The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
161
|
sequence length |
465
|
structure length |
431
|
Chain Sequence |
b'MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKK'
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Cofactor binding triggers a molecular switch to allosterically activate human UDP-{alpha}-D-glucose 6-dehydrogenase.
pubmed doi rcsb |
| molecule keywords |
UDP-glucose 6-dehydrogenase
|
| source organism |
Homo sapiens
|
| molecule tags |
Oxidoreductase
|
| total genus |
161
|
| structure length |
431
|
| sequence length |
465
|
| chains with identical sequence |
B, C, D
|
| ec nomenclature |
ec
1.1.1.22: UDP-glucose 6-dehydrogenase. |
| pdb deposition date | 2012-03-27 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00984 | UDPG_MGDP_dh | UDP-glucose/GDP-mannose dehydrogenase family, central domain |
| A | PF03720 | UDPG_MGDP_dh_C | UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain |
| A | PF03721 | UDPG_MGDP_dh_N | UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Up-down Bundle | Single alpha-helices involved in coiled-coils or other helix-helix interfaces | Cytochrome c1, transmembrane anchor, C-terminal | ||
| Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain | ||
| Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain |
