4DHNA

Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
235
structure length
228
Chain Sequence
AMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Protein binding/inhibitor
molecule keywords 14-3-3 protein sigma
publication title Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions.
pubmed doi rcsb
source organism Homo sapiens
total genus 99
structure length 228
sequence length 235
ec nomenclature
pdb deposition date 2012-01-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 4dhnA00
2NPMA 5IQPA 1O9CA 4N7GA 1A37A 5J31A 1O9EA 4JC3A 3T0LA 4N84A 5LVZA 2C74A 4DHOA 3NKXA 4DHMA 4DATA 3LW1A 3IQJA 5EXAA 4DHQA 3EFZA 4DAUA 4JDDA 4DHUA 4DHSA 2B05A 4Y3BA 4IEAA 3P1SA 1QJAA 3SPRA 4DHPA 4IHLA 4HKCA 5LX2A 3U9XA 4ZDRA 3UBWA 3IQVA 3P1QA 3SMKA 3SMMA 3UALA 2BQ0A 3P1NA 3P1OA 3M50A 5BY9A 4ZQ0A 3P1PA 5D3EA 4DHNA 1YWTA 4DHTA 1QJBA 3CU8A 5BTVA 5LU1A 5EWZA 2V7DA 3MHRA 5D3FA 2BTPA 4DHRA 4Y32A 1O9FA 4GNTA 4FL5A 2O02A 2BR9A 5LU2A 1O9DA 1A38A 3SMLA 4BG6A 2O8PA 4FR3A 2WH0A 4E2EA 3E6YA 4Y5IA 3T0MA 2C63A 4F7RA 3P1RA 3SMNA 3AXYC 5HF3A 3IQUA 5F74A 4DX0A 4N7YA 5LHOA 2C23A 4FJ3A 4J6SA 4O46A 3RDHA 2C1NA 2C1JA 4WRQA 3UX0A 1IB1A 3UZDA 3SMOA 3O8IA 4QLIA 1YZ5A 5D2DA 2O98A 4DNKA 3M51A 3SP5A 1A4OA
chains in the Genus database with same CATH superfamily
2NPMA 5IQPA 1O9CA 4QX0A 4N7GA 1A37A 4QX2A 5J31A 1DLCA 4ARYA 1O9EA 4JC3A 3T0LA 4N84A 5LVZA 4D8MA 4W8JA 2C74A 4DHOA 3NKXA 4DHMA 4DATA 3LW1A 3IQJA 5EXAA 4DHQA 3EFZA 4ARXA 4DAUA 4JDDA 4DHUA 4DHSA 2B05A 4Y3BA 2C9KA 4IEAA 3P1SA 1QJAA 3SPRA 4DHPA 1CIYA 4IHLA 4HKCA 5LX2A 3U9XA 4ZDRA 3UBWA 3IQVA 3P1QA 3SMKA 3SMMA 3CQGA 3UALA 2BQ0A 1S2XA 3P1NA 3P1OA 3M50A 5BY9A 4ZQ0A 3P1PA 5D3EA 4DHNA 1I5PA 3X0UA 1YWTA 4DHTA 1QJBA 3CU8A 3I4RA 5BTVA 5LU1A 5EWZA 2V7DA 3MHRA 5D3FA 2BTPA 4DHRA 4Y32A 1O9FA 4GNTA 4QX3A 4QX1A 4FL5A 2O02A 2BR9A 5LU2A 3ZHEB 1O9DA 1A38A 3SMLA 1URJA 3CQCA 1JI6A 4BG6A 2O8PA 4FR3A 2WH0A 4E2EA 3E6YA 4Y5IA 3T0MA 2C63A 4F7RA 3P1RA 3SMNA 3AXYC 5HF3A 3IQUA 5F74A 4DX0A 4N7YA 5LHOA 2C23A 4FJ3A 4J6SA 1W99A 4MOAA 4O46A 3RDHA 2C1NA 2C1JA 4WRQA 3UX0A 1IB1A 3UZDA 3SMOA 3O8IA 4QLIA 1YZ5A 3EB7A 5D2DA 2O98A 4DNKA 3M51A 3SP5A 1A4OA
chains in the Genus database with same CATH topology
