4DHPA

Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening
Total Genus 101
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
235
structure length
227
Chain Sequence
AMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Protein binding/inhibitor
molecule keywords 14-3-3 protein sigma
publication title Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions.
pubmed doi rcsb
source organism Homo sapiens
total genus 101
structure length 227
sequence length 235
ec nomenclature
pdb deposition date 2012-01-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 4dhpA00
5D3FA 1A38A 1A4OA 3IQVA 5EWZA 4N7YA 4JDDA 1IB1A 2C1JA 4WRQA 3AXYC 3SP5A 3P1RA 3SMLA 3SMNA 4FR3A 4DHOA 3P1PA 2C74A 1O9EA 4FJ3A 5BY9A 2O98A 1A37A 2C23A 4Y5IA 3P1SA 4ZQ0A 3IQUA 2O02A 4DHRA 3IQJA 5HF3A 3M50A 5LHOA 3P1OA 3LW1A 3NKXA 4N84A 5LX2A 2C63A 3RDHA 4DHPA 3E6YA 5D3EA 4DHSA 1QJAA 3SMOA 2WH0A 4E2EA 2O8PA 4F7RA 5LVZA 4O46A 3MHRA 4DHMA 3T0MA 3EFZA 5EXAA 2BQ0A 3T0LA 3P1QA 4DX0A 4DHUA 1O9DA 1O9CA 4QLIA 3M51A 4Y32A 4IEAA 1QJBA 4DHQA 4BG6A 3SPRA 3UZDA 5IQPA 3P1NA 2BTPA 4J6SA 4DHTA 4JC3A 3UX0A 4ZDRA 4GNTA 4FL5A 3O8IA 5J31A 1O9FA 3SMMA 3CU8A 1YWTA 3U9XA 3UBWA 2C1NA 3SMKA 5F74A 4HKCA 4DHNA 4N7GA 4IHLA 2B05A 4DAUA 5BTVA 1YZ5A 2BR9A 5D2DA 3UALA 4DATA 2NPMA 5LU2A 5LU1A 4DNKA 2V7DA 4Y3BA
chains in the Genus database with same CATH superfamily
5D3FA 1A38A 1A4OA 3IQVA 5EWZA 4N7YA 4JDDA 1IB1A 2C1JA 4WRQA 3AXYC 3SP5A 4QX1A 4ARYA 3P1RA 3SMLA 3SMNA 4FR3A 4DHOA 3P1PA 2C74A 4W8JA 1O9EA 1JI6A 4FJ3A 3EB7A 5BY9A 2O98A 1A37A 4QX3A 2C23A 4Y5IA 3P1SA 4ZQ0A 3IQUA 2O02A 1W99A 4DHRA 3IQJA 5HF3A 3M50A 5LHOA 3P1OA 3LW1A 3NKXA 4N84A 5LX2A 2C63A 3RDHA 4DHPA 3E6YA 5D3EA 4DHSA 1QJAA 3SMOA 2WH0A 2C9KA 3CQGA 4E2EA 2O8PA 4F7RA 5LVZA 4O46A 3MHRA 3X0UA 4DHMA 3T0MA 3EFZA 5EXAA 4ARXA 2BQ0A 1I5PA 3P1QA 3T0LA 4DX0A 1CIYA 4DHUA 1S2XA 4QX0A 1O9DA 1O9CA 4QLIA 3M51A 4Y32A 4IEAA 4MOAA 1QJBA 4D8MA 4DHQA 4BG6A 3SPRA 3UZDA 5IQPA 3P1NA 2BTPA 4J6SA 4DHTA 4JC3A 3UX0A 4GNTA 4ZDRA 4FL5A 3O8IA 5J31A 1O9FA 3SMMA 3ZHEB 3CQCA 3CU8A 1YWTA 3U9XA 3UBWA 1DLCA 2C1NA 3SMKA 1URJA 5F74A 4HKCA 3I4RA 4DHNA 4N7GA 4IHLA 2B05A 4DAUA 5BTVA 1YZ5A 2BR9A 5D2DA 4QX2A 3UALA 4DATA 2NPMA 5LU2A 5LU1A 4DNKA 2V7DA 4Y3BA
