4CLAA

Alternative binding modes for chloramphenicol and 1-substituted chloramphenicol analogues revealed by site-directed mutagenesis and x-ray crystallography of chloramphenicol acetyltransferase
Total Genus 58
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
58
sequence length
213
structure length
213
Chain Sequence
MNYTKFDVKNWVRREHFEFYRHRLPCGFSLTSKIDITTLKKSLDDSAYKFYPVMIYLIAQAVNQFDELRMAIKDDELIVWDSVDPQFTVFHQETETFSALSCPYSSDIDQFMVNYLSVMERYKSDTKLFPQGVTPENHLNISALPWVNFDSFNFNVANFTDYFAPIITMAKYQQEGDRLLLPLSVQVHHAVCDGFHVARFINRLQELCNSKLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Alternative binding modes for chloramphenicol and 1-substituted chloramphenicol analogues revealed by site-directed mutagenesis and X-ray crystallography of chloramphenicol acetyltransferase.
pubmed doi rcsb
molecule tags Transferase (acyltransferase)
source organism Escherichia coli
molecule keywords TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE
total genus 58
structure length 213
sequence length 213
ec nomenclature ec 2.3.1.28: Chloramphenicol O-acetyltransferase.
pdb deposition date 1990-10-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00302 CAT Chloramphenicol acetyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.10 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol acetyltransferase-like domain 4claA00
1EAAA 2CLAA 3FOTA 1DPDA 1L5AA 5KJVA 5DUAA 1C4TA 1E2OA 1EADA 1XMDA 4G22A 5DU9A 1EABA 1DPBA 2E1UA 4JN3A 1XL8A 1XL7A 1XMCA 3MAEA 5KJUA 4KE4A 1NOCB 1QCAA 2RKTA 1EACA 5FANA 3U9FA 5KJTA 1Q9JA 2JGPA 3U9BA 5FALA 5KJSA 2II4A 4HVMA 2E1TA 4CLAA 3B30A 2RKVA 2I9DA 2ZBAA 2VSQA 1EAFA 2E1VA 1DPCA 4G2MA 3FP0A 1Q23A 1SCZA 1CLAA 2IHWA 2II3A 5T3EA 4N72A 1PD5A 3CLAA 1EAEA 2BGHA 4G0BA 4JN5A 4KECA 5KJWA 3B2SA 1CIAA 2XR7A 2II5A 2XHGA 3L60A
chains in the Genus database with same CATH superfamily
2E1UA 1XL8A 1XMCA 3MAEA 4KE4A 1NOCB 3U9FA 2FYOA 1Q9JA 2JGPA 3U9BA 3B30A 2I9DA 2H4TA 4EPHA 2RCUA 2E1VA 2H3PA 3FP0A 2FW3A 1T1UA 4KECA 2FY2A 2H3UA 1NDFA 4EYWA 1C4TA 1E2OA 1EADA 1QCAA 1EACA 5KJSA 1NDBA 1DPCA 1SCZA 2II3A 4N72A 3CLAA 1EAEA 2BGHA 4G0BA 3B2SA 3L60A 5KJTA 3FOTA 1L5AA 1S5OA 5DUAA 5KJVA 1XMDA 4G22A 5DU9A 4JN3A 5KJUA 2FY4A 1T7NA 2II4A 2E1TA 4CLAA 4EP9A 1T7QA 4G2MA 2FY3A 1PD5A 1CIAA 2II5A 2H3WA 1EAAA 2CLAA 1NM8A 1DPDA 1T7OA 1EABA 1DPBA 1XL7A 5FANA 2RKTA 2DEBA 5FALA 4HVMA 1NDIA 2RKVA 2ZBAA 2VSQA 2FY5A 1EAFA 1Q23A 1CLAA 2IHWA 5T3EA 4JN5A 1Q6XA 5KJWA 2XR7A 2XHGA
chains in the Genus database with same CATH topology
