4E9HA

Structure of glycosylase domain of mbd4 bound to 5hmu containing dna
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
137
structure length
137
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEAHKLNKYHDWLWENH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
pubmed doi rcsb
molecule keywords Methyl-CpG-binding domain protein 4
molecule tags Hydrolase/dna
source organism Homo sapiens
total genus 49
structure length 137
sequence length 137
ec nomenclature ec 3.2.2.-:
pdb deposition date 2012-03-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4e9hA00
1P7MA 1N3AA 4EA5A 4AI4A 1XQOA 4YPRA 1FN7A 1P59A 3CWTA 4B23A 3CVTA 4AIAA 1N3CA 3N0UA 3F10A 2NOIA 3I0XA 3KNTA 4B21A 1PU8A 1XQPA 1WEIA 2NOLA 3CVSA 3IH7A 1KG5A 1ORPA 1PU6A 2JHJA 2YG9A 4E9EA 2I5WA 1MUNA 2NOBA 3CW7A 3FHGA 4EW0A 4B24A 1LWVA 1KG3A 2OFKA 1N39A 2JHNA 3D4VA 4UNFA 4OFEA 1VRLA 2JG6A 4EVVA 1KG7A 5KN9A 4EA4A 1RRSA 1YQLA 1MPGA 1ORNA 3OGDA 4OFAA 1PVSA 4E9GA 2OFIA 1EBMA 1WEFA 5CHZA 3CWSA 3FSPA 1M3HA 4EJZA 5DPKA 5AN4A 1RRQA 4E9FA 4EW4A 4DK9A 1MUDA 3OH6A 4E9HA 1MUYA 3G0QA 4B22A 1KQJA 4YPHA 3KTUA 4PIIA 3S6IA 3F0ZA 1KG2A 1KEAA 2NOEA 3I0WA 1LWYA 5KN8A 4OFHA 1KO9A 1PU7A 1M3QA 1KG4A 1XG7A 1NGNA 4EJYA 1HU0A 4YOQA 3N5NX 2NOFA 1YQRA 2NOHA 1DIZA 3FHFA 1WEGA 4UOBA 3OH9A 4HSBA 1LWWA 1NKUA 2XHIA 3IHOA 1KG6A 2H56A 3CWUA 2YG8A 1YQMA 3CWAA 1LMZA 2ABKA 1YQKA 4AI5A 2NOZA
chains in the Genus database with same CATH superfamily
1P7MA 1N3AA 4EA5A 4AI4A 3OYLA 1XQOA 4YPRA 4NZGA 1P59A 1FN7A 3CWTA 4B23A 3CVTA 4AIAA 1N3CA 3N0UA 3F10A 3OYFA 2NOIA 3I0XA 3KNTA 4B21A 3OYDA 1PU8A 1XQPA 2W04A 1WEIA 4BDYA 3S3OA 3OYEA 2NOLA 3CVSA 3IH7A 1KG5A 1ORPA 1PU6A 2JHJA 2YG9A 4E9EA 2I5WA 1MUNA 2NOBA 3CW7A 3FHGA 4EW0A 4B24A 3OYIA 1KG3A 1LWVA 2OFKA 1N39A 2JHNA 3D4VA 4UNFA 4OFEA 4IKFA 4E7KA 3OYMA 1VRLA 2JG6A 4ZTFA 4EVVA 1KG7A 5KN9A 2JPSA 3OYHA 4EA4A 4E7JA 1RRSA 4E7IA 1YQLA 1MPGA 3L2VA 3S3NA 5FRMA 2NOZA 1ORNA 3OYCA 3L2UA 3OGDA 4OFAA 3OYBA 1PVSA 5FROA 3OY9A 4E9GA 2OFIA 1EBMA 3OS0A 1WEFA 5CHZA 3CWSA 3FSPA 1M3HA 4EJZA 5DPKA 5AN4A 3VW4A 3L2WA 1RRQA 3NNQA 3LCNA 4BDZA 4BE0A 4E9FA 4EW4A 4DK9A 1MUDA 3OYGA 3OH6A 4E9HA 3R2XC 1MUYA 3G0QA 4B22A 1KQJA 5FRNA 4YPHA 3S3MA 3KTUA 4E7HA 4PIIA 3S6IA 3OYJA 4BE2A 3F0ZA 1KG2A 3OYKA 1KEAA 2NOEA 4E7LA 3I0WA 3OYNA 1LWYA 5KN8A 4OFHA 4BACA 1KO9A 1PU7A 1M3QA 1KG4A 3OYAA 2W03A 3L2RA 3OS1A 1XG7A 1NGNA 4BE1A 4EJYA 1HU0A 4YOQA 3N5NX 4ZTJA 1YQRA 2NOHA 2NOFA 2V75A 1DIZA 3FHFA 1WEGA 4UOBA 3OH9A 4HSBA 1LWWA 1NKUA 1U84A 2XHIA 3IHOA 1KG6A 2H56A 3CWUA 2YG8A 1YQMA 3CWAA 1LMZA 2ABKA 3OS2A 4AI5A 1YQKA 3L2QA
