4EWIA

Crystal structure of the nlrp4 pyrin domain
Total Genus 35
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
35
sequence length
91
structure length
91
Chain Sequence
FFSDFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWNITLRIFQKMDRKDLCMKVMRERTGY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and Functional Analysis of the NLRP4 Pyrin Domain.
pubmed doi rcsb
molecule tags Signaling protein, protein binding
source organism Homo sapiens
molecule keywords NACHT, LRR and PYD domains-containing protein 4
total genus 35
structure length 91
sequence length 91
chains with identical sequence B
ec nomenclature
pdb deposition date 2012-04-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02758 PYRIN PAAD/DAPIN/Pyrin domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.533.10 Mainly Alpha Orthogonal Bundle Death Domain, Fas Death Domain, Fas 4ewiA00
1FADA 3EZQA 4UZ0A 1Z6TA 2OF5A 4O7QA 3T6PA 3KATA 4RHWE 1C15A 2MS8A 4O6XA 2M5VA 2MN4A 4DWNA 2G7RA 2YU0A 2DBGA 3CRDA 1E3YA 1N3KA 4N1KA 2HM2Q 4M9ZA 3YGSP 3YGSC 1D2ZA 3QF2A 2BBRA 4LWDA 2LS7A 2A9IA 2B1WA 2N83A 2N80A 3J6JA 2YQFA 1WMGA 2OF5H 3LQRA 3MOPG 4JUPA 4N1LA 4F44A 1UCPA 2P1HA 4QOBA 1YGOA 4EWIA 2MB9A 1ICHA 4M9XA 2A5YB 4D8OA 2GF5A 4O9FA 4IZ7B 2D96A 1A1WA 2N97A 1DGNA 4JQWA 2NAQA 2VGQA 3MOPA 2DBHA 4A2QA 1CY5A 2BBZA 1A1ZA 2N7ZA 2LWDA 2O71A 1NGRA 2KM6A 1WH4A 1PN5A 2DBFA 2MPCA 2DO9A 4ZBWA 4NQKA 2F1SA 4A2WA 2LWEA 4E9MA 4P4HI 2NSNA 2L6AA 4I16A 2L9MA 2N1FA 3J63A 1D2ZB 2YVIA 2N00A 4P4HA 2KN6A 4F42A 3CL3A 4IZAB 4RHWA 2YGSA 2IB1A 3EZQB 2NZ7A 2DBDA 1CWWA 1WXPA 3MOPK 4N1JA 4FH0A 4M9SA 3LQQA 1DDFA 4IZ5E 4O9LA 1E41A 2MS7A
chains in the Genus database with same CATH superfamily
1FADA 3EZQA 4UZ0A 1Z6TA 2OF5A 4O7QA 3T6PA 3KATA 4RHWE 1C15A 2MS8A 4O6XA 2M5VA 2MN4A 4DWNA 2G7RA 2YU0A 2DBGA 3CRDA 1E3YA 1N3KA 4N1KA 2HM2Q 4M9ZA 3YGSP 3YGSC 1D2ZA 3QF2A 2BBRA 4LWDA 2LS7A 2A9IA 2B1WA 2N83A 2N80A 3J6JA 2XV9A 2YQFA 1WMGA 2OF5H 3LQRA 3MOPG 4JUPA 4N1LA 4F44A 1UCPA 2P1HA 4QOBA 1YGOA 4EWIA 2MB9A 1ICHA 4M9XA 2A5YB 4D8OA 2GF5A 4O9FA 4IZ7B 2D96A 1A1WA 2N97A 1DGNA 4JQWA 2NAQA 2VGQA 3MOPA 2DBHA 4A2QA 1CY5A 2BBZA 1A1ZA 2N7ZA 2LWDA 2O71A 1NGRA 2KM6A 1WH4A 1PN5A 2DBFA 2MPCA 2DO9A 4ZBWA 4NQKA 2F1SA 4A2WA 2LWEA 4E9MA 4P4HI 2NSNA 2L6AA 4I16A 2L9MA 2N1FA 3J63A 1D2ZB 2YVIA 2N00A 4P4HA 2KN6A 4F42A 3CL3A 4IZAB 4RHWA 2YGSA 2IB1A 3EZQB 2NZ7A 2DBDA 2MJMA 1CWWA 1WXPA 3MOPK 4N1JA 4FH0A 4M9SA 3LQQA 1DDFA 4IZ5E 4O9LA 1E41A 2MS7A
