4FW5A

Crystal structure of the lpxc in complex with 4'-bromo-n-[(2s,3r)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]biphenyl-4-carboxamide inhibitor
Total Genus 92
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
92
sequence length
301
structure length
301
Chain Sequence
b'NAMIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRP'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
molecule tags Hydrolase/hydrolase inhibitor
source organism Pseudomonas aeruginosa
publication title Crystal Structure of the LpxC
rcsb
total genus 92
structure length 301
sequence length 301
chains with identical sequence B, C, D
ec nomenclature ec 3.5.1.108: UDP-3-O-acyl-N-acetylglucosamine deacetylase.
pdb deposition date 2012-06-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03331 LpxC UDP-3-O-acyl N-acetylglycosamine deacetylase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.230.20 Alpha Beta 2-Layer Sandwich Ribosomal Protein S5; domain 2 lpxc deacetylase, domain 1 4fw5A01
3.30.1700.10 Alpha Beta 2-Layer Sandwich lpxc deacetylase, domain 1 lpxc deacetylase, domain 2 4fw5A02
5DRQA 4LCFA 3P76A 2VESA 4FW4A 3P3GA 4LCGA 2IERA 1YH8A 3PS1A 4MDTA 5DRRA 1P42A 3NZKA 5DRPA 4J3DA 2JT2A 2GO4A 3P3EA 2IESA 4OZEA 4FW7A 3PS2A 4FW3A 4U3BA 3U1YA 4IS9A 4FW5A 3P3CA 1XXEA 4U3DA 4ISAA 2O3ZA 5DROA 2GO3A 3PS3A 1YHCA 4MQYA 4FW6A 2J65A 4LCHA 4OKGA 3UHMA
chains in the Genus database with same CATH superfamily
3P76A 2CZ9A 1I94I 1H7SA 2HFUA 3B4TA 1NHHA 4B3MI 4JI8E 2PO0A 5EL9A 3M7NG 4K0KE 5LMUE 3T1HE 1J5EE 2JT2A 4UT4A 1Z5BA 2IESA 1KIJA 2UXBI 1Y4SA 4JI7E 2R3VA 2WNRB 3Q1QA 3QT7A 3LPSA 5JEAB 3ZZTA 4XTJA 5JEAE 1N0VC 4DXLA 4DR5E 2UXCI 2Z5CA 2UUAE 5A2QC 4DPTA 4KHPI 4DR7I 4JYAI 4X65E 1ZXNA 4OO1C 2NN6F 4LF5I 3HJCA 4DV6E 5DRPA 2BA0D 2HK2A 4K0KI 1J5EI 1RREA 1EI1A 4DV2E 4GKJE 2E1RA 2BA0G 2UUCI 1NHIA 3Q6NA 4ISAA 2F1DA 2O3ZA 4MU4A 4X64E 1YHCA 4NBQA 4LFCI 4LCHA 1XMQE 2C38B 3L7ZA 4WUBA 1N36E 4LF4I 2WP8A 3CWVA 4FW4A 4QNKA 4LF5E 