4ETKA

Crystal structure of e6a/l130d/a155h variant of de novo designed serine hydrolase, northeast structural genomics consortium (nesg) target or186
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
166
structure length
166
Chain Sequence
ARIRAVQGDITEFQGDAIVNAANNYLKLGAGVAGAILRKGGPSIQEECDRIGKIRVGEAAVTGAGNLPVRYVIHAAVLGDEPASLETVRKATKSALEKAVELGLKTVAFTALGAWVGGLPAEAVLRVMDEEIKKAPDTLEVTGVHGTEKSAEAHRRALLEHHHHHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Design of activated serine-containing catalytic triads with atomic-level accuracy.
pubmed doi rcsb
molecule tags Hydrolase
source organism Artificial gene
molecule keywords De novo designed serine hydrolase
total genus 62
structure length 166
sequence length 166
chains with identical sequence B
ec nomenclature
pdb deposition date 2012-04-24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 4etkA00
4J5QA 5FSXA 4JLLA 5CMSA 5FSUA 4R6TA 4K0CA 4ZY1A 3GQOA 4X2TA 1SPVA 5FSYA 4ESSA 3EJFA 4D86A 4ABKA 1GYTA 3EWQA 2FG1A 3H8FA 3Q71A 3EWOA 3VFQA 4ZYQA 3JRUA 4ETKA 4TU0A 3EW5A 3SIGA 4K3NA 1LAPA 5CB3A 2BFRA 4ZY2A 3T8WA 3EWRA 4R7MA 3ETIA 2L8RA 3GPOA 4ZX9A 4ETJA 3SIHA 4J5SA 2EEEA 3KQXA 5HOLA 2ACFA 1NJRA 2VRIA 1BPMA 3EKEA 3IIFA 5CBMA 4GUAA 1YD9A 3Q6ZA 1HJZA 4IQYA 4R76A 4ZX8A 4JCAA 1TXZA 1LCPA 2FAVA 2BFQA 3H8EA 1BPNA 4KYBA 1BLLE 4GVWA 2DX6A 1TY8A 4GVVA 1ZR3A 3V45A 4JGKA 3EJGA 3IIDA 5D8NA 2X47A 4J4ZA 3IJ3A 5FSZA 3KQZA 4KSIA 4ABLA 3SIIA 4J5RA 1LAMA 3PEIA 2XD7A 3EWPA 4UMLA 5FSVA 1LANA 3SIJA 3GQEA 3JZTA 5DUSA 2FXKA 1ZR5A 2EWBA 5HIHA 4ZI6A 3H8GA 5E3BA 2J9AA 4ZY0A 3V2BA 3GPQA 3GPGA 1VHUA 3KR5A 4JVVA 3KZWA 2LGRA 2AFCA 5CB5A 3KR4A 5AILA
chains in the Genus database with same CATH superfamily
2JZFA 4J5QA 5FSXA 4JLLA 5CMSA 5FSUA 4R6TA 4K0CA 4ZY1A 3GQOA 4X2TA 1SPVA 5FSYA 4ESSA 3EJFA 4D86A 4ABKA 1GYTA 2WCTA 3EWQA 2FG1A 3H8FA 3Q71A 3EWOA 3VFQA 2JZDA 4ZYQA 3JRUA 4ETKA 4TU0A 3EW5A 3SIGA 1LAPA 4K3NA 5CB3A 2BFRA 4ZY2A 3T8WA 3EWRA 4R7MA 3ETIA 2L8RA 3GPOA 4ZX9A 4ETJA 3SIHA 4J5SA 2EEEA 3KQXA 5HOLA 2ACFA 1NJRA 2VRIA 1BPMA 3EKEA 3IIFA 5CBMA 4GUAA 3Q6ZA 1YD9A 2JZEA 1HJZA 4IQYA 4R76A 4ZX8A 4JCAA 1TXZA 1LCPA 2FAVA 2BFQA 3H8EA 1BPNA 4KYBA 1BLLE 2W2GA 4GVWA 2DX6A 1TY8A 4GVVA 1ZR3A 3V45A 4JGKA 3EJGA 3IIDA 5D8NA 2X47A 4J4ZA 3IJ3A 2KQVA 5FSZA 3KQZA 4KSIA 4ABLA 3SIIA 4J5RA 1LAMA 2RNKA 3PEIA 2XD7A 3EWPA 4UMLA 5FSVA 1LANA 3SIJA 3GQEA 3JZTA 5DUSA 2FXKA 1ZR5A 2EWBA 5HIHA 4ZI6A 3H8GA 5E3BA 2J9AA 4ZY0A 3V2BA 3GPQA 3GPGA 1VHUA 3KR5A 4JVVA 3KZWA 2LGRA 2AFCA 5CB5A 3KR4A 5AILA
