4E45B

Crystal structure of the hmhf1/hmhf2 histone-fold tetramer in complex with fanconi anemia associated helicase hfancm
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
74
structure length
74
Chain Sequence
SGFRKELVSRLLHLHFKDDKTKVSGDALQLMVELLKVFVVEAAVRGVRQAQAEDALRVDVDQLEKVLPQLLLDF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Dna binding protein/hydrolase
molecule keywords Centromere protein S
publication title Crystal Structures Reveal that FANCM remodels the MHF Tetramer in favor of binding Branched DNA
rcsb
source organism Homo sapiens
total genus 25
structure length 74
sequence length 74
chains with identical sequence D, G, I, L, N
ec nomenclature
pdb deposition date 2012-03-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF09415 CENP-X CENP-S associating Centromere protein X
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.286.100 Mainly Alpha Orthogonal Bundle GTP Cyclohydrolase I; Chain A, domain 1 GTP Cyclohydrolase I; Chain A, domain 1 4e45B02
4DRBJ 3B0BC 4NE6B 4E45B 4NE5B 4NE3B 4E44B 4DRAE
chains in the Genus database with same CATH superfamily
2WSFG 1AIPC 1N3TA 4R8QA 1IS7A 1IS8A 1A9CA 2WSFK 2WSEK 1GTPA 1WURA 4E45B 1EL6A 2O01G 4NE3B 4JA3A 1N3SA 1FB1A 1WUQA 3B0BC 1TFEA 1WPLA 4NE5B 2LNZA 4E44B 4DRAE 2PN0A 4DU6A 1FBXA 2P11A 4DRBJ 1EFUB 3LW5G 4NE6B 4Q7JA 2WSCG 3VEJA 2KR1A 2LO0A 4QPMA 5DMZA 3BMBA 1WM9A 1N3RA 2WSCK 3LW5K 2WSEG 1A8RA
chains in the Genus database with same CATH topology
1AIPC 1N3TA 4R8QA 1IS7A 1IS8A 1A9CA 1GTPA 1WURA 4E45B 1EL6A 4NE3B 4JA3A 1N3SA 1FB1A 1WUQA 3B0BC 1TFEA 1WPLA 4NE5B 2LNZA 4E44B 4DRAE 2PN0A 4DU6A 1FBXA 2P11A 4DRBJ 1EFUB 4NE6B 4Q7JA 3VEJA 2KR1A 2LO0A 4QPMA 5DMZA 3BMBA 1WM9A 1N3RA 1A8RA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4DRB J;  3B0B C;  4NE6 B;  4E45 B;  4NE5 B;  4NE3 B;  4E44 B;  4DRA E; 
#chains in the Genus database with same CATH topology
 2WSF G;  1AIP C;  1N3T A;  4R8Q A;  1IS7 A;  1IS8 A;  1A9C A;  2WSF K;  2WSE K;  1GTP A;  1WUR A;  4E45 B;  1EL6 A;  2O01 G;  4NE3 B;  4JA3 A;  1N3S A;  1FB1 A;  1WUQ A;  3B0B C;  1TFE A;  1WPL A;  4NE5 B;  2LNZ A;  4E44 B;  4DRA E;  2PN0 A;  4DU6 A;  1FBX A;  2P11 A;  4DRB J;  1EFU B;  3LW5 G;  4NE6 B;  4Q7J A;  2WSC G;  3VEJ A;  2KR1 A;  2LO0 A;  4QPM A;  5DMZ A;  3BMB A;  1WM9 A;  1N3R A;  2WSC K;  3LW5 K;  2WSE G;  1A8R A; 
#chains in the Genus database with same CATH homology
 1AIP C;  1N3T A;  4R8Q A;  1IS7 A;  1IS8 A;  1A9C A;  1GTP A;  1WUR A;  4E45 B;  1EL6 A;  4NE3 B;  4JA3 A;  1N3S A;  1FB1 A;  1WUQ A;  3B0B C;  1TFE A;  1WPL A;  4NE5 B;  2LNZ A;  4E44 B;  4DRA E;  2PN0 A;  4DU6 A;  1FBX A;  2P11 A;  4DRB J;  1EFU B;  4NE6 B;  4Q7J A;  3VEJ A;  2KR1 A;  2LO0 A;  4QPM A;  5DMZ A;  3BMB A;  1WM9 A;  1N3R A;  1A8R A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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