4X65I 3QT6A 4IFDC 4KHPE 1D6TA 3NZKA 2UUAI 1FJGE 4DV3E 3J7AG 2JEBB 3K1JA 2V2VA 4DV1E 5DNLA 4U3BA 4UTGA 1XXEA 4B3TI 2PO1B 2UXDE 2X36A 1S16A 5EKWA 4EMDA 5LMNI 1N32I 5LMUI 4JI3I 3T1HI 5L3JA 4DR6E 2PO2B 4NXMI 4DV4E 4I3HA 4X64I 5C0XE 2ZITA 3V2UC 2VQFE 2JE6B 3WU5A 1IBKI 4LFAI 4X62I 4USKA 1Z0BA 3Q6MA 4DR1E 4JV5I 2PNMA 5IWAE 5ELWA 4OZEA 1U2RA 3D4JA 4FW3A 2NN6E 3B82A 4IFDB 2WNRA 4JYAE 3HULA 5JEAA 4OX9E 4BA2B 1KKHA 2JEAA 4LF6I 2V2ZA 4JI6I 4LCGA 4JI1I 4JI2E 1H72C 2NN6D 1USVA 2HK3A 1ZM3A 2AJ4A 1HNZI 4DV0I 2HFSA 4YY3I 1UDQA 2AE8A 2BV3A 2PNLA 5K36B 4DUZI 4HACA 4LF7E 1Y4UA 3M85D 2VESA 1Y60A 2IOQA 2UU9E 4NXNI 4JI5I 2C37A 1NZ0A 4GKJI 1USUA 4DR6I 4AQYI 4MU0A 3V5RA 1HK7A 4J3DA 1K47A 5LMNE 2O1UA 3KRNA 4DR5I 2UXCE 4M1KA 2HHHE 4JI1E 1FKAE 4FW5A 3PYFA 5DROA 4JI7I 2BM1A 4FW6A 2PO1A 2NPFA 1H73A 1XMOE 3K85A 4HY1A 4DU7A 4OX9I 3QT8A 4MYTA 5K36F 2PO2A 3PYGA 4IZKA 3OTOE 4JI5E 1BKNA 2UU9I 5FWKA 2JE6A 1UDOA 2E5LI 1ELOA 2C39B 2CVEA 1Z0VA 2DEIA 1Z0CA 1XHKA 4B3ME 4X66I 1NHJA 2UUCE 3QT5A 2WW4A 1N33I 3B78A 4IFDA 4KQVA 4N3OA 4JI4I 1FI4A 1B63A 4DPWA 4BA2A 2JEAB 1Z0GA 1FWLA 4JG4A 1ZXMA 2ZBKB 3PRYA 3GMEA 3M6AA 4IFDE 4DV1I 4LFBI 2BR2A 1MG7A 1VISA 1ZM4A 1FJGI 1XNQI 1PVGA 1Z0WA 3PYDA 2O1TA 5C0XD 4Z7CA 5A2QQ 1Z59A 3P3CA 3ZZ0A 2ZM6E 4DR3E 4NXNE 1IBMI 5K36A 1UDSA 4HACB 2XEXA 4LFCE 4DR1I 2A2DA 3P3GA 1IBKE 4LFAE 1HNWE 4IZJB 4PU9A 4NXME 2C37B 5JEAD 1P42A 2V8PA 3DD6A 4DR4I 3HKMA 4OO1E 1XMOI 1Z5AA 2HKEA 4DV7I 4LF9I 3OTOI 2O1WA 4U3DA 3M85G 4AIDA 4JI2I 1XNQE 1DARA 4DR7E 3H1CA 4OKGA 2NN6C 4RPFA 4DUYI 3UHMA 4DV5E 1N34E 2Q2EB 2R42A 1IBLI 5BR8E 1ZM2A 4DPXA 4HYMA 4IZKB 2UXBE 1FWKA 5DNXA 5DRRA 4GKKI 2C39A 4ZVIA 1MU5A 4DR4E 3P3EA 4URLA 4B3SE 2NN6B 1HR0I 3GONA 1ZM9A 3F0NA 1H7UA 3U1KA 4WUCA 4LF7I 2IOPA 4DUZE 1N32E 3JAMC 4QNJA 2LJPA 1IBME 4B3TE 1N0UA 4GQUA 3ZKDA 3J80C 2A2CA 1OYSA 4P52A 1XNRE 5C0XC 2PNZA 2BR2B 4DV5I 4LPFA 1S4EA 1XNRI 1EA6A 3JAMQ 4IFDF 4AM3A 4IS9A 3T1YI 4P7AA 4DPUA 4BA1A 3PS3A 3ZZUA 4MQYA 4LF8I 2DEJA 2J7KA 5JEAF 3LNUA 4JI8I 2IERA 5C0XB 2GS8A 