4EVHA

Crystal structure of calcium-bound alpha-1 giardin
Total Genus 120
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
120
sequence length
294
structure length
294
Chain Sequence
PKVTDIANELKQAIDAKDEVQIAFIASEYSAESREKIAKAYVASYGKELPDDIKKALKGGSEESLLMDLFSDRHEVRAQHIRDALSGRNDHMAFFDTVILCTPEDWHETVAAYTRMFKKPLVEDFMKDVGRKEDWCLLMEKWMAHERVSRPGSPEDEAQRLDQAFDQKNTAYLIDFFGTVPSAEYRPIAEAFKAQNGKSIEQAIATIYTKTDYYTFYCAHFALLGMHRLAAYLINCACNDKGDEKRMRRITGMMVDKCLGAKHAYKIYGDMGTDIERCFDKRMAPILRTLWRVK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Giardin subunit alpha-1
publication title Alpha-1 giardin is an annexin with highly unusual calcium-regulated mechanisms
pubmed doi rcsb
source organism Giardia intestinalis
molecule tags Metal binding protein
total genus 120
structure length 294
sequence length 294
ec nomenclature
pdb deposition date 2012-04-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00191 Annexin Annexin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 4evhA02
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 4evhA03
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 4evhA01
1.10.220.10 Mainly Alpha Orthogonal Bundle Annexin V; domain 1 Annexin 4evhA04
1HVFA 2HYWA 2Q4CA 1MCXA 1YIIA 2IICA 1YCNA 1ANXA 1AOWA 3BRXA 1ANNA 1I4AA 2HYVA 4MDUA 1A8AA 1AVCA 1BC3A 1SAVA 2H0LA 1N41A 1ANWA 2XO2A 1BO9A 1HVEA 1G5NA 1HVDA 1AEIA 2HYUA 2IE6A 4X9PA 2RANA 1AIIA 2ZOCA 4EVHA 1AVHA 1BC1A 2XO3A 4MDVA 1M9IA 1A8BA 1W45A 2ZHJA 1HVGA 2II2A 1BCYA 1XJLA 1N00A 1DM5A 1BC0A 1N44A 2H0MA 2IE7A 1HM6A 1DK5A 2ZHIA 1HAKA 4EVFA 1ALAA 1W7BA 1BCZA 1YJ0A 2H0KA 1BCWA 4HREA 1AVRA 1W3WA 1N42A 1AXNA
chains in the Genus database with same CATH superfamily
1BC9A 1YCNA 1ANXA 1ANNA 1I4AA 1AVCA 1SAVA 2H0LA 2XO2A 1YGMA 1HVEA 4Z21A 1G5NA 1AIIA 4MDVA 1R8ME 1A8BA 1RE0B 1HVGA 2R0DA 1XJLA 3USYA 1XSZA 1N44A 4L5MA 3ABQA 2IE7A 3ANYA 1DK5A 2ZHIA 1HAKA 1QC7A 4EVFA 1ALAA 1Q8DA 4HREA 4MDUA 4D7QA 2Q4CA 4JMIA 1XT0B 3AO0A 3BRXA 3ABRA 2HYVA 1A8AA 1BC3A 1BO9A 4JMOA 2HYUA 2IE6A 2ZOCA 1AVHA 2XO3A 1PBVA 1M9IA 1BCYA 3AJCA 3SWVA 1N00A 1C1KA 1W7BA 1BCZA 1BCWA 1W3WA 1AXNA 1HVFA 1R4AE 1YIIA 3USWA 1N41A 1ANWA 1R8QE 4KN4X 1HVDA 1BC1A 4A4PA 1KU1A 1UPTB 2ZHJA 2II2A 4FQ0C 4Q2SA 1BC0A 2QEZA 2OY9A 4D7RA 2VXGA 1AVRA 1R8SE 2HYWA 2R09A 2K6XA 1MCXA 2IICA 1AOWA 3ABOA 3L8NA 4FHRB 1LKVX 4JK1X 4X9PA 1AEIA 2RANA 4KMUX 3SOHB 4EVHA 4C7PA 1S9DE 3TW5A 1W45A 2HSNA 4C0AA 3ABSA 4JXHA 1DM5A 2H0MA 1HM6A 4JWLA 3HJLA 3LTLA 2H0KA 1YJ0A 4OIYA 4KN7X 1N42A
chains in the Genus database with same CATH topology
