4DKEA

Crystal structure of human interleukin-34 bound to fab1.1
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
159
structure length
157
Chain Sequence
ECTVTGFLRDKLQYRSRLQYMKHYFPINYKISVPYEGVFRIANVTRLQRAQVSERELRYLWVLVSLSATESVQDVLLEGHPSWKYLQEVETLLLNVQQGLTDVEVSPKVESVLSLLNAPGLKLVRPKALLDNCFRVMELLYCSCCKQSSVLNWQDCE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R.
pubmed doi rcsb
molecule keywords Interleukin-34
molecule tags Cytokine/immune system
source organism Homo sapiens
total genus 49
structure length 157
sequence length 159
chains with identical sequence B
ec nomenclature
pdb deposition date 2012-02-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF15036 IL34 Interleukin 34
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.1250.80 Mainly Alpha Up-down Bundle Growth Hormone; Chain: A; Growth Hormone; Chain: A; 4dkeA00
4DKFA 4DKDA 4EXNA 4EXPA 4DKCA 4DKEA
chains in the Genus database with same CATH superfamily
5IYDD 1SCFA 5D59A 4MHLA 2Y5YA 4U4TA 1F6FA 4ZWBA 1AXIA 5TS9A 4A3KD 4PS4A 5D72A 4YDYI 3VA2A 1BP3A 5L6YC 1P9MB 4TPGA 1Y6KL 4NEJA 2ILKA 4DOHA 5D22A 2JA7D 3DLQI 4IU9A 1BGCA 4U4VA 2O27A 1Y6NL 4A3LD 5EQIA 1V7NV 3WDOA 4J05A 1M4RA 1BUYA 3PIVA 4NN5A 3G9VB 3OQ3A 2VUMD 1I1RB 4BBSD 4RS1A 3HOWD 1A22A 4X51A 1WU3I 2Z3RA 1HIJA 3Q1SI 4Z5RD 3QT2C 4J4LC 4NI7A 1A7MA 1BBNA 4NN6A 1PV6A 5FLMD 4NEMA 1ITFA 3L5WI 1PY2A 3LB6A 4GBYA 1FG9A 1AX8A 4BY7D 1ITMA 3DUHC 1B5LA 2CFPA 4GRWA 1VLKA 3NCEA 3DI3A 3HOYD 1YKBA 4QIQA 5LQBA 4BXXD 3NCCA 2GMFA 1LQSL 3QAZA 2PSMA 1ITLA 3NPZA 4JA3A 1BCNA 4JR9A 4NN7A 1LK3A 2Q14A 4A3GD 3PO2D 1INRA 1IARA 3NCFA 4DKEA 1LKIA 2B8YA 3DGCL 3AYHA 5IP7D 5C4XD 4LRLA 1HULA 3LB6B 5KNHI 2IL6A 1CNT1 3QB1A 5EQHA 3D87A 3G6DA 4IU8A 5C44D 2JA5D 3BPNA 1IK0A 4XNIA 4OAAA 2E9WC 1PGRA 2LMSA 4BBRD 2R92D 1HWHA 5FUCA 4A3ID 2Z3QA 3BPLA 1ILKA 4IKWA 3N0PA 4IKZA 2JA6D 3QWRB 5D6KA 2B91A 1IRLA 1F45B 3I4MD 4APSA 3SE4B 3OG4A 4UVMA 4NKQC 1Y6ML 4GS7A 4YBQA 3HOVD 1BGEA 1RCBA 1ETEA 4ZYRA 2B63D 4TPHA 1HGUA 5C3ED 2HYMB 4LDSA 2CYKA 3HOUD 4D2DA 2L3YA 5IYBD 3HMXB 2KZ1A 3INKC 1AU1A 3O7PA 1N1FA 4GBZA 4W6VA 1EVSA 1FYHA 2H24A 4A3BD 3O7QA 1D9GA 1M4BA 2C35A 1M47A 2Q7NB 4IKXA 1QVNA 5D71A 1Z7CA 1JLIA 5IYCD 4IKVA 2O26A 3UF2A 3N06A 