4IZJD 3ZKBA 4DU8A 4IZJA 1A6FA 4OO1A 1QZRA 4FWHA 4DV2I 2E5LE 4JI3E 4GKKE 4X62E 4LOMA 4YHHE 2UXDI 2VQFI 1HNXE 5BR8I 4DV4I 1Z5CA 4PRVA 4B3RE 5DRQA 2VF3A 1VI7A 3GCMA 5FLXC 4LF8E 3CDJA 4OO1D 5IT9C 1OYPA 2HKJA 1RHYA 3T1YE 1WUUA 1RR9A 3WU3A 4DPYA 4JI0E 4DV7E 1Y6ZA 3J80Q 1Z0EA 2UUBI 5GMDA 4OO1F 3M7ND 1H74A 4FN5A 1E3HA 4FW7A 2BM0A 2Z5BB 4WUDA 2NN6A 1HNWI 4FWGA 1XMQI 3LTOA 4DR2E 4MYUA 1B62A 2CG9A 3B8HA 3ZM7A 4R1FA 2PO0B 3H4LA 1YH8A 3GLLA 4YY3E 3WU4A 3PS1A 4FW9A 4MDTA 1HNZE 4DV0E 2EFGA 2GO4A 4DV6I 4JI0I 2PNZB 4Z7YA 1PIEA 4PRXA 3WU6A 3K17A 3P06A 4LF9E 1IBLE 4JI6E 1OYRA 5K36C 2Z5CB 4BA1B 4DV3I 4DUYE 1N34I 2GQ0A 2V34A 3U1YA 4MU3A 2VQEI 4LCFA 4AQYE 3CDIA 5FLXQ 1UDNA 2BA1G 5IT9Q 1N33E 1Z0TA 4YHHI 4FWDA 1FNMA 1HNXI 2BA1D 5C0XA 3J81C 4X66E 1N36I 1UEKA 2O1VA 4ED4A 4DR2I 4OO1B 2CGEA 2Z5EA 3PS2A 1HR0E 4B3SI 2OI2A 2X7IA 2F4VE 2GO3A 1I94E 1E3PA 2C38A 3J81Q 3L7ZB 4USMA 5K36E 5GMEA 2V2QA 2WP8B 2VQEE 1OJ4A 2UUBE 3J7AM 1KTVA 4LFBE 2ZM6I 4DR3I 5C0XF 1KVKA 1Y5YA 4AIMA 2HHHI 4LF6E 5K36D 4B3RI 2JEBA 1PKPA 5LL6R 1R6MA 4JI4E 3PYEA 2F4VI 5JEAC 1R6LA 4MU1A 5IWAI 4IFDD 2Z5BA 2J65A 1MX0A 4LF4E 4HXZA 4JV5E
chains in the Genus database with same CATH topology
5DRQA 4LCFA 3P76A 2VESA 4FW4A 3P3GA 4LCGA 2IERA 1YH8A 3PS1A 4MDTA 5DRRA 1P42A 3NZKA 5DRPA 4J3DA 2JT2A 2GO4A 3P3EA 2IESA 4OZEA 4FW7A 3PS2A 4FW3A 4U3BA 3U1YA 4IS9A 4FW5A 3P3CA 1XXEA 4U3DA 4ISAA 2O3ZA 5DROA 2GO3A 3PS3A 1YHCA 4MQYA 4FW6A 2J65A 4LCHA 4OKGA 3UHMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5DRQ A;  4LCF A;  3P76 A;  2VES A;  4FW4 A;  3P3G A;  4LCG A;  2IER A;  1YH8 A;  3PS1 A;  4MDT A;  5DRR A;  1P42 A;  3NZK A;  5DRP A;  4J3D A;  2JT2 A;  2GO4 A;  3P3E A;  2IES A;  4OZE A;  4FW7 A;  3PS2 A;  4FW3 A;  4U3B A;  3U1Y A;  4IS9 A;  4FW5 A;  3P3C A;  1XXE A;  4U3D A;  4ISA A;  2O3Z A;  5DRO A;  2GO3 A;  3PS3 A;  1YHC A;  4MQY A;  4FW6 A;  2J65 A;  4LCH A;  4OKG A;  3UHM A; 
#chains in the Genus database with same CATH topology
