4ETKA

Crystal structure of e6a/l130d/a155h variant of de novo designed serine hydrolase, northeast structural genomics consortium (nesg) target or186
Total Genus 62
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
62
sequence length
166
structure length
166
Chain Sequence
ARIRAVQGDITEFQGDAIVNAANNYLKLGAGVAGAILRKGGPSIQEECDRIGKIRVGEAAVTGAGNLPVRYVIHAAVLGDEPASLETVRKATKSALEKAVELGLKTVAFTALGAWVGGLPAEAVLRVMDEEIKKAPDTLEVTGVHGTEKSAEAHRRALLEHHHHHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Design of activated serine-containing catalytic triads with atomic-level accuracy.
pubmed doi rcsb
source organism Artificial gene
molecule tags Hydrolase
molecule keywords De novo designed serine hydrolase
total genus 62
structure length 166
sequence length 166
chains with identical sequence B
ec nomenclature
pdb deposition date 2012-04-24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E; domain 1 Leucine Aminopeptidase, subunit E, domain 1 4etkA00
3EWRA 4ZY0A 3EWQA 1VHUA 3ETIA 3SIHA 5D8NA 1LAPA 5CBMA 4J5RA 1TY8A 3T8WA 4ETJA 5FSVA 3EWPA 4JGKA 2FXKA 3Q6ZA 2FG1A 1LANA 4ZI6A 5CB3A 5FSZA 2BFQA 4GVVA 1LAMA 5DUSA 3SIGA 1GYTA 2EEEA 4ZYQA 3IIDA 2FAVA 5HOLA 5CB5A 1BPMA 3GPGA 4KSIA 2L8RA 3KR4A 3H8EA 3EJFA 3KQZA 4GUAA 2BFRA 4GVWA 4J5SA 3KZWA 4R76A 2XD7A 1SPVA 1ZR3A 3KQXA 4KYBA 3EKEA 3KR5A 4IQYA 4TU0A 3V2BA 1HJZA 2X47A 4JVVA 3GQEA 5CMSA 2EWBA 3IJ3A 3JZTA 4K3NA 5FSXA 2ACFA 3SIJA 1YD9A 4ABLA 3EJGA 2VRIA 4ZY1A 3IIFA 3PEIA 3V45A 3VFQA 4ZY2A 1LCPA 2AFCA 4ABKA 3GQOA 1NJRA 4R6TA 1TXZA 4ETKA 4ZX9A 1BPNA 3JRUA 1ZR5A 4X2TA 5E3BA 3EWOA 5AILA 3Q71A 3GPQA 4ESSA 3H8GA 4R7MA 4ZX8A 4K0CA 5FSYA 4UMLA 3H8FA 2J9AA 5HIHA 4JCAA 3EW5A 4D86A 4J5QA 2LGRA 3SIIA 2DX6A 4JLLA 4J4ZA 3GPOA 1BLLE 5FSUA
chains in the Genus database with same CATH superfamily
3EWRA 4ZY0A 3EWQA 1VHUA 3ETIA 3SIHA 5D8NA 1LAPA 5CBMA 4J5RA 1TY8A 3T8WA 4ETJA 2JZEA 5FSVA 3EWPA 4JGKA 2FXKA 3Q6ZA 2FG1A 1LANA 4ZI6A 5CB3A 5FSZA 2BFQA 4GVVA 1LAMA 5DUSA 3SIGA 2WCTA 1GYTA 2EEEA 4ZYQA 3IIDA 2FAVA 5HOLA 5CB5A 1BPMA 3GPGA 4KSIA 2L8RA 3KR4A 3H8EA 3EJFA 3KQZA 4GUAA 2BFRA 4GVWA 2W2GA 3KZWA 4J5SA 4R76A 2XD7A 1SPVA 1ZR3A 3KQXA 4KYBA 3EKEA 3KR5A 4IQYA 4TU0A 3V2BA 1HJZA 2X47A 4JVVA 3GQEA 5CMSA 2EWBA 3IJ3A 3JZTA 4K3NA 5FSXA 2ACFA 3SIJA 1YD9A 4ABLA 3EJGA 2VRIA 4ZY1A 3IIFA 3PEIA 3V45A 3VFQA 4ZY2A 1LCPA 2AFCA 4ABKA 3GQOA 1NJRA 4R6TA 1TXZA 4ETKA 4ZX9A 1BPNA 3JRUA 2JZFA 1ZR5A 4X2TA 5E3BA 2RNKA 3EWOA 5AILA 3Q71A 3GPQA 4ESSA 3H8GA 4R7MA 4ZX8A 4K0CA 5FSYA 3H8FA 2J9AA 4UMLA 5HIHA 4JCAA 3EW5A 4D86A 4J5QA 2JZDA 2LGRA 3SIIA 2DX6A 4JLLA 4J4ZA 2KQVA 3GPOA 1BLLE 5FSUA