3I4ND 1D9CA 3BESL 1RHGA 4ZW9A 4YUEC 3UEZE 1PVHB 5D28B 3HOZD 3PO3D 4D2CA 4XNJA 1V7MV 2B8XA 5A2OA 3HHCA 4ZF7A 4DKCA 1RW5A 4A3DD 3FKID 1HZIA 1PV7A 3SE3B 4GC0A 3MZGA 2XUTA 3D48P 3S9DA 1CSGA 3UX9A 4JREA 2B8ZA 3TGXB 1HUWA 1HWGA 1Y1WD 4ZWCA 2ERJD 2B90A 1M4CA 1J7VL 4A3JD 4D2BA 4Q65A 3B5KA 4OH3A 3QB7A 2L3OA 3H0GD 1KF9A 3NCBA 1BGDA 2LAGA 4YPGC 4A3CD 1Z92A 1CN4C 1Y1VD 2R7ZD 3UF5A 1GA3A 1IJZA 5C65A 3D85C 3H3VE 1ITIA 1PW6A 5FHXA 3EJJA 4O6KA 3HHRA 2INTA 5E4EA 4FA8E 4EXNA 1PW4A 5D70A 1EXZA 4O9HA 4PYPA 4WRLB 2R93D 2JA8D 1ALUA 2O6IA 1CD9A 4EXPA 4TPJA 4LEPA 4BY1D 1NBPA 4DKFA 3EW3A 4A93D 4YB9D 1M4AA 1CYLA 4A3ED 1IL6A 4I77Z 3IRHA 1EKUA 5IP9D 3DI2A 1WCMD 1EERA 1M48A 4YQXA 3PIWA 5EQGA 4DKDA 4ZS7A 4A3FD 2B5IA 4CNIC 5D58A 1EMRA 5C7XA 1HIKA 2XQBA 4NI9A 4A3MD 1GNCA 5A2NA 4U4WA 2D9QA 2B8UA 3L5XA 4IKYA 2D48A 2OQPA 1RFBA 3HOXD 5GXBA 2Q98A 3OG6A 3WCYI 2V8NA 2CFQA 3BPOA 1Y14A 1M49A
chains in the Genus database with same CATH topology
3H3VE 5IYDD 2L3YA 1ITIA 1SCFA 1LQSL 5IYBD 3QAZA 2PSMA 3HMXB 1PW6A 5FHXA 1ITLA 2KZ1A 3INKC 1AU1A 4MHLA 3EJJA 4O6KA 3NPZA 3HHRA 1N1FA 2INTA 1BCNA 1EVSA 5E4EA 1FYHA 2H24A 1F6FA 4NN7A 1LK3A 1AXIA 5TS9A 4FA8E 4A3BD 2Q14A 4EXNA 4A3GD 1D9GA 3PO2D 4A3KD 1M4BA 2C35A 1EXZA 5D70A 1M47A 4PS4A 2Q7NB 4O9HA 1INRA 5D72A 1QVNA 1IARA 3NCFA 4YDYI 5D71A 4DKEA 4WRLB 1LKIA 2B8YA 1JLIA 3DGCL 3VA2A 1BP3A 5IYCD 2R93D 3AYHA 2O26A 5IP7D 1ALUA 1HULA 1P9MB 3LB6B 4LRLA 2O6IA 5KNHI 1CD9A 5C4XD 3UF2A 3N06A 4EXPA 2JA8D 1Y6KL 2IL6A 4NEJA 3I4ND 4BY1D 2ILKA 1NBPA 4DKFA 1CNT1 3QB1A 5D22A 1D9CA 4DOHA 3BESL 2JA7D 3D87A 3DLQI 3EW3A 3G6DA 1BGCA 1RHGA 4A93D 5C44D 2JA5D 2O27A 1M4AA 4YUEC 1CYLA 1Y6NL 3BPNA 3UEZE 1PVHB 4A3LD 4A3ED 5D28B 1IK0A 1IL6A 3HOZD 1V7NV 2E9WC 3PO3D 1PGRA 4I77Z 2LMSA 4BBRD 2R92D 1HWHA 1M4RA 1BUYA 1V7MV 3PIVA 4NN5A 3G9VB 5FUCA 3IRHA 3OQ3A 1EKUA 2B8XA 5IP9D 4A3ID 2VUMD 1I1RB 2Z3QA 3BPLA 3HHCA 4BBSD 4ZF7A 3DI2A 1WCMD 1ILKA 1RW5A 4DKCA 4A3DD 3FKID 1HZIA 4RS1A 1EERA 1M48A 3HOWD 1A22A 4YQXA 4X51A 1WU3I 2Z3RA 3SE3B 1HIJA 3N0PA 3Q1SI 3MZGA 4Z5RD 2JA6D 3QT2C 3PIWA 3QWRB 3D48P 4J4LC 4DKDA 4NI7A 4ZS7A 3S9DA 4A3FD 1A7MA 2B5IA 1BBNA 1CSGA 4NN6A 5FLMD 3UX9A 4NEMA 2B91A 4CNIC 1IRLA 1ITFA 1EMRA 2B8ZA 1F45B 3TGXB 1HUWA 1HWGA 1PY2A 3L5WI 