The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
104
|
sequence length |
297
|
structure length |
297
|
Chain Sequence |
MPEAVVIDGRAVAKAIQKELTEEVALLERRYKGRRPGLSTIICGKRKDSQTYVRLKRKAAAACGFRNFSVELPANVTQEALEREVIRLNEEEACHSIVVQLPLPPHIDKVAALSKIKPEKDADCLLPVNVGQLHIRERNPAIVPCTASAVMELLRCSGVEICGKRVVVLGRGDIAGLPVATLLANEDATVTVVHSATPLCDIADIVRASDIVVSAAGQPGLVRGEWIKLGAAVIDVGTTPVADPSKVPGYRLVGDVCFDVARKRAAYITPVPGGVGPVTVSMLLKNTLTMFKRSVRA
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
publication title |
Characterization of 2,4-Diamino-6-Oxo-1,6-Dihydropyrimidin-5-Yl Ureido Based Inhibitors of Trypanosoma Brucei Fold and Testing for Antiparasitic Activity.
pubmed doi rcsb |
molecule keywords |
C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC, PUTATIVE
|
molecule tags |
Oxidoreductase
|
source organism |
Trypanosoma brucei brucei strain 927/4 gutat10.1
|
total genus |
104
|
structure length |
297
|
sequence length |
297
|
chains with identical sequence |
B
|
ec nomenclature |
ec
1.5.1.5: Methylenetetrahydrofolate dehydrogenase (NADP(+)). |
pdb deposition date | 2013-12-23 |
chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
---|---|---|---|
A | PF00763 | THF_DHG_CYH | Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain |
A | PF02882 | THF_DHG_CYH_C | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain |
cath code
| Class | Architecture | Topology | Homology | Domain |
---|---|---|---|---|---|
Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain | ||
Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | Leucine Dehydrogenase, chain A, domain 1 |