4DHSA

Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening
Total Genus 100
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
100
sequence length
235
structure length
227
Chain Sequence
AMGSMERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Protein binding/inhibitor
molecule keywords 14-3-3 PROTEIN SIGMA
publication title Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions.
pubmed doi rcsb
source organism Homo sapiens
total genus 100
structure length 227
sequence length 235
ec nomenclature
pdb deposition date 2012-01-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00244 14-3-3 14-3-3 protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.190.20 Mainly Alpha Up-down Bundle Delta-Endotoxin; domain 1 14-3-3 domain 4dhsA00
2C1JA 3O8IA 2C74A 4IHLA 4DAUA 4O46A 5BY9A 3NKXA 1YWTA 2WH0A 4N7GA 5D3EA 4DHMA 3UBWA 3E6YA 4QLIA 5D3FA 5F74A 4J6SA 5LHOA 1A4OA 4DNKA 2BTPA 4JDDA 5BTVA 5LU1A 5LU2A 4DHTA 5LX2A 3P1PA 2V7DA 4N84A 5EWZA 3IQJA 3P1QA 3P1OA 3UZDA 5HF3A 3T0LA 1O9DA 3CU8A 3IQVA 4DHSA 2O02A 5D2DA 2C23A 3SP5A 2O8PA 4DHUA 1YZ5A 4IEAA 3SMLA 4DHOA 4Y3BA 4F7RA 1A38A 3SMOA 4DHNA 1QJBA 4FJ3A 3SMKA 5LVZA 4FR3A 4BG6A 4DATA 1O9FA 4JC3A 3RDHA 3T0MA 4HKCA 3U9XA 3AXYC 3IQUA 4FL5A 5J31A 3P1NA 4DHRA 3P1RA 3LW1A 3SMMA 1A37A 2BR9A 4DHQA 3SMNA 3UX0A 4Y5IA 3MHRA 2B05A 2C1NA 1O9CA 5IQPA 1QJAA 4WRQA 4DX0A 3M51A 3P1SA 3EFZA 3UALA 4ZDRA 4Y32A 4ZQ0A 4DHPA 1O9EA 5EXAA 4N7YA 3SPRA 4GNTA 4E2EA 2O98A 1IB1A 3M50A 2BQ0A 2C63A 2NPMA
chains in the Genus database with same CATH superfamily
2C1JA 3O8IA 2C74A 4QX2A 4IHLA 4QX3A 4DAUA 3EB7A 4O46A 5BY9A 3NKXA 1YWTA 2WH0A 4N7GA 5D3EA 4DHMA 3UBWA 3E6YA 4QLIA 5D3FA 5F74A 4J6SA 5LHOA 1A4OA 2C9KA 4DNKA 2BTPA 4JDDA 4QX0A 5BTVA 5LU1A 5LU2A 4DHTA 5LX2A 3P1PA 2V7DA 4N84A 5EWZA 3IQJA 3P1QA 3P1OA 3CQGA 3UZDA 5HF3A 3T0LA 1O9DA 3CU8A 3IQVA 4DHSA 2O02A 3I4RA 5D2DA 2C23A 3SP5A 2O8PA 3CQCA 4DHUA 1YZ5A 4IEAA 3SMLA 4DHOA 4Y3BA 4F7RA 1A38A 3SMOA 4DHNA 1QJBA 4FJ3A 3SMKA 5LVZA 4FR3A 4BG6A 4DATA 1O9FA 4JC3A 3RDHA 3T0MA 4HKCA 3U9XA 3AXYC 3IQUA 4FL5A 1CIYA 5J31A 3P1NA 4DHRA 3P1RA 4ARXA 3LW1A 3SMMA 1A37A 2BR9A 4W8JA 1I5PA 1W99A 4DHQA 3SMNA 3UX0A 4Y5IA 3MHRA 2B05A 2C1NA 1JI6A 1O9CA 4ARYA 5IQPA 1QJAA 4WRQA 4DX0A 3ZHEB 3M51A 3P1SA 3X0UA 1URJA 1DLCA 3EFZA 3UALA 4ZDRA 4Y32A 4ZQ0A 4DHPA 1O9EA 4MOAA 5EXAA 4N7YA 3SPRA 4GNTA 4E2EA 2O98A 1IB1A 3M50A 2BQ0A 4D8MA 1S2XA 2C63A 4QX1A 2NPMA