3I4MD 3LB6A 1Y1WD 3SE4B 3OG4A 5C7XA 2ERJD 1FG9A 1HIKA 2B90A 4NKQC 1Y6ML 2XQBA 1AX8A 5L6YC 1M4CA 4NI9A 4A3MD 4BY7D 4GS7A 1ITMA 1J7VL 3DUHC 1GNCA 1B5LA 3BPOA 4A3JD 3B5KA 3QB7A 2L3OA 3H0GD 1KF9A 2D9QA 3NCBA 4GRWA 1BGDA 2LAGA 4YPGC 1VLKA 3NCEA 3HOVD 1Z92A 3DI3A 4A3CD 2B8UA 3L5XA 1BGEA 2D48A 2OQPA 1RCBA 1RFBA 1CN4C 3HOXD 3HOYD 1YKBA 1ETEA 2Q98A 2B63D 1Y1VD 2R7ZD 3UF5A 1GA3A 5LQBA 3OG6A 3WCYI 1HGUA 5C3ED 4BXXD 3NCCA 1IJZA 2HYMB 2GMFA 1Z7CA 1Y14A 1M49A 2CYKA 3HOUD 3D85C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4DKF A;  4DKD A;  4EXN A;  4EXP A;  4DKC A;  4DKE A; 
#chains in the Genus database with same CATH topology
 5IYD D;  1SCF A;  5D59 A;  4MHL A;  2Y5Y A;  4U4T A;  1F6F A;  4ZWB A;  1AXI A;  5TS9 A;  4A3K D;  4PS4 A;  5D72 A;  4YDY I;  3VA2 A;  1BP3 A;  5L6Y C;  1P9M B;  4TPG A;  1Y6K L;  4NEJ A;  2ILK A;  4DOH A;  5D22 A;  2JA7 D;  3DLQ I;  4IU9 A;  1BGC A;  4U4V A;  2O27 A;  1Y6N L;  4A3L D;  5EQI A;  1V7N V;  3WDO A;  4J05 A;  1M4R A;  1BUY A;  3PIV A;  4NN5 A;  3G9V B;  3OQ3 A;  2VUM D;  1I1R B;  4BBS D;  4RS1 A;  3HOW D;  1A22 A;  4X51 A;  1WU3 I;  2Z3R A;  1HIJ A;  3Q1S I;  4Z5R D;  3QT2 C;  4J4L C;  4NI7 A;  1A7M A;  1BBN A;  4NN6 A;  1PV6 A;  5FLM D;  4NEM A;  1ITF A;  3L5W I;  1PY2 A;  3LB6 A;  4GBY A;  1FG9 A;  1AX8 A;  4BY7 D;  1ITM A;  3DUH C;  1B5L A;  2CFP A;  4GRW A;  1VLK A;  3NCE A;  3DI3 A;  3HOY D;  1YKB A;  4QIQ A;  5LQB A;  4BXX D;  3NCC A;  2GMF A;  1LQS L;  3QAZ A;  2PSM A;  1ITL A;  3NPZ A;  4JA3 A;  1BCN A;  4JR9 A;  4NN7 A;  1LK3 A;  2Q14 A;  4A3G D;  3PO2 D;  1INR A;  1IAR A;  3NCF A;  4DKE A;  1LKI A;  2B8Y A;  3DGC L;  3AYH A;  5IP7 D;  5C4X D;  4LRL A;  1HUL A;  3LB6 B;  5KNH I;  2IL6 A;  1CNT 1;  3QB1 A;  5EQH A;  3D87 A;  3G6D A;  4IU8 A;  5C44 D;  2JA5 D;  3BPN A;  1IK0 A;  4XNI A;  4OAA A;  2E9W C;  1PGR A;  2LMS A;  4BBR D;  2R92 D;  1HWH A;  5FUC A;  4A3I D;  2Z3Q A;  3BPL A;  1ILK A;  4IKW A;  3N0P A;  4IKZ A;  2JA6 D;  3QWR B;  5D6K A;  2B91 A;  1IRL A;  1F45 B;  3I4M D;  4APS A;  3SE4 B;  3OG4 A;  4UVM A;  4NKQ C;  1Y6M L;  4GS7 A;  4YBQ A;  3HOV D;  1BGE A;  1RCB A;  1ETE A;  4ZYR A;  2B63 D;  4TPH A;  1HGU A;  5C3E D;  2HYM B;  4LDS A;  2CYK A;  