chains in the Genus database with same CATH topology
4J5QA 5FSXA 4JLLA 5CMSA 5FSUA 4R6TA 4K0CA 4ZY1A 3GQOA 4X2TA 1SPVA 5FSYA 4ESSA 3EJFA 4D86A 4ABKA 1GYTA 3EWQA 2FG1A 3H8FA 3Q71A 3EWOA 3VFQA 4ZYQA 3JRUA 4ETKA 4TU0A 3EW5A 3SIGA 4K3NA 1LAPA 5CB3A 2BFRA 4ZY2A 3T8WA 3EWRA 4R7MA 3ETIA 2L8RA 3GPOA 4ZX9A 4ETJA 3SIHA 4J5SA 2EEEA 3KQXA 5HOLA 2ACFA 1NJRA 2VRIA 1BPMA 3EKEA 3IIFA 5CBMA 4GUAA 1YD9A 3Q6ZA 1HJZA 4IQYA 4R76A 4ZX8A 4JCAA 1TXZA 1LCPA 2FAVA 2BFQA 3H8EA 1BPNA 4KYBA 1BLLE 4GVWA 2DX6A 1TY8A 4GVVA 1ZR3A 3V45A 4JGKA 3EJGA 3IIDA 5D8NA 2X47A 4J4ZA 3IJ3A 5FSZA 3KQZA 4KSIA 4ABLA 3SIIA 4J5RA 1LAMA 3PEIA 2XD7A 3EWPA 4UMLA 5FSVA 1LANA 3SIJA 3GQEA 3JZTA 5DUSA 2FXKA 1ZR5A 2EWBA 5HIHA 4ZI6A 3H8GA 5E3BA 2J9AA 4ZY0A 3V2BA 3GPQA 3GPGA 1VHUA 3KR5A 4JVVA 3KZWA 2LGRA 2AFCA 5CB5A 3KR4A 5AILA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4J5Q A;  5FSX A;  4JLL A;  5CMS A;  5FSU A;  4R6T A;  4K0C A;  4ZY1 A;  3GQO A;  4X2T A;  1SPV A;  5FSY A;  4ESS A;  3EJF A;  4D86 A;  4ABK A;  1GYT A;  3EWQ A;  2FG1 A;  3H8F A;  3Q71 A;  3EWO A;  3VFQ A;  4ZYQ A;  3JRU A;  4ETK A;  4TU0 A;  3EW5 A;  3SIG A;  4K3N A;  1LAP A;  5CB3 A;  2BFR A;  4ZY2 A;  3T8W A;  3EWR A;  4R7M A;  3ETI A;  2L8R A;  3GPO A;  4ZX9 A;  4ETJ A;  3SIH A;  4J5S A;  2EEE A;  3KQX A;  5HOL A;  2ACF A;  1NJR A;  2VRI A;  1BPM A;  3EKE A;  3IIF A;  5CBM A;  4GUA A;  1YD9 A;  3Q6Z A;  1HJZ A;  4IQY A;  4R76 A;  4ZX8 A;  4JCA A;  1TXZ A;  1LCP A;  2FAV A;  2BFQ A;  3H8E A;  1BPN A;  4KYB A;  1BLL E;  4GVW A;  2DX6 A;  1TY8 A;  4GVV A;  1ZR3 A;  3V45 A;  4JGK A;  3EJG A;  3IID A;  5D8N A;  2X47 A;  4J4Z A;  3IJ3 A;  5FSZ A;  3KQZ A;  4KSI A;  4ABL A;  3SII A;  4J5R A;  1LAM A;  3PEI A;  2XD7 A;  3EWP A;  4UML A;  5FSV A;  1LAN A;  3SIJ A;  3GQE A;  3JZT A;  5DUS A;  2FXK A;  1ZR5 A;  2EWB A;  5HIH A;  4ZI6 A;  3H8G A;  5E3B A;  2J9A A;  4ZY0 A;  3V2B A;  3GPQ A;  3GPG A;  1VHU A;  3KR5 A;  4JVV A;  3KZW A;  2LGR A;  2AFC A;  5CB5 A;  3KR4 A;  5AIL A; 
#chains in the Genus database with same CATH topology
