4D01A

Crystal structure of the extracellular domain of the human alpha9 nicotinic acetylcholine receptor
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
214
structure length
212
Chain Sequence
DGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDEEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSHHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures of Free and Antagonist-Bound States of Human Alpha9 Nicotinic Receptor Extracellular Domain
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-9
total genus 46
structure length 212
sequence length 214
ec nomenclature
pdb deposition date 2014-04-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.170.10 Mainly Beta Distorted Sandwich Acetylcholine Binding Protein; Chain: A, Neurotransmitter-gated ion-channel ligand-binding domain 4d01A00
4QH4A 5AFNA 2BJ0A 4HFEA 2WZYA 3LSVA 3RQUA 2XNUA 2XQ9A 2WN9A 2UZ6A 3U8MA 4D01A 3IGQA 4DBMA 3TLTA 5HCMA 1UV6A 2XNVA 5JMEA 5KZUA 4ZJSA 2W8GA 2BYPA 2PH9A 5AFKA 4ZK4A 5J0ZA 4HFCA 2Y57A 4ILCA 3JADA 5FJVA 4AFGA 3TLVA 4BQTA 5L47A 3UU5A 4A98A 5TVCA 3ZKRA 3C84A 5J5IA 5BRXA 3U8NA 4HQPA 2XQ8A 3UU8A 4UY2A 4ZR6A 3RIFA 1UX2A 4ILAA 2BG9E 2BYNA 2XQ5A 4LMKA 4AFHA 4B5DA 2X00D 4TNVA 3WTKA 5J5FA 4WV9A 4QH1A 2WNJA 3PEOA 4ALXA 4TWFA 2BR7A 3T4MA 3EAMA 5AFMB 3UQ4A 5BP0A 3U8LA 4HFBA 2XZ6A 4QAAA 4TNWA 3TLWA 3WTHA 3RIAA 3RHWA 4NZBA 4ZZBA 4TWHA 4HFDA 5L4EA 5AFJA 4COFA 3C79A 2YMEA 4UM3A 4BFQA 2XQ3A 2Y54A 3WTMA 4FRRA 4ZJTA 2BR8A 5HEGA 2BYSA 3SH1A 2BG9A 3EI0A 3U8KA 4EZ1A 4UXUA 4AFTA 1UW6A 4X5TA 4LMLA 3UU3A 2BG9C 4ZZCA 3UU4A 3WTNA 3P50A 5L4HA 5BW2A 2Y58A 3WIPA 3UU6A 5IUXA 4TWDA 5LG3A 2X00A 2C9TA 2ZJUA 2WNCA 2BYRA 1I9BA 2XNTA 3GUAA 5SYOA 4QABA 4QH5A 3WTLA 3WTOA 3SQ9A 5KE4A 5J5HA 4ZK1A 2W8FA 2XQAA 3EHZA 5AFMA 2XQ7A 2XYSA 2PGZA 4A97A 5AINA 5HEJA 5LXBA 4ZRUA 2XQ4A 3JAFA 3P4WA 5HCJA 5J5GA 4UM3P 2YN6A 4ILBA 2BYQA 4LMJA 2XQ6A 2YKSA 2ZJVA 4Z90A 4HFHA 4Z91A 3SQ6A 4F8HA 5AFHA 3U8JA 2Y56A 2QC1B 4QACA 3JAEA 5CO5A 3SIOA 2YMDA 4IL4A 3TLUA 3PMZA 4IREA 3WTJA 4IL9A 2BG9B 3ZDHA 4XK9A 5HEHA 5CFBA 5HEOA 3UUBA 2Y7YA 4UM1A 4UM3S 2VL0A 4HFIA 3TLSA 5HEUA 2WNLA 3RI5A 3RQWA 2YOEA 4NPPA 3ZDGA 4XHEA 5AFLA 4PIRA 3WTIA 2XYTA 2XZ5A 3UQ7A
chains in the Genus database with same CATH superfamily