3HOU D;  4D2D A;  2L3Y A;  5IYB D;  3HMX B;  2KZ1 A;  3INK C;  1AU1 A;  3O7P A;  1N1F A;  4GBZ A;  4W6V A;  1EVS A;  1FYH A;  2H24 A;  4A3B D;  3O7Q A;  1D9G A;  1M4B A;  2C35 A;  1M47 A;  2Q7N B;  4IKX A;  1QVN A;  5D71 A;  1Z7C A;  1JLI A;  5IYC D;  4IKV A;  2O26 A;  3UF2 A;  3N06 A;  3I4N D;  1D9C A;  3BES L;  1RHG A;  4ZW9 A;  4YUE C;  3UEZ E;  1PVH B;  5D28 B;  3HOZ D;  3PO3 D;  4D2C A;  4XNJ A;  1V7M V;  2B8X A;  5A2O A;  3HHC A;  4ZF7 A;  4DKC A;  1RW5 A;  4A3D D;  3FKI D;  1HZI A;  1PV7 A;  3SE3 B;  4GC0 A;  3MZG A;  2XUT A;  3D48 P;  3S9D A;  1CSG A;  3UX9 A;  4JRE A;  2B8Z A;  3TGX B;  1HUW A;  1HWG A;  1Y1W D;  4ZWC A;  2ERJ D;  2B90 A;  1M4C A;  1J7V L;  4A3J D;  4D2B A;  4Q65 A;  3B5K A;  4OH3 A;  3QB7 A;  2L3O A;  3H0G D;  1KF9 A;  3NCB A;  1BGD A;  2LAG A;  4YPG C;  4A3C D;  1Z92 A;  1CN4 C;  1Y1V D;  2R7Z D;  3UF5 A;  1GA3 A;  1IJZ A;  5C65 A;  3D85 C;  3H3V E;  1ITI A;  1PW6 A;  5FHX A;  3EJJ A;  4O6K A;  3HHR A;  2INT A;  5E4E A;  4FA8 E;  4EXN A;  1PW4 A;  5D70 A;  1EXZ A;  4O9H A;  4PYP A;  4WRL B;  2R93 D;  2JA8 D;  1ALU A;  2O6I A;  1CD9 A;  4EXP A;  4TPJ A;  4LEP A;  4BY1 D;  1NBP A;  4DKF A;  3EW3 A;  4A93 D;  4YB9 D;  1M4A A;  1CYL A;  4A3E D;  1IL6 A;  4I77 Z;  3IRH A;  1EKU A;  5IP9 D;  3DI2 A;  1WCM D;  1EER A;  1M48 A;  4YQX A;  3PIW A;  5EQG A;  4DKD A;  4ZS7 A;  4A3F D;  2B5I A;  4CNI C;  5D58 A;  1EMR A;  5C7X A;  1HIK A;  2XQB A;  4NI9 A;  4A3M D;  1GNC A;  5A2N A;  4U4W A;  2D9Q A;  2B8U A;  3L5X A;  4IKY A;  2D48 A;  2OQP A;  1RFB A;  3HOX D;  5GXB A;  2Q98 A;  3OG6 A;  3WCY I;  2V8N A;  2CFQ A;  3BPO A;  1Y14 A;  1M49 A; 
#chains in the Genus database with same CATH homology
 3H3V E;  5IYD D;  2L3Y A;  1ITI A;  1SCF A;  1LQS L;  5IYB D;  3QAZ A;  2PSM A;  3HMX B;  1PW6 A;  5FHX A;  1ITL A;  2KZ1 A;  3INK C;  1AU1 A;  4MHL A;  3EJJ A;  4O6K A;  3NPZ A;  3HHR A;  1N1F A;  2INT A;  1BCN A;  1EVS A;  5E4E A;  1FYH A;  2H24 A;  1F6F A;  4NN7 A;  1LK3 A;  1AXI A;  5TS9 A;  4FA8 E;  4A3B D;  2Q14 A;  4EXN A;  4A3G D;  1D9G A;  3PO2 D;  4A3K D;  1M4B A;  2C35 A;  1EXZ A;  5D70 A;  1M47 A;  4PS4 A;  2Q7N B;  4O9H A;  1INR A;  5D72 A;  1QVN A;  1IAR A;  3NCF A;  4YDY I;  