4FLCA

Structural and biochemical characterization of human adenylosuccinate lyase (adsl) and the r303c adsl deficiency associated mutation
Total Genus 160
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
160
sequence length
470
structure length
460
Chain Sequence
b'HGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIREMKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIPYKRNPMRSECCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVYPLLKPYESVM'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural and Biochemical Characterization of Human Adenylosuccinate Lyase (ADSL) and the R303C ADSL Deficiency-Associated Mutation.
pubmed doi rcsb
molecule keywords Adenylosuccinate lyase
source organism Homo sapiens
molecule tags Lyase
total genus 160
structure length 460
sequence length 470
chains with identical sequence B, C, D
ec nomenclature ec 4.3.2.2: Adenylosuccinate lyase.
pdb deposition date 2012-06-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10397 ADSL_C Adenylosuccinate lyase C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4flcA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4flcA02
3TV2A 1XWOA 4CQ5A 1C3CA 3OCFA 5F91A 1FUOA 3GTDA 1U15A 2NYFA 2O78A 2E9FA 4FFXA 1YFMA 5EYVA 2J91A 3UNVA 4BABA 2X75A 3NZ4A 2VD6A 3OCEA 1I0AA 1KQ7A 1Y2MA 4ADMA 1GKMA 1YISA 2HVGA 3C8TA 3NO9A 1GK3A 1VDKA 1T6PA 1TJUA 2PTRA 3RD8A 3BHGA 4EFCA 1TJVA 4APAA 4BAAA 5HW2A 2QVEA 1J3UA 4NLEA 4NSLA 5D6BA 2O7EA 1AUWA 2PTQA 2OHYA 1JSWA 3GZHA 4C5UA 4MX2A 3KDYA 1FUPA 1U16A 1W27A 2RJRA 4V2QA 1TJWA 2O7DA 2O6YA 2O7BA 3QBPA 2RJSA 4ADLA 3R6QA 1K62A 1TJ7A 2YIIA 1RE5A 2O7FA 1FUQA 1HY0A 1HY1A 3KDZA 4FLCA 5F92A 1DOFA 2PTSA 3R6VA 1B8FA 1EB4A 3CZOA 1GKJA 4C6GA 1DCNA 4V2RA 3E04A 1FURA 4APBA 4C5SA 2PFMA 3R6YA 1T6JA 1YFEA 2FUSA 3RRPA 1Q5NA 1GK2A 1C3UA 4C5RA 4EEIA 2QGAB 2NYNA 1K7WA 5EYTA 4HGVA
chains in the Genus database with same CATH superfamily
3TV2A 1XWOA 4CQ5A 1XMCA 2FELA 1C3CA 3OCFA 5F91A 1FUOA 3GTDA 1U15A 2NYFA 2O78A 2E9FA 4FFXA 1YFMA 5EYVA 2J91A 3UNVA 4BABA 2X75A 3NZ4A 2VD6A 3OCEA 1I0AA 1KQ7A 1Y2MA 4ADMA 1GKMA 2FENA 1YISA 2HVGA 3C8TA 3NO9A 2VSFA 5M0JA 1GK3A 2VL7A 3CRVA 1VDKA 3CRW1 1T6PA 1TJUA 2PTRA 3RD8A 3BHGA 4EFCA 1TJVA 4APAA 4BAAA 5HW2A 2QVEA 1J3UA 4NLEA 4NSLA 5D6BA 2O7EA 1AUWA 2PTQA 2OHYA 1JSWA 3GZHA 