4QH4A 5AFNA 2BJ0A 4HFEA 2WZYA 3LSVA 3RQUA 2XNUA 2XQ9A 2WN9A 2UZ6A 3U8MA 4D01A 3IGQA 4DBMA 3TLTA 5HCMA 1UV6A 2XNVA 5JMEA 5KZUA 4ZJSA 2W8GA 2BYPA 2PH9A 5AFKA 4ZK4A 5J0ZA 4HFCA 2Y57A 4ILCA 3JADA 5FJVA 4AFGA 3TLVA 4BQTA 5L47A 3UU5A 4A98A 5TVCA 3ZKRA 3C84A 5J5IA 5BRXA 3U8NA 4HQPA 2XQ8A 3UU8A 4UY2A 4ZR6A 3RIFA 1UX2A 4ILAA 2BG9E 2BYNA 2XQ5A 4LMKA 4AFHA 4B5DA 2X00D 4TNVA 3WTKA 5J5FA 4WV9A 4QH1A 2WNJA 3PEOA 4ALXA 4TWFA 2BR7A 3T4MA 3EAMA 5AFMB 3UQ4A 5BP0A 3U8LA 4HFBA 2XZ6A 4QAAA 4TNWA 3TLWA 3WTHA 3RIAA 3RHWA 4NZBA 4ZZBA 4TWHA 4HFDA 5L4EA 5AFJA 4COFA 3C79A 2YMEA 4UM3A 4BFQA 2XQ3A 2Y54A 3WTMA 4FRRA 4ZJTA 2BR8A 5HEGA 2BYSA 3SH1A 2BG9A 3EI0A 3U8KA 4EZ1A 4UXUA 4AFTA 1UW6A 4X5TA 4LMLA 3UU3A 2BG9C 4ZZCA 3UU4A 3WTNA 3P50A 5L4HA 5BW2A 2Y58A 3WIPA 3UU6A 5IUXA 4TWDA 5LG3A 2X00A 2C9TA 2ZJUA 2WNCA 2BYRA 1I9BA 2XNTA 3GUAA 5SYOA 4QABA 4QH5A 3WTLA 3WTOA 3SQ9A 5KE4A 5J5HA 4ZK1A 2W8FA 2XQAA 3EHZA 5AFMA 2XQ7A 2XYSA 2PGZA 4A97A 5AINA 5HEJA 5LXBA 4ZRUA 2XQ4A 3JAFA 3P4WA 5HCJA 5J5GA 4UM3P 2YN6A 4ILBA 2BYQA 4LMJA 2XQ6A 2YKSA 2ZJVA 4Z90A 4HFHA 4Z91A 3SQ6A 4F8HA 5AFHA 3U8JA 2Y56A 2QC1B 4QACA 3JAEA 5CO5A 3SIOA 2YMDA 4IL4A 3TLUA 3PMZA 4IREA 3WTJA 4IL9A 2BG9B 3ZDHA 4XK9A 5HEHA 5CFBA 5HEOA 3UUBA 2Y7YA 4UM1A 4UM3S 2VL0A 4HFIA 3TLSA 5HEUA 2WNLA 3RI5A 3RQWA 2YOEA 4NPPA 3ZDGA 4XHEA 5AFLA 4PIRA 3WTIA 2XYTA 2XZ5A 3UQ7A
chains in the Genus database with same CATH topology
4QH4A 5AFNA 2BJ0A 4HFEA 2WZYA 3LSVA 3RQUA 2XNUA 2XQ9A 2WN9A 2UZ6A 3U8MA 4D01A 3IGQA 4DBMA 3TLTA 5HCMA 1UV6A 2XNVA 5JMEA 5KZUA 4ZJSA 2W8GA 2BYPA 2PH9A 5AFKA 4ZK4A 5J0ZA 4HFCA 2Y57A 4ILCA 3JADA 5FJVA 4AFGA 3TLVA 4BQTA 5L47A 3UU5A 4A98A 5TVCA 3ZKRA 3C84A 5J5IA 5BRXA 3U8NA 4HQPA 2XQ8A 3UU8A 4UY2A 4ZR6A 3RIFA 1UX2A 4ILAA 2BG9E 2BYNA 2XQ5A 4LMKA 4AFHA 4B5DA 2X00D 4TNVA 3WTKA 5J5FA 4WV9A 4QH1A 2WNJA 3PEOA 4ALXA 4TWFA 2BR7A 3T4MA 3EAMA 5AFMB 3UQ4A 5BP0A 3U8LA 4HFBA 2XZ6A 4QAAA 4TNWA 3TLWA 3WTHA 3RIAA 3RHWA 4NZBA 4ZZBA 4TWHA 4HFDA 5L4EA 5AFJA 4COFA 3C79A 2YMEA 4UM3A 4BFQA 2XQ3A 2Y54A 3WTMA 4FRRA 4ZJTA 2BR8A 5HEGA 2BYSA 3SH1A 2BG9A 3EI0A 3U8KA 4EZ1A 4UXUA 4AFTA 1UW6A 4X5TA 4LMLA 3UU3A 2BG9C 4ZZCA 3UU4A 3WTNA 3P50A 5L4HA 5BW2A 2Y58A 3WIPA 3UU6A 5IUXA 4TWDA 5LG3A 2X00A 2C9TA 2ZJUA 2WNCA 2BYRA 1I9BA 2XNTA 3GUAA 5SYOA 4QABA 4QH5A 3WTLA 3WTOA 3SQ9A 