5D71 A;  4DKE A;  4WRL B;  1LKI A;  2B8Y A;  1JLI A;  3DGC L;  3VA2 A;  1BP3 A;  5IYC D;  2R93 D;  3AYH A;  2O26 A;  5IP7 D;  1ALU A;  1HUL A;  1P9M B;  3LB6 B;  4LRL A;  2O6I A;  5KNH I;  1CD9 A;  5C4X D;  3UF2 A;  3N06 A;  4EXP A;  2JA8 D;  1Y6K L;  2IL6 A;  4NEJ A;  3I4N D;  4BY1 D;  2ILK A;  1NBP A;  4DKF A;  1CNT 1;  3QB1 A;  5D22 A;  1D9C A;  4DOH A;  3BES L;  2JA7 D;  3D87 A;  3DLQ I;  3EW3 A;  3G6D A;  1BGC A;  1RHG A;  4A93 D;  5C44 D;  2JA5 D;  2O27 A;  1M4A A;  4YUE C;  1CYL A;  1Y6N L;  3BPN A;  3UEZ E;  1PVH B;  4A3L D;  4A3E D;  5D28 B;  1IK0 A;  1IL6 A;  3HOZ D;  1V7N V;  2E9W C;  3PO3 D;  1PGR A;  4I77 Z;  2LMS A;  4BBR D;  2R92 D;  1HWH A;  1M4R A;  1BUY A;  1V7M V;  3PIV A;  4NN5 A;  3G9V B;  5FUC A;  3IRH A;  3OQ3 A;  1EKU A;  2B8X A;  5IP9 D;  4A3I D;  2VUM D;  1I1R B;  2Z3Q A;  3BPL A;  3HHC A;  4BBS D;  4ZF7 A;  3DI2 A;  1WCM D;  1ILK A;  1RW5 A;  4DKC A;  4A3D D;  3FKI D;  1HZI A;  4RS1 A;  1EER A;  1M48 A;  3HOW D;  1A22 A;  4YQX A;  4X51 A;  1WU3 I;  2Z3R A;  3SE3 B;  1HIJ A;  3N0P A;  3Q1S I;  3MZG A;  4Z5R D;  2JA6 D;  3QT2 C;  3PIW A;  3QWR B;  3D48 P;  4J4L C;  4DKD A;  4NI7 A;  4ZS7 A;  3S9D A;  4A3F D;  1A7M A;  2B5I A;  1BBN A;  1CSG A;  4NN6 A;  5FLM D;  3UX9 A;  4NEM A;  2B91 A;  4CNI C;  1IRL A;  1ITF A;  1EMR A;  2B8Z A;  1F45 B;  3TGX B;  1HUW A;  1HWG A;  1PY2 A;  3L5W I;  3I4M D;  3LB6 A;  1Y1W D;  3SE4 B;  3OG4 A;  5C7X A;  2ERJ D;  1FG9 A;  1HIK A;  2B90 A;  4NKQ C;  1Y6M L;  2XQB A;  1AX8 A;  5L6Y C;  1M4C A;  4NI9 A;  4A3M D;  4BY7 D;  4GS7 A;  1ITM A;  1J7V L;  3DUH C;  1GNC A;  1B5L A;  3BPO A;  4A3J D;  3B5K A;  3QB7 A;  2L3O A;  3H0G D;  1KF9 A;  2D9Q A;  3NCB A;  4GRW A;  1BGD A;  2LAG A;  4YPG C;  1VLK A;  3NCE A;  3HOV D;  1Z92 A;  3DI3 A;  4A3C D;  2B8U A;  3L5X A;  1BGE A;  2D48 A;  2OQP A;  1RCB A;  1RFB A;  1CN4 C;  3HOX D;  3HOY D;  1YKB A;  1ETE A;  2Q98 A;  2B63 D;  1Y1V D;  2R7Z D;  3UF5 A;  1GA3 A;  5LQB A;  3OG6 A;  3WCY I;  1HGU A;  5C3E D;  4BXX D;  3NCC A;  1IJZ A;  2HYM B;  2GMF A;  1Z7C A;  1Y14 A;  1M49 A;  2CYK A;  3HOU D;  3D85 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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