chains in the Genus database with same CATH topology
1FADA 3EZQA 4UZ0A 1Z6TA 2OF5A 4O7QA 3T6PA 3KATA 4RHWE 1C15A 2MS8A 4O6XA 2M5VA 2MN4A 4DWNA 2G7RA 2YU0A 2DBGA 3CRDA 1E3YA 1N3KA 4N1KA 2HM2Q 4M9ZA 3YGSP 3YGSC 1D2ZA 3QF2A 2BBRA 4LWDA 2LS7A 2A9IA 2B1WA 2N83A 2N80A 3J6JA 2XV9A 2YQFA 1WMGA 2OF5H 3LQRA 3MOPG 4JUPA 4N1LA 4F44A 1UCPA 2P1HA 4QOBA 1YGOA 4EWIA 2MB9A 1ICHA 4M9XA 2A5YB 4D8OA 2GF5A 4O9FA 4IZ7B 2D96A 1A1WA 2N97A 1DGNA 4JQWA 2NAQA 2VGQA 3MOPA 2DBHA 4A2QA 1CY5A 2BBZA 1A1ZA 2N7ZA 2LWDA 2O71A 1NGRA 2KM6A 1WH4A 1PN5A 2DBFA 2MPCA 2DO9A 4ZBWA 4NQKA 2F1SA 4A2WA 2LWEA 4E9MA 4P4HI 2NSNA 2L6AA 4I16A 2L9MA 2N1FA 3J63A 1D2ZB 2YVIA 2N00A 4P4HA 2KN6A 4F42A 3CL3A 4IZAB 4RHWA 2YGSA 2IB1A 3EZQB 2NZ7A 2DBDA 2MJMA 1CWWA 1WXPA 3MOPK 4N1JA 4FH0A 4M9SA 3LQQA 1DDFA 4IZ5E 4O9LA 1E41A 2MS7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FAD A;  3EZQ A;  4UZ0 A;  1Z6T A;  2OF5 A;  4O7Q A;  3T6P A;  3KAT A;  4RHW E;  1C15 A;  2MS8 A;  4O6X A;  2M5V A;  2MN4 A;  4DWN A;  2G7R A;  2YU0 A;  2DBG A;  3CRD A;  1E3Y A;  1N3K A;  4N1K A;  2HM2 Q;  4M9Z A;  3YGS P;  3YGS C;  1D2Z A;  3QF2 A;  2BBR A;  4LWD A;  2LS7 A;  2A9I A;  2B1W A;  2N83 A;  2N80 A;  3J6J A;  2YQF A;  1WMG A;  2OF5 H;  3LQR A;  3MOP G;  4JUP A;  4N1L A;  4F44 A;  1UCP A;  2P1H A;  4QOB A;  1YGO A;  4EWI A;  2MB9 A;  1ICH A;  4M9X A;  2A5Y B;  4D8O A;  2GF5 A;  4O9F A;  4IZ7 B;  2D96 A;  1A1W A;  2N97 A;  1DGN A;  4JQW A;  2NAQ A;  2VGQ A;  3MOP A;  2DBH A;  4A2Q A;  1CY5 A;  2BBZ A;  1A1Z A;  2N7Z A;  2LWD A;  2O71 A;  1NGR A;  2KM6 A;  1WH4 A;  1PN5 A;  2DBF A;  2MPC A;  2DO9 A;  4ZBW A;  4NQK A;  2F1S A;  4A2W A;  2LWE A;  4E9M A;  4P4H I;  2NSN A;  2L6A A;  4I16 A;  2L9M A;  2N1F A;  3J63 A;  1D2Z B;  2YVI A;  2N00 A;  4P4H A;  2KN6 A;  4F42 A;  3CL3 A;  4IZA B;  4RHW A;  2YGS A;  2IB1 A;  3EZQ B;  2NZ7 A;  2DBD A;  1CWW A;  1WXP A;  3MOP K;  4N1J A;  4FH0 A;  4M9S A;  3LQQ A;  1DDF A;  4IZ5 E;  4O9L A;  1E41 A;  2MS7 A; 
#chains in the Genus database with same CATH topology