1HVFA 2HYWA 2Q4CA 1MCXA 1YIIA 2IICA 1YCNA 1ANXA 1AOWA 3BRXA 1ANNA 1I4AA 2HYVA 4MDUA 1A8AA 1AVCA 1BC3A 1SAVA 2H0LA 1N41A 1ANWA 2XO2A 1BO9A 1HVEA 1G5NA 1HVDA 1AEIA 2HYUA 2IE6A 4X9PA 2RANA 1AIIA 2ZOCA 4EVHA 1AVHA 1BC1A 2XO3A 4MDVA 1M9IA 1A8BA 1W45A 2ZHJA 1HVGA 2II2A 1BCYA 1XJLA 1N00A 1DM5A 1BC0A 1N44A 2H0MA 2IE7A 1HM6A 1DK5A 2ZHIA 1HAKA 4EVFA 1ALAA 1W7BA 1BCZA 1YJ0A 2H0KA 1BCWA 4HREA 1AVRA 1W3WA 1N42A 1AXNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HVF A;  2HYW A;  2Q4C A;  1MCX A;  1YII A;  2IIC A;  1YCN A;  1ANX A;  1AOW A;  3BRX A;  1ANN A;  1I4A A;  2HYV A;  4MDU A;  1A8A A;  1AVC A;  1BC3 A;  1SAV A;  2H0L A;  1N41 A;  1ANW A;  2XO2 A;  1BO9 A;  1HVE A;  1G5N A;  1HVD A;  1AEI A;  2HYU A;  2IE6 A;  4X9P A;  2RAN A;  1AII A;  2ZOC A;  4EVH A;  1AVH A;  1BC1 A;  2XO3 A;  4MDV A;  1M9I A;  1A8B A;  1W45 A;  2ZHJ A;  1HVG A;  2II2 A;  1BCY A;  1XJL A;  1N00 A;  1DM5 A;  1BC0 A;  1N44 A;  2H0M A;  2IE7 A;  1HM6 A;  1DK5 A;  2ZHI A;  1HAK A;  4EVF A;  1ALA A;  1W7B A;  1BCZ A;  1YJ0 A;  2H0K A;  1BCW A;  4HRE A;  1AVR A;  1W3W A;  1N42 A;  1AXN A; 
#chains in the Genus database with same CATH topology
 1BC9 A;  1YCN A;  1ANX A;  1ANN A;  1I4A A;  1AVC A;  1SAV A;  2H0L A;  2XO2 A;  1YGM A;  1HVE A;  4Z21 A;  1G5N A;  1AII A;  4MDV A;  1R8M E;  1A8B A;  1RE0 B;  1HVG A;  2R0D A;  1XJL A;  3USY A;  1XSZ A;  1N44 A;  4L5M A;  3ABQ A;  2IE7 A;  3ANY A;  1DK5 A;  2ZHI A;  1HAK A;  1QC7 A;  4EVF A;  1ALA A;  1Q8D A;  4HRE A;  4MDU A;  4D7Q A;  2Q4C A;  4JMI A;  1XT0 B;  3AO0 A;  3BRX A;  3ABR A;  2HYV A;  1A8A A;  1BC3 A;  1BO9 A;  4JMO A;  2HYU A;  2IE6 A;  2ZOC A;  1AVH A;  2XO3 A;  1PBV A;  1M9I A;  1BCY A;  3AJC A;  3SWV A;  1N00 A;  1C1K A;  1W7B A;  1BCZ A;  1BCW A;  1W3W A;  1AXN A;  1HVF A;  1R4A E;  1YII A;  3USW A;  1N41 A;  1ANW A;  1R8Q E;  4KN4 X;  1HVD A;  1BC1 A;  4A4P A;  1KU1 A;  1UPT B;  2ZHJ A;  2II2 A;  4FQ0 C;  4Q2S A;  1BC0 A;  2QEZ A;  2OY9 A;  4D7R A;  2VXG A;  1AVR A;  1R8S E;  2HYW A;  2R09 A;  2K6X A;  1MCX A;  2IIC A;  1AOW A;  3ABO A;  3L8N A;  4FHR B;  1LKV X;  4JK1 X;  4X9P A;  1AEI A;  2RAN A;  4KMU X;  3SOH B;  4EVH A;  4C7P A;  1S9D E;  3TW5 A;  1W45 A;  2HSN A;  4C0A A;  3ABS A;  4JXH A;  1DM5 A;  2H0M A;  1HM6 A;  4JWL A;  3HJL A;  3LTL A;  2H0K A;  1YJ0 A;  4OIY A;  4KN7 X;  1N42 A; 
#chains in the Genus database with same CATH homology
 1HVF A;  2HYW A;  2Q4C A;  1MCX A;  1YII A;  2IIC A;  1YCN A;  1ANX A;  1AOW A;  3BRX A;  1ANN A;  1I4A A;  2HYV A;  4MDU A;  1A8A A;  1AVC A;  1BC3 A;  1SAV A;  2H0L A;  1N41 A;  1ANW A;  2XO2 A;  1BO9 A;  1HVE A;  1G5N A;  1HVD A;  1AEI A;  2HYU A;  2IE6 A;  4X9P A;  2RAN A;  1AII A;  2ZOC A;  4EVH A;  1AVH A;  1BC1 A;  2XO3 A;  4MDV A;  1M9I A;  1A8B A;  1W45 A;  2ZHJ A;  1HVG A;  2II2 A;  1BCY A;  1XJL A;  1N00 A;  1DM5 A;  1BC0 A;  1N44 A;  2H0M A;  2IE7 A;  1HM6 A;  1DK5 A;  2ZHI A;  1HAK A;  4EVF A;  1ALA A;  1W7B A;  1BCZ A;  1YJ0 A;  2H0K A;  1BCW A;  4HRE A;  1AVR A;  1W3W A;  1N42 A;  1AXN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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