4FLCA

Structural and biochemical characterization of human adenylosuccinate lyase (adsl) and the r303c adsl deficiency associated mutation
Total Genus 160
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
160
sequence length
470
structure length
460
Chain Sequence
HGSPDSYRSPLASRYASPEMCFVFSDRYKFRTWRQLWLWLAEAEQTLGLPITDEQIREMKSNLENIDFKMAAEEEKRLRHDVMAHVHTFGHCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTTGTQASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIPYKRNPMRSECCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVYPLLKPYESVM
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Lyase
source organism Homo sapiens
publication title Structural and Biochemical Characterization of Human Adenylosuccinate Lyase (ADSL) and the R303C ADSL Deficiency-Associated Mutation.
pubmed doi rcsb
molecule keywords Adenylosuccinate lyase
total genus 160
structure length 460
sequence length 470
chains with identical sequence B, C, D
ec nomenclature ec 4.3.2.2: Adenylosuccinate lyase.
pdb deposition date 2012-06-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00206 Lyase_1 Lyase
A PF10397 ADSL_C Adenylosuccinate lyase C-terminus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.275.10 Mainly Alpha Orthogonal Bundle Fumarase C; Chain B, domain 1 Fumarase/aspartase (N-terminal domain) 4flcA01
1.20.200.10 Mainly Alpha Up-down Bundle Fumarase C; Chain A, domain 2 Fumarase/aspartase (Central domain) 4flcA02
2PFMA 3R6YA 2PTQA 1T6PA 4V2QA 2O7BA 1YFEA 1K62A 3RD8A 3OCEA 1KQ7A 3NZ4A 3KDYA 1B8FA 3R6VA 2E9FA 1T6JA 1C3UA 2X75A 4FLCA 1U15A 1FURA 4APAA 1K7WA 2RJRA 3RRPA 1FUOA 1EB4A 1VDKA 4C5RA 1JSWA 4C6GA 1J3UA 2NYFA 4V2RA 4ADLA 4BAAA 5EYVA 4C5SA 1DCNA 3GTDA 3E04A 5F91A 4NSLA 1XWOA 1HY0A 2YIIA 2FUSA 2J91A 2O7FA 5EYTA 1HY1A 4EFCA 3TV2A 2O7DA 3GZHA 4NLEA 3CZOA 1RE5A 2O78A 4BABA 3NO9A 3OCFA 1DOFA 1YFMA 5F92A 3BHGA 2PTSA 1FUPA 2OHYA 3UNVA 2QVEA 1GK3A 1C3CA 1TJVA 2RJSA 3QBPA 3KDZA 2VD6A 3R6QA 1AUWA 4FFXA 1TJ7A 1GKMA 4APBA 3C8TA 1Y2MA 2PTRA 2QGAB 2NYNA 1FUQA 4EEIA 1Q5NA 1TJWA 1GK2A 4MX2A 1GKJA 2O6YA 4ADMA 1W27A 4CQ5A 5HW2A 1YISA 2O7EA 5D6BA 1TJUA 4C5UA 1I0AA 4HGVA 1U16A 2HVGA
chains in the Genus database with same CATH superfamily