 1FAD A;  3EZQ A;  4UZ0 A;  1Z6T A;  2OF5 A;  4O7Q A;  3T6P A;  3KAT A;  4RHW E;  1C15 A;  2MS8 A;  4O6X A;  2M5V A;  2MN4 A;  4DWN A;  2G7R A;  2YU0 A;  2DBG A;  3CRD A;  1E3Y A;  1N3K A;  4N1K A;  2HM2 Q;  4M9Z A;  3YGS P;  3YGS C;  1D2Z A;  3QF2 A;  2BBR A;  4LWD A;  2LS7 A;  2A9I A;  2B1W A;  2N83 A;  2N80 A;  3J6J A;  2XV9 A;  2YQF A;  1WMG A;  2OF5 H;  3LQR A;  3MOP G;  4JUP A;  4N1L A;  4F44 A;  1UCP A;  2P1H A;  4QOB A;  1YGO A;  4EWI A;  2MB9 A;  1ICH A;  4M9X A;  2A5Y B;  4D8O A;  2GF5 A;  4O9F A;  4IZ7 B;  2D96 A;  1A1W A;  2N97 A;  1DGN A;  4JQW A;  2NAQ A;  2VGQ A;  3MOP A;  2DBH A;  4A2Q A;  1CY5 A;  2BBZ A;  1A1Z A;  2N7Z A;  2LWD A;  2O71 A;  1NGR A;  2KM6 A;  1WH4 A;  1PN5 A;  2DBF A;  2MPC A;  2DO9 A;  4ZBW A;  4NQK A;  2F1S A;  4A2W A;  2LWE A;  4E9M A;  4P4H I;  2NSN A;  2L6A A;  4I16 A;  2L9M A;  2N1F A;  3J63 A;  1D2Z B;  2YVI A;  2N00 A;  4P4H A;  2KN6 A;  4F42 A;  3CL3 A;  4IZA B;  4RHW A;  2YGS A;  2IB1 A;  3EZQ B;  2NZ7 A;  2DBD A;  2MJM A;  1CWW A;  1WXP A;  3MOP K;  4N1J A;  4FH0 A;  4M9S A;  3LQQ A;  1DDF A;  4IZ5 E;  4O9L A;  1E41 A;  2MS7 A; 
#chains in the Genus database with same CATH homology
 1FAD A;  3EZQ A;  4UZ0 A;  1Z6T A;  2OF5 A;  4O7Q A;  3T6P A;  3KAT A;  4RHW E;  1C15 A;  2MS8 A;  4O6X A;  2M5V A;  2MN4 A;  4DWN A;  2G7R A;  2YU0 A;  2DBG A;  3CRD A;  1E3Y A;  1N3K A;  4N1K A;  2HM2 Q;  4M9Z A;  3YGS P;  3YGS C;  1D2Z A;  3QF2 A;  2BBR A;  4LWD A;  2LS7 A;  2A9I A;  2B1W A;  2N83 A;  2N80 A;  3J6J A;  2XV9 A;  2YQF A;  1WMG A;  2OF5 H;  3LQR A;  3MOP G;  4JUP A;  4N1L A;  4F44 A;  1UCP A;  2P1H A;  4QOB A;  1YGO A;  4EWI A;  2MB9 A;  1ICH A;  4M9X A;  2A5Y B;  4D8O A;  2GF5 A;  4O9F A;  4IZ7 B;  2D96 A;  1A1W A;  2N97 A;  1DGN A;  4JQW A;  2NAQ A;  2VGQ A;  3MOP A;  2DBH A;  4A2Q A;  1CY5 A;  2BBZ A;  1A1Z A;  2N7Z A;  2LWD A;  2O71 A;  1NGR A;  2KM6 A;  1WH4 A;  1PN5 A;  2DBF A;  2MPC A;  2DO9 A;  4ZBW A;  4NQK A;  2F1S A;  4A2W A;  2LWE A;  4E9M A;  4P4H I;  2NSN A;  2L6A A;  4I16 A;  2L9M A;  2N1F A;  3J63 A;  1D2Z B;  2YVI A;  2N00 A;  4P4H A;  2KN6 A;  4F42 A;  3CL3 A;  4IZA B;  4RHW A;  2YGS A;  2IB1 A;  3EZQ B;  2NZ7 A;  2DBD A;  2MJM A;  1CWW A;  1WXP A;  3MOP K;  4N1J A;  4FH0 A;  4M9S A;  3LQQ A;  1DDF A;  4IZ5 E;  4O9L A;  1E41 A;  2MS7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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