1EAAA 2CLAA 3FOTA 1DPDA 1L5AA 5KJVA 5DUAA 1C4TA 1E2OA 1EADA 1XMDA 4G22A 5DU9A 1EABA 1DPBA 2E1UA 4JN3A 1XL8A 1XL7A 1XMCA 3MAEA 5KJUA 4KE4A 1NOCB 1QCAA 2RKTA 1EACA 5FANA 3U9FA 5KJTA 1Q9JA 2JGPA 3U9BA 5FALA 5KJSA 2II4A 4HVMA 2E1TA 4CLAA 3B30A 2RKVA 2I9DA 2ZBAA 2VSQA 1EAFA 2E1VA 1DPCA 4G2MA 3FP0A 1Q23A 1SCZA 1CLAA 2IHWA 2II3A 5T3EA 4N72A 1PD5A 3CLAA 1EAEA 2BGHA 4G0BA 4JN5A 4KECA 5KJWA 3B2SA 1CIAA 2XR7A 2II5A 2XHGA 3L60A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1EAA A;  2CLA A;  3FOT A;  1DPD A;  1L5A A;  5KJV A;  5DUA A;  1C4T A;  1E2O A;  1EAD A;  1XMD A;  4G22 A;  5DU9 A;  1EAB A;  1DPB A;  2E1U A;  4JN3 A;  1XL8 A;  1XL7 A;  1XMC A;  3MAE A;  5KJU A;  4KE4 A;  1NOC B;  1QCA A;  2RKT A;  1EAC A;  5FAN A;  3U9F A;  5KJT A;  1Q9J A;  2JGP A;  3U9B A;  5FAL A;  5KJS A;  2II4 A;  4HVM A;  2E1T A;  4CLA A;  3B30 A;  2RKV A;  2I9D A;  2ZBA A;  2VSQ A;  1EAF A;  2E1V A;  1DPC A;  4G2M A;  3FP0 A;  1Q23 A;  1SCZ A;  1CLA A;  2IHW A;  2II3 A;  5T3E A;  4N72 A;  1PD5 A;  3CLA A;  1EAE A;  2BGH A;  4G0B A;  4JN5 A;  4KEC A;  5KJW A;  3B2S A;  1CIA A;  2XR7 A;  2II5 A;  2XHG A;  3L60 A; 
#chains in the Genus database with same CATH topology
 2E1U A;  1XL8 A;  1XMC A;  3MAE A;  4KE4 A;  1NOC B;  3U9F A;  2FYO A;  1Q9J A;  2JGP A;  3U9B A;  3B30 A;  2I9D A;  2H4T A;  4EPH A;  2RCU A;  2E1V A;  2H3P A;  3FP0 A;  2FW3 A;  1T1U A;  4KEC A;  2FY2 A;  2H3U A;  1NDF A;  4EYW A;  1C4T A;  1E2O A;  1EAD A;  1QCA A;  1EAC A;  5KJS A;  1NDB A;  1DPC A;  1SCZ A;  2II3 A;  4N72 A;  3CLA A;  1EAE A;  2BGH A;  4G0B A;  3B2S A;  3L60 A;  5KJT A;  3FOT A;  1L5A A;  1S5O A;  5DUA A;  5KJV A;  1XMD A;  4G22 A;  5DU9 A;  4JN3 A;  5KJU A;  2FY4 A;  1T7N A;  2II4 A;  2E1T A;  4CLA A;  4EP9 A;  1T7Q A;  4G2M A;  2FY3 A;  1PD5 A;  1CIA A;  2II5 A;  2H3W A;  1EAA A;  2CLA A;  1NM8 A;  1DPD A;  1T7O A;  1EAB A;  1DPB A;  1XL7 A;  5FAN A;  2RKT A;  2DEB A;  5FAL A;  4HVM A;  1NDI A;  2RKV A;  2ZBA A;  2VSQ A;  2FY5 A;  1EAF A;  1Q23 A;  1CLA A;  2IHW A;  5T3E A;  4JN5 A;  1Q6X A;  5KJW A;  2XR7 A;  2XHG A; 
#chains in the Genus database with same CATH homology
 1EAA A;  2CLA A;  3FOT A;  1DPD A;  1L5A A;  5KJV A;  5DUA A;  1C4T A;  1E2O A;  1EAD A;  1XMD A;  4G22 A;  5DU9 A;  1EAB A;  1DPB A;  2E1U A;  4JN3 A;  1XL8 A;  1XL7 A;  1XMC A;  3MAE A;  5KJU A;  4KE4 A;  1NOC B;  1QCA A;  2RKT A;  1EAC A;  5FAN A;  3U9F A;  5KJT A;  1Q9J A;  2JGP A;  3U9B A;  5FAL A;  5KJS A;  2II4 A;  4HVM A;  2E1T A;  4CLA A;  3B30 A;  2RKV A;  2I9D A;  2ZBA A;  2VSQ A;  1EAF A;  2E1V A;  1DPC A;  4G2M A;  3FP0 A;  1Q23 A;  1SCZ A;  1CLA A;  2IHW A;  2II3 A;  5T3E A;  4N72 A;  1PD5 A;  3CLA A;  1EAE A;  2BGH A;  4G0B A;  4JN5 A;  4KEC A;  5KJW A;  3B2S A;  1CIA A;  2XR7 A;  2II5 A;  2XHG A;  3L60 A; 
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