2PFMA 3R6YA 2PTQA 1T6PA 4V2QA 2O7BA 1YFEA 1K62A 3RD8A 3OCEA 1KQ7A 3NZ4A 3KDYA 1B8FA 3R6VA 2E9FA 1T6JA 1C3UA 2X75A 4FLCA 1U15A 1FURA 4APAA 1K7WA 2RJRA 3RRPA 1FUOA 1EB4A 1VDKA 4C5RA 1JSWA 4C6GA 1J3UA 2NYFA 4V2RA 4ADLA 4BAAA 5EYVA 4C5SA 1DCNA 3GTDA 3E04A 5F91A 4NSLA 1XWOA 1HY0A 2VL7A 2YIIA 4A15A 2FUSA 2J91A 2O7FA 5EYTA 1HY1A 4EFCA 3TV2A 1XL7A 2O7DA 2VSFA 1XL8A 3GZHA 4NLEA 3CZOA 5M0IA 1RE5A 2O78A 4BABA 3NO9A 3OCFA 1DOFA 1YFMA 1XMDA 5F92A 3BHGA 2PTSA 1FUPA 5H8WA 2OHYA 4WNLA 3UNVA 2QVEA 1GK3A 1C3CA 1TJVA 2RJSA 3QBPA 3KDZA 2VD6A 3CRVA 3R6QA 1AUWA 4FFXA 1TJ7A 1GKMA 4APBA 3C8TA 3CRW1 1Y2MA 2PTRA 2QGAB 2NYNA 1FUQA 4EEIA 1Q5NA 1TJWA 1GK2A 4MX2A 2FENA 1GKJA 2O6YA 5M0JA 1XLYA 4ADMA 1W27A 4CQ5A 5HW2A 1YISA 2O7EA 5D6BA 1TJUA 4C5UA 1I0AA 4HGVA 1XMCA 1U16A 2HVGA 2FELA
chains in the Genus database with same CATH topology
2PFMA 3R6YA 2PTQA 1T6PA 4V2QA 2O7BA 1YFEA 1K62A 3RD8A 3OCEA 1KQ7A 3NZ4A 3KDYA 1B8FA 3R6VA 2E9FA 1T6JA 1C3UA 2X75A 4FLCA 1U15A 1FURA 4APAA 1K7WA 2RJRA 3RRPA 1FUOA 1EB4A 1VDKA 4C5RA 1JSWA 4C6GA 1J3UA 2NYFA 4V2RA 4ADLA 4BAAA 5EYVA 4C5SA 1DCNA 3GTDA 3E04A 5F91A 4NSLA 1XWOA 1HY0A 2YIIA 2FUSA 2J91A 2O7FA 5EYTA 1HY1A 4EFCA 3TV2A 2O7DA 3GZHA 4NLEA 3CZOA 1RE5A 2O78A 4BABA 3NO9A 3OCFA 1DOFA 1YFMA 5F92A 3BHGA 2PTSA 1FUPA 2OHYA 3UNVA 2QVEA 1GK3A 1C3CA 1TJVA 2RJSA 3QBPA 3KDZA 2VD6A 3R6QA 1AUWA 4FFXA 1TJ7A 1GKMA 4APBA 3C8TA 1Y2MA 2PTRA 2QGAB 2NYNA 1FUQA 4EEIA 1Q5NA 1TJWA 1GK2A 4MX2A 1GKJA 2O6YA 4ADMA 1W27A 4CQ5A 5HW2A 1YISA 2O7EA 5D6BA 1TJUA 4C5UA 1I0AA 4HGVA 1U16A 2HVGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PFM A;  3R6Y A;  2PTQ A;  1T6P A;  4V2Q A;  2O7B A;  1YFE A;  1K62 A;  3RD8 A;  3OCE A;  1KQ7 A;  3NZ4 A;  3KDY A;  1B8F A;  3R6V A;  2E9F A;  1T6J A;  1C3U A;  2X75 A;  4FLC A;  1U15 A;  1FUR A;  4APA A;  1K7W A;  2RJR A;  3RRP A;  1FUO A;  1EB4 A;  1VDK A;  4C5R A;  1JSW A;  4C6G A;  1J3U A;  2NYF A;  4V2R A;  4ADL A;  4BAA A;  5EYV A;  4C5S A;  1DCN A;  3GTD A;  3E04 A;  5F91 A;  4NSL A;  1XWO A;  1HY0 A;  2YII A;  2FUS A;  2J91 A;  2O7F A;  5EYT A;  1HY1 A;  4EFC A;  3TV2 A;  2O7D A;  3GZH A;  4NLE A;  3CZO A;  1RE5 A;  2O78 A;  4BAB A;  3NO9 A;  3OCF A;  1DOF A;  1YFM A;  5F92 A;  3BHG A;  2PTS A;  1FUP A;  2OHY A;  3UNV A;  2QVE A;  1GK3 A;  1C3C A;  1TJV A;  2RJS A;  3QBP A;  3KDZ A;  2VD6 A;  3R6Q A;  1AUW A;  4FFX A;  1TJ7 A;  1GKM A;  4APB A;  3C8T A;  1Y2M A;  2PTR A;  2QGA B;  2NYN A;  1FUQ A;  4EEI A;  1Q5N A;  1TJW A;  1GK2 A;  4MX2 A;  1GKJ A;  2O6Y A;  4ADM A;  1W27 A;  4CQ5 A;  5HW2 A;  1YIS A;  2O7E A;  5D6B A;  1TJU A;  4C5U A;  1I0A A;  4HGV A;  1U16 A;  2HVG A; 
