4EAGA

Co-crystal structure of an chimeric ampk core with atp
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
125
structure length
98
Chain Sequence
AKWHLGIRSQSKPNDIMLEVYRAMKALSYEWKIINPYHVRVRRQNVKTGKFSKMSLQLYQVDAKSYLLDFKSLTLQPTGHHTMEFFEMCAALIIQLAR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
pubmed doi rcsb
molecule tags Transferase
source organism Drosophila melanogaster
molecule keywords EG:132E8.2 protein
total genus 21
structure length 98
sequence length 125
ec nomenclature ec 2.7.11.-:
pdb deposition date 2012-03-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF16579 AdenylateSensor Adenylate sensor of SNF1-like protein kinase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.310.80 Alpha Beta 2-Layer Sandwich TATA-Binding Protein Kinase associated domain 1, KA1 4eagA01
2OOYA 2QRDA 2YA3A 3TE5A 4EAJA 1UL7A 2Y8LA 2QREA 2V8QA 1V5SA 2QLVA 2QR1A 3T4NA 2EHBD 2Y8QA 2ZFDB 3TDHA 2QRCA 2OOXA 3OSEA 4EALA 2V9JA 4CFFA 2V92A 4EAGA 4EAKA 4EAIA
chains in the Genus database with same CATH superfamily
4IL8A 4ROCB 2JHNA 1KYFA 2FUVA 1UL7A 1VTLE 1QN5A 3H1ZA 2I5WA 1EUVA 2F7LA 4TPSA 1XSZA 1V5SA 3DPUA 2MZ8A 3CVTA 4RODB 2H4LX 3KRMA 5BMNA 3CWTA 2NLVA 1J3MA 2Y8QA 2NOLA 2ZFDB 4EAIA 1TBAB 1JFIC 1NGMA 2QRCA 4BJUA 3NA5A 2HL8A 1VKLA 2JHJA 3ENOC 3UW2A 1QTSA 4I8OA 4C7PA 2V9JA 2R5XA 4CFFA 2PWWA 1LWVA 1MP9A 2YH5A 3RSMA 2D0BA 1D3UA 3VN5A 1MPGA 1CDWA 2OOYA 1HU0A 1KYUA 1QNAA 3CWUA 3TE5A 4Q11A 2IV8A 2NOFA 2HL9A 4EAJA 3RPJA 5HSHA 2Y8LA 1YTFA 2VJ0A 1R4XA 3DPTA 3SNSA 3EIKA 1PCZA 1AISA 2G30A 2QLVA 3ASMA 2DKDA 2QR1A 1VTOA 3PMGA 4WXAA 2MJ7A 1M3QA 3CVSA 1TGHA 5IYDP 5JN5A 1Q9UA 1W80A 2Z8UA 1P5GX 1PCJX 1LWWA 2DKCA 2IV9A 1QN8A 3KTUA 4WZSD 3IH7A 1E42A 1FN7A 3I0WA 2FGTA 1N3AA 4EAGA 1TUOA 2JOIA 1PCMX 4D7RA 1T6AA 1KFQA 2QRDA 1YQRA 4WX8A 1NVPA 2YA3A 3ULXA 2XHIA 3OH9A 2HZMA 4DULA 1UT7A 5AN4A 4ROEB 1C47A 4D7QA 1YQMA 1C4GA 3N89A 2NOIA 1PZDA 1C9BB 2HKPA 2DKAA 2NVMA 1NH2A 1M5Q1 3ENCA 2NWVA 3F10A 5IYBP 1QTPA 2HZSA 4EJZA 2D0CA 4PY5A 3T4NA 1N3CA 3BKQX 1KFIA 1K2YX 1QN9A 1LWYA 2NOEA 3CWAA 3CWSA 1WQAA 1QNBA 2FKFA 1VOKA 2JPIA 2OOXA 1KY6A 2H5AX 3OGDA 2NOZA 1QN3A 4MRQA 2Z0FA 1YQLA 5KL0A 3CW7A 1K35A 1PVSA 1B9KA 3PDKA 1KYDA 3C04A 2LAEA 5EPCA 2NOBA 2O3OA 1QNCA 3F0ZA 1M3HA 1UT4A 4EJYA 3I0XA 3OC3C 1KO9A 3HS9A 2QREA 3OH6A 5IYCP 1YTBA 2V8QA 4QG5A 2D0AA 1YQKA 3OCIA 4B0AA 2FKMX 2NOHA 2EHBD 3D7QA 1QN7A 1VOLB 1QNEA 1EBMA 3TDHA 1RM1A 5BMPA 4HJHA 1QN4A 1N39A 3I3WA 1KY7A 1LXTA 3EAYA 1P5DX 5F9CA 1DIZA 3OSEA 1JDYA 3D4VA 1TBPA 4EALA 3HS8A 2V92A 1WJWA 1QN6A 4EAKA 3OLPA 3OSTA 5JMVD 3OSMA
chains in the Genus database with same CATH topology
2OOYA 2QRDA 2YA3A 3TE5A 4EAJA 1UL7A 2Y8LA 2QREA 2V8QA 1V5SA 2QLVA 2QR1A 3T4NA 2EHBD 2Y8QA 2ZFDB 3TDHA 2QRCA 2OOXA 3OSEA 4EALA 2V9JA 4CFFA 2V92A 4EAGA 4EAKA 4EAIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2OOY A;  2QRD A;  2YA3 A;  3TE5 A;  4EAJ A;  1UL7 A;  2Y8L A;  2QRE A;  2V8Q A;  1V5S A;  2QLV A;  2QR1 A;  3T4N A;  2EHB D;  2Y8Q A;  2ZFD B;  3TDH A;  2QRC A;  2OOX A;  3OSE A;  4EAL A;  2V9J A;  4CFF A;  2V92 A;  4EAG A;  4EAK A;  4EAI A; 
