4E9GA

Structure of the glycosylase domain of mbd4 bound to thymine containing dna
Total Genus 43
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
138
structure length
138
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEAHKLNKYHDWLWENHE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
pubmed doi rcsb
molecule tags Hydrolase/dna
source organism Homo sapiens
molecule keywords Methyl-CpG-binding domain protein 4
total genus 43
structure length 138
sequence length 138
ec nomenclature ec 3.2.2.-:
pdb deposition date 2012-03-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4e9gA00
2XHIA 1KG5A 4E9FA 1EBMA 1PU8A 1WEIA 3G0QA 1YQMA 2JG6A 1MUDA 1YQLA 4EA5A 3OH9A 1YQKA 1LMZA 4YPHA 2OFKA 3F0ZA 1DIZA 3CW7A 1FN7A 1PU7A 2YG8A 3N5NX 2JHNA 2OFIA 1KG7A 1NGNA 1P7MA 1PVSA 1XQOA 4AI5A 4YOQA 1MUYA 3OH6A 1M3HA 2NOIA 1ORPA 3KTUA 1XG7A 3FHGA 1VRLA 4OFEA 1LWVA 1MUNA 4UNFA 3CWAA 3FSPA 4EW0A 4EJZA 3CVTA 1ORNA 2YG9A 3I0XA 4E9EA 2ABKA 1HU0A 3CWSA 1XQPA 4DK9A 3I0WA 3CWTA 4YPRA 1LWYA 1WEGA 5DPKA 5KN9A 5CHZA 3CWUA 1P59A 4UOBA 2I5WA 3IHOA 4EJYA 3S6IA 1KG2A 4B23A 3OGDA 3N0UA 1N3AA 3KNTA 1MPGA 4EW4A 1KG3A 1RRQA 4E9HA 1KQJA 1N39A 4B24A 2H56A 2NOHA 4EA4A 1PU6A 1KO9A 2NOFA 4OFHA 4B21A 1M3QA 3F10A 4B22A 1RRSA 2NOEA 2NOZA 4OFAA 3IH7A 1KG4A 4PIIA 4AIAA 1NKUA 1YQRA 1WEFA 5AN4A 3FHFA 5KN8A 2NOBA 2NOLA 4AI4A 4HSBA 1LWWA 1KEAA 4EVVA 3CVSA 4E9GA 3D4VA 1N3CA 2JHJA 1KG6A
chains in the Genus database with same CATH superfamily
2XHIA 1KG5A 4E9FA 1EBMA 1PU8A 1WEIA 3S3MA 3G0QA 1YQMA 2JG6A 3OYIA 1MUDA 3OYBA 1YQLA 4ZTJA 4EA5A 3OH9A 1YQKA 1LMZA 3L2VA 4YPHA 3OS1A 2OFKA 3F0ZA 1DIZA 3CW7A 2W04A 3OS2A 1FN7A 1PU7A 2YG8A 3N5NX 2JHNA 3OYFA 3LCNA 2JPSA 2OFIA 4IKFA 1KG7A 1NGNA 1P7MA 3OY9A 1PVSA 1XQOA 4AI5A 4YOQA 4BE1A 1MUYA 4E7LA 3OH6A 1M3HA 2NOIA 1ORPA 3KTUA 1XG7A 3FHGA 3OYMA 1VRLA 4OFEA 3R2XC 3OYLA 3S3OA 3OYGA 1LWVA 3OS0A 1MUNA 4UNFA 4E7KA 4BE2A 3CWAA 3FSPA 4EW0A 4EJZA 3CVTA 1ORNA 2YG9A 3I0XA 4E9EA 2ABKA 4BDZA 3OYCA 1HU0A 3OYEA 4E7JA 3CWSA 1XQPA 2W03A 3OYKA 5FRNA 3L2UA 3L2QA 4BE0A 4DK9A 3I0WA 3CWTA 4YPRA 1LWYA 1WEGA 5DPKA 5KN9A 4E7IA 3VW4A 5FROA 3OYAA 5CHZA 2V75A 3OYDA 3CWUA 4ZTFA 1P59A 3NNQA 4NZGA 4UOBA 2I5WA 3IHOA 4EJYA 3S6IA 1KG2A 4B23A 3OGDA 3N0UA 1N3AA 3KNTA 1MPGA 3OYHA 4EW4A 1KG3A 1RRQA 4E9HA 1KQJA 1N39A 4B24A 4BACA 2H56A 3OYNA 2NOHA 4EA4A 1PU6A 1KO9A 2NOFA 4OFHA 4B21A 1M3QA 3F10A 4E7HA 4B22A 1RRSA 2NOEA 2NOZA 4OFAA 3L2WA 4BDYA 3L2RA 3IH7A 1KG4A 4PIIA 4AIAA 3OYJA 5FRMA 1NKUA 1YQRA 1WEFA 5AN4A 3FHFA 5KN8A 2NOBA 3S3NA 2NOLA 4AI4A 4HSBA 1LWWA 1KEAA 4EVVA 1U84A 3CVSA 4E9GA 3D4VA 1N3CA 2JHJA 1KG6A