chains in the Genus database with same CATH topology
5D3FA 1A38A 1A4OA 3IQVA 5EWZA 4N7YA 4JDDA 1IB1A 2C1JA 4WRQA 3AXYC 3SP5A 3P1RA 3SMLA 3SMNA 4FR3A 4DHOA 3P1PA 2C74A 1O9EA 4FJ3A 5BY9A 2O98A 1A37A 2C23A 4Y5IA 3P1SA 4ZQ0A 3IQUA 2O02A 4DHRA 3IQJA 5HF3A 3M50A 5LHOA 3P1OA 3LW1A 3NKXA 4N84A 5LX2A 2C63A 3RDHA 4DHPA 3E6YA 5D3EA 4DHSA 1QJAA 3SMOA 2WH0A 4E2EA 2O8PA 4F7RA 5LVZA 4O46A 3MHRA 4DHMA 3T0MA 3EFZA 5EXAA 2BQ0A 3T0LA 3P1QA 4DX0A 4DHUA 1O9DA 1O9CA 4QLIA 3M51A 4Y32A 4IEAA 1QJBA 4DHQA 4BG6A 3SPRA 3UZDA 5IQPA 3P1NA 2BTPA 4J6SA 4DHTA 4JC3A 3UX0A 4ZDRA 4GNTA 4FL5A 3O8IA 5J31A 1O9FA 3SMMA 3CU8A 1YWTA 3U9XA 3UBWA 2C1NA 3SMKA 5F74A 4HKCA 4DHNA 4N7GA 4IHLA 2B05A 4DAUA 5BTVA 1YZ5A 2BR9A 5D2DA 3UALA 4DATA 2NPMA 5LU2A 5LU1A 4DNKA 2V7DA 4Y3BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5D3F A;  1A38 A;  1A4O A;  3IQV A;  5EWZ A;  4N7Y A;  4JDD A;  1IB1 A;  2C1J A;  4WRQ A;  3AXY C;  3SP5 A;  3P1R A;  3SML A;  3SMN A;  4FR3 A;  4DHO A;  3P1P A;  2C74 A;  1O9E A;  4FJ3 A;  5BY9 A;  2O98 A;  1A37 A;  2C23 A;  4Y5I A;  3P1S A;  4ZQ0 A;  3IQU A;  2O02 A;  4DHR A;  3IQJ A;  5HF3 A;  3M50 A;  5LHO A;  3P1O A;  3LW1 A;  3NKX A;  4N84 A;  5LX2 A;  2C63 A;  3RDH A;  4DHP A;  3E6Y A;  5D3E A;  4DHS A;  1QJA A;  3SMO A;  2WH0 A;  4E2E A;  2O8P A;  4F7R A;  5LVZ A;  4O46 A;  3MHR A;  4DHM A;  3T0M A;  3EFZ A;  5EXA A;  2BQ0 A;  3T0L A;  3P1Q A;  4DX0 A;  4DHU A;  1O9D A;  1O9C A;  4QLI A;  3M51 A;  4Y32 A;  4IEA A;  1QJB A;  4DHQ A;  4BG6 A;  3SPR A;  3UZD A;  5IQP A;  3P1N A;  2BTP A;  4J6S A;  4DHT A;  4JC3 A;  3UX0 A;  4ZDR A;  4GNT A;  4FL5 A;  3O8I A;  5J31 A;  1O9F A;  3SMM A;  3CU8 A;  1YWT A;  3U9X A;  3UBW A;  2C1N A;  3SMK A;  5F74 A;  4HKC A;  4DHN A;  4N7G A;  4IHL A;  2B05 A;  4DAU A;  5BTV A;  1YZ5 A;  2BR9 A;  5D2D A;  3UAL A;  4DAT A;  2NPM A;  5LU2 A;  5LU1 A;  4DNK A;  2V7D A;  4Y3B A; 
#chains in the Genus database with same CATH topology