5KE4A 5J5HA 4ZK1A 2W8FA 2XQAA 3EHZA 5AFMA 2XQ7A 2XYSA 2PGZA 4A97A 5AINA 5HEJA 5LXBA 4ZRUA 2XQ4A 3JAFA 3P4WA 5HCJA 5J5GA 4UM3P 2YN6A 4ILBA 2BYQA 4LMJA 2XQ6A 2YKSA 2ZJVA 4Z90A 4HFHA 4Z91A 3SQ6A 4F8HA 5AFHA 3U8JA 2Y56A 2QC1B 4QACA 3JAEA 5CO5A 3SIOA 2YMDA 4IL4A 3TLUA 3PMZA 4IREA 3WTJA 4IL9A 2BG9B 3ZDHA 4XK9A 5HEHA 5CFBA 5HEOA 3UUBA 2Y7YA 4UM1A 4UM3S 2VL0A 4HFIA 3TLSA 5HEUA 2WNLA 3RI5A 3RQWA 2YOEA 4NPPA 3ZDGA 4XHEA 5AFLA 4PIRA 3WTIA 2XYTA 2XZ5A 3UQ7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4QH4 A;  5AFN A;  2BJ0 A;  4HFE A;  2WZY A;  3LSV A;  3RQU A;  2XNU A;  2XQ9 A;  2WN9 A;  2UZ6 A;  3U8M A;  4D01 A;  3IGQ A;  4DBM A;  3TLT A;  5HCM A;  1UV6 A;  2XNV A;  5JME A;  5KZU A;  4ZJS A;  2W8G A;  2BYP A;  2PH9 A;  5AFK A;  4ZK4 A;  5J0Z A;  4HFC A;  2Y57 A;  4ILC A;  3JAD A;  5FJV A;  4AFG A;  3TLV A;  4BQT A;  5L47 A;  3UU5 A;  4A98 A;  5TVC A;  3ZKR A;  3C84 A;  5J5I A;  5BRX A;  3U8N A;  4HQP A;  2XQ8 A;  3UU8 A;  4UY2 A;  4ZR6 A;  3RIF A;  1UX2 A;  4ILA A;  2BG9 E;  2BYN A;  2XQ5 A;  4LMK A;  4AFH A;  4B5D A;  2X00 D;  4TNV A;  3WTK A;  5J5F A;  4WV9 A;  4QH1 A;  2WNJ A;  3PEO A;  4ALX A;  4TWF A;  2BR7 A;  3T4M A;  3EAM A;  5AFM B;  3UQ4 A;  5BP0 A;  3U8L A;  4HFB A;  2XZ6 A;  4QAA A;  4TNW A;  3TLW A;  3WTH A;  3RIA A;  3RHW A;  4NZB A;  4ZZB A;  4TWH A;  4HFD A;  5L4E A;  5AFJ A;  4COF A;  3C79 A;  2YME A;  4UM3 A;  4BFQ A;  2XQ3 A;  2Y54 A;  3WTM A;  4FRR A;  4ZJT A;  2BR8 A;  5HEG A;  2BYS A;  3SH1 A;  2BG9 A;  3EI0 A;  3U8K A;  4EZ1 A;  4UXU A;  4AFT A;  1UW6 A;  4X5T A;  4LML A;  3UU3 A;  2BG9 C;  4ZZC A;  3UU4 A;  3WTN A;  3P50 A;  5L4H A;  5BW2 A;  2Y58 A;  3WIP A;  3UU6 A;  5IUX A;  4TWD A;  5LG3 A;  2X00 A;  2C9T A;  2ZJU A;  2WNC A;  2BYR A;  1I9B A;  2XNT A;  3GUA A;  5SYO A;  4QAB A;  4QH5 A;  3WTL A;  3WTO A;  3SQ9 A;  5KE4 A;  5J5H A;  4ZK1 A;  2W8F A;  2XQA A;  3EHZ A;  5AFM A;  2XQ7 A;  2XYS A;  2PGZ A;  4A97 A;  5AIN A;  5HEJ A;  5LXB A;  4ZRU A;  2XQ4 A;  3JAF A;  3P4W A;  5HCJ A;  5J5G A;  4UM3 P;  2YN6 A;  4ILB A;  2BYQ A;  4LMJ A;  2XQ6 A;  2YKS A;  2ZJV A;  4Z90 A;  4HFH A;  4Z91 A;  3SQ6 A;  4F8H A;  5AFH A;  3U8J A;  2Y56 A;  2QC1 B;  4QAC A;  3JAE A;  5CO5 A;  3SIO A;  2YMD A;  4IL4 A;  3TLU A;  3PMZ A;  4IRE A;  3WTJ A;  4IL9 A;  2BG9 B;  3ZDH A;  4XK9 A;  5HEH A;  5CFB A;  5HEO A;  3UUB A;  2Y7Y A;  4UM1 A;  4UM3 S;  2VL0 A;  4HFI A;  3TLS A;  5HEU A;  2WNL A;  3RI5 A;  3RQW A;  2YOE A;  4NPP A;  3ZDG A;  4XHE A;  5AFL A;  4PIR A;  3WTI A;  2XYT A;  2XZ5 A;  3UQ7 A; 
