4GKMA

Bianthranilate-like analogue bound in the outer site of anthranilate phosphoribosyltransferase (anprt; trpd)
Total Genus 122
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
122
sequence length
346
structure length
346
Chain Sequence
PSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMKAPTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMAAIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEVGIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCAFADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKLTFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAGAIVAHAGLSSRAEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase/transferase inhibitor
molecule keywords Anthranilate phosphoribosyltransferase
publication title Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
total genus 122
structure length 346
sequence length 346
chains with identical sequence B
ec nomenclature ec 2.4.2.18: Anthranilate phosphoribosyltransferase.
pdb deposition date 2012-08-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00591 Glycos_transf_3 Glycosyl transferase family, a/b domain
A PF02885 Glycos_trans_3N Glycosyl transferase family, helical bundle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.970.10 Mainly Alpha Up-down Bundle Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 4gkmA01
3.40.1030.10 Alpha Beta 3-Layer(aba) Sandwich Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2 Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 4gkmA02
1V8GA 1VQUA 3QSAA 4GA4A 5EY3A 5EP8A 4X5AA 4OWOA 3R88A 4GA6A 2WK6A 1KGZA 1BRWA 4X5CA 5C1RA 5BNEA 2ELCA 3R6CA 4MUOA 4YEKA 5BO3A 2J0FA 4ZOKA 4OWVA 1KHDA 4EAFA 4N5VA 4X59A 4ZTVA 4ZOJA 3UU1A 2TPTA 4OWSA 1ZYKA 4YI7A 2DSJA 5C2LA 4OWNA 3TWPA 3QS8A 2BPQA 4X5EA 1OTPA 2GVQA 5BO2A 1AZYA 3QQSA 4N8QA 3GBRA 4GA5A 4X58A 4ZOFA 1O17A 1ZVWA 4EADA 4GIUA 1UOUA 5BYTA 4GKMA 4OWQA 1ZXYA 4YYYA 1GXBA 4IJ1A 3QR9A 4X5BA 4OWUA 4XR5A 4OWMA 5C7SA 4X46A 4M0RA 4N93A 4LHMA 4GTNA 3H5QA 4X5DA 4HKMA 2WK5A
chains in the Genus database with same CATH superfamily
1V8GA 1VQUA 3QSAA 4GA4A 5EY3A 5EP8A 4X5AA 4OWOA 3R88A 4F3FC 4GA6A 2WK6A 1KGZA 1BRWA 4X5CA 5C1RA 5BNEA 2ELCA 3R6CA 4MUOA 4YEKA 5BO3A 2J0FA 4ZOKA 4OWVA 1KHDA 4EAFA 4N5VA 4X59A 4ZTVA 4ZOJA 3UU1A 2TPTA 4OWSA 1ZYKA 4YI7A 2DSJA 5C2LA 4OWNA 3TWPA 3QS8A 2BPQA 4X5EA 1OTPA 2GVQA 5BO2A 1AZYA 3QQSA 4N8QA 3GBRA 4GA5A 4X58A 4ZOFA 1O17A 1ZVWA 4EADA 4GIUA 1UOUA 1RRZA 5BYTA 4GKMA 4OWQA 1ZXYA 4YYYA 1GXBA 4IJ1A 3QR9A 4X5BA 1RF8B 4OWUA 4XR5A 4OWMA 5C7SA 4X46A 4M0RA 4N93A 4LHMA 4GTNA 3H5QA 4X5DA 4HKMA 2WK5A
chains in the Genus database with same CATH topology