chains in the Genus database with same CATH topology
3EWRA 4ZY0A 3EWQA 1VHUA 3ETIA 3SIHA 5D8NA 1LAPA 5CBMA 4J5RA 1TY8A 3T8WA 4ETJA 5FSVA 3EWPA 4JGKA 2FXKA 3Q6ZA 2FG1A 1LANA 4ZI6A 5CB3A 5FSZA 2BFQA 4GVVA 1LAMA 5DUSA 3SIGA 1GYTA 2EEEA 4ZYQA 3IIDA 2FAVA 5HOLA 5CB5A 1BPMA 3GPGA 4KSIA 2L8RA 3KR4A 3H8EA 3EJFA 3KQZA 4GUAA 2BFRA 4GVWA 4J5SA 3KZWA 4R76A 2XD7A 1SPVA 1ZR3A 3KQXA 4KYBA 3EKEA 3KR5A 4IQYA 4TU0A 3V2BA 1HJZA 2X47A 4JVVA 3GQEA 5CMSA 2EWBA 3IJ3A 3JZTA 4K3NA 5FSXA 2ACFA 3SIJA 1YD9A 4ABLA 3EJGA 2VRIA 4ZY1A 3IIFA 3PEIA 3V45A 3VFQA 4ZY2A 1LCPA 2AFCA 4ABKA 3GQOA 1NJRA 4R6TA 1TXZA 4ETKA 4ZX9A 1BPNA 3JRUA 1ZR5A 4X2TA 5E3BA 3EWOA 5AILA 3Q71A 3GPQA 4ESSA 3H8GA 4R7MA 4ZX8A 4K0CA 5FSYA 4UMLA 3H8FA 2J9AA 5HIHA 4JCAA 3EW5A 4D86A 4J5QA 2LGRA 3SIIA 2DX6A 4JLLA 4J4ZA 3GPOA 1BLLE 5FSUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3EWR A;  4ZY0 A;  3EWQ A;  1VHU A;  3ETI A;  3SIH A;  5D8N A;  1LAP A;  5CBM A;  4J5R A;  1TY8 A;  3T8W A;  4ETJ A;  5FSV A;  3EWP A;  4JGK A;  2FXK A;  3Q6Z A;  2FG1 A;  1LAN A;  4ZI6 A;  5CB3 A;  5FSZ A;  2BFQ A;  4GVV A;  1LAM A;  5DUS A;  3SIG A;  1GYT A;  2EEE A;  4ZYQ A;  3IID A;  2FAV A;  5HOL A;  5CB5 A;  1BPM A;  3GPG A;  4KSI A;  2L8R A;  3KR4 A;  3H8E A;  3EJF A;  3KQZ A;  4GUA A;  2BFR A;  4GVW A;  4J5S A;  3KZW A;  4R76 A;  2XD7 A;  1SPV A;  1ZR3 A;  3KQX A;  4KYB A;  3EKE A;  3KR5 A;  4IQY A;  4TU0 A;  3V2B A;  1HJZ A;  2X47 A;  4JVV A;  3GQE A;  5CMS A;  2EWB A;  3IJ3 A;  3JZT A;  4K3N A;  5FSX A;  2ACF A;  3SIJ A;  1YD9 A;  4ABL A;  3EJG A;  2VRI A;  4ZY1 A;  3IIF A;  3PEI A;  3V45 A;  3VFQ A;  4ZY2 A;  1LCP A;  2AFC A;  4ABK A;  3GQO A;  1NJR A;  4R6T A;  1TXZ A;  4ETK A;  4ZX9 A;  1BPN A;  3JRU A;  1ZR5 A;  4X2T A;  5E3B A;  3EWO A;  5AIL A;  3Q71 A;  3GPQ A;  4ESS A;  3H8G A;  4R7M A;  4ZX8 A;  4K0C A;  5FSY A;  4UML A;  3H8F A;  2J9A A;  5HIH A;  4JCA A;  3EW5 A;  4D86 A;  4J5Q A;  2LGR A;  3SII A;  2DX6 A;  4JLL A;  4J4Z A;  3GPO A;  1BLL E;  5FSU A; 
#chains in the Genus database with same CATH topology