#chains in the Genus database with same CATH topology
 4QH4 A;  5AFN A;  2BJ0 A;  4HFE A;  2WZY A;  3LSV A;  3RQU A;  2XNU A;  2XQ9 A;  2WN9 A;  2UZ6 A;  3U8M A;  4D01 A;  3IGQ A;  4DBM A;  3TLT A;  5HCM A;  1UV6 A;  2XNV A;  5JME A;  5KZU A;  4ZJS A;  2W8G A;  2BYP A;  2PH9 A;  5AFK A;  4ZK4 A;  5J0Z A;  4HFC A;  2Y57 A;  4ILC A;  3JAD A;  5FJV A;  4AFG A;  3TLV A;  4BQT A;  5L47 A;  3UU5 A;  4A98 A;  5TVC A;  3ZKR A;  3C84 A;  5J5I A;  5BRX A;  3U8N A;  4HQP A;  2XQ8 A;  3UU8 A;  4UY2 A;  4ZR6 A;  3RIF A;  1UX2 A;  4ILA A;  2BG9 E;  2BYN A;  2XQ5 A;  4LMK A;  4AFH A;  4B5D A;  2X00 D;  4TNV A;  3WTK A;  5J5F A;  4WV9 A;  4QH1 A;  2WNJ A;  3PEO A;  4ALX A;  4TWF A;  2BR7 A;  3T4M A;  3EAM A;  5AFM B;  3UQ4 A;  5BP0 A;  3U8L A;  4HFB A;  2XZ6 A;  4QAA A;  4TNW A;  3TLW A;  3WTH A;  3RIA A;  3RHW A;  4NZB A;  4ZZB A;  4TWH A;  4HFD A;  5L4E A;  5AFJ A;  4COF A;  3C79 A;  2YME A;  4UM3 A;  4BFQ A;  2XQ3 A;  2Y54 A;  3WTM A;  4FRR A;  4ZJT A;  2BR8 A;  5HEG A;  2BYS A;  3SH1 A;  2BG9 A;  3EI0 A;  3U8K A;  4EZ1 A;  4UXU A;  4AFT A;  1UW6 A;  4X5T A;  4LML A;  3UU3 A;  2BG9 C;  4ZZC A;  3UU4 A;  3WTN A;  3P50 A;  5L4H A;  5BW2 A;  2Y58 A;  3WIP A;  3UU6 A;  5IUX A;  4TWD A;  5LG3 A;  2X00 A;  2C9T A;  2ZJU A;  2WNC A;  2BYR A;  1I9B A;  2XNT A;  3GUA A;  5SYO A;  4QAB A;  4QH5 A;  3WTL A;  3WTO A;  3SQ9 A;  5KE4 A;  5J5H A;  4ZK1 A;  2W8F A;  2XQA A;  3EHZ A;  5AFM A;  2XQ7 A;  2XYS A;  2PGZ A;  4A97 A;  5AIN A;  5HEJ A;  5LXB A;  4ZRU A;  2XQ4 A;  3JAF A;  3P4W A;  5HCJ A;  5J5G A;  4UM3 P;  2YN6 A;  4ILB A;  2BYQ A;  4LMJ A;  2XQ6 A;  2YKS A;  2ZJV A;  4Z90 A;  4HFH A;  4Z91 A;  3SQ6 A;  4F8H A;  5AFH A;  3U8J A;  2Y56 A;  2QC1 B;  4QAC A;  3JAE A;  5CO5 A;  3SIO A;  2YMD A;  4IL4 A;  3TLU A;  3PMZ A;  4IRE A;  3WTJ A;  4IL9 A;  2BG9 B;  3ZDH A;  4XK9 A;  5HEH A;  5CFB A;  5HEO A;  3UUB A;  2Y7Y A;  4UM1 A;  4UM3 S;  2VL0 A;  4HFI A;  3TLS A;  5HEU A;  2WNL A;  3RI5 A;  3RQW A;  2YOE A;  4NPP A;  3ZDG A;  4XHE A;  5AFL A;  4PIR A;  3WTI A;  2XYT A;  2XZ5 A;  3UQ7 A; 