#chains in the Genus database with same CATH topology
 2PFM A;  3R6Y A;  2PTQ A;  1T6P A;  4V2Q A;  2O7B A;  1YFE A;  1K62 A;  3RD8 A;  3OCE A;  1KQ7 A;  3NZ4 A;  3KDY A;  1B8F A;  3R6V A;  2E9F A;  1T6J A;  1C3U A;  2X75 A;  4FLC A;  1U15 A;  1FUR A;  4APA A;  1K7W A;  2RJR A;  3RRP A;  1FUO A;  1EB4 A;  1VDK A;  4C5R A;  1JSW A;  4C6G A;  1J3U A;  2NYF A;  4V2R A;  4ADL A;  4BAA A;  5EYV A;  4C5S A;  1DCN A;  3GTD A;  3E04 A;  5F91 A;  4NSL A;  1XWO A;  1HY0 A;  2VL7 A;  2YII A;  4A15 A;  2FUS A;  2J91 A;  2O7F A;  5EYT A;  1HY1 A;  4EFC A;  3TV2 A;  1XL7 A;  2O7D A;  2VSF A;  1XL8 A;  3GZH A;  4NLE A;  3CZO A;  5M0I A;  1RE5 A;  2O78 A;  4BAB A;  3NO9 A;  3OCF A;  1DOF A;  1YFM A;  1XMD A;  5F92 A;  3BHG A;  2PTS A;  1FUP A;  5H8W A;  2OHY A;  4WNL A;  3UNV A;  2QVE A;  1GK3 A;  1C3C A;  1TJV A;  2RJS A;  3QBP A;  3KDZ A;  2VD6 A;  3CRV A;  3R6Q A;  1AUW A;  4FFX A;  1TJ7 A;  1GKM A;  4APB A;  3C8T A;  3CRW 1;  1Y2M A;  2PTR A;  2QGA B;  2NYN A;  1FUQ A;  4EEI A;  1Q5N A;  1TJW A;  1GK2 A;  4MX2 A;  2FEN A;  1GKJ A;  2O6Y A;  5M0J A;  1XLY A;  4ADM A;  1W27 A;  4CQ5 A;  5HW2 A;  1YIS A;  2O7E A;  5D6B A;  1TJU A;  4C5U A;  1I0A A;  4HGV A;  1XMC A;  1U16 A;  2HVG A;  2FEL A; 
#chains in the Genus database with same CATH homology
 2PFM A;  3R6Y A;  2PTQ A;  1T6P A;  4V2Q A;  2O7B A;  1YFE A;  1K62 A;  3RD8 A;  3OCE A;  1KQ7 A;  3NZ4 A;  3KDY A;  1B8F A;  3R6V A;  2E9F A;  1T6J A;  1C3U A;  2X75 A;  4FLC A;  1U15 A;  1FUR A;  4APA A;  1K7W A;  2RJR A;  3RRP A;  1FUO A;  1EB4 A;  1VDK A;  4C5R A;  1JSW A;  4C6G A;  1J3U A;  2NYF A;  4V2R A;  4ADL A;  4BAA A;  5EYV A;  4C5S A;  1DCN A;  3GTD A;  3E04 A;  5F91 A;  4NSL A;  1XWO A;  1HY0 A;  2YII A;  2FUS A;  2J91 A;  2O7F A;  5EYT A;  1HY1 A;  4EFC A;  3TV2 A;  2O7D A;  3GZH A;  4NLE A;  3CZO A;  1RE5 A;  2O78 A;  4BAB A;  3NO9 A;  3OCF A;  1DOF A;  1YFM A;  5F92 A;  3BHG A;  2PTS A;  1FUP A;  2OHY A;  3UNV A;  2QVE A;  1GK3 A;  1C3C A;  1TJV A;  2RJS A;  3QBP A;  3KDZ A;  2VD6 A;  3R6Q A;  1AUW A;  4FFX A;  1TJ7 A;  1GKM A;  4APB A;  3C8T A;  1Y2M A;  2PTR A;  2QGA B;  2NYN A;  1FUQ A;  4EEI A;  1Q5N A;  1TJW A;  1GK2 A;  4MX2 A;  1GKJ A;  2O6Y A;  4ADM A;  1W27 A;  4CQ5 A;  5HW2 A;  1YIS A;  2O7E A;  5D6B A;  1TJU A;  4C5U A;  1I0A A;  4HGV A;  1U16 A;  2HVG A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...