 3P76 A;  2CZ9 A;  1I94 I;  1H7S A;  2HFU A;  3B4T A;  1NHH A;  4B3M I;  4JI8 E;  2PO0 A;  5EL9 A;  3M7N G;  4K0K E;  5LMU E;  3T1H E;  1J5E E;  2JT2 A;  4UT4 A;  1Z5B A;  2IES A;  1KIJ A;  2UXB I;  1Y4S A;  4JI7 E;  2R3V A;  2WNR B;  3Q1Q A;  3QT7 A;  3LPS A;  5JEA B;  3ZZT A;  4XTJ A;  5JEA E;  1N0V C;  4DXL A;  4DR5 E;  2UXC I;  2Z5C A;  2UUA E;  5A2Q C;  4DPT A;  4KHP I;  4DR7 I;  4JYA I;  4X65 E;  1ZXN A;  4OO1 C;  2NN6 F;  4LF5 I;  3HJC A;  4DV6 E;  5DRP A;  2BA0 D;  2HK2 A;  4K0K I;  1J5E I;  1RRE A;  1EI1 A;  4DV2 E;  4GKJ E;  2E1R A;  2BA0 G;  2UUC I;  1NHI A;  3Q6N A;  4ISA A;  2F1D A;  2O3Z A;  4MU4 A;  4X64 E;  1YHC A;  4NBQ A;  4LFC I;  4LCH A;  1XMQ E;  2C38 B;  3L7Z A;  4WUB A;  1N36 E;  4LF4 I;  2WP8 A;  3CWV A;  4FW4 A;  4QNK A;  4LF5 E;  4X65 I;  3QT6 A;  4IFD C;  4KHP E;  1D6T A;  3NZK A;  2UUA I;  1FJG E;  4DV3 E;  3J7A G;  2JEB B;  3K1J A;  2V2V A;  4DV1 E;  5DNL A;  4U3B A;  4UTG A;  1XXE A;  4B3T I;  2PO1 B;  2UXD E;  2X36 A;  1S16 A;  5EKW A;  4EMD A;  5LMN I;  1N32 I;  5LMU I;  4JI3 I;  3T1H I;  5L3J A;  4DR6 E;  2PO2 B;  4NXM I;  4DV4 E;  4I3H A;  4X64 I;  5C0X E;  2ZIT A;  3V2U C;  2VQF E;  2JE6 B;  3WU5 A;  1IBK I;  4LFA I;  4X62 I;  4USK A;  1Z0B A;  3Q6M A;  4DR1 E;  4JV5 I;  2PNM A;  5IWA E;  5ELW A;  4OZE A;  1U2R A;  3D4J A;  4FW3 A;  2NN6 E;  3B82 A;  4IFD B;  2WNR A;  4JYA E;  3HUL A;  5JEA A;  4OX9 E;  4BA2 B;  1KKH A;  2JEA A;  4LF6 I;  2V2Z A;  4JI6 I;  4LCG A;  4JI1 I;  4JI2 E;  1H72 C;  2NN6 D;  1USV A;  2HK3 A;  1ZM3 A;  2AJ4 A;  1HNZ I;  4DV0 I;  2HFS A;  4YY3 I;  1UDQ A;  2AE8 A;  2BV3 A;  2PNL A;  5K36 B;  4DUZ I;  4HAC A;  4LF7 E;  1Y4U A;  3M85 D;  2VES A;  1Y60 A;  2IOQ A;  2UU9 E;  4NXN I;  4JI5 I;  2C37 A;  1NZ0 A;  4GKJ I;  1USU A;  4DR6 I;  4AQY I;  4MU0 A;  3V5R A;  1HK7 A;  4J3D A;  1K47 A;  5LMN E;  2O1U A;  3KRN A;  4DR5 I;  2UXC E;  4M1K A;  2HHH E;  4JI1 E;  1FKA E;  4FW5 A;  3PYF A;  5DRO A;  4JI7 I;  2BM1 A;  4FW6 A;  2PO1 A;  2NPF A;  1H73 A;  1XMO E;  3K85 A;  4HY1 A;  4DU7 A;  