 A;  5HUK A;  2IAV A;  1MS1 A;  4FPL A;  4K1J A;  4YW4 A;  2HTY A;  2YA5 A;  2Z32 A;  1NCC N;  3VNH A;  4A0P A;  2XZK A;  4ASC A;  1Z4X A;  2QE8 A;  1V3B A;  2HTW A;  2HU4 A;  1V3E A;  4HZW A;  1WCQ A;  1F8E A;  4X49 A;  1E1A A;  3A71 A;  3VNG A;  3ALW A;  2F10 A;  1N7D A;  3NO0 A;  4O5S A;  5EO8 A;  2GVW A;  4QN7 A;  5M1Z A;  4ZLR A;  4L7B A;  1MS0 A;  4YZ4 A;  1VCU A;  1ZGK A;  4GZS A;  1W8N A;  4HW6 A;  3V1S A;  1NNC A;  1N6E A;  3CKZ A;  4CPY A;  4GZQ A;  4AHA A;  4MWJ A;  4JML A;  1S0I A;  2WOZ A;  5GX4 A;  1C9U A;  4GB1 A;  4MWW A;  2SIM A;  1QLG A;  4FPH A;  3I1C A;  1SLI A;  5B2D A;  5JYY A;  5FWW A;  4HZV A;  4NCS A;  4R40 A;  4YZ2 A;  3TI4 A;  3GVL A;  4GN8 A;  1N1T A;  3TIC A;  2OJH A;  4GNA A;  2VW2 A;  3JU4 A;  4FPJ A;  5GTQ A;  4YW5 A;  4JF7 A;  4FPE A;  1USX A;  4AH4 A;  1CRU A;  4Q6K A;  2FPB A;  3K3A A;  1EUS A;  4YW1 A;  4QNP A;  1X2R A;  5HUG A;  4CH9 A;  2BF6 A;  4N1B A;  4SLI A;  4K3Y A;  2F26 A;  4UF7 A;  3ZGD A;  3G4H A;  1V3D A;  4CPM A;  1A4G A;  4XHX A;  1NCA N;  1B9S A;  3B69 A;  1L7F A;  3D12 A;  1ZI0 A;  2ZB6 A;  3FVZ A;  4XJA A;  2W5O A;  1KIT A;  2SIL A;  3P5B L;  4B7Q A;  2XCY A;  3DAS A;  2W38 A;  2QWC A;  5FNT A;  5FNU A;  5D9C A;  1QBI A;  3Q6T A;  4FPC A;  2VAQ A;  2VW0 A;  1B9T A;  5NN9 A;  3G4E A;  3II7 A;  2ZWA A;  3GVJ A;  4Q1U A;  2IVZ A;  3TI3 A;  4IQK A;  1INV A;  2QWF A;  1NCB N;  4XJU A;  4YY8 A;  4NN9 A;  4XOG A;  1L7G A;  3W09 A;  5HX0 A;  1RWI A;  1W1X A;  2IAX A;  2VK7 A;  2JKB A;  3KYA A;  1IVC A;  1L7H A;  3DR2 A;  2QWE A;  4XJQ A;  2QWH A;  4FPF A;  3WDZ A;  1IVG A;  2IAT A;  3HRP A;  4B7M A;  1A14 N;  2IAP A;  5B2C A;  1Q7F A;  1MR5 A;  4KS1 A;  1N6F A;  4D52 A;  1WP5 A;  1E8V A;  1MS9 A;  4MWU A;  4XJZ A;  3S8Z A;  2VSK A;  1EUT A;  3U0S A;  1DIL A;  2VWD A;  1MS8 A;  4XHB A;  4HZZ A;  1U6D X;  1NSB A;  4YZ5 A;  5H47 A;  3TC9 A;  2IAS A;  4FOW A;  5EX7 A;  4J9T A;  4HHO A;  4IFN X;  2FP8 A;  4FJ6 A;  1MS3 A;  3SIL A;  2H2U A;  2F25 A;  3NSS A;  2H2N A;  3Q6K A;  1CRZ A;  4HHQ A;  4HZY A;  2HT7 A;  2W8B A;  4MJU A;  4M4N A;  3SRG A;  4L7D A;  3INB A;  4CPN A;  1Z50 A;  1F8B A;  3CL2 A;  4GNC A;  2VW1 A;  4UOU