2NPMA 5IQPA 1O9CA 4N7GA 1A37A 5J31A 1O9EA 4JC3A 3T0LA 4N84A 5LVZA 2C74A 4DHOA 3NKXA 4DHMA 4DATA 3LW1A 3IQJA 5EXAA 4DHQA 3EFZA 4DAUA 4JDDA 4DHUA 4DHSA 2B05A 4Y3BA 4IEAA 3P1SA 1QJAA 3SPRA 4DHPA 4IHLA 4HKCA 5LX2A 3U9XA 4ZDRA 3UBWA 3IQVA 3P1QA 3SMKA 3SMMA 3UALA 2BQ0A 3P1NA 3P1OA 3M50A 5BY9A 4ZQ0A 3P1PA 5D3EA 4DHNA 1YWTA 4DHTA 1QJBA 3CU8A 5BTVA 5LU1A 5EWZA 2V7DA 3MHRA 5D3FA 2BTPA 4DHRA 4Y32A 1O9FA 4GNTA 4FL5A 2O02A 2BR9A 5LU2A 1O9DA 1A38A 3SMLA 4BG6A 2O8PA 4FR3A 2WH0A 4E2EA 3E6YA 4Y5IA 3T0MA 2C63A 4F7RA 3P1RA 3SMNA 3AXYC 5HF3A 3IQUA 5F74A 4DX0A 4N7YA 5LHOA 2C23A 4FJ3A 4J6SA 4O46A 3RDHA 2C1NA 2C1JA 4WRQA 3UX0A 1IB1A 3UZDA 3SMOA 3O8IA 4QLIA 1YZ5A 5D2DA 2O98A 4DNKA 3M51A 3SP5A 1A4OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NPM A;  5IQP A;  1O9C A;  4N7G A;  1A37 A;  5J31 A;  1O9E A;  4JC3 A;  3T0L A;  4N84 A;  5LVZ A;  2C74 A;  4DHO A;  3NKX A;  4DHM A;  4DAT A;  3LW1 A;  3IQJ A;  5EXA A;  4DHQ A;  3EFZ A;  4DAU A;  4JDD A;  4DHU A;  4DHS A;  2B05 A;  4Y3B A;  4IEA A;  3P1S A;  1QJA A;  3SPR A;  4DHP A;  4IHL A;  4HKC A;  5LX2 A;  3U9X A;  4ZDR A;  3UBW A;  3IQV A;  3P1Q A;  3SMK A;  3SMM A;  3UAL A;  2BQ0 A;  3P1N A;  3P1O A;  3M50 A;  5BY9 A;  4ZQ0 A;  3P1P A;  5D3E A;  4DHN A;  1YWT A;  4DHT A;  1QJB A;  3CU8 A;  5BTV A;  5LU1 A;  5EWZ A;  2V7D A;  3MHR A;  5D3F A;  2BTP A;  4DHR A;  4Y32 A;  1O9F A;  4GNT A;  4FL5 A;  2O02 A;  2BR9 A;  5LU2 A;  1O9D A;  1A38 A;  3SML A;  4BG6 A;  2O8P A;  4FR3 A;  2WH0 A;  4E2E A;  3E6Y A;  4Y5I A;  3T0M A;  2C63 A;  4F7R A;  3P1R A;  3SMN A;  3AXY C;  5HF3 A;  3IQU A;  5F74 A;  4DX0 A;  4N7Y A;  5LHO A;  2C23 A;  4FJ3 A;  4J6S A;  4O46 A;  3RDH A;  2C1N A;  2C1J A;  4WRQ A;  3UX0 A;  1IB1 A;  3UZD A;  3SMO A;  3O8I A;  4QLI A;  1YZ5 A;  5D2D A;  2O98 A;  4DNK A;  3M51 A;  3SP5 A;  1A4O A; 
#chains in the Genus database with same CATH topology