 2JZF A;  4J5Q A;  5FSX A;  4JLL A;  5CMS A;  5FSU A;  4R6T A;  4K0C A;  4ZY1 A;  3GQO A;  4X2T A;  1SPV A;  5FSY A;  4ESS A;  3EJF A;  4D86 A;  4ABK A;  1GYT A;  2WCT A;  3EWQ A;  2FG1 A;  3H8F A;  3Q71 A;  3EWO A;  3VFQ A;  2JZD A;  4ZYQ A;  3JRU A;  4ETK A;  4TU0 A;  3EW5 A;  3SIG A;  1LAP A;  4K3N A;  5CB3 A;  2BFR A;  4ZY2 A;  3T8W A;  3EWR A;  4R7M A;  3ETI A;  2L8R A;  3GPO A;  4ZX9 A;  4ETJ A;  3SIH A;  4J5S A;  2EEE A;  3KQX A;  5HOL A;  2ACF A;  1NJR A;  2VRI A;  1BPM A;  3EKE A;  3IIF A;  5CBM A;  4GUA A;  3Q6Z A;  1YD9 A;  2JZE A;  1HJZ A;  4IQY A;  4R76 A;  4ZX8 A;  4JCA A;  1TXZ A;  1LCP A;  2FAV A;  2BFQ A;  3H8E A;  1BPN A;  4KYB A;  1BLL E;  2W2G A;  4GVW A;  2DX6 A;  1TY8 A;  4GVV A;  1ZR3 A;  3V45 A;  4JGK A;  3EJG A;  3IID A;  5D8N A;  2X47 A;  4J4Z A;  3IJ3 A;  2KQV A;  5FSZ A;  3KQZ A;  4KSI A;  4ABL A;  3SII A;  4J5R A;  1LAM A;  2RNK A;  3PEI A;  2XD7 A;  3EWP A;  4UML A;  5FSV A;  1LAN A;  3SIJ A;  3GQE A;  3JZT A;  5DUS A;  2FXK A;  1ZR5 A;  2EWB A;  5HIH A;  4ZI6 A;  3H8G A;  5E3B A;  2J9A A;  4ZY0 A;  3V2B A;  3GPQ A;  3GPG A;  1VHU A;  3KR5 A;  4JVV A;  3KZW A;  2LGR A;  2AFC A;  5CB5 A;  3KR4 A;  5AIL A; 
#chains in the Genus database with same CATH homology
 4J5Q A;  5FSX A;  4JLL A;  5CMS A;  5FSU A;  4R6T A;  4K0C A;  4ZY1 A;  3GQO A;  4X2T A;  1SPV A;  5FSY A;  4ESS A;  3EJF A;  4D86 A;  4ABK A;  1GYT A;  3EWQ A;  2FG1 A;  3H8F A;  3Q71 A;  3EWO A;  3VFQ A;  4ZYQ A;  3JRU A;  4ETK A;  4TU0 A;  3EW5 A;  3SIG A;  4K3N A;  1LAP A;  5CB3 A;  2BFR A;  4ZY2 A;  3T8W A;  3EWR A;  4R7M A;  3ETI A;  2L8R A;  3GPO A;  4ZX9 A;  4ETJ A;  3SIH A;  4J5S A;  2EEE A;  3KQX A;  5HOL A;  2ACF A;  1NJR A;  2VRI A;  1BPM A;  3EKE A;  3IIF A;  5CBM A;  4GUA A;  1YD9 A;  3Q6Z A;  1HJZ A;  4IQY A;  4R76 A;  4ZX8 A;  4JCA A;  1TXZ A;  1LCP A;  2FAV A;  2BFQ A;  3H8E A;  1BPN A;  4KYB A;  1BLL E;  4GVW A;  2DX6 A;  1TY8 A;  4GVV A;  1ZR3 A;  3V45 A;  4JGK A;  3EJG A;  3IID A;  5D8N A;  2X47 A;  4J4Z A;  3IJ3 A;  5FSZ A;  3KQZ A;  4KSI A;  4ABL A;  3SII A;  4J5R A;  1LAM A;  3PEI A;  2XD7 A;  3EWP A;  4UML A;  5FSV A;  1LAN A;  3SIJ A;  3GQE A;  3JZT A;  5DUS A;  2FXK A;  1ZR5 A;  2EWB A;  5HIH A;  4ZI6 A;  3H8G A;  5E3B A;  2J9A A;  4ZY0 A;  3V2B A;  3GPQ A;  3GPG A;  1VHU A;  3KR5 A;  4JVV A;  3KZW A;  2LGR A;  2AFC A;  5CB5 A;  3KR4 A;  5AIL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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