#chains in the Genus database with same CATH homology
 4QH4 A;  5AFN A;  2BJ0 A;  4HFE A;  2WZY A;  3LSV A;  3RQU A;  2XNU A;  2XQ9 A;  2WN9 A;  2UZ6 A;  3U8M A;  4D01 A;  3IGQ A;  4DBM A;  3TLT A;  5HCM A;  1UV6 A;  2XNV A;  5JME A;  5KZU A;  4ZJS A;  2W8G A;  2BYP A;  2PH9 A;  5AFK A;  4ZK4 A;  5J0Z A;  4HFC A;  2Y57 A;  4ILC A;  3JAD A;  5FJV A;  4AFG A;  3TLV A;  4BQT A;  5L47 A;  3UU5 A;  4A98 A;  5TVC A;  3ZKR A;  3C84 A;  5J5I A;  5BRX A;  3U8N A;  4HQP A;  2XQ8 A;  3UU8 A;  4UY2 A;  4ZR6 A;  3RIF A;  1UX2 A;  4ILA A;  2BG9 E;  2BYN A;  2XQ5 A;  4LMK A;  4AFH A;  4B5D A;  2X00 D;  4TNV A;  3WTK A;  5J5F A;  4WV9 A;  4QH1 A;  2WNJ A;  3PEO A;  4ALX A;  4TWF A;  2BR7 A;  3T4M A;  3EAM A;  5AFM B;  3UQ4 A;  5BP0 A;  3U8L A;  4HFB A;  2XZ6 A;  4QAA A;  4TNW A;  3TLW A;  3WTH A;  3RIA A;  3RHW A;  4NZB A;  4ZZB A;  4TWH A;  4HFD A;  5L4E A;  5AFJ A;  4COF A;  3C79 A;  2YME A;  4UM3 A;  4BFQ A;  2XQ3 A;  2Y54 A;  3WTM A;  4FRR A;  4ZJT A;  2BR8 A;  5HEG A;  2BYS A;  3SH1 A;  2BG9 A;  3EI0 A;  3U8K A;  4EZ1 A;  4UXU A;  4AFT A;  1UW6 A;  4X5T A;  4LML A;  3UU3 A;  2BG9 C;  4ZZC A;  3UU4 A;  3WTN A;  3P50 A;  5L4H A;  5BW2 A;  2Y58 A;  3WIP A;  3UU6 A;  5IUX A;  4TWD A;  5LG3 A;  2X00 A;  2C9T A;  2ZJU A;  2WNC A;  2BYR A;  1I9B A;  2XNT A;  3GUA A;  5SYO A;  4QAB A;  4QH5 A;  3WTL A;  3WTO A;  3SQ9 A;  5KE4 A;  5J5H A;  4ZK1 A;  2W8F A;  2XQA A;  3EHZ A;  5AFM A;  2XQ7 A;  2XYS A;  2PGZ A;  4A97 A;  5AIN A;  5HEJ A;  5LXB A;  4ZRU A;  2XQ4 A;  3JAF A;  3P4W A;  5HCJ A;  5J5G A;  4UM3 P;  2YN6 A;  4ILB A;  2BYQ A;  4LMJ A;  2XQ6 A;  2YKS A;  2ZJV A;  4Z90 A;  4HFH A;  4Z91 A;  3SQ6 A;  4F8H A;  5AFH A;  3U8J A;  2Y56 A;  2QC1 B;  4QAC A;  3JAE A;  5CO5 A;  3SIO A;  2YMD A;  4IL4 A;  3TLU A;  3PMZ A;  4IRE A;  3WTJ A;  4IL9 A;  2BG9 B;  3ZDH A;  4XK9 A;  5HEH A;  5CFB A;  5HEO A;  3UUB A;  2Y7Y A;  4UM1 A;  4UM3 S;  2VL0 A;  4HFI A;  3TLS A;  5HEU A;  2WNL A;  3RI5 A;  3RQW A;  2YOE A;  4NPP A;  3ZDG A;  4XHE A;  5AFL A;  4PIR A;  3WTI A;  2XYT A;  2XZ5 A;  3UQ7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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