4E9GA

Structure of the glycosylase domain of mbd4 bound to thymine containing dna
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
138
structure length
138
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEAHKLNKYHDWLWENHE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Methyl-CpG-binding domain protein 4
publication title Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase/dna
total genus 43
structure length 138
sequence length 138
ec nomenclature ec 3.2.2.-:
pdb deposition date 2012-03-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4e9gA00
1P7MA 1XQOA 1KO9A 3IHOA 1N39A 2NOZA 3N0UA 1YQMA 4EA4A 4YPRA 1XQPA 2JG6A 4OFAA 3OGDA 4UNFA 3FHFA 2NOHA 1HU0A 3OH9A 3N5NX 4AI4A 4B22A 1KG2A 3F10A 4EW0A 1M3HA 2YG9A 2NOFA 1KG5A 1MUYA 2OFIA 1RRSA 4B21A 5KN9A 4E9HA 4EJYA 1VRLA 1ORPA 1KQJA 1PU7A 3CW7A 4HSBA 2JHNA 1YQLA 4YPHA 3F0ZA 1WEIA 3FHGA 3FSPA 1PU6A 4EVVA 1LWYA 1LWWA 2I5WA 4UOBA 4PIIA 1MPGA 3G0QA 4OFHA 3KTUA 3CWSA 4EW4A 1P59A 1YQKA 5DPKA 1N3CA 2NOLA 1WEFA 1KG6A 4DK9A 4B24A 1KG3A 1LWVA 2OFKA 1MUDA 1LMZA 1PU8A 3CWAA 1KEAA 3KNTA 4E9EA 5CHZA 1KG4A 1YQRA 3I0WA 2YG8A 1WEGA 4OFEA 1DIZA 4E9FA 1M3QA 1NKUA 4EA5A 2JHJA 3I0XA 1PVSA 3CWTA 5AN4A 1N3AA 2NOBA 1FN7A 1EBMA 4AIAA 3CWUA 3CVTA 1MUNA 3CVSA 2NOIA 3S6IA 1KG7A 2NOEA 4B23A 1ORNA 1NGNA 2ABKA 2XHIA 3IH7A 4E9GA 4EJZA 4YOQA 1XG7A 3OH6A 1RRQA 5KN8A 4AI5A 2H56A 3D4VA
chains in the Genus database with same CATH superfamily
1P7MA 1XQOA 2W03A 3S3MA 3L2RA 4BDZA 1KO9A 3IHOA 1N39A 2NOZA 3N0UA 1YQMA 4EA4A 4YPRA 1XQPA 2JG6A 4OFAA 3OGDA 4UNFA 3FHFA 3OYFA 3L2WA 4E7HA 2NOHA 3OYLA 4BE2A 1HU0A 3OH9A 3N5NX 4AI4A 4B22A 5FRMA 1KG2A 3F10A 4EW0A 1M3HA 2YG9A 2NOFA 3S3NA 4ZTJA 1KG5A 2JPSA 1MUYA 2OFIA 1RRSA 4B21A 5KN9A 4E9HA 4EJYA 1VRLA 3OYBA 1ORPA 1KQJA 1PU7A 3OYHA 4BE0A 4E7IA 3CW7A 3D4VA 4HSBA 2W04A 2JHNA 4E7JA 1YQLA 4YPHA 3OYCA 3F0ZA 1WEIA 1U84A 3S3OA 3OY9A 3OYKA 3OS0A 3OYJA 3OYDA 4BDYA 4BE1A 3FHGA 3FSPA 1PU6A 4EVVA 1LWYA 1LWWA 2I5WA 4UOBA 4PIIA 1MPGA 3G0QA 3OYIA 4OFHA 3KTUA 4BACA 3CWSA 4EW4A 1P59A 3OYEA 1YQKA 2V75A 5DPKA 1N3CA 2NOLA 1WEFA 1KG6A 4DK9A 4B24A 1KG3A 4ZTFA 1LWVA 4NZGA 3OYAA 3OYNA 3VW4A 3OS1A 2OFKA 1MUDA 1LMZA 1PU8A 4E7KA 3CWAA 1KEAA 3KNTA 4E9EA 3L2QA 5CHZA 1KG4A 1YQRA 3I0WA 2YG8A 1WEGA 4OFEA 1DIZA 4E9FA 1M3QA 1NKUA 4EA5A 2JHJA 3I0XA 1PVSA 4E7LA 3CWTA 5AN4A 1N3AA 3OYMA 3OYGA 3L2VA 2NOBA 1FN7A 1EBMA 4AIAA 3CWUA 3OS2A 5FROA 3CVTA 1MUNA 3CVSA 4IKFA 2NOIA 5FRNA 3L2UA 3S6IA 1KG7A 2NOEA 4B23A 1ORNA 1NGNA 2ABKA 2XHIA 3IH7A 4E9GA 3LCNA 4EJZA 4YOQA 1XG7A 3R2XC 3OH6A 1RRQA 5KN8A 4AI5A 2H56A 3NNQA