1XL8A 4C5UA 4MX2A 3KDYA 1FUPA 1U16A 1W27A 2RJRA 4V2QA 1TJWA 2O7DA 2O6YA 2O7BA 3QBPA 2RJSA 4ADLA 3R6QA 1K62A 1TJ7A 1XLYA 2YIIA 1RE5A 2O7FA 5H8WA 5M0IA 1FUQA 1HY0A 1HY1A 3KDZA 4FLCA 5F92A 1DOFA 2PTSA 3R6VA 1B8FA 1EB4A 3CZOA 1GKJA 4C6GA 1DCNA 1XMDA 4V2RA 1XL7A 3E04A 1FURA 4APBA 4C5SA 2PFMA 3R6YA 1T6JA 1YFEA 2FUSA 3RRPA 1Q5NA 4WNLA 1GK2A 1C3UA 4C5RA 4EEIA 2QGAB 2NYNA 4A15A 1K7WA 5EYTA 4HGVA
chains in the Genus database with same CATH topology
3TV2A 1XWOA 4CQ5A 1C3CA 3OCFA 5F91A 1FUOA 3GTDA 1U15A 2NYFA 2O78A 2E9FA 4FFXA 1YFMA 5EYVA 2J91A 3UNVA 4BABA 2X75A 3NZ4A 2VD6A 3OCEA 1I0AA 1KQ7A 1Y2MA 4ADMA 1GKMA 1YISA 2HVGA 3C8TA 3NO9A 1GK3A 1VDKA 1T6PA 1TJUA 2PTRA 3RD8A 3BHGA 4EFCA 1TJVA 4APAA 4BAAA 5HW2A 2QVEA 1J3UA 4NLEA 4NSLA 5D6BA 2O7EA 1AUWA 2PTQA 2OHYA 1JSWA 3GZHA 4C5UA 4MX2A 3KDYA 1FUPA 1U16A 1W27A 2RJRA 4V2QA 1TJWA 2O7DA 2O6YA 2O7BA 3QBPA 2RJSA 4ADLA 3R6QA 1K62A 1TJ7A 2YIIA 1RE5A 2O7FA 1FUQA 1HY0A 1HY1A 3KDZA 4FLCA 5F92A 1DOFA 2PTSA 3R6VA 1B8FA 1EB4A 3CZOA 1GKJA 4C6GA 1DCNA 4V2RA 3E04A 1FURA 4APBA 4C5SA 2PFMA 3R6YA 1T6JA 1YFEA 2FUSA 3RRPA 1Q5NA 1GK2A 1C3UA 4C5RA 4EEIA 2QGAB 2NYNA 1K7WA 5EYTA 4HGVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TV2 A;  1XWO A;  4CQ5 A;  1C3C A;  3OCF A;  5F91 A;  1FUO A;  3GTD A;  1U15 A;  2NYF A;  2O78 A;  2E9F A;  4FFX A;  1YFM A;  5EYV A;  2J91 A;  3UNV A;  4BAB A;  2X75 A;  3NZ4 A;  2VD6 A;  3OCE A;  1I0A A;  1KQ7 A;  1Y2M A;  4ADM A;  1GKM A;  1YIS A;  2HVG A;  3C8T A;  3NO9 A;  1GK3 A;  1VDK A;  1T6P A;  1TJU A;  2PTR A;  3RD8 A;  3BHG A;  4EFC A;  1TJV A;  4APA A;  4BAA A;  5HW2 A;  2QVE A;  1J3U A;  4NLE A;  4NSL A;  5D6B A;  2O7E A;  1AUW A;  2PTQ A;  2OHY A;  1JSW A;  3GZH A;  4C5U A;  4MX2 A;  3KDY A;  1FUP A;  1U16 A;  1W27 A;  2RJR A;  4V2Q A;  1TJW A;  2O7D A;  2O6Y A;  2O7B A;  3QBP A;  2RJS A;  4ADL A;  3R6Q A;  1K62 A;  1TJ7 A;  2YII A;  1RE5 A;  2O7F A;  1FUQ A;  1HY0 A;  1HY1 A;  3KDZ A;  4FLC A;  5F92 A;  1DOF A;  2PTS A;  3R6V A;  1B8F A;  1EB4 A;  3CZO A;  1GKJ A;  4C6G A;  1DCN A;  4V2R A;  3E04 A;  1FUR A;  4APB A;  4C5S A;  2PFM A;  3R6Y A;  1T6J A;  1YFE A;  2FUS A;  3RRP A;  1Q5N A;  1GK2 A;  1C3U A;  4C5R A;  4EEI A;  2QGA B;  2NYN A;  1K7W A;  5EYT A;  4HGV A; 
#chains in the Genus database with same CATH topology