 2NPM A;  5IQP A;  1O9C A;  4QX0 A;  4N7G A;  1A37 A;  4QX2 A;  5J31 A;  1DLC A;  4ARY A;  1O9E A;  4JC3 A;  3T0L A;  4N84 A;  5LVZ A;  4D8M A;  4W8J A;  2C74 A;  4DHO A;  3NKX A;  4DHM A;  4DAT A;  3LW1 A;  3IQJ A;  5EXA A;  4DHQ A;  3EFZ A;  4ARX A;  4DAU A;  4JDD A;  4DHU A;  4DHS A;  2B05 A;  4Y3B A;  2C9K A;  4IEA A;  3P1S A;  1QJA A;  3SPR A;  4DHP A;  1CIY A;  4IHL A;  4HKC A;  5LX2 A;  3U9X A;  4ZDR A;  3UBW A;  3IQV A;  3P1Q A;  3SMK A;  3SMM A;  3CQG A;  3UAL A;  2BQ0 A;  1S2X A;  3P1N A;  3P1O A;  3M50 A;  5BY9 A;  4ZQ0 A;  3P1P A;  5D3E A;  4DHN A;  1I5P A;  3X0U A;  1YWT A;  4DHT A;  1QJB A;  3CU8 A;  3I4R A;  5BTV A;  5LU1 A;  5EWZ A;  2V7D A;  3MHR A;  5D3F A;  2BTP A;  4DHR A;  4Y32 A;  1O9F A;  4GNT A;  4QX3 A;  4QX1 A;  4FL5 A;  2O02 A;  2BR9 A;  5LU2 A;  3ZHE B;  1O9D A;  1A38 A;  3SML A;  1URJ A;  3CQC A;  1JI6 A;  4BG6 A;  2O8P A;  4FR3 A;  2WH0 A;  4E2E A;  3E6Y A;  4Y5I A;  3T0M A;  2C63 A;  4F7R A;  3P1R A;  3SMN A;  3AXY C;  5HF3 A;  3IQU A;  5F74 A;  4DX0 A;  4N7Y A;  5LHO A;  2C23 A;  4FJ3 A;  4J6S A;  1W99 A;  4MOA A;  4O46 A;  3RDH A;  2C1N A;  2C1J A;  4WRQ A;  3UX0 A;  1IB1 A;  3UZD A;  3SMO A;  3O8I A;  4QLI A;  1YZ5 A;  3EB7 A;  5D2D A;  2O98 A;  4DNK A;  3M51 A;  3SP5 A;  1A4O A; 
#chains in the Genus database with same CATH homology
 2NPM A;  5IQP A;  1O9C A;  4N7G A;  1A37 A;  5J31 A;  1O9E A;  4JC3 A;  3T0L A;  4N84 A;  5LVZ A;  2C74 A;  4DHO A;  3NKX A;  4DHM A;  4DAT A;  3LW1 A;  3IQJ A;  5EXA A;  4DHQ A;  3EFZ A;  4DAU A;  4JDD A;  4DHU A;  4DHS A;  2B05 A;  4Y3B A;  4IEA A;  3P1S A;  1QJA A;  3SPR A;  4DHP A;  4IHL A;  4HKC A;  5LX2 A;  3U9X A;  4ZDR A;  3UBW A;  3IQV A;  3P1Q A;  3SMK A;  3SMM A;  3UAL A;  2BQ0 A;  3P1N A;  3P1O A;  3M50 A;  5BY9 A;  4ZQ0 A;  3P1P A;  5D3E A;  4DHN A;  1YWT A;  4DHT A;  1QJB A;  3CU8 A;  5BTV A;  5LU1 A;  5EWZ A;  2V7D A;  3MHR A;  5D3F A;  2BTP A;  4DHR A;  4Y32 A;  1O9F A;  4GNT A;  4FL5 A;  2O02 A;  2BR9 A;  5LU2 A;  1O9D A;  1A38 A;  3SML A;  4BG6 A;  2O8P A;  4FR3 A;  2WH0 A;  4E2E A;  3E6Y A;  4Y5I A;  3T0M A;  2C63 A;  4F7R A;  3P1R A;  3SMN A;  3AXY C;  5HF3 A;  3IQU A;  5F74 A;  4DX0 A;  4N7Y A;  5LHO A;  2C23 A;  4FJ3 A;  4J6S A;  4O46 A;  3RDH A;  2C1N A;  2C1J A;  4WRQ A;  3UX0 A;  1IB1 A;  3UZD A;  3SMO A;  3O8I A;  4QLI A;  1YZ5 A;  5D2D A;  2O98 A;  4DNK A;  3M51 A;  3SP5 A;  1A4O A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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