#chains in the Genus database with same CATH topology
 4IL8 A;  4ROC B;  2JHN A;  1KYF A;  2FUV A;  1UL7 A;  1VTL E;  1QN5 A;  3H1Z A;  2I5W A;  1EUV A;  2F7L A;  4TPS A;  1XSZ A;  1V5S A;  3DPU A;  2MZ8 A;  3CVT A;  4ROD B;  2H4L X;  3KRM A;  5BMN A;  3CWT A;  2NLV A;  1J3M A;  2Y8Q A;  2NOL A;  2ZFD B;  4EAI A;  1TBA B;  1JFI C;  1NGM A;  2QRC A;  4BJU A;  3NA5 A;  2HL8 A;  1VKL A;  2JHJ A;  3ENO C;  3UW2 A;  1QTS A;  4I8O A;  4C7P A;  2V9J A;  2R5X A;  4CFF A;  2PWW A;  1LWV A;  1MP9 A;  2YH5 A;  3RSM A;  2D0B A;  1D3U A;  3VN5 A;  1MPG A;  1CDW A;  2OOY A;  1HU0 A;  1KYU A;  1QNA A;  3CWU A;  3TE5 A;  4Q11 A;  2IV8 A;  2NOF A;  2HL9 A;  4EAJ A;  3RPJ A;  5HSH A;  2Y8L A;  1YTF A;  2VJ0 A;  1R4X A;  3DPT A;  3SNS A;  3EIK A;  1PCZ A;  1AIS A;  2G30 A;  2QLV A;  3ASM A;  2DKD A;  2QR1 A;  1VTO A;  3PMG A;  4WXA A;  2MJ7 A;  1M3Q A;  3CVS A;  1TGH A;  5IYD P;  5JN5 A;  1Q9U A;  1W80 A;  2Z8U A;  1P5G X;  1PCJ X;  1LWW A;  2DKC A;  2IV9 A;  1QN8 A;  3KTU A;  4WZS D;  3IH7 A;  1E42 A;  1FN7 A;  3I0W A;  2FGT A;  1N3A A;  4EAG A;  1TUO A;  2JOI A;  1PCM X;  4D7R A;  1T6A A;  1KFQ A;  2QRD A;  1YQR A;  4WX8 A;  1NVP A;  2YA3 A;  3ULX A;  2XHI A;  3OH9 A;  2HZM A;  4DUL A;  1UT7 A;  5AN4 A;  4ROE B;  1C47 A;  4D7Q A;  1YQM A;  1C4G A;  3N89 A;  2NOI A;  1PZD A;  1C9B B;  2HKP A;  2DKA A;  2NVM A;  1NH2 A;  1M5Q 1;  3ENC A;  2NWV A;  3F10 A;  5IYB P;  1QTP A;  2HZS A;  4EJZ A;  2D0C A;  4PY5 A;  3T4N A;  1N3C A;  3BKQ X;  1KFI A;  1K2Y X;  1QN9 A;  1LWY A;  2NOE A;  3CWA A;  3CWS A;  1WQA A;  1QNB A;  2FKF A;  1VOK A;  2JPI A;  2OOX A;  1KY6 A;  2H5A X;  3OGD A;  2NOZ A;  1QN3 A;  4MRQ A;  2Z0F A;  1YQL A;  5KL0 A;  3CW7 A;  1K35 A;  1PVS A;  1B9K A;  3PDK A;  1KYD A;  3C04 A;  2LAE A;  5EPC A;  2NOB A;  2O3O A;  1QNC A;  3F0Z A;  1M3H A;  1UT4 A;  4EJY A;  3I0X A;  3OC3 C;  1KO9 A;  3HS9 A;  2QRE A;  3OH6 A;  5IYC P;  1YTB A;  2V8Q A;  4QG5 A;  2D0A A;  1YQK A;  3OCI A;  4B0A A;  2FKM X;  2NOH A;  2EHB D;  3D7Q A;  1QN7 A;  1VOL B;  1QNE A;  1EBM A;  3TDH A;  1RM1 A;  5BMP A;  4HJH A;  1QN4 A;  1N39 A;  3I3W A;  1KY7 A;  1LXT A;  3EAY A;  1P5D X;  5F9C A;  1DIZ A;  3OSE A;  1JDY A;  3D4V A;  1TBP A;  4EAL A;  3HS8 A;  2V92 A;  1WJW A;  1QN6 A;  4EAK A;  3OLP A;  3OST A;  5JMV D;  3OSM A; 
#chains in the Genus database with same CATH homology
 2OOY A;  2QRD A;  2YA3 A;  3TE5 A;  4EAJ A;  1UL7 A;  2Y8L A;  2QRE A;  2V8Q A;  1V5S A;  2QLV A;  2QR1 A;  3T4N A;  2EHB D;  2Y8Q A;  2ZFD B;  3TDH A;  2QRC A;  2OOX A;  3OSE A;  4EAL A;  2V9J A;  4CFF A;  2V92 A;  4EAG A;  4EAK A;  4EAI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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