chains in the Genus database with same CATH topology
1P7MA 1N3AA 4EA5A 4AI4A 1XQOA 4YPRA 1FN7A 1P59A 3CWTA 4B23A 3CVTA 4AIAA 1N3CA 3N0UA 3F10A 2NOIA 3I0XA 3KNTA 4B21A 1PU8A 1XQPA 1WEIA 2NOLA 3CVSA 3IH7A 1KG5A 1ORPA 1PU6A 2JHJA 2YG9A 4E9EA 2I5WA 1MUNA 2NOBA 3CW7A 3FHGA 4EW0A 4B24A 1LWVA 1KG3A 2OFKA 1N39A 2JHNA 3D4VA 4UNFA 4OFEA 1VRLA 2JG6A 4EVVA 1KG7A 5KN9A 4EA4A 1RRSA 1YQLA 1MPGA 1ORNA 3OGDA 4OFAA 1PVSA 4E9GA 2OFIA 1EBMA 1WEFA 5CHZA 3CWSA 3FSPA 1M3HA 4EJZA 5DPKA 5AN4A 1RRQA 4E9FA 4EW4A 4DK9A 1MUDA 3OH6A 4E9HA 1MUYA 3G0QA 4B22A 1KQJA 4YPHA 3KTUA 4PIIA 3S6IA 3F0ZA 1KG2A 1KEAA 2NOEA 3I0WA 1LWYA 5KN8A 4OFHA 1KO9A 1PU7A 1M3QA 1KG4A 1XG7A 1NGNA 4EJYA 1HU0A 4YOQA 3N5NX 2NOFA 1YQRA 2NOHA 1DIZA 3FHFA 1WEGA 4UOBA 3OH9A 4HSBA 1LWWA 1NKUA 2XHIA 3IHOA 1KG6A 2H56A 3CWUA 2YG8A 1YQMA 3CWAA 1LMZA 2ABKA 1YQKA 4AI5A 2NOZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1P7M A;  1N3A A;  4EA5 A;  4AI4 A;  1XQO A;  4YPR A;  1FN7 A;  1P59 A;  3CWT A;  4B23 A;  3CVT A;  4AIA A;  1N3C A;  3N0U A;  3F10 A;  2NOI A;  3I0X A;  3KNT A;  4B21 A;  1PU8 A;  1XQP A;  1WEI A;  2NOL A;  3CVS A;  3IH7 A;  1KG5 A;  1ORP A;  1PU6 A;  2JHJ A;  2YG9 A;  4E9E A;  2I5W A;  1MUN A;  2NOB A;  3CW7 A;  3FHG A;  4EW0 A;  4B24 A;  1LWV A;  1KG3 A;  2OFK A;  1N39 A;  2JHN A;  3D4V A;  4UNF A;  4OFE A;  1VRL A;  2JG6 A;  4EVV A;  1KG7 A;  5KN9 A;  4EA4 A;  1RRS A;  1YQL A;  1MPG A;  1ORN A;  3OGD A;  4OFA A;  1PVS A;  4E9G A;  2OFI A;  1EBM A;  1WEF A;  5CHZ A;  3CWS A;  3FSP A;  1M3H A;  4EJZ A;  5DPK A;  5AN4 A;  1RRQ A;  4E9F A;  4EW4 A;  4DK9 A;  1MUD A;  3OH6 A;  4E9H A;  1MUY A;  3G0Q A;  4B22 A;  1KQJ A;  4YPH A;  3KTU A;  4PII A;  3S6I A;  3F0Z A;  1KG2 A;  1KEA A;  2NOE A;  3I0W A;  1LWY A;  5KN8 A;  4OFH A;  1KO9 A;  1PU7 A;  1M3Q A;  1KG4 A;  1XG7 A;  1NGN A;  4EJY A;  1HU0 A;  4YOQ A;  3N5N X;  2NOF A;  1YQR A;  2NOH A;  1DIZ A;  3FHF A;  1WEG A;  4UOB A;  3OH9 A;  4HSB A;  1LWW A;  1NKU A;  2XHI A;  3IHO A;  1KG6 A;  2H56 A;  3CWU A;  2YG8 A;  1YQM A;  3CWA A;  1LMZ A;  2ABK A;  1YQK A;  4AI5 A;  2NOZ A; 
#chains in the Genus database with same CATH topology
 1P7M A;  1N3A A;  4EA5 A;  4AI4 A;  3OYL A;  1XQO A;  4YPR A;  4NZG A;  1P59 A;  1FN7 A;  3CWT A;  4B23 A;  3CVT A;  4AIA A;  1N3C A;  3N0U A;  3F10 A;  3OYF A;  2NOI A;  3I0X A;  3KNT A;  4B21 A;  3OYD A;  1PU8 A;  1XQP A;  2W04 A;  1WEI A;  4BDY A;  3S3O A;  3OYE A;  2NOL A;  3CVS A;  3IH7 A;  1KG5 A;  1ORP A;  1PU6 A;  2JHJ A;  2YG9 A;  4E9E A;  2I5W A;  1MUN A;  2NOB A;  3CW7 A;  3FHG A;  4EW0 A;  4B24 A;  3OYI A;  1KG3 A;  