4OX9 I;  3QT8 A;  4MYT A;  5K36 F;  2PO2 A;  3PYG A;  4IZK A;  3OTO E;  4JI5 E;  1BKN A;  2UU9 I;  5FWK A;  2JE6 A;  1UDO A;  2E5L I;  1ELO A;  2C39 B;  2CVE A;  1Z0V A;  2DEI A;  1Z0C A;  1XHK A;  4B3M E;  4X66 I;  1NHJ A;  2UUC E;  3QT5 A;  2WW4 A;  1N33 I;  3B78 A;  4IFD A;  4KQV A;  4N3O A;  4JI4 I;  1FI4 A;  1B63 A;  4DPW A;  4BA2 A;  2JEA B;  1Z0G A;  1FWL A;  4JG4 A;  1ZXM A;  2ZBK B;  3PRY A;  3GME A;  3M6A A;  4IFD E;  4DV1 I;  4LFB I;  2BR2 A;  1MG7 A;  1VIS A;  1ZM4 A;  1FJG I;  1XNQ I;  1PVG A;  1Z0W A;  3PYD A;  2O1T A;  5C0X D;  4Z7C A;  5A2Q Q;  1Z59 A;  3P3C A;  3ZZ0 A;  2ZM6 E;  4DR3 E;  4NXN E;  1IBM I;  5K36 A;  1UDS A;  4HAC B;  2XEX A;  4LFC E;  4DR1 I;  2A2D A;  3P3G A;  1IBK E;  4LFA E;  1HNW E;  4IZJ B;  4PU9 A;  4NXM E;  2C37 B;  5JEA D;  1P42 A;  2V8P A;  3DD6 A;  4DR4 I;  3HKM A;  4OO1 E;  1XMO I;  1Z5A A;  2HKE A;  4DV7 I;  4LF9 I;  3OTO I;  2O1W A;  4U3D A;  3M85 G;  4AID A;  4JI2 I;  1XNQ E;  1DAR A;  4DR7 E;  3H1C A;  4OKG A;  2NN6 C;  4RPF A;  4DUY I;  3UHM A;  4DV5 E;  1N34 E;  2Q2E B;  2R42 A;  1IBL I;  5BR8 E;  1ZM2 A;  4DPX A;  4HYM A;  4IZK B;  2UXB E;  1FWK A;  5DNX A;  5DRR A;  4GKK I;  2C39 A;  4ZVI A;  1MU5 A;  4DR4 E;  3P3E A;  4URL A;  4B3S E;  2NN6 B;  1HR0 I;  3GON A;  1ZM9 A;  3F0N A;  1H7U A;  3U1K A;  4WUC A;  4LF7 I;  2IOP A;  4DUZ E;  1N32 E;  3JAM C;  4QNJ A;  2LJP A;  1IBM E;  4B3T E;  1N0U A;  4GQU A;  3ZKD A;  3J80 C;  2A2C A;  1OYS A;  4P52 A;  1XNR E;  5C0X C;  2PNZ A;  2BR2 B;  4DV5 I;  4LPF A;  1S4E A;  1XNR I;  1EA6 A;  3JAM Q;  4IFD F;  4AM3 A;  4IS9 A;  3T1Y I;  4P7A A;  4DPU A;  4BA1 A;  3PS3 A;  3ZZU A;  4MQY A;  4LF8 I;  2DEJ A;  2J7K A;  5JEA F;  3LNU A;  4JI8 I;  2IER A;  5C0X B;  2GS8 A;  4IZJ D;  3ZKB A;  4DU8 A;  4IZJ A;  1A6F A;  4OO1 A;  1QZR A;  4FWH A;  4DV2 I;  2E5L E;  4JI3 E;  4GKK E;  4X62 E;  4LOM A;  4YHH E;  2UXD I;  2VQF I;  1HNX E;  5BR8 I;  4DV4 I;  1Z5C A;  4PRV A;  4B3R E;  5DRQ A;  2VF3 A;  1VI7 A;  3GCM A;  