A;  1BJI A;  4QN6 A;  2DG1 A;  4ZY3 A;  3ALX A;  2W5N A;  4YZ3 A;  1NMC A;  2QWI A;  1N1S A;  2P4O A;  4XJR A;  1VCJ A;  4PWZ A;  4X47 A;  1V0E A;  1Z4Y A;  2A75 A;  2ISM A;  4XE9 A;  4M3M A;  3H6J A;  4D52 B;  1B9V A;  4YW3 A;  3OPZ A;  1MS5 A;  3TI8 A;  2QWG A;  2IAW A;  2F12 A;  4WEF A;  2IAO A;  5F72 C;  3LI5 A;  4XJ9 A;  3S2K A;  4GJT A;  2GVU A;  1W21 A;  4YZ1 A;  4IFJ A;  3A9G A;  4B7R A;  1N1V A;  4AGT A;  1V0F A;  2ZB5 A;  4FVK A;  4FP2 A;  3S8V A;  4XYX A;  4GZW A;  4XIL A;  2AH2 A;  3AMR A;  2DSO A;  2F0Z A;  4IN4 A;  2AEP A;  2YA6 A;  4MWR A;  3SOB B;  1POO A;  2G8S A;  2YDT A;  1MZ6 A;  4FPG A;  2DYH A;  3BEQ A;  4FPY A;  2POO A;  4B7N A;  2C4L A;  4XIO A;  3HLH A;  3GVK A;  4QN4 A;  3PJQ A;  4WEG A;  3H71 A;  1NNA A;  2HTR A;  1V0Z A;  4FOY A;  3KGG A;  3V65 B;  4GN7 A;  2YA4 A;  3TI6 A;  3UC1 A;  4H53 A;  4IYG A;  2HTU A;  4GZT A;  4KS2 A;  2QWB A;  3WWA A;  4MC7 A;  5GX5 A;  2VK6 A;  2GHS A;  4XMB A;  4BBW A;  1INW A;  1NN2 A;  3AMS A;  3S94 A;  4MWX A;  4MX0 A;  1IVE A;  1W0P A;  4C1Y A;  4KS5 A;  3LI3 A;  4K1I A;  4WA4 A;  2RKC A;  5FNQ A;  1CQ1 A;  5FZN A;  3L6V A;  3K38 A;  2AGS A;  4X6K A;  3A9H A;  1S0J A;  3BYC A;  2BER A;  2BAT A;  4CPL A;  1EUR A;  3O9J A;  1W20 A;  4M4V A;  2IAU A;  2IAQ A;  1INY A;  4WA3 A;  4I00 A;  2BZD A;  3K37 A;  4X4A A;  2AEQ A;  1ING A;  4M4U A;  4GEZ A;  4CPO A;  1MZ5 A;  1NNB A;  1K32 A;  4HIZ A;  1N6D A;  3D11 A;  2F28 A;  3T1E A;  3TIB A;  4CPZ A;  4QN5 A;  3Q6P A;  4K1H A;  2GVV A;  1INX A;  2FPC A;  4FOV A;  1IVB A;  2FP9 A;  1XOE A;  2HU0 A; 
#chains in the Genus database with same CATH homology
 2VPJ A;  2ZZK A;  2ZW9 A;  5FZJ A;  5CGJ A;  3WDZ A;  3ZGC A;  2WOZ A;  3VNG A;  5FNT A;  5FNU A;  4L7D A;  5FNQ A;  1X2R A;  2FLU X;  4IN4 A;  5FNR A;  5FZN A;  4CHB A;  4CH9 A;  3ADE A;  4N1B A;  3WN7 A;  3II7 A;  2ZWA A;  3ZGD A;  2Z32 A;  4ZGC A;  3VNH A;  2DYH A;  4L7C A;  4IQK A;  5F72 C;  4ASC A;  4ZY3 A;  4IFL X;  1X2J A;  1U6D X;  4L7B A;  4YY8 A;  4XMB A;  5FNS A;  2XN4 A;  1ZGK A;  4IFJ A;  4IFN X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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