chains in the Genus database with same CATH topology
1P7MA 1XQOA 1KO9A 3IHOA 1N39A 2NOZA 3N0UA 1YQMA 4EA4A 4YPRA 1XQPA 2JG6A 4OFAA 3OGDA 4UNFA 3FHFA 2NOHA 1HU0A 3OH9A 3N5NX 4AI4A 4B22A 1KG2A 3F10A 4EW0A 1M3HA 2YG9A 2NOFA 1KG5A 1MUYA 2OFIA 1RRSA 4B21A 5KN9A 4E9HA 4EJYA 1VRLA 1ORPA 1KQJA 1PU7A 3CW7A 4HSBA 2JHNA 1YQLA 4YPHA 3F0ZA 1WEIA 3FHGA 3FSPA 1PU6A 4EVVA 1LWYA 1LWWA 2I5WA 4UOBA 4PIIA 1MPGA 3G0QA 4OFHA 3KTUA 3CWSA 4EW4A 1P59A 1YQKA 5DPKA 1N3CA 2NOLA 1WEFA 1KG6A 4DK9A 4B24A 1KG3A 1LWVA 2OFKA 1MUDA 1LMZA 1PU8A 3CWAA 1KEAA 3KNTA 4E9EA 5CHZA 1KG4A 1YQRA 3I0WA 2YG8A 1WEGA 4OFEA 1DIZA 4E9FA 1M3QA 1NKUA 4EA5A 2JHJA 3I0XA 1PVSA 3CWTA 5AN4A 1N3AA 2NOBA 1FN7A 1EBMA 4AIAA 3CWUA 3CVTA 1MUNA 3CVSA 2NOIA 3S6IA 1KG7A 2NOEA 4B23A 1ORNA 1NGNA 2ABKA 2XHIA 3IH7A 4E9GA 4EJZA 4YOQA 1XG7A 3OH6A 1RRQA 5KN8A 4AI5A 2H56A 3D4VA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1P7M A;  1XQO A;  1KO9 A;  3IHO A;  1N39 A;  2NOZ A;  3N0U A;  1YQM A;  4EA4 A;  4YPR A;  1XQP A;  2JG6 A;  4OFA A;  3OGD A;  4UNF A;  3FHF A;  2NOH A;  1HU0 A;  3OH9 A;  3N5N X;  4AI4 A;  4B22 A;  1KG2 A;  3F10 A;  4EW0 A;  1M3H A;  2YG9 A;  2NOF A;  1KG5 A;  1MUY A;  2OFI A;  1RRS A;  4B21 A;  5KN9 A;  4E9H A;  4EJY A;  1VRL A;  1ORP A;  1KQJ A;  1PU7 A;  3CW7 A;  4HSB A;  2JHN A;  1YQL A;  4YPH A;  3F0Z A;  1WEI A;  3FHG A;  3FSP A;  1PU6 A;  4EVV A;  1LWY A;  1LWW A;  2I5W A;  4UOB A;  4PII A;  1MPG A;  3G0Q A;  4OFH A;  3KTU A;  3CWS A;  4EW4 A;  1P59 A;  1YQK A;  5DPK A;  1N3C A;  2NOL A;  1WEF A;  1KG6 A;  4DK9 A;  4B24 A;  1KG3 A;  1LWV A;  2OFK A;  1MUD A;  1LMZ A;  1PU8 A;  3CWA A;  1KEA A;  3KNT A;  4E9E A;  5CHZ A;  1KG4 A;  1YQR A;  3I0W A;  2YG8 A;  1WEG A;  4OFE A;  1DIZ A;  4E9F A;  1M3Q A;  1NKU A;  4EA5 A;  2JHJ A;  3I0X A;  1PVS A;  3CWT A;  5AN4 A;  1N3A A;  2NOB A;  1FN7 A;  1EBM A;  4AIA A;  3CWU A;  3CVT A;  1MUN A;  3CVS A;  2NOI A;  3S6I A;  1KG7 A;  2NOE A;  4B23 A;  1ORN A;  1NGN A;  2ABK A;  2XHI A;  3IH7 A;  4E9G A;  4EJZ A;  4YOQ A;  1XG7 A;  3OH6 A;  1RRQ A;  5KN8 A;  4AI5 A;  2H56 A;  3D4V A; 
#chains in the Genus database with same CATH topology
 1P7M A;  1XQO A;  2W03 A;  3S3M A;  3L2R A;  4BDZ A;  1KO9 A;  3IHO A;  1N39 A;  2NOZ A;  3N0U A;  1YQM A;  4EA4 A;  4YPR A;  1XQP A;  2JG6 A;  4OFA A;  3OGD A;  4UNF A;  3FHF A;  3OYF A;  3L2W A;  4E7H A;  2NOH A;  3OYL A;  4BE2 A;  1HU0 A;  3OH9 A;  3N5N X;  4AI4 A;  4B22 A;  5FRM A;  1KG2 A;  3F10 A;  4EW0 A;  1M3H A;  2YG9 A;  2NOF A;  3S3N A;  4ZTJ A;  1KG5 A;  2JPS A;  1MUY A;  2OFI A;  1RRS A;  4B21 A;  5KN9 A;  4E9H A;  4EJY