5FLX C;  4LF8 E;  3CDJ A;  4OO1 D;  5IT9 C;  1OYP A;  2HKJ A;  1RHY A;  3T1Y E;  1WUU A;  1RR9 A;  3WU3 A;  4DPY A;  4JI0 E;  4DV7 E;  1Y6Z A;  3J80 Q;  1Z0E A;  2UUB I;  5GMD A;  4OO1 F;  3M7N D;  1H74 A;  4FN5 A;  1E3H A;  4FW7 A;  2BM0 A;  2Z5B B;  4WUD A;  2NN6 A;  1HNW I;  4FWG A;  1XMQ I;  3LTO A;  4DR2 E;  4MYU A;  1B62 A;  2CG9 A;  3B8H A;  3ZM7 A;  4R1F A;  2PO0 B;  3H4L A;  1YH8 A;  3GLL A;  4YY3 E;  3WU4 A;  3PS1 A;  4FW9 A;  4MDT A;  1HNZ E;  4DV0 E;  2EFG A;  2GO4 A;  4DV6 I;  4JI0 I;  2PNZ B;  4Z7Y A;  1PIE A;  4PRX A;  3WU6 A;  3K17 A;  3P06 A;  4LF9 E;  1IBL E;  4JI6 E;  1OYR A;  5K36 C;  2Z5C B;  4BA1 B;  4DV3 I;  4DUY E;  1N34 I;  2GQ0 A;  2V34 A;  3U1Y A;  4MU3 A;  2VQE I;  4LCF A;  4AQY E;  3CDI A;  5FLX Q;  1UDN A;  2BA1 G;  5IT9 Q;  1N33 E;  1Z0T A;  4YHH I;  4FWD A;  1FNM A;  1HNX I;  2BA1 D;  5C0X A;  3J81 C;  4X66 E;  1N36 I;  1UEK A;  2O1V A;  4ED4 A;  4DR2 I;  4OO1 B;  2CGE A;  2Z5E A;  3PS2 A;  1HR0 E;  4B3S I;  2OI2 A;  2X7I A;  2F4V E;  2GO3 A;  1I94 E;  1E3P A;  2C38 A;  3J81 Q;  3L7Z B;  4USM A;  5K36 E;  5GME A;  2V2Q A;  2WP8 B;  2VQE E;  1OJ4 A;  2UUB E;  3J7A M;  1KTV A;  4LFB E;  2ZM6 I;  4DR3 I;  5C0X F;  1KVK A;  1Y5Y A;  4AIM A;  2HHH I;  4LF6 E;  5K36 D;  4B3R I;  2JEB A;  1PKP A;  5LL6 R;  1R6M A;  4JI4 E;  3PYE A;  2F4V I;  5JEA C;  1R6L A;  4MU1 A;  5IWA I;  4IFD D;  2Z5B A;  2J65 A;  1MX0 A;  4LF4 E;  4HXZ A;  4JV5 E; 
#chains in the Genus database with same CATH homology
 5DRQ A;  4LCF A;  3P76 A;  2VES A;  4FW4 A;  3P3G A;  4LCG A;  2IER A;  1YH8 A;  3PS1 A;  4MDT A;  5DRR A;  1P42 A;  3NZK A;  5DRP A;  4J3D A;  2JT2 A;  2GO4 A;  3P3E A;  2IES A;  4OZE A;  4FW7 A;  3PS2 A;  4FW3 A;  4U3B A;  3U1Y A;  4IS9 A;  4FW5 A;  3P3C A;  1XXE A;  4U3D A;  4ISA A;  2O3Z A;  5DRO A;  2GO3 A;  3PS3 A;  1YHC A;  4MQY A;  4FW6 A;  2J65 A;  4LCH A;  4OKG A;  3UHM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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