chains in the Genus database with same CATH topology
2C1JA 3O8IA 2C74A 4IHLA 4DAUA 4O46A 5BY9A 3NKXA 1YWTA 2WH0A 4N7GA 5D3EA 4DHMA 3UBWA 3E6YA 4QLIA 5D3FA 5F74A 4J6SA 5LHOA 1A4OA 4DNKA 2BTPA 4JDDA 5BTVA 5LU1A 5LU2A 4DHTA 5LX2A 3P1PA 2V7DA 4N84A 5EWZA 3IQJA 3P1QA 3P1OA 3UZDA 5HF3A 3T0LA 1O9DA 3CU8A 3IQVA 4DHSA 2O02A 5D2DA 2C23A 3SP5A 2O8PA 4DHUA 1YZ5A 4IEAA 3SMLA 4DHOA 4Y3BA 4F7RA 1A38A 3SMOA 4DHNA 1QJBA 4FJ3A 3SMKA 5LVZA 4FR3A 4BG6A 4DATA 1O9FA 4JC3A 3RDHA 3T0MA 4HKCA 3U9XA 3AXYC 3IQUA 4FL5A 5J31A 3P1NA 4DHRA 3P1RA 3LW1A 3SMMA 1A37A 2BR9A 4DHQA 3SMNA 3UX0A 4Y5IA 3MHRA 2B05A 2C1NA 1O9CA 5IQPA 1QJAA 4WRQA 4DX0A 3M51A 3P1SA 3EFZA 3UALA 4ZDRA 4Y32A 4ZQ0A 4DHPA 1O9EA 5EXAA 4N7YA 3SPRA 4GNTA 4E2EA 2O98A 1IB1A 3M50A 2BQ0A 2C63A 2NPMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2C1J A;  3O8I A;  2C74 A;  4IHL A;  4DAU A;  4O46 A;  5BY9 A;  3NKX A;  1YWT A;  2WH0 A;  4N7G A;  5D3E A;  4DHM A;  3UBW A;  3E6Y A;  4QLI A;  5D3F A;  5F74 A;  4J6S A;  5LHO A;  1A4O A;  4DNK A;  2BTP A;  4JDD A;  5BTV A;  5LU1 A;  5LU2 A;  4DHT A;  5LX2 A;  3P1P A;  2V7D A;  4N84 A;  5EWZ A;  3IQJ A;  3P1Q A;  3P1O A;  3UZD A;  5HF3 A;  3T0L A;  1O9D A;  3CU8 A;  3IQV A;  4DHS A;  2O02 A;  5D2D A;  2C23 A;  3SP5 A;  2O8P A;  4DHU A;  1YZ5 A;  4IEA A;  3SML A;  4DHO A;  4Y3B A;  4F7R A;  1A38 A;  3SMO A;  4DHN A;  1QJB A;  4FJ3 A;  3SMK A;  5LVZ A;  4FR3 A;  4BG6 A;  4DAT A;  1O9F A;  4JC3 A;  3RDH A;  3T0M A;  4HKC A;  3U9X A;  3AXY C;  3IQU A;  4FL5 A;  5J31 A;  3P1N A;  4DHR A;  3P1R A;  3LW1 A;  3SMM A;  1A37 A;  2BR9 A;  4DHQ A;  3SMN A;  3UX0 A;  4Y5I A;  3MHR A;  2B05 A;  2C1N A;  1O9C A;  5IQP A;  1QJA A;  4WRQ A;  4DX0 A;  3M51 A;  3P1S A;  3EFZ A;  3UAL A;  4ZDR A;  4Y32 A;  4ZQ0 A;  4DHP A;  1O9E A;  5EXA A;  4N7Y A;  3SPR A;  4GNT A;  4E2E A;  2O98 A;  1IB1 A;  3M50 A;  2BQ0 A;  2C63 A;  2NPM A; 
#chains in the Genus database with same CATH topology
