4GR3A

Crystal structure of the catalytic domain of human mmp12 in complex with selective phosphinic inhibitor rxp470a
Total Genus 45
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
45
sequence length
159
structure length
159
Chain Sequence
MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular determinants of a selective matrix metalloprotease-12 inhibitor: insights from crystallography and thermodynamic studies.
pubmed doi rcsb
molecule keywords Macrophage metalloelastase
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
total genus 45
structure length 159
sequence length 159
ec nomenclature ec 3.4.24.65: Macrophage elastase.
pdb deposition date 2012-08-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00413 Peptidase_M10 Matrixin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.390.10 Alpha Beta 3-Layer(aba) Sandwich Collagenase (Catalytic Domain) Collagenase (Catalytic Domain) 4gr3A00
1XFXA 1AYKA 2W0DA 1GO7P 1QICA 3B92A 1QJJA 3EDZA 1JIWP 2W14A 5D1UA 1ZTQA 1BZSA 1MMQA 2X3BA 2DDYA 1ND1A 2MLRA 1H71P 5BOTA 4H30A 1HFCA 1CGLA 4GR8A 1JKYA 3K7NA 5L7FA 1ATLA 2OY2A 3ZUKA 3LUNA 3SHIA 1OO9A 3AYUA 3EDGA 5D2BA 1O0QA 4GF1A 1ZXCA 1BM6A 2OXUA 4FXYP 1Y8JA 4DV8A 1G4KA 2FV9A 1HFSA 1Y0VA 2RJQA 4EFSA 2JNPA 1YCMA 1PWWA 3EWJA 1R1JA 3HY9A 1OMJA 1OS2A 1O0TA 3LIKA 1WNIA 1C3IA 1JAPA 3KRYA 1RMZA 2JT5A 1QJIA 2WO9A 1CGEA 3UVCA 3LILA 2KRJA 3WV1A 1KUFA 4IUWA 3TSKA 1K7QA 5D1TA 4AUOA 1OM6A 1BQQM 1JAOA 4I35A 4PKRA 2OW1A 5LABA 1SATA 1SU3A 2OVXA 1KUIA 4H76A 1SLMA 1JAQA 2A8HA 1SMPA 2D1NA 1HY7A 1BIWA 4XM6A 2W13A 4AIGA 3KEKA 3CKIA 1YOUA 4GR0A 3KWVC 1GO8P 4G0DA 4DF9A 2X7MA 830CA 1JJ9A 1UTZA 3VTGA 2CKIA 1MNCA 3GBOA 1R54A 1JIZA 2YB9A 4G9LA 4JPAA 3OHOA 1BKCA 1XFYA 3EHXA 3LIRA 3DWBA 3EDHA 1GKDA 1D7XA 1IAAA 3WV2A 4HX3A 2V4BA 3EDIA 2AIGP 1UMSA 2JSDA 3LE9A 4WF6A 1QUAA 2XS4A 3NX7A 3LKAA 1HV5A 1AF0A 4XM7A 1D5JA 4Q1LA 1BKCE 4GR3A 4A7BA 4A3WA 5B5OA 1ASTA 2X3AA 3O64A 1R1IA 2K9CA 1FLSA 3LGPA 3K7LA 4R3VA 4IN9A 3G42A 1IAEA 4DD8A 2N8RA 4J4MA 1K7IA 3HDBA 4PKTA 1QIAA 1ZXVA 4WK7A 4ON1A 2MLSA 1DMTA 1ZVXA 3LEAA 1CQRA 2OW0A 1FM1A 2Z2DA 1OS9A 1SLNA 2OXZA 1C7KA 4GWNA 4PKWA 3O2XA 1S4BP 1MMPA 3F1AA 1ZP5A 3F15A 1BQOA 1FBLA 4QKZA 2HU6A 2USNA 3KHIA 4WKIA 1HTDA 1PWQA 2OW9A 3F18A 1EAKA 2DW0A 4AXQA 1AKLA 456CA 4I03A 1PWVA 4PKQA 3TS4A 2Y6DA 3L0TA 5I0LA 2D1OA 3KMCA 4XBHA 2I47A 2SRTA 1JANA 4H2EA 4PKVA 1XFUA 1BKCI 1B8YA 3F17A 1BUVM 1GE5A 1ZS0A 3LMCA 4FVLA 3N2UA 3B2ZA 4GWMA 3USNA 4JIJA 1XFZA 1J7NA 1Y93A 3F16A 1EUBA 1SRPA 1L6JA 4L6TA 1CIZA 2Y6CA 4JQGA 1G49A 2W15A 3LUMA 3KECA 1G12A 3LQ0A 3LJGA 1OM8A 3Q2HA 1IAGA 1I76A 1C8TA 1BSWA 1Z3JA 1B3DA 2WOAA 4L19A 1UTTA 2MZHA 4FU4A 1KUHA 2DW2A 1XURA 5CXAA 1OM7A 5CUHA 2W12A 1KUGA 3DPFA 