1LWV A;  2OFK A;  1N39 A;  2JHN A;  3D4V A;  4UNF A;  4OFE A;  4IKF A;  4E7K A;  3OYM A;  1VRL A;  2JG6 A;  4ZTF A;  4EVV A;  1KG7 A;  5KN9 A;  2JPS A;  3OYH A;  4EA4 A;  4E7J A;  1RRS A;  4E7I A;  1YQL A;  1MPG A;  3L2V A;  3S3N A;  5FRM A;  2NOZ A;  1ORN A;  3OYC A;  3L2U A;  3OGD A;  4OFA A;  3OYB A;  1PVS A;  5FRO A;  3OY9 A;  4E9G A;  2OFI A;  1EBM A;  3OS0 A;  1WEF A;  5CHZ A;  3CWS A;  3FSP A;  1M3H A;  4EJZ A;  5DPK A;  5AN4 A;  3VW4 A;  3L2W A;  1RRQ A;  3NNQ A;  3LCN A;  4BDZ A;  4BE0 A;  4E9F A;  4EW4 A;  4DK9 A;  1MUD A;  3OYG A;  3OH6 A;  4E9H A;  3R2X C;  1MUY A;  3G0Q A;  4B22 A;  1KQJ A;  5FRN A;  4YPH A;  3S3M A;  3KTU A;  4E7H A;  4PII A;  3S6I A;  3OYJ A;  4BE2 A;  3F0Z A;  1KG2 A;  3OYK A;  1KEA A;  2NOE A;  4E7L A;  3I0W A;  3OYN A;  1LWY A;  5KN8 A;  4OFH A;  4BAC A;  1KO9 A;  1PU7 A;  1M3Q A;  1KG4 A;  3OYA A;  2W03 A;  3L2R A;  3OS1 A;  1XG7 A;  1NGN A;  4BE1 A;  4EJY A;  1HU0 A;  4YOQ A;  3N5N X;  4ZTJ A;  1YQR A;  2NOH A;  2NOF A;  2V75 A;  1DIZ A;  3FHF A;  1WEG A;  4UOB A;  3OH9 A;  4HSB A;  1LWW A;  1NKU A;  1U84 A;  2XHI A;  3IHO A;  1KG6 A;  2H56 A;  3CWU A;  2YG8 A;  1YQM A;  3CWA A;  1LMZ A;  2ABK A;  3OS2 A;  4AI5 A;  1YQK A;  3L2Q A; 
#chains in the Genus database with same CATH homology
 1P7M A;  1N3A A;  4EA5 A;  4AI4 A;  1XQO A;  4YPR A;  1FN7 A;  1P59 A;  3CWT A;  4B23 A;  3CVT A;  4AIA A;  1N3C A;  3N0U A;  3F10 A;  2NOI A;  3I0X A;  3KNT A;  4B21 A;  1PU8 A;  1XQP A;  1WEI A;  2NOL A;  3CVS A;  3IH7 A;  1KG5 A;  1ORP A;  1PU6 A;  2JHJ A;  2YG9 A;  4E9E A;  2I5W A;  1MUN A;  2NOB A;  3CW7 A;  3FHG A;  4EW0 A;  4B24 A;  1LWV A;  1KG3 A;  2OFK A;  1N39 A;  2JHN A;  3D4V A;  4UNF A;  4OFE A;  1VRL A;  2JG6 A;  4EVV A;  1KG7 A;  5KN9 A;  4EA4 A;  1RRS A;  1YQL A;  1MPG A;  1ORN A;  3OGD A;  4OFA A;  1PVS A;  4E9G A;  2OFI A;  1EBM A;  1WEF A;  5CHZ A;  3CWS A;  3FSP A;  1M3H A;  4EJZ A;  5DPK A;  5AN4 A;  1RRQ A;  4E9F A;  4EW4 A;  4DK9 A;  1MUD A;  3OH6 A;  4E9H A;  1MUY A;  3G0Q A;  4B22 A;  1KQJ A;  4YPH A;  3KTU A;  4PII A;  3S6I A;  3F0Z A;  1KG2 A;  1KEA A;  2NOE A;  3I0W A;  1LWY A;  5KN8 A;  4OFH A;  1KO9 A;  1PU7 A;  1M3Q A;  1KG4 A;  1XG7 A;  1NGN A;  4EJY A;  1HU0 A;  4YOQ A;  3N5N X;  2NOF A;  1YQR A;  2NOH A;  1DIZ A;  3FHF A;  1WEG A;  4UOB A;  3OH9 A;  4HSB A;  1LWW A;  1NKU A;  2XHI A;  3IHO A;  1KG6 A;  2H56 A;  3CWU A;  2YG8 A;  1YQM A;  3CWA A;  1LMZ A;  2ABK A;  1YQK A;  4AI5 A;  2NOZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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