chains in the Genus database with same CATH topology
2XHIA 1KG5A 4E9FA 1EBMA 1PU8A 1WEIA 3G0QA 1YQMA 2JG6A 1MUDA 1YQLA 4EA5A 3OH9A 1YQKA 1LMZA 4YPHA 2OFKA 3F0ZA 1DIZA 3CW7A 1FN7A 1PU7A 2YG8A 3N5NX 2JHNA 2OFIA 1KG7A 1NGNA 1P7MA 1PVSA 1XQOA 4AI5A 4YOQA 1MUYA 3OH6A 1M3HA 2NOIA 1ORPA 3KTUA 1XG7A 3FHGA 1VRLA 4OFEA 1LWVA 1MUNA 4UNFA 3CWAA 3FSPA 4EW0A 4EJZA 3CVTA 1ORNA 2YG9A 3I0XA 4E9EA 2ABKA 1HU0A 3CWSA 1XQPA 4DK9A 3I0WA 3CWTA 4YPRA 1LWYA 1WEGA 5DPKA 5KN9A 5CHZA 3CWUA 1P59A 4UOBA 2I5WA 3IHOA 4EJYA 3S6IA 1KG2A 4B23A 3OGDA 3N0UA 1N3AA 3KNTA 1MPGA 4EW4A 1KG3A 1RRQA 4E9HA 1KQJA 1N39A 4B24A 2H56A 2NOHA 4EA4A 1PU6A 1KO9A 2NOFA 4OFHA 4B21A 1M3QA 3F10A 4B22A 1RRSA 2NOEA 2NOZA 4OFAA 3IH7A 1KG4A 4PIIA 4AIAA 1NKUA 1YQRA 1WEFA 5AN4A 3FHFA 5KN8A 2NOBA 2NOLA 4AI4A 4HSBA 1LWWA 1KEAA 4EVVA 3CVSA 4E9GA 3D4VA 1N3CA 2JHJA 1KG6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XHI A;  1KG5 A;  4E9F A;  1EBM A;  1PU8 A;  1WEI A;  3G0Q A;  1YQM A;  2JG6 A;  1MUD A;  1YQL A;  4EA5 A;  3OH9 A;  1YQK A;  1LMZ A;  4YPH A;  2OFK A;  3F0Z A;  1DIZ A;  3CW7 A;  1FN7 A;  1PU7 A;  2YG8 A;  3N5N X;  2JHN A;  2OFI A;  1KG7 A;  1NGN A;  1P7M A;  1PVS A;  1XQO A;  4AI5 A;  4YOQ A;  1MUY A;  3OH6 A;  1M3H A;  2NOI A;  1ORP A;  3KTU A;  1XG7 A;  3FHG A;  1VRL A;  4OFE A;  1LWV A;  1MUN A;  4UNF A;  3CWA A;  3FSP A;  4EW0 A;  4EJZ A;  3CVT A;  1ORN A;  2YG9 A;  3I0X A;  4E9E A;  2ABK A;  1HU0 A;  3CWS A;  1XQP A;  4DK9 A;  3I0W A;  3CWT A;  4YPR A;  1LWY A;  1WEG A;  5DPK A;  5KN9 A;  5CHZ A;  3CWU A;  1P59 A;  4UOB A;  2I5W A;  3IHO A;  4EJY A;  3S6I A;  1KG2 A;  4B23 A;  3OGD A;  3N0U A;  1N3A A;  3KNT A;  1MPG A;  4EW4 A;  1KG3 A;  1RRQ A;  4E9H A;  1KQJ A;  1N39 A;  4B24 A;  2H56 A;  2NOH A;  4EA4 A;  1PU6 A;  1KO9 A;  2NOF A;  4OFH A;  4B21 A;  1M3Q A;  3F10 A;  4B22 A;  1RRS A;  2NOE A;  2NOZ A;  4OFA A;  3IH7 A;  1KG4 A;  4PII A;  4AIA A;  1NKU A;  1YQR A;  1WEF A;  5AN4 A;  3FHF A;  5KN8 A;  2NOB A;  2NOL A;  4AI4 A;  4HSB A;  1LWW A;  1KEA A;  4EVV A;  3CVS A;  4E9G A;  3D4V A;  1N3C A;  2JHJ A;  1KG6 A; 
#chains in the Genus database with same CATH topology
 2XHI A;  1KG5 A;  4E9F A;  1EBM A;  1PU8 A;  1WEI A;  3S3M A;  3G0Q A;  1YQM A;  2JG6 A;  3OYI A;  1MUD A;  3OYB A;  1YQL A;  4ZTJ A;  4EA5 A;  3OH9 A;  1YQK A;  1LMZ A;  3L2V A;  4YPH A;  3OS1 A;  2OFK A;  3F0Z A;  1DIZ A;  3CW7 A;  2W04 A;  3OS2 A;  1FN7 A;  1PU7 A;  2YG8 A;  3N5N X;  2JHN A;  3OYF A;  3LCN A;  2JPS A;  2OFI A;  4IKF A;  1KG7 A;  1NGN A;  1P7M A;  3OY9 A;  1PVS A;  1XQO A;  4AI5 A;  4YOQ A;  4BE1 A;  