4E9FA

Structure of the glycosylase domain of mbd4 bound to ap site containing dna
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
138
structure length
138
Chain Sequence
KWTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEDHKLNKYHDWLWENH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Methyl-CpG-binding domain protein 4
publication title Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase/dna
total genus 46
structure length 138
sequence length 138
ec nomenclature ec 3.2.2.-:
pdb deposition date 2012-03-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4e9fA00
1KQJA 2NOHA 2NOIA 2NOEA 2H56A 4E9GA 1EBMA 2XHIA 1YQMA 4UOBA 3I0XA 1ORPA 3CW7A 4E9EA 1XQPA 3G0QA 2I5WA 4YPHA 4AI4A 3IH7A 1KG7A 3CWTA 3IHOA 3FHFA 2JG6A 3CVSA 4HSBA 1WEFA 3FSPA 2NOBA 1PU8A 1LWWA 2YG9A 1YQLA 1N3AA 3D4VA 3N0UA 4DK9A 2JHNA 3CWSA 3OH6A 4EVVA 3FHGA 4EW0A 1ORNA 1YQRA 3CWUA 1LWVA 1PU7A 1HU0A 1MUNA 1WEIA 3CVTA 3F10A 2ABKA 3F0ZA 3S6IA 3KNTA 1PVSA 5AN4A 4EJYA 3N5NX 1P59A 1FN7A 4AI5A 1NGNA 4EJZA 3KTUA 1DIZA 1KG3A 4OFEA 4B23A 5CHZA 1PU6A 1MUDA 1XG7A 4E9FA 4AIAA 1KO9A 1RRSA 1YQKA 2NOZA 4EA4A 1KG6A 2OFIA 4B24A 4YPRA 1NKUA 4PIIA 4EA5A 1RRQA 3OGDA 3I0WA 2NOLA 1N3CA 1N39A 1KG5A 4UNFA 2YG8A 1LMZA 4YOQA 5DPKA 2NOFA 4E9HA 1KG4A 1MPGA 1MUYA 1M3HA 1WEGA 1M3QA 1LWYA 4EW4A 2OFKA 1KEAA 1VRLA 1KG2A 5KN9A 1P7MA 1XQOA 5KN8A 2JHJA 3OH9A 4OFAA 4OFHA 4B21A 4B22A 3CWAA
chains in the Genus database with same CATH superfamily
1KQJA 4IKFA 2NOHA 2NOIA 2NOEA 2H56A 3OY9A 4E9GA 1EBMA 2XHIA 3L2RA 4BE2A 4BACA 1YQMA 4UOBA 3I0XA 1ORPA 3CW7A 4ZTFA 4E9EA 1XQPA 3G0QA 2I5WA 4YPHA 3OYKA 3OYLA 4AI4A 3IH7A 1KG7A 3CWTA 3IHOA 3OYCA 3FHFA 2JPSA 2JG6A 3CVSA 4HSBA 1WEFA 3FSPA 2NOBA 1PU8A 3R2XC 3OS0A 2YG9A 1LWWA 1YQLA 1N3AA 3D4VA 3OYHA 3N0UA 4DK9A 2JHNA 3CWSA 3NNQA 3OYIA 3OYDA 3OH6A 4EVVA 3L2WA 3FHGA 5FRMA 2V75A 4EW0A 1ORNA 4E7LA 1YQRA 3CWUA 1LWVA 1PU7A 1HU0A 1MUNA 1WEIA 3CVTA 3F10A 2ABKA 3F0ZA 2W04A 3OS1A 3KNTA 3S6IA 1PVSA 5AN4A 4EJYA 3LCNA 3N5NX 4BE1A 1P59A 1U84A 1FN7A 4AI5A 3S3OA 1NGNA 4NZGA 3S3NA 4BDZA 3OYMA 4EJZA 3KTUA 1DIZA 1KG3A 4OFEA 4B23A 5CHZA 4ZTJA 1PU6A 1MUDA 1XG7A 4E9FA 3L2UA 4AIAA 3OYNA 1KO9A 1RRSA 1YQKA 3OYEA 4E7HA 4BE0A 2NOZA 4EA4A 1KG6A 2OFIA 3VW4A 4B24A 4YPRA 1NKUA 4PIIA 4EA5A 1RRQA 3OS2A 3OGDA 3I0WA 2NOLA 3OYFA 3OYAA 1N3CA 1N39A 1KG5A 5FROA 4UNFA 2YG8A 1LMZA 4YOQA 5DPKA 5FRNA 3S3MA 3OYJA 3L2QA 2NOFA 4E9HA 2W03A 1KG4A 1MPGA 1MUYA 1M3HA 1WEGA 1M3QA 4E7JA 1LWYA 3L2VA 4EW4A 2OFKA 1KEAA 4E7IA 1VRLA 1KG2A 3OYGA 5KN9A 1P7MA 1XQOA 5KN8A 2JHJA 3OH9A 4BDYA 3OYBA 4E7KA 4OFAA 4OFHA 4B21A 4B22A 3CWAA
