4CU4A

Fhua from e. coli in complex with the lasso peptide microcin j25 (mccj25)
Total Genus 209
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
209
sequence length
706
structure length
693
Chain Sequence
SAWGPAATIAARQSATGTKTDTPIQKVPQSISVVTAEEMALHQPKSVKEALSYTPGVSVGTRGASNTYDHLIIRGFAAEGQSQNNYLNGLKLQGNFYNDAVIDPYMLERAEIMRGPVSVLYGKSSPGGLLNMVSKRPTTEPLKEVQFKAGTDSLFQTGFDFSDSLDDDGVYSYRLTGLARSANAQQKGSEEQRYAIAPAFTWRPDDKTNFTFLSYFQNEPETGYYGWLPKEGTVEPLPNGKRLPTDFNEGAKNNTYSRNEKMVGYSFDHEFNDTFTVRQNLRFAENKTSQNSVYGYGVCSDPANAYSKQCAALAPADKGHYLARKYVVDDEKLQNFSVDTQLQSKFATGDIDHTLLTGVDFMRMRNDINAWFGYDDSVPLLNLYNNTDFDFNAKDPANSGPYRILNKQKQTGVYVQDQAQWDKVLVTLGGRYDWADQESLNRVAGTTDKRDDKQFTWRGGVNYLFDNGVTPYFSYSESFEPSSQVGKDGNIFAPSKGKQYEVGVKYVPEDRPIVVTGAVYNLTKTNNLMADPEGSFFSVEGGEIRARGVEIEAKAALSASVNVVGSYTYTDAEYTTDTTYKGNTPAQVPKHMASLWADYTFFDGPLSGLTLGTGGRYTGSSYGDPANSFKVGSYTVVDALVRYDLARVGMAGSNVALHVNNLFDREYVASCFNTYGCFWGAERQVVATATFRF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Basis for Hijacking Siderophore Receptors by Antimicrobial Lasso Peptides.
pubmed doi rcsb
molecule tags Transport protein/antibiotic
source organism Escherichia coli str. k-12 substr. mg1655
molecule keywords FERRICHROME-IRON RECEPTOR
total genus 209
structure length 693
sequence length 706
ec nomenclature
pdb deposition date 2014-03-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00593 TonB_dep_Rec TonB dependent receptor
A PF07715 Plug TonB-dependent Receptor Plug Domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.170.20 Mainly Beta Beta Barrel Maltoporin; Chain A TonB-dependent receptor, beta-barrel domain 4cu4A02
2.170.130.10 Mainly Beta Beta Complex Ferric Hydroxamate Uptake Protein; Chain A, domain 1 TonB-dependent receptor, plug domain 4cu4A01
3EFMA 3M8DA 4RDRA 1NQFA 1XKHA 1QFFA 4RDTA 1FCPA 2W77A 2IAHA 3RGMA 2FCPA 2W6UA 4B7OA 4CU4A 2W76A 2GRXA 5FOKA 2O5PA 3QLBA 3RGNA 1FEPA 4EPAA 3M8BA 1FI1A 1PO0A 1UJWA 1XKWA 2W75A 2GUFA 1BY5A 1NQHA 3CSNA 2HDFA 2W16A 4AIQA 3V8XA 2HDIA 3CSLA 2GSKA 3V89A 1PO3A 1NQGA 2YSUA 3DDRA 2W6TA 1KMOA 1QFGA 2W78A 1QKCA 1PNZA 1KMPA 3FHHA 1BY3A 1QJQA 4AIPA 1NQEA
chains in the Genus database with same CATH superfamily
1OH2P 1JBIA 3EFMA 3M8DA 4RDRA 1NQFA 1MPRA 1QFFA 1MPOA 1AF6A 1XKHA 4RDTA 1FCPA 2W77A 2IAHA 3RGMA 2FCPA 2W6UA 4B7OA 4CU4A 2W76A 2GRXA 5FOKA 2O5PA 1A0SP 3QLBA 1FEPA 3RGNA 3M8BA 1MPQA 4EPAA 1MPNA 1FI1A 1PO0A 1UJWA 1XKWA 2W75A 2GUFA 1BY5A 1NQHA 3CSNA 2HDFA 2W16A 4AIQA 3V8XA 2HDIA 3CSLA 2GSKA 3V89A 1PO3A 2MPRA 1NQGA 2YSUA 1MALA 3DDRA 2W6TA 1KMOA 1QFGA 2W78A 1MPMA 1QKCA 1PNZA 1KMPA 3FHHA 1BY3A 1A0TP 1QJQA 4AIPA 1OH2Q 1NQEA
