4E9HA

Structure of glycosylase domain of mbd4 bound to 5hmu containing dna
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
137
structure length
137
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEAHKLNKYHDWLWENH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Methyl-CpG-binding domain protein 4
publication title Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase/dna
total genus 49
structure length 137
sequence length 137
ec nomenclature ec 3.2.2.-:
pdb deposition date 2012-03-21
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4e9hA00
1P59A 4DK9A 1ORNA 4EW0A 4EA5A 4UOBA 2NOFA 4EJYA 1KG3A 5KN9A 4OFEA 2NOHA 4EW4A 1LWWA 1N3AA 1KG5A 4B22A 1WEFA 1WEIA 3S6IA 5CHZA 4EJZA 4YPHA 1NGNA 4YPRA 4YOQA 1MPGA 3KTUA 3N0UA 1N39A 4UNFA 5DPKA 2NOZA 1ORPA 3OGDA 4E9FA 1PU7A 3CWSA 3CVTA 1HU0A 3CWAA 1M3HA 1FN7A 1YQLA 3IH7A 1RRQA 1KG4A 3G0QA 1MUYA 1KG2A 1YQKA 1KEAA 2OFKA 3D4VA 4E9EA 1DIZA 3CWUA 3F10A 4HSBA 2I5WA 4AIAA 1KO9A 2JHNA 2JHJA 1XQOA 3OH6A 1YQRA 1KG7A 4EA4A 2JG6A 1RRSA 3CVSA 1XQPA 2NOBA 4EVVA 4B21A 4E9GA 2NOIA 3N5NX 2XHIA 2YG8A 3FSPA 1YQMA 3KNTA 4OFHA 1VRLA 4E9HA 2YG9A 1KG6A 1MUNA 1M3QA 1LWYA 3CWTA 1MUDA 1PU6A 2NOLA 3CW7A 2NOEA 3I0WA 1PU8A 1N3CA 2H56A 5KN8A 4B24A 4AI4A 3OH9A 4PIIA 5AN4A 3F0ZA 4B23A 1LWVA 1LMZA 1NKUA 4OFAA 1WEGA 3FHGA 1PVSA 1EBMA 2ABKA 2OFIA 1KQJA 1P7MA 3IHOA 3I0XA 3FHFA 4AI5A 1XG7A
chains in the Genus database with same CATH superfamily
1P59A 4DK9A 4E7JA 1ORNA 4BE1A 4EW0A 3OYBA 3OYFA 4EA5A 4UOBA 2NOFA 4EJYA 1KG3A 5KN9A 4BACA 4OFEA 2NOHA 4EW4A 4BDZA 1N3AA 1LWWA 1KG5A 2V75A 4B22A 1WEFA 1WEIA 3S6IA 5CHZA 4EJZA 4YPHA 1NGNA 3L2RA 4YPRA 3OYDA 2W04A 4YOQA 1MPGA 3OYKA 3KTUA 3OYGA 3L2VA 4E7HA 4IKFA 3N0UA 3R2XC 1N39A 4UNFA 3OY9A 3OYMA 5DPKA 2NOZA 1ORPA 3OGDA 4E7LA 4E9FA 1PU7A 3OYHA 3CWSA 3CVTA 1HU0A 3CWAA 1M3HA 4E7IA 1FN7A 1YQLA 3IH7A 1RRQA 1KG4A 3G0QA 1MUYA 1KG2A 1YQKA 1KEAA 2OFKA 3D4VA 4E9EA 1DIZA 3CWUA 3F10A 3OS2A 3S3OA 4HSBA 3L2WA 2I5WA 4AIAA 1KO9A 2JHNA 2JHJA 5FRMA 1XQOA 3OH6A 1YQRA 3OYJA 2JPSA 3S3MA 1KG7A 4EA4A 3NNQA 2JG6A 1RRSA 1U84A 3LCNA 3CVSA 1XQPA 3OYCA 2NOBA 4EVVA 2W03A 4B21A 5FROA 3VW4A 4E9GA 2NOIA 3OYIA 3L2UA 3N5NX 2XHIA 2YG8A 3FSPA 3L2QA 1YQMA 3KNTA 4OFHA 1VRLA 4E9HA 2YG9A 1KG6A 4ZTJA 4NZGA 1MUNA 1M3QA 5FRNA 1LWYA 4BE2A 3CWTA 1MUDA 1PU6A 2NOLA 3CW7A 2NOEA 3S3NA 3OYNA 3I0WA 1PU8A 1N3CA 2H56A 5KN8A 3OYAA 4B24A 4AI4A 3OH9A 4PIIA 5AN4A 3F0ZA 4B23A 1LWVA 1LMZA 1NKUA 4OFAA 1WEGA 3FHGA 4BDYA 4ZTFA 3OS1A 1PVSA 1EBMA 2ABKA 4BE0A 2OFIA 1KQJA 1P7MA 3IHOA 3I0XA 3FHFA 3OYLA 4E7KA 3OYEA 4AI5A 1XG7A 3OS0A