1V8GA 1VQUA 3QSAA 4GA4A 5EY3A 5EP8A 4X5AA 4OWOA 3R88A 4GA6A 2WK6A 1KGZA 1BRWA 4X5CA 5C1RA 5BNEA 2ELCA 3R6CA 4MUOA 4YEKA 5BO3A 2J0FA 4ZOKA 4OWVA 1KHDA 4EAFA 4N5VA 4X59A 4ZTVA 4ZOJA 3UU1A 2TPTA 4OWSA 1ZYKA 4YI7A 2DSJA 5C2LA 4OWNA 3TWPA 3QS8A 2BPQA 4X5EA 1OTPA 2GVQA 5BO2A 1AZYA 3QQSA 4N8QA 3GBRA 4GA5A 4X58A 4ZOFA 1O17A 1ZVWA 4EADA 4GIUA 1UOUA 5BYTA 4GKMA 4OWQA 1ZXYA 4YYYA 1GXBA 4IJ1A 3QR9A 4X5BA 4OWUA 4XR5A 4OWMA 5C7SA 4X46A 4M0RA 4N93A 4LHMA 4GTNA 3H5QA 4X5DA 4HKMA 2WK5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1V8G A;  1VQU A;  3QSA A;  4GA4 A;  5EY3 A;  5EP8 A;  4X5A A;  4OWO A;  3R88 A;  4GA6 A;  2WK6 A;  1KGZ A;  1BRW A;  4X5C A;  5C1R A;  5BNE A;  2ELC A;  3R6C A;  4MUO A;  4YEK A;  5BO3 A;  2J0F A;  4ZOK A;  4OWV A;  1KHD A;  4EAF A;  4N5V A;  4X59 A;  4ZTV A;  4ZOJ A;  3UU1 A;  2TPT A;  4OWS A;  1ZYK A;  4YI7 A;  2DSJ A;  5C2L A;  4OWN A;  3TWP A;  3QS8 A;  2BPQ A;  4X5E A;  1OTP A;  2GVQ A;  5BO2 A;  1AZY A;  3QQS A;  4N8Q A;  3GBR A;  4GA5 A;  4X58 A;  4ZOF A;  1O17 A;  1ZVW A;  4EAD A;  4GIU A;  1UOU A;  5BYT A;  4GKM A;  4OWQ A;  1ZXY A;  4YYY A;  1GXB A;  4IJ1 A;  3QR9 A;  4X5B A;  4OWU A;  4XR5 A;  4OWM A;  5C7S A;  4X46 A;  4M0R A;  4N93 A;  4LHM A;  4GTN A;  3H5Q A;  4X5D A;  4HKM A;  2WK5 A; 
#chains in the Genus database with same CATH topology
 1V8G A;  1VQU A;  3QSA A;  4GA4 A;  5EY3 A;  5EP8 A;  4X5A A;  4OWO A;  3R88 A;  4F3F C;  4GA6 A;  2WK6 A;  1KGZ A;  1BRW A;  4X5C A;  5C1R A;  5BNE A;  2ELC A;  3R6C A;  4MUO A;  4YEK A;  5BO3 A;  2J0F A;  4ZOK A;  4OWV A;  1KHD A;  4EAF A;  4N5V A;  4X59 A;  4ZTV A;  4ZOJ A;  3UU1 A;  2TPT A;  4OWS A;  1ZYK A;  4YI7 A;  2DSJ A;  5C2L A;  4OWN A;  3TWP A;  3QS8 A;  2BPQ A;  4X5E A;  1OTP A;  2GVQ A;  5BO2 A;  1AZY A;  3QQS A;  4N8Q A;  3GBR A;  4GA5 A;  4X58 A;  4ZOF A;  1O17 A;  1ZVW A;  4EAD A;  4GIU A;  1UOU A;  1RRZ A;  5BYT A;  4GKM A;  4OWQ A;  1ZXY A;  4YYY A;  1GXB A;  4IJ1 A;  3QR9 A;  4X5B A;  1RF8 B;  4OWU A;  4XR5 A;  4OWM A;  5C7S A;  4X46 A;  4M0R A;  4N93 A;  4LHM A;  4GTN A;  3H5Q A;  4X5D A;  4HKM A;  2WK5 A; 
#chains in the Genus database with same CATH homology
 1V8G A;  1VQU A;  3QSA A;  4GA4 A;  5EY3 A;  5EP8 A;  4X5A A;  4OWO A;  3R88 A;  4GA6 A;  2WK6 A;  1KGZ A;  1BRW A;  4X5C A;  5C1R A;  5BNE A;  2ELC A;  3R6C A;  4MUO A;  4YEK A;  5BO3 A;  2J0F A;  4ZOK A;  4OWV A;  1KHD A;  4EAF A;  4N5V A;  4X59 A;  4ZTV A;  4ZOJ A;  3UU1 A;  2TPT A;  4OWS A;  1ZYK A;  4YI7 A;  2DSJ A;  5C2L A;  4OWN A;  3TWP A;  3QS8 A;  2BPQ A;  4X5E A;  1OTP A;  2GVQ A;  5BO2 A;  1AZY A;  3QQS A;  4N8Q A;  3GBR A;  4GA5 A;  4X58 A;  4ZOF A;  1O17 A;  1ZVW A;  4EAD A;  4GIU A;  1UOU A;  5BYT A;  4GKM A;  4OWQ A;  1ZXY A;  4YYY A;  1GXB A;  4IJ1 A;  3QR9 A;  4X5B A;  4OWU A;  4XR5 A;  4OWM A;  5C7S A;  4X46 A;  4M0R A;  4N93 A;  4LHM A;  4GTN A;  3H5Q A;  4X5D A;  4HKM A;  2WK5 A; 
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