 5D3F A;  1A38 A;  1A4O A;  3IQV A;  5EWZ A;  4N7Y A;  4JDD A;  1IB1 A;  2C1J A;  4WRQ A;  3AXY C;  3SP5 A;  4QX1 A;  4ARY A;  3P1R A;  3SML A;  3SMN A;  4FR3 A;  4DHO A;  3P1P A;  2C74 A;  4W8J A;  1O9E A;  1JI6 A;  4FJ3 A;  3EB7 A;  5BY9 A;  2O98 A;  1A37 A;  4QX3 A;  2C23 A;  4Y5I A;  3P1S A;  4ZQ0 A;  3IQU A;  2O02 A;  1W99 A;  4DHR A;  3IQJ A;  5HF3 A;  3M50 A;  5LHO A;  3P1O A;  3LW1 A;  3NKX A;  4N84 A;  5LX2 A;  2C63 A;  3RDH A;  4DHP A;  3E6Y A;  5D3E A;  4DHS A;  1QJA A;  3SMO A;  2WH0 A;  2C9K A;  3CQG A;  4E2E A;  2O8P A;  4F7R A;  5LVZ A;  4O46 A;  3MHR A;  3X0U A;  4DHM A;  3T0M A;  3EFZ A;  5EXA A;  4ARX A;  2BQ0 A;  1I5P A;  3P1Q A;  3T0L A;  4DX0 A;  1CIY A;  4DHU A;  1S2X A;  4QX0 A;  1O9D A;  1O9C A;  4QLI A;  3M51 A;  4Y32 A;  4IEA A;  4MOA A;  1QJB A;  4D8M A;  4DHQ A;  4BG6 A;  3SPR A;  3UZD A;  5IQP A;  3P1N A;  2BTP A;  4J6S A;  4DHT A;  4JC3 A;  3UX0 A;  4GNT A;  4ZDR A;  4FL5 A;  3O8I A;  5J31 A;  1O9F A;  3SMM A;  3ZHE B;  3CQC A;  3CU8 A;  1YWT A;  3U9X A;  3UBW A;  1DLC A;  2C1N A;  3SMK A;  1URJ A;  5F74 A;  4HKC A;  3I4R A;  4DHN A;  4N7G A;  4IHL A;  2B05 A;  4DAU A;  5BTV A;  1YZ5 A;  2BR9 A;  5D2D A;  4QX2 A;  3UAL A;  4DAT A;  2NPM A;  5LU2 A;  5LU1 A;  4DNK A;  2V7D A;  4Y3B A; 
#chains in the Genus database with same CATH homology
 5D3F A;  1A38 A;  1A4O A;  3IQV A;  5EWZ A;  4N7Y A;  4JDD A;  1IB1 A;  2C1J A;  4WRQ A;  3AXY C;  3SP5 A;  3P1R A;  3SML A;  3SMN A;  4FR3 A;  4DHO A;  3P1P A;  2C74 A;  1O9E A;  4FJ3 A;  5BY9 A;  2O98 A;  1A37 A;  2C23 A;  4Y5I A;  3P1S A;  4ZQ0 A;  3IQU A;  2O02 A;  4DHR A;  3IQJ A;  5HF3 A;  3M50 A;  5LHO A;  3P1O A;  3LW1 A;  3NKX A;  4N84 A;  5LX2 A;  2C63 A;  3RDH A;  4DHP A;  3E6Y A;  5D3E A;  4DHS A;  1QJA A;  3SMO A;  2WH0 A;  4E2E A;  2O8P A;  4F7R A;  5LVZ A;  4O46 A;  3MHR A;  4DHM A;  3T0M A;  3EFZ A;  5EXA A;  2BQ0 A;  3T0L A;  3P1Q A;  4DX0 A;  4DHU A;  1O9D A;  1O9C A;  4QLI A;  3M51 A;  4Y32 A;  4IEA A;  1QJB A;  4DHQ A;  4BG6 A;  3SPR A;  3UZD A;  5IQP A;  3P1N A;  2BTP A;  4J6S A;  4DHT A;  4JC3 A;  3UX0 A;  4ZDR A;  4GNT A;  4FL5 A;  3O8I A;  5J31 A;  1O9F A;  3SMM A;  3CU8 A;  1YWT A;  3U9X A;  3UBW A;  2C1N A;  3SMK A;  5F74 A;  4HKC A;  4DHN A;  4N7G A;  4IHL A;  2B05 A;  4DAU A;  5BTV A;  1YZ5 A;  2BR9 A;  5D2D A;  3UAL A;  4DAT A;  2NPM A;  5LU2 A;  5LU1 A;  4DNK A;  2V7D A;  4Y3B A; 
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similar chains in the Genus database (?% sequence similarity)
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