chains in the Genus database with same CATH topology
1P59A 4DK9A 1ORNA 4EW0A 4EA5A 4UOBA 2NOFA 4EJYA 1KG3A 5KN9A 4OFEA 2NOHA 4EW4A 1LWWA 1N3AA 1KG5A 4B22A 1WEFA 1WEIA 3S6IA 5CHZA 4EJZA 4YPHA 1NGNA 4YPRA 4YOQA 1MPGA 3KTUA 3N0UA 1N39A 4UNFA 5DPKA 2NOZA 1ORPA 3OGDA 4E9FA 1PU7A 3CWSA 3CVTA 1HU0A 3CWAA 1M3HA 1FN7A 1YQLA 3IH7A 1RRQA 1KG4A 3G0QA 1MUYA 1KG2A 1YQKA 1KEAA 2OFKA 3D4VA 4E9EA 1DIZA 3CWUA 3F10A 4HSBA 2I5WA 4AIAA 1KO9A 2JHNA 2JHJA 1XQOA 3OH6A 1YQRA 1KG7A 4EA4A 2JG6A 1RRSA 3CVSA 1XQPA 2NOBA 4EVVA 4B21A 4E9GA 2NOIA 3N5NX 2XHIA 2YG8A 3FSPA 1YQMA 3KNTA 4OFHA 1VRLA 4E9HA 2YG9A 1KG6A 1MUNA 1M3QA 1LWYA 3CWTA 1MUDA 1PU6A 2NOLA 3CW7A 2NOEA 3I0WA 1PU8A 1N3CA 2H56A 5KN8A 4B24A 4AI4A 3OH9A 4PIIA 5AN4A 3F0ZA 4B23A 1LWVA 1LMZA 1NKUA 4OFAA 1WEGA 3FHGA 1PVSA 1EBMA 2ABKA 2OFIA 1KQJA 1P7MA 3IHOA 3I0XA 3FHFA 4AI5A 1XG7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1P59 A;  4DK9 A;  1ORN A;  4EW0 A;  4EA5 A;  4UOB A;  2NOF A;  4EJY A;  1KG3 A;  5KN9 A;  4OFE A;  2NOH A;  4EW4 A;  1LWW A;  1N3A A;  1KG5 A;  4B22 A;  1WEF A;  1WEI A;  3S6I A;  5CHZ A;  4EJZ A;  4YPH A;  1NGN A;  4YPR A;  4YOQ A;  1MPG A;  3KTU A;  3N0U A;  1N39 A;  4UNF A;  5DPK A;  2NOZ A;  1ORP A;  3OGD A;  4E9F A;  1PU7 A;  3CWS A;  3CVT A;  1HU0 A;  3CWA A;  1M3H A;  1FN7 A;  1YQL A;  3IH7 A;  1RRQ A;  1KG4 A;  3G0Q A;  1MUY A;  1KG2 A;  1YQK A;  1KEA A;  2OFK A;  3D4V A;  4E9E A;  1DIZ A;  3CWU A;  3F10 A;  4HSB A;  2I5W A;  4AIA A;  1KO9 A;  2JHN A;  2JHJ A;  1XQO A;  3OH6 A;  1YQR A;  1KG7 A;  4EA4 A;  2JG6 A;  1RRS A;  3CVS A;  1XQP A;  2NOB A;  4EVV A;  4B21 A;  4E9G A;  2NOI A;  3N5N X;  2XHI A;  2YG8 A;  3FSP A;  1YQM A;  3KNT A;  4OFH A;  1VRL A;  4E9H A;  2YG9 A;  1KG6 A;  1MUN A;  1M3Q A;  1LWY A;  3CWT A;  1MUD A;  1PU6 A;  2NOL A;  3CW7 A;  2NOE A;  3I0W A;  1PU8 A;  1N3C A;  2H56 A;  5KN8 A;  4B24 A;  4AI4 A;  3OH9 A;  4PII A;  5AN4 A;  3F0Z A;  4B23 A;  1LWV A;  1LMZ A;  1NKU A;  4OFA A;  1WEG A;  3FHG A;  1PVS A;  1EBM A;  2ABK A;  2OFI A;  1KQJ A;  1P7M A;  3IHO A;  3I0X A;  3FHF A;  4AI5 A;  1XG7 A; 
#chains in the Genus database with same CATH topology
 1P59 A;  4DK9 A;  4E7J A;  1ORN A;  4BE1 A;  4EW0 A;  3OYB A;  3OYF A;  4EA5 A;  4UOB A;  2NOF A;  4EJY A;  1KG3 A;  5KN9 A;  4BAC A;  4OFE A;  2NOH A;  4EW4 A;  4BDZ A;  1N3A A;  1LWW A;  1KG5 A;  2V75 A;  4B22 A;  1WEF A;  1WEI A;  3S6I A;  5CHZ A;  4EJZ A;  4YPH A;  1NGN A;  3L2R A;  4YPR A;  3OYD A;  2W04 A;  4YOQ A;  1MPG A;  3OYK A;  3KTU A;  3OYG A;  3L2V A;  4E7H A;  4IKF A;  3N0U A;  3R2X C;  1N39 A;  4UNF A;  3OY9 A;  3OYM