chains in the Genus database with same CATH topology
1KQJA 2NOHA 2NOIA 2NOEA 2H56A 4E9GA 1EBMA 2XHIA 1YQMA 4UOBA 3I0XA 1ORPA 3CW7A 4E9EA 1XQPA 3G0QA 2I5WA 4YPHA 4AI4A 3IH7A 1KG7A 3CWTA 3IHOA 3FHFA 2JG6A 3CVSA 4HSBA 1WEFA 3FSPA 2NOBA 1PU8A 1LWWA 2YG9A 1YQLA 1N3AA 3D4VA 3N0UA 4DK9A 2JHNA 3CWSA 3OH6A 4EVVA 3FHGA 4EW0A 1ORNA 1YQRA 3CWUA 1LWVA 1PU7A 1HU0A 1MUNA 1WEIA 3CVTA 3F10A 2ABKA 3F0ZA 3S6IA 3KNTA 1PVSA 5AN4A 4EJYA 3N5NX 1P59A 1FN7A 4AI5A 1NGNA 4EJZA 3KTUA 1DIZA 1KG3A 4OFEA 4B23A 5CHZA 1PU6A 1MUDA 1XG7A 4E9FA 4AIAA 1KO9A 1RRSA 1YQKA 2NOZA 4EA4A 1KG6A 2OFIA 4B24A 4YPRA 1NKUA 4PIIA 4EA5A 1RRQA 3OGDA 3I0WA 2NOLA 1N3CA 1N39A 1KG5A 4UNFA 2YG8A 1LMZA 4YOQA 5DPKA 2NOFA 4E9HA 1KG4A 1MPGA 1MUYA 1M3HA 1WEGA 1M3QA 1LWYA 4EW4A 2OFKA 1KEAA 1VRLA 1KG2A 5KN9A 1P7MA 1XQOA 5KN8A 2JHJA 3OH9A 4OFAA 4OFHA 4B21A 4B22A 3CWAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KQJ A;  2NOH A;  2NOI A;  2NOE A;  2H56 A;  4E9G A;  1EBM A;  2XHI A;  1YQM A;  4UOB A;  3I0X A;  1ORP A;  3CW7 A;  4E9E A;  1XQP A;  3G0Q A;  2I5W A;  4YPH A;  4AI4 A;  3IH7 A;  1KG7 A;  3CWT A;  3IHO A;  3FHF A;  2JG6 A;  3CVS A;  4HSB A;  1WEF A;  3FSP A;  2NOB A;  1PU8 A;  1LWW A;  2YG9 A;  1YQL A;  1N3A A;  3D4V A;  3N0U A;  4DK9 A;  2JHN A;  3CWS A;  3OH6 A;  4EVV A;  3FHG A;  4EW0 A;  1ORN A;  1YQR A;  3CWU A;  1LWV A;  1PU7 A;  1HU0 A;  1MUN A;  1WEI A;  3CVT A;  3F10 A;  2ABK A;  3F0Z A;  3S6I A;  3KNT A;  1PVS A;  5AN4 A;  4EJY A;  3N5N X;  1P59 A;  1FN7 A;  4AI5 A;  1NGN A;  4EJZ A;  3KTU A;  1DIZ A;  1KG3 A;  4OFE A;  4B23 A;  5CHZ A;  1PU6 A;  1MUD A;  1XG7 A;  4E9F A;  4AIA A;  1KO9 A;  1RRS A;  1YQK A;  2NOZ A;  4EA4 A;  1KG6 A;  2OFI A;  4B24 A;  4YPR A;  1NKU A;  4PII A;  4EA5 A;  1RRQ A;  3OGD A;  3I0W A;  2NOL A;  1N3C A;  1N39 A;  1KG5 A;  4UNF A;  2YG8 A;  1LMZ A;  4YOQ A;  5DPK A;  2NOF A;  4E9H A;  1KG4 A;  1MPG A;  1MUY A;  1M3H A;  1WEG A;  1M3Q A;  1LWY A;  4EW4 A;  2OFK A;  1KEA A;  1VRL A;  1KG2 A;  5KN9 A;  1P7M A;  1XQO A;  5KN8 A;  2JHJ A;  3OH9 A;  4OFA A;  4OFH A;  4B21 A;  4B22 A;  3CWA A; 
#chains in the Genus database with same CATH topology
 1KQJ A;  4IKF A;  2NOH A;  2NOI A;  2NOE A;  2H56 A;  3OY9 A;  4E9G A;  1EBM A;  2XHI A;  3L2R A;  4BE2 A;  4BAC A;  1YQM A;  4UOB A;  3I0X A;  1ORP A;  3CW7 A;  4ZTF A;  4E9E A;  1XQP A;  3G0Q A;  2I5W A;  4YPH A;  3OYK A;  3OYL A;  4AI4 A;  3IH7 A;  1KG7 A;  3CWT A;  3IHO A;  3OYC A;  3FHF A;  2JPS A;  2JG6 A;  3CVS A;  4HSB A;  1WEF A;  3FSP A;  2NOB A;  1PU8 A;  3R2X C;  3OS0 A;  2YG9 A;  1LWW A;  1YQL A;  1N3A A;  3D4V