chains in the Genus database with same CATH topology
3EFMA 3M8DA 4RDRA 1NQFA 1XKHA 1QFFA 4RDTA 1FCPA 2W77A 2IAHA 3RGMA 2FCPA 2W6UA 4B7OA 4CU4A 2W76A 2GRXA 5FOKA 2O5PA 3QLBA 3RGNA 1FEPA 4EPAA 3M8BA 1FI1A 1PO0A 1UJWA 1XKWA 2W75A 2GUFA 1BY5A 1NQHA 3CSNA 2HDFA 2W16A 4AIQA 3V8XA 2HDIA 3CSLA 2GSKA 3V89A 1PO3A 1NQGA 2YSUA 3DDRA 2W6TA 1KMOA 1QFGA 2W78A 1QKCA 1PNZA 1KMPA 3FHHA 1BY3A 1QJQA 4AIPA 1NQEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3EFM A;  3M8D A;  4RDR A;  1NQF A;  1XKH A;  1QFF A;  4RDT A;  1FCP A;  2W77 A;  2IAH A;  3RGM A;  2FCP A;  2W6U A;  4B7O A;  4CU4 A;  2W76 A;  2GRX A;  5FOK A;  2O5P A;  3QLB A;  3RGN A;  1FEP A;  4EPA A;  3M8B A;  1FI1 A;  1PO0 A;  1UJW A;  1XKW A;  2W75 A;  2GUF A;  1BY5 A;  1NQH A;  3CSN A;  2HDF A;  2W16 A;  4AIQ A;  3V8X A;  2HDI A;  3CSL A;  2GSK A;  3V89 A;  1PO3 A;  1NQG A;  2YSU A;  3DDR A;  2W6T A;  1KMO A;  1QFG A;  2W78 A;  1QKC A;  1PNZ A;  1KMP A;  3FHH A;  1BY3 A;  1QJQ A;  4AIP A;  1NQE A; 
#chains in the Genus database with same CATH topology
 1OH2 P;  1JBI A;  3EFM A;  3M8D A;  4RDR A;  1NQF A;  1MPR A;  1QFF A;  1MPO A;  1AF6 A;  1XKH A;  4RDT A;  1FCP A;  2W77 A;  2IAH A;  3RGM A;  2FCP A;  2W6U A;  4B7O A;  4CU4 A;  2W76 A;  2GRX A;  5FOK A;  2O5P A;  1A0S P;  3QLB A;  1FEP A;  3RGN A;  3M8B A;  1MPQ A;  4EPA A;  1MPN A;  1FI1 A;  1PO0 A;  1UJW A;  1XKW A;  2W75 A;  2GUF A;  1BY5 A;  1NQH A;  3CSN A;  2HDF A;  2W16 A;  4AIQ A;  3V8X A;  2HDI A;  3CSL A;  2GSK A;  3V89 A;  1PO3 A;  2MPR A;  1NQG A;  2YSU A;  1MAL A;  3DDR A;  2W6T A;  1KMO A;  1QFG A;  2W78 A;  1MPM A;  1QKC A;  1PNZ A;  1KMP A;  3FHH A;  1BY3 A;  1A0T P;  1QJQ A;  4AIP A;  1OH2 Q;  1NQE A; 
#chains in the Genus database with same CATH homology
 3EFM A;  3M8D A;  4RDR A;  1NQF A;  1XKH A;  1QFF A;  4RDT A;  1FCP A;  2W77 A;  2IAH A;  3RGM A;  2FCP A;  2W6U A;  4B7O A;  4CU4 A;  2W76 A;  2GRX A;  5FOK A;  2O5P A;  3QLB A;  3RGN A;  1FEP A;  4EPA A;  3M8B A;  1FI1 A;  1PO0 A;  1UJW A;  1XKW A;  2W75 A;  2GUF A;  1BY5 A;  1NQH A;  3CSN A;  2HDF A;  2W16 A;  4AIQ A;  3V8X A;  2HDI A;  3CSL A;  2GSK A;  3V89 A;  1PO3 A;  1NQG A;  2YSU A;  3DDR A;  2W6T A;  1KMO A;  1QFG A;  2W78 A;  1QKC A;  1PNZ A;  1KMP A;  3FHH A;  1BY3 A;  1QJQ A;  4AIP A;  1NQE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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