4FMMA

Dimeric sec14 family homolog 3 from saccharomyces cerevisiae presents some novel features of structure that lead to a surprising "dimer-monomer" state change induced by substrate binding
Total Genus 105
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
105
sequence length
331
structure length
324
Chain Sequence
PKNLINIDKPIKELPASIAIPKEKPLTGEQQKMYDEVLKHFSNPDLKVYTSEKNKSEDDLKPLEEEEKAWLTRECFLRYLRATKWVLKDCIDRITMTLAWRREFGISHLGEEHGDKITADLVAVENESGKQVILGYENDARPILYLKPGRQNTKTSHRQVQHLVFMLERVIDFMPAGQDSLALLIDFKDYPDVPKVPIGVGKEVLHILQTHYPERLGKALLTNIPWLAWTFLKLIHPFIDPLTREKLVFDEPFVKYVPKNELDSLYGGDLKFKYNHDVYWPALVETAREKRDHYFKRFQSFGGIVGLSEVDLRGTHEKLLYPVK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Dimeric Sfh3 has structural changes in its binding pocket that are associated with a dimer-monomer state transformation induced by substrate binding.
pubmed doi rcsb
molecule tags Lipid binding protein
source organism Saccharomyces cerevisiae
molecule keywords Phosphatidylinositol transfer protein PDR16
total genus 105
structure length 324
sequence length 331
chains with identical sequence B
ec nomenclature
pdb deposition date 2012-06-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00650 CRAL_TRIO CRAL/TRIO domain
A PF03765 CRAL_TRIO_N CRAL/TRIO, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.525.10 Alpha Beta 3-Layer(aba) Sandwich Phosphatidylinositol Transfer Protein Sec14p CRAL-TRIO lipid binding domain 4fmmA00
4OMKA 4J7PA 3HY5A 3B7NA 4FMMA 2D4QA 1OIPA 3P7ZA 1OLMA 3PEGA 3Q8GA 3W67A 1OIZA 4TLGA 4J7QA 4OMJA 3B7ZA 3PG7A 4CIZA 1R5LA 1AUAA 3W68A 3HX3A 1OLME 1O6UA 2E2XA 4UYBA 3B74A 4CJ6A 4M8ZA 3B7QA
chains in the Genus database with same CATH superfamily
4OMKA 4J7PA 3HY5A 3B7NA 4FMMA 2D4QA 1OIPA 3P7ZA 1OLMA 3PEGA 3Q8GA 3W67A 1OIZA 4TLGA 4J7QA 4OMJA 3B7ZA 3PG7A 4CIZA 1R5LA 1AUAA 3W68A 3HX3A 1OLME 1O6UA 2E2XA 4UYBA 3B74A 4CJ6A 4M8ZA 3B7QA
chains in the Genus database with same CATH topology
4OMKA 4J7PA 3HY5A 3B7NA 4FMMA 2D4QA 1OIPA 3P7ZA 1OLMA 3PEGA 3Q8GA 3W67A 1OIZA 4TLGA 4J7QA 4OMJA 3B7ZA 3PG7A 4CIZA 1R5LA 1AUAA 3W68A 3HX3A 1OLME 1O6UA 2E2XA 4UYBA 3B74A 4CJ6A 4M8ZA 3B7QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4OMK A;  4J7P A;  3HY5 A;  3B7N A;  4FMM A;  2D4Q A;  1OIP A;  3P7Z A;  1OLM A;  3PEG A;  3Q8G A;  3W67 A;  1OIZ A;  4TLG A;  4J7Q A;  4OMJ A;  3B7Z A;  3PG7 A;  4CIZ A;  1R5L A;  1AUA A;  3W68 A;  3HX3 A;  1OLM E;  1O6U A;  2E2X A;  4UYB A;  3B74 A;  4CJ6 A;  4M8Z A;  3B7Q A; 
#chains in the Genus database with same CATH topology
 4OMK A;  4J7P A;  3HY5 A;  3B7N A;  4FMM A;  2D4Q A;  1OIP A;  3P7Z A;  1OLM A;  3PEG A;  3Q8G A;  3W67 A;  1OIZ A;  4TLG A;  4J7Q A;  4OMJ A;  3B7Z A;  3PG7 A;  4CIZ A;  1R5L A;  1AUA A;  3W68 A;  3HX3 A;  1OLM E;  1O6U A;  2E2X A;  4UYB A;  3B74 A;  4CJ6 A;  4M8Z A;  3B7Q A; 
#chains in the Genus database with same CATH homology
 4OMK A;  4J7P A;  3HY5 A;  3B7N A;  4FMM A;  2D4Q A;  1OIP A;  3P7Z A;  1OLM A;  3PEG A;  3Q8G A;  3W67 A;  1OIZ A;  4TLG A;  4J7Q A;  4OMJ A;  3B7Z A;  3PG7 A;  4CIZ A;  1R5L A;  1AUA A;  3W68 A;  3HX3 A;  1OLM E;  1O6U A;  2E2X A;  4UYB A;  3B74 A;  4CJ6 A;  4M8Z A;  3B7Q A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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