 3EWR A;  4ZY0 A;  3EWQ A;  1VHU A;  3ETI A;  3SIH A;  5D8N A;  1LAP A;  5CBM A;  4J5R A;  1TY8 A;  3T8W A;  4ETJ A;  2JZE A;  5FSV A;  3EWP A;  4JGK A;  2FXK A;  3Q6Z A;  2FG1 A;  1LAN A;  4ZI6 A;  5CB3 A;  5FSZ A;  2BFQ A;  4GVV A;  1LAM A;  5DUS A;  3SIG A;  2WCT A;  1GYT A;  2EEE A;  4ZYQ A;  3IID A;  2FAV A;  5HOL A;  5CB5 A;  1BPM A;  3GPG A;  4KSI A;  2L8R A;  3KR4 A;  3H8E A;  3EJF A;  3KQZ A;  4GUA A;  2BFR A;  4GVW A;  2W2G A;  3KZW A;  4J5S A;  4R76 A;  2XD7 A;  1SPV A;  1ZR3 A;  3KQX A;  4KYB A;  3EKE A;  3KR5 A;  4IQY A;  4TU0 A;  3V2B A;  1HJZ A;  2X47 A;  4JVV A;  3GQE A;  5CMS A;  2EWB A;  3IJ3 A;  3JZT A;  4K3N A;  5FSX A;  2ACF A;  3SIJ A;  1YD9 A;  4ABL A;  3EJG A;  2VRI A;  4ZY1 A;  3IIF A;  3PEI A;  3V45 A;  3VFQ A;  4ZY2 A;  1LCP A;  2AFC A;  4ABK A;  3GQO A;  1NJR A;  4R6T A;  1TXZ A;  4ETK A;  4ZX9 A;  1BPN A;  3JRU A;  2JZF A;  1ZR5 A;  4X2T A;  5E3B A;  2RNK A;  3EWO A;  5AIL A;  3Q71 A;  3GPQ A;  4ESS A;  3H8G A;  4R7M A;  4ZX8 A;  4K0C A;  5FSY A;  3H8F A;  2J9A A;  4UML A;  5HIH A;  4JCA A;  3EW5 A;  4D86 A;  4J5Q A;  2JZD A;  2LGR A;  3SII A;  2DX6 A;  4JLL A;  4J4Z A;  2KQV A;  3GPO A;  1BLL E;  5FSU A; 
#chains in the Genus database with same CATH homology
 3EWR A;  4ZY0 A;  3EWQ A;  1VHU A;  3ETI A;  3SIH A;  5D8N A;  1LAP A;  5CBM A;  4J5R A;  1TY8 A;  3T8W A;  4ETJ A;  5FSV A;  3EWP A;  4JGK A;  2FXK A;  3Q6Z A;  2FG1 A;  1LAN A;  4ZI6 A;  5CB3 A;  5FSZ A;  2BFQ A;  4GVV A;  1LAM A;  5DUS A;  3SIG A;  1GYT A;  2EEE A;  4ZYQ A;  3IID A;  2FAV A;  5HOL A;  5CB5 A;  1BPM A;  3GPG A;  4KSI A;  2L8R A;  3KR4 A;  3H8E A;  3EJF A;  3KQZ A;  4GUA A;  2BFR A;  4GVW A;  4J5S A;  3KZW A;  4R76 A;  2XD7 A;  1SPV A;  1ZR3 A;  3KQX A;  4KYB A;  3EKE A;  3KR5 A;  4IQY A;  4TU0 A;  3V2B A;  1HJZ A;  2X47 A;  4JVV A;  3GQE A;  5CMS A;  2EWB A;  3IJ3 A;  3JZT A;  4K3N A;  5FSX A;  2ACF A;  3SIJ A;  1YD9 A;  4ABL A;  3EJG A;  2VRI A;  4ZY1 A;  3IIF A;  3PEI A;  3V45 A;  3VFQ A;  4ZY2 A;  1LCP A;  2AFC A;  4ABK A;  3GQO A;  1NJR A;  4R6T A;  1TXZ A;  4ETK A;  4ZX9 A;  1BPN A;  3JRU A;  1ZR5 A;  4X2T A;  5E3B A;  3EWO A;  5AIL A;  3Q71 A;  3GPQ A;  4ESS A;  3H8G A;  4R7M A;  4ZX8 A;  4K0C A;  5FSY A;  4UML A;  3H8F A;  2J9A A;  5HIH A;  4JCA A;  3EW5 A;  4D86 A;  4J5Q A;  2LGR A;  3SII A;  2DX6 A;  4JLL A;  4J4Z A;  3GPO A;  1BLL E;  5FSU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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