A;  5DPK A;  2NOZ A;  1ORP A;  3OGD A;  4E7L A;  4E9F A;  1PU7 A;  3OYH A;  3CWS A;  3CVT A;  1HU0 A;  3CWA A;  1M3H A;  4E7I A;  1FN7 A;  1YQL A;  3IH7 A;  1RRQ A;  1KG4 A;  3G0Q A;  1MUY A;  1KG2 A;  1YQK A;  1KEA A;  2OFK A;  3D4V A;  4E9E A;  1DIZ A;  3CWU A;  3F10 A;  3OS2 A;  3S3O A;  4HSB A;  3L2W A;  2I5W A;  4AIA A;  1KO9 A;  2JHN A;  2JHJ A;  5FRM A;  1XQO A;  3OH6 A;  1YQR A;  3OYJ A;  2JPS A;  3S3M A;  1KG7 A;  4EA4 A;  3NNQ A;  2JG6 A;  1RRS A;  1U84 A;  3LCN A;  3CVS A;  1XQP A;  3OYC A;  2NOB A;  4EVV A;  2W03 A;  4B21 A;  5FRO A;  3VW4 A;  4E9G A;  2NOI A;  3OYI A;  3L2U A;  3N5N X;  2XHI A;  2YG8 A;  3FSP A;  3L2Q A;  1YQM A;  3KNT A;  4OFH A;  1VRL A;  4E9H A;  2YG9 A;  1KG6 A;  4ZTJ A;  4NZG A;  1MUN A;  1M3Q A;  5FRN A;  1LWY A;  4BE2 A;  3CWT A;  1MUD A;  1PU6 A;  2NOL A;  3CW7 A;  2NOE A;  3S3N A;  3OYN A;  3I0W A;  1PU8 A;  1N3C A;  2H56 A;  5KN8 A;  3OYA A;  4B24 A;  4AI4 A;  3OH9 A;  4PII A;  5AN4 A;  3F0Z A;  4B23 A;  1LWV A;  1LMZ A;  1NKU A;  4OFA A;  1WEG A;  3FHG A;  4BDY A;  4ZTF A;  3OS1 A;  1PVS A;  1EBM A;  2ABK A;  4BE0 A;  2OFI A;  1KQJ A;  1P7M A;  3IHO A;  3I0X A;  3FHF A;  3OYL A;  4E7K A;  3OYE A;  4AI5 A;  1XG7 A;  3OS0 A; 
#chains in the Genus database with same CATH homology
 1P59 A;  4DK9 A;  1ORN A;  4EW0 A;  4EA5 A;  4UOB A;  2NOF A;  4EJY A;  1KG3 A;  5KN9 A;  4OFE A;  2NOH A;  4EW4 A;  1LWW A;  1N3A A;  1KG5 A;  4B22 A;  1WEF A;  1WEI A;  3S6I A;  5CHZ A;  4EJZ A;  4YPH A;  1NGN A;  4YPR A;  4YOQ A;  1MPG A;  3KTU A;  3N0U A;  1N39 A;  4UNF A;  5DPK A;  2NOZ A;  1ORP A;  3OGD A;  4E9F A;  1PU7 A;  3CWS A;  3CVT A;  1HU0 A;  3CWA A;  1M3H A;  1FN7 A;  1YQL A;  3IH7 A;  1RRQ A;  1KG4 A;  3G0Q A;  1MUY A;  1KG2 A;  1YQK A;  1KEA A;  2OFK A;  3D4V A;  4E9E A;  1DIZ A;  3CWU A;  3F10 A;  4HSB A;  2I5W A;  4AIA A;  1KO9 A;  2JHN A;  2JHJ A;  1XQO A;  3OH6 A;  1YQR A;  1KG7 A;  4EA4 A;  2JG6 A;  1RRS A;  3CVS A;  1XQP A;  2NOB A;  4EVV A;  4B21 A;  4E9G A;  2NOI A;  3N5N X;  2XHI A;  2YG8 A;  3FSP A;  1YQM A;  3KNT A;  4OFH A;  1VRL A;  4E9H A;  2YG9 A;  1KG6 A;  1MUN A;  1M3Q A;  1LWY A;  3CWT A;  1MUD A;  1PU6 A;  2NOL A;  3CW7 A;  2NOE A;  3I0W A;  1PU8 A;  1N3C A;  2H56 A;  5KN8 A;  4B24 A;  4AI4 A;  3OH9 A;  4PII A;  5AN4 A;  3F0Z A;  4B23 A;  1LWV A;  1LMZ A;  1NKU A;  4OFA A;  1WEG A;  3FHG A;  1PVS A;  1EBM A;  2ABK A;  2OFI A;  1KQJ A;  1P7M A;  3IHO A;  3I0X A;  3FHF A;  4AI5 A;  1XG7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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