 3TV2 A;  1XWO A;  4CQ5 A;  1XMC A;  2FEL A;  1C3C A;  3OCF A;  5F91 A;  1FUO A;  3GTD A;  1U15 A;  2NYF A;  2O78 A;  2E9F A;  4FFX A;  1YFM A;  5EYV A;  2J91 A;  3UNV A;  4BAB A;  2X75 A;  3NZ4 A;  2VD6 A;  3OCE A;  1I0A A;  1KQ7 A;  1Y2M A;  4ADM A;  1GKM A;  2FEN A;  1YIS A;  2HVG A;  3C8T A;  3NO9 A;  2VSF A;  5M0J A;  1GK3 A;  2VL7 A;  3CRV A;  1VDK A;  3CRW 1;  1T6P A;  1TJU A;  2PTR A;  3RD8 A;  3BHG A;  4EFC A;  1TJV A;  4APA A;  4BAA A;  5HW2 A;  2QVE A;  1J3U A;  4NLE A;  4NSL A;  5D6B A;  2O7E A;  1AUW A;  2PTQ A;  2OHY A;  1JSW A;  3GZH A;  1XL8 A;  4C5U A;  4MX2 A;  3KDY A;  1FUP A;  1U16 A;  1W27 A;  2RJR A;  4V2Q A;  1TJW A;  2O7D A;  2O6Y A;  2O7B A;  3QBP A;  2RJS A;  4ADL A;  3R6Q A;  1K62 A;  1TJ7 A;  1XLY A;  2YII A;  1RE5 A;  2O7F A;  5H8W A;  5M0I A;  1FUQ A;  1HY0 A;  1HY1 A;  3KDZ A;  4FLC A;  5F92 A;  1DOF A;  2PTS A;  3R6V A;  1B8F A;  1EB4 A;  3CZO A;  1GKJ A;  4C6G A;  1DCN A;  1XMD A;  4V2R A;  1XL7 A;  3E04 A;  1FUR A;  4APB A;  4C5S A;  2PFM A;  3R6Y A;  1T6J A;  1YFE A;  2FUS A;  3RRP A;  1Q5N A;  4WNL A;  1GK2 A;  1C3U A;  4C5R A;  4EEI A;  2QGA B;  2NYN A;  4A15 A;  1K7W A;  5EYT A;  4HGV A; 
#chains in the Genus database with same CATH homology
 3TV2 A;  1XWO A;  4CQ5 A;  1C3C A;  3OCF A;  5F91 A;  1FUO A;  3GTD A;  1U15 A;  2NYF A;  2O78 A;  2E9F A;  4FFX A;  1YFM A;  5EYV A;  2J91 A;  3UNV A;  4BAB A;  2X75 A;  3NZ4 A;  2VD6 A;  3OCE A;  1I0A A;  1KQ7 A;  1Y2M A;  4ADM A;  1GKM A;  1YIS A;  2HVG A;  3C8T A;  3NO9 A;  1GK3 A;  1VDK A;  1T6P A;  1TJU A;  2PTR A;  3RD8 A;  3BHG A;  4EFC A;  1TJV A;  4APA A;  4BAA A;  5HW2 A;  2QVE A;  1J3U A;  4NLE A;  4NSL A;  5D6B A;  2O7E A;  1AUW A;  2PTQ A;  2OHY A;  1JSW A;  3GZH A;  4C5U A;  4MX2 A;  3KDY A;  1FUP A;  1U16 A;  1W27 A;  2RJR A;  4V2Q A;  1TJW A;  2O7D A;  2O6Y A;  2O7B A;  3QBP A;  2RJS A;  4ADL A;  3R6Q A;  1K62 A;  1TJ7 A;  2YII A;  1RE5 A;  2O7F A;  1FUQ A;  1HY0 A;  1HY1 A;  3KDZ A;  4FLC A;  5F92 A;  1DOF A;  2PTS A;  3R6V A;  1B8F A;  1EB4 A;  3CZO A;  1GKJ A;  4C6G A;  1DCN A;  4V2R A;  3E04 A;  1FUR A;  4APB A;  4C5S A;  2PFM A;  3R6Y A;  1T6J A;  1YFE A;  2FUS A;  3RRP A;  1Q5N A;  1GK2 A;  1C3U A;  4C5R A;  4EEI A;  2QGA B;  2NYN A;  1K7W A;  5EYT A;  4HGV A; 
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