A;  3OYH A;  3N0U A;  4DK9 A;  2JHN A;  3CWS A;  3NNQ A;  3OYI A;  3OYD A;  3OH6 A;  4EVV A;  3L2W A;  3FHG A;  5FRM A;  2V75 A;  4EW0 A;  1ORN A;  4E7L A;  1YQR A;  3CWU A;  1LWV A;  1PU7 A;  1HU0 A;  1MUN A;  1WEI A;  3CVT A;  3F10 A;  2ABK A;  3F0Z A;  2W04 A;  3OS1 A;  3KNT A;  3S6I A;  1PVS A;  5AN4 A;  4EJY A;  3LCN A;  3N5N X;  4BE1 A;  1P59 A;  1U84 A;  1FN7 A;  4AI5 A;  3S3O A;  1NGN A;  4NZG A;  3S3N A;  4BDZ A;  3OYM A;  4EJZ A;  3KTU A;  1DIZ A;  1KG3 A;  4OFE A;  4B23 A;  5CHZ A;  4ZTJ A;  1PU6 A;  1MUD A;  1XG7 A;  4E9F A;  3L2U A;  4AIA A;  3OYN A;  1KO9 A;  1RRS A;  1YQK A;  3OYE A;  4E7H A;  4BE0 A;  2NOZ A;  4EA4 A;  1KG6 A;  2OFI A;  3VW4 A;  4B24 A;  4YPR A;  1NKU A;  4PII A;  4EA5 A;  1RRQ A;  3OS2 A;  3OGD A;  3I0W A;  2NOL A;  3OYF A;  3OYA A;  1N3C A;  1N39 A;  1KG5 A;  5FRO A;  4UNF A;  2YG8 A;  1LMZ A;  4YOQ A;  5DPK A;  5FRN A;  3S3M A;  3OYJ A;  3L2Q A;  2NOF A;  4E9H A;  2W03 A;  1KG4 A;  1MPG A;  1MUY A;  1M3H A;  1WEG A;  1M3Q A;  4E7J A;  1LWY A;  3L2V A;  4EW4 A;  2OFK A;  1KEA A;  4E7I A;  1VRL A;  1KG2 A;  3OYG A;  5KN9 A;  1P7M A;  1XQO A;  5KN8 A;  2JHJ A;  3OH9 A;  4BDY A;  3OYB A;  4E7K A;  4OFA A;  4OFH A;  4B21 A;  4B22 A;  3CWA A; 
#chains in the Genus database with same CATH homology
 1KQJ A;  2NOH A;  2NOI A;  2NOE A;  2H56 A;  4E9G A;  1EBM A;  2XHI A;  1YQM A;  4UOB A;  3I0X A;  1ORP A;  3CW7 A;  4E9E A;  1XQP A;  3G0Q A;  2I5W A;  4YPH A;  4AI4 A;  3IH7 A;  1KG7 A;  3CWT A;  3IHO A;  3FHF A;  2JG6 A;  3CVS A;  4HSB A;  1WEF A;  3FSP A;  2NOB A;  1PU8 A;  1LWW A;  2YG9 A;  1YQL A;  1N3A A;  3D4V A;  3N0U A;  4DK9 A;  2JHN A;  3CWS A;  3OH6 A;  4EVV A;  3FHG A;  4EW0 A;  1ORN A;  1YQR A;  3CWU A;  1LWV A;  1PU7 A;  1HU0 A;  1MUN A;  1WEI A;  3CVT A;  3F10 A;  2ABK A;  3F0Z A;  3S6I A;  3KNT A;  1PVS A;  5AN4 A;  4EJY A;  3N5N X;  1P59 A;  1FN7 A;  4AI5 A;  1NGN A;  4EJZ A;  3KTU A;  1DIZ A;  1KG3 A;  4OFE A;  4B23 A;  5CHZ A;  1PU6 A;  1MUD A;  1XG7 A;  4E9F A;  4AIA A;  1KO9 A;  1RRS A;  1YQK A;  2NOZ A;  4EA4 A;  1KG6 A;  2OFI A;  4B24 A;  4YPR A;  1NKU A;  4PII A;  4EA5 A;  1RRQ A;  3OGD A;  3I0W A;  2NOL A;  1N3C A;  1N39 A;  1KG5 A;  4UNF A;  2YG8 A;  1LMZ A;  4YOQ A;  5DPK A;  2NOF A;  4E9H A;  1KG4 A;  1MPG A;  1MUY A;  1M3H A;  1WEG A;  1M3Q A;  1LWY A;  4EW4 A;  2OFK A;  1KEA A;  1VRL A;  1KG2 A;  5KN9 A;  1P7M A;  1XQO A;  5KN8 A;  2JHJ A;  3OH9 A;  4OFA A;  4OFH A;  4B21 A;  4B22 A;  3CWA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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