 2C1J A;  3O8I A;  2C74 A;  4QX2 A;  4IHL A;  4QX3 A;  4DAU A;  3EB7 A;  4O46 A;  5BY9 A;  3NKX A;  1YWT A;  2WH0 A;  4N7G A;  5D3E A;  4DHM A;  3UBW A;  3E6Y A;  4QLI A;  5D3F A;  5F74 A;  4J6S A;  5LHO A;  1A4O A;  2C9K A;  4DNK A;  2BTP A;  4JDD A;  4QX0 A;  5BTV A;  5LU1 A;  5LU2 A;  4DHT A;  5LX2 A;  3P1P A;  2V7D A;  4N84 A;  5EWZ A;  3IQJ A;  3P1Q A;  3P1O A;  3CQG A;  3UZD A;  5HF3 A;  3T0L A;  1O9D A;  3CU8 A;  3IQV A;  4DHS A;  2O02 A;  3I4R A;  5D2D A;  2C23 A;  3SP5 A;  2O8P A;  3CQC A;  4DHU A;  1YZ5 A;  4IEA A;  3SML A;  4DHO A;  4Y3B A;  4F7R A;  1A38 A;  3SMO A;  4DHN A;  1QJB A;  4FJ3 A;  3SMK A;  5LVZ A;  4FR3 A;  4BG6 A;  4DAT A;  1O9F A;  4JC3 A;  3RDH A;  3T0M A;  4HKC A;  3U9X A;  3AXY C;  3IQU A;  4FL5 A;  1CIY A;  5J31 A;  3P1N A;  4DHR A;  3P1R A;  4ARX A;  3LW1 A;  3SMM A;  1A37 A;  2BR9 A;  4W8J A;  1I5P A;  1W99 A;  4DHQ A;  3SMN A;  3UX0 A;  4Y5I A;  3MHR A;  2B05 A;  2C1N A;  1JI6 A;  1O9C A;  4ARY A;  5IQP A;  1QJA A;  4WRQ A;  4DX0 A;  3ZHE B;  3M51 A;  3P1S A;  3X0U A;  1URJ A;  1DLC A;  3EFZ A;  3UAL A;  4ZDR A;  4Y32 A;  4ZQ0 A;  4DHP A;  1O9E A;  4MOA A;  5EXA A;  4N7Y A;  3SPR A;  4GNT A;  4E2E A;  2O98 A;  1IB1 A;  3M50 A;  2BQ0 A;  4D8M A;  1S2X A;  2C63 A;  4QX1 A;  2NPM A; 
#chains in the Genus database with same CATH homology
 2C1J A;  3O8I A;  2C74 A;  4IHL A;  4DAU A;  4O46 A;  5BY9 A;  3NKX A;  1YWT A;  2WH0 A;  4N7G A;  5D3E A;  4DHM A;  3UBW A;  3E6Y A;  4QLI A;  5D3F A;  5F74 A;  4J6S A;  5LHO A;  1A4O A;  4DNK A;  2BTP A;  4JDD A;  5BTV A;  5LU1 A;  5LU2 A;  4DHT A;  5LX2 A;  3P1P A;  2V7D A;  4N84 A;  5EWZ A;  3IQJ A;  3P1Q A;  3P1O A;  3UZD A;  5HF3 A;  3T0L A;  1O9D A;  3CU8 A;  3IQV A;  4DHS A;  2O02 A;  5D2D A;  2C23 A;  3SP5 A;  2O8P A;  4DHU A;  1YZ5 A;  4IEA A;  3SML A;  4DHO A;  4Y3B A;  4F7R A;  1A38 A;  3SMO A;  4DHN A;  1QJB A;  4FJ3 A;  3SMK A;  5LVZ A;  4FR3 A;  4BG6 A;  4DAT A;  1O9F A;  4JC3 A;  3RDH A;  3T0M A;  4HKC A;  3U9X A;  3AXY C;  3IQU A;  4FL5 A;  5J31 A;  3P1N A;  4DHR A;  3P1R A;  3LW1 A;  3SMM A;  1A37 A;  2BR9 A;  4DHQ A;  3SMN A;  3UX0 A;  4Y5I A;  3MHR A;  2B05 A;  2C1N A;  1O9C A;  5IQP A;  1QJA A;  4WRQ A;  4DX0 A;  3M51 A;  3P1S A;  3EFZ A;  3UAL A;  4ZDR A;  4Y32 A;  4ZQ0 A;  4DHP A;  1O9E A;  5EXA A;  4N7Y A;  3SPR A;  4GNT A;  4E2E A;  2O98 A;  1IB1 A;  3M50 A;  2BQ0 A;  2C63 A;  2NPM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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