1MUY A;  4E7L A;  3OH6 A;  1M3H A;  2NOI A;  1ORP A;  3KTU A;  1XG7 A;  3FHG A;  3OYM A;  1VRL A;  4OFE A;  3R2X C;  3OYL A;  3S3O A;  3OYG A;  1LWV A;  3OS0 A;  1MUN A;  4UNF A;  4E7K A;  4BE2 A;  3CWA A;  3FSP A;  4EW0 A;  4EJZ A;  3CVT A;  1ORN A;  2YG9 A;  3I0X A;  4E9E A;  2ABK A;  4BDZ A;  3OYC A;  1HU0 A;  3OYE A;  4E7J A;  3CWS A;  1XQP A;  2W03 A;  3OYK A;  5FRN A;  3L2U A;  3L2Q A;  4BE0 A;  4DK9 A;  3I0W A;  3CWT A;  4YPR A;  1LWY A;  1WEG A;  5DPK A;  5KN9 A;  4E7I A;  3VW4 A;  5FRO A;  3OYA A;  5CHZ A;  2V75 A;  3OYD A;  3CWU A;  4ZTF A;  1P59 A;  3NNQ A;  4NZG A;  4UOB A;  2I5W A;  3IHO A;  4EJY A;  3S6I A;  1KG2 A;  4B23 A;  3OGD A;  3N0U A;  1N3A A;  3KNT A;  1MPG A;  3OYH A;  4EW4 A;  1KG3 A;  1RRQ A;  4E9H A;  1KQJ A;  1N39 A;  4B24 A;  4BAC A;  2H56 A;  3OYN A;  2NOH A;  4EA4 A;  1PU6 A;  1KO9 A;  2NOF A;  4OFH A;  4B21 A;  1M3Q A;  3F10 A;  4E7H A;  4B22 A;  1RRS A;  2NOE A;  2NOZ A;  4OFA A;  3L2W A;  4BDY A;  3L2R A;  3IH7 A;  1KG4 A;  4PII A;  4AIA A;  3OYJ A;  5FRM A;  1NKU A;  1YQR A;  1WEF A;  5AN4 A;  3FHF A;  5KN8 A;  2NOB A;  3S3N A;  2NOL A;  4AI4 A;  4HSB A;  1LWW A;  1KEA A;  4EVV A;  1U84 A;  3CVS A;  4E9G A;  3D4V A;  1N3C A;  2JHJ A;  1KG6 A; 
#chains in the Genus database with same CATH homology
 2XHI A;  1KG5 A;  4E9F A;  1EBM A;  1PU8 A;  1WEI A;  3G0Q A;  1YQM A;  2JG6 A;  1MUD A;  1YQL A;  4EA5 A;  3OH9 A;  1YQK A;  1LMZ A;  4YPH A;  2OFK A;  3F0Z A;  1DIZ A;  3CW7 A;  1FN7 A;  1PU7 A;  2YG8 A;  3N5N X;  2JHN A;  2OFI A;  1KG7 A;  1NGN A;  1P7M A;  1PVS A;  1XQO A;  4AI5 A;  4YOQ A;  1MUY A;  3OH6 A;  1M3H A;  2NOI A;  1ORP A;  3KTU A;  1XG7 A;  3FHG A;  1VRL A;  4OFE A;  1LWV A;  1MUN A;  4UNF A;  3CWA A;  3FSP A;  4EW0 A;  4EJZ A;  3CVT A;  1ORN A;  2YG9 A;  3I0X A;  4E9E A;  2ABK A;  1HU0 A;  3CWS A;  1XQP A;  4DK9 A;  3I0W A;  3CWT A;  4YPR A;  1LWY A;  1WEG A;  5DPK A;  5KN9 A;  5CHZ A;  3CWU A;  1P59 A;  4UOB A;  2I5W A;  3IHO A;  4EJY A;  3S6I A;  1KG2 A;  4B23 A;  3OGD A;  3N0U A;  1N3A A;  3KNT A;  1MPG A;  4EW4 A;  1KG3 A;  1RRQ A;  4E9H A;  1KQJ A;  1N39 A;  4B24 A;  2H56 A;  2NOH A;  4EA4 A;  1PU6 A;  1KO9 A;  2NOF A;  4OFH A;  4B21 A;  1M3Q A;  3F10 A;  4B22 A;  1RRS A;  2NOE A;  2NOZ A;  4OFA A;  3IH7 A;  1KG4 A;  4PII A;  4AIA A;  1NKU A;  1YQR A;  1WEF A;  5AN4 A;  3FHF A;  5KN8 A;  2NOB A;  2NOL A;  4AI4 A;  4HSB A;  1LWW A;  1KEA A;  4EVV A;  3CVS A;  4E9G A;  3D4V A;  1N3C A;  2JHJ A;  1KG6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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