A;  1VRL A;  3OYB A;  1ORP A;  1KQJ A;  1PU7 A;  3OYH A;  4BE0 A;  4E7I A;  3CW7 A;  3D4V A;  4HSB A;  2W04 A;  2JHN A;  4E7J A;  1YQL A;  4YPH A;  3OYC A;  3F0Z A;  1WEI A;  1U84 A;  3S3O A;  3OY9 A;  3OYK A;  3OS0 A;  3OYJ A;  3OYD A;  4BDY A;  4BE1 A;  3FHG A;  3FSP A;  1PU6 A;  4EVV A;  1LWY A;  1LWW A;  2I5W A;  4UOB A;  4PII A;  1MPG A;  3G0Q A;  3OYI A;  4OFH A;  3KTU A;  4BAC A;  3CWS A;  4EW4 A;  1P59 A;  3OYE A;  1YQK A;  2V75 A;  5DPK A;  1N3C A;  2NOL A;  1WEF A;  1KG6 A;  4DK9 A;  4B24 A;  1KG3 A;  4ZTF A;  1LWV A;  4NZG A;  3OYA A;  3OYN A;  3VW4 A;  3OS1 A;  2OFK A;  1MUD A;  1LMZ A;  1PU8 A;  4E7K A;  3CWA A;  1KEA A;  3KNT A;  4E9E A;  3L2Q A;  5CHZ A;  1KG4 A;  1YQR A;  3I0W A;  2YG8 A;  1WEG A;  4OFE A;  1DIZ A;  4E9F A;  1M3Q A;  1NKU A;  4EA5 A;  2JHJ A;  3I0X A;  1PVS A;  4E7L A;  3CWT A;  5AN4 A;  1N3A A;  3OYM A;  3OYG A;  3L2V A;  2NOB A;  1FN7 A;  1EBM A;  4AIA A;  3CWU A;  3OS2 A;  5FRO A;  3CVT A;  1MUN A;  3CVS A;  4IKF A;  2NOI A;  5FRN A;  3L2U A;  3S6I A;  1KG7 A;  2NOE A;  4B23 A;  1ORN A;  1NGN A;  2ABK A;  2XHI A;  3IH7 A;  4E9G A;  3LCN A;  4EJZ A;  4YOQ A;  1XG7 A;  3R2X C;  3OH6 A;  1RRQ A;  5KN8 A;  4AI5 A;  2H56 A;  3NNQ A; 
#chains in the Genus database with same CATH homology
 1P7M A;  1XQO A;  1KO9 A;  3IHO A;  1N39 A;  2NOZ A;  3N0U A;  1YQM A;  4EA4 A;  4YPR A;  1XQP A;  2JG6 A;  4OFA A;  3OGD A;  4UNF A;  3FHF A;  2NOH A;  1HU0 A;  3OH9 A;  3N5N X;  4AI4 A;  4B22 A;  1KG2 A;  3F10 A;  4EW0 A;  1M3H A;  2YG9 A;  2NOF A;  1KG5 A;  1MUY A;  2OFI A;  1RRS A;  4B21 A;  5KN9 A;  4E9H A;  4EJY A;  1VRL A;  1ORP A;  1KQJ A;  1PU7 A;  3CW7 A;  4HSB A;  2JHN A;  1YQL A;  4YPH A;  3F0Z A;  1WEI A;  3FHG A;  3FSP A;  1PU6 A;  4EVV A;  1LWY A;  1LWW A;  2I5W A;  4UOB A;  4PII A;  1MPG A;  3G0Q A;  4OFH A;  3KTU A;  3CWS A;  4EW4 A;  1P59 A;  1YQK A;  5DPK A;  1N3C A;  2NOL A;  1WEF A;  1KG6 A;  4DK9 A;  4B24 A;  1KG3 A;  1LWV A;  2OFK A;  1MUD A;  1LMZ A;  1PU8 A;  3CWA A;  1KEA A;  3KNT A;  4E9E A;  5CHZ A;  1KG4 A;  1YQR A;  3I0W A;  2YG8 A;  1WEG A;  4OFE A;  1DIZ A;  4E9F A;  1M3Q A;  1NKU A;  4EA5 A;  2JHJ A;  3I0X A;  1PVS A;  3CWT A;  5AN4 A;  1N3A A;  2NOB A;  1FN7 A;  1EBM A;  4AIA A;  3CWU A;  3CVT A;  1MUN A;  3CVS A;  2NOI A;  3S6I A;  1KG7 A;  2NOE A;  4B23 A;  1ORN A;  1NGN A;  2ABK A;  2XHI A;  3IH7 A;  4E9G A;  4EJZ A;  4YOQ A;  1XG7 A;  3OH6 A;  1RRQ A;  5KN8 A;  4AI5 A;  2H56 A;  3D4V A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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