3DPEA 2ERQA 2J0TA 2WO8A 2E2DA 3DNGA 1KUKA 5B5PA 2JT6A 5BOYA 1I1IP 3P1VA 2ERPA 3TT4A 1PWUA 3HBVP 2QPJA 3WV3A 2FV5A 3DL1A 1GXDA 3KEJA 1XFVA 4AYKA 4WZVA 1IADA 2J83A 1CAQA 3L0VA 1R55A 1PWPA 4H84A 3OHLA 2DDFA 4GUYA 5CZMA 3LJTA 3I7IA 1QIBA 1R1HA 1USNA 2O36A 1XUDA 1HOVA 1GE6A 1D8FA 1GKCA 1YQYA 2E3XA 3HY7A 1DTHA 3AIGA 1GE7A 3HYGA 5I43A 2K2GA 2RJPA 4JA1A 1K7GA 4H82A 4IJOA 2XS3A 2MZIA 5JMYA 3V96B 2O3EA 4H1QA 2POJA 1D8MA 2OXWA 1JH1A 1MMRA 4PKUA 2OI0A 1JK3A 2DW1A 3LJZA 4JP4A 3MA2A 5BPAA 2MZEA 3ZXHA 3RTSA 5I2ZA 4H3XA 966CA 3DSLA 4H49A 2PJTA 1YP1A 3LQBA 3EHYA 2EROA 1IACA 3F19A 3U1RA 5I12A 1A86A 1G05A 2AYKA 3ZVSA 3VI1A 1I73A 4PKSA 2OVZA 2X3CA 1CXVA 1MMBA 3BA0A 4L63A 1ROSA 1Q3AA 4HMAA 5D7WA 1UMTA 2TCLA 1RM8A 1CGFA 3RTTA 4ILWD 5D3CA 3TVCA 1A85A 1XFWA 4XCTA 4ZR5A 3I7GA 1UEAA 3P24A 2CLTA 1IABA 3LK8A 3AYKA 1G9KA 5H8XA 3KMEA 2YIGA 1XUCA 4WKEA 2OW2A 2OZRA 3G5CA 4DPEA 3HDAP 5I3MA 2L0RA 3Q2GA 3HBUP 2OY4A 5L79A 5D1SA 2JIHA 3E8RA 5I4OA 1CK7A 3N2VA 1BUDA 3HB2P 4GQLA 3ELMA 4CTHA 3B8ZA 1KAPP 4XM8A 1KBCA 4FXQA 1EB6A
chains in the Genus database with same CATH superfamily
1XFXA 1AYKA 2W0DA 1GO7P 1QICA 3B92A 1QJJA 3EDZA 1JIWP 2W14A 5D1UA 1ZTQA 1BZSA 1MMQA 2X3BA 2DDYA 1ND1A 2MLRA 1H71P 5BOTA 4H30A 1HFCA 1CGLA 4GR8A 1JKYA 3K7NA 5L7FA 1ATLA 2OY2A 3DTEA 3ZUKA 3LUNA 3SHIA 1OO9A 3AYUA 3EDGA 5D2BA 1O0QA 4GF1A 1ZXCA 1BM6A 2OXUA 4FXYP 1Y8JA 4DV8A 1G4KA 2FV9A 1HFSA 1Y0VA 2RJQA 4EFSA 2JNPA 1YCMA 1PWWA 3EWJA 1R1JA 3HY9A 1OMJA 1OS2A 1O0TA 3LIKA 1WNIA 1C3IA 1JAPA 3KRYA 1RMZA 2JT5A 1QJIA 2WO9A 1CGEA 3UVCA 3LILA 2KRJA 3WV1A 1KUFA 4IUWA 3TSKA 1K7QA 5D1TA 4AUOA 1OM6A 1BQQM 1JAOA 4I35A 4PKRA 2OW1A 5LABA 1SATA 1SU3A 2OVXA 1KUIA 4H76A 1SLMA 1JAQA 2A8HA 1SMPA 2D1NA 1HY7A 1BIWA 4XM6A 2W13A 4AIGA 3KEKA 3CKIA 1YOUA 4GR0A 3KWVC 1GO8P 4G0DA 4DF9A 1XM5A 2X7MA 830CA 1JJ9A 1UTZA 3VTGA 2CKIA 1MNCA 3GBOA 1R54A 3DTKA 1JIZA 2YB9A 4G9LA 4JPAA 3OHOA 1BKCA 1XFYA 3EHXA 3LIRA 3DWBA 3EDHA 1GKDA 1D7XA 1IAAA 3WV2A 4HX3A 2V4BA 3EDIA 2AIGP 1UMSA 2JSDA 1OZ9A 3LE9A 4WF6A 1QUAA 2XS4A 3NX7A 3LKAA 1HV5A 1AF0A 4XM7A 1D5JA 4Q1LA 1BKCE 4GR3A 4A7BA 4A3WA 5B5OA 1ASTA 2X3AA 3O64A 1R1IA 2K9CA 1FLSA 3LGPA 3K7LA 4R3VA 4IN9A 3G42A 1IAEA 4DD8A 2N8RA 4J4MA 1K7IA 3HDBA 4PKTA 1QIAA 1ZXVA 4WK7A 4ON1A 2MLSA 1DMTA 1ZVXA 3LEAA 1CQRA 2OW0A 2YUFA 1FM1A 2Z2DA 1OS9A 1SLNA 2OXZA 1C7KA 4GWNA 4PKWA 3O2XA 1S4BP 1MMPA 3F1AA 1ZP5A 3F15A 1BQOA 1FBLA 4QKZA 2HU6A 2USNA 3KHIA 4WKIA 1HTDA 1PWQA 2OW9A 3F18A 1EAKA 2DW0A 4AXQA 1AKLA 1TVIA 456CA 3DTIA 4I03A 1PWVA 4PKQA 3TS4A 2Y6DA 3L0TA 5I0LA 2D1OA 3KMCA 4XBHA 2I47A 2SRTA 1JANA 4H2EA 4PKVA 1XFUA 1BKCI 1B8YA 3F17A 1BUVM 1GE5A 1ZS0A 3LMCA 4FVLA 3N2UA 3B2ZA 4GWMA 3USNA 4JIJA 1XFZA 1J7NA 1Y93A 3F16A 1EUBA 1SRPA 1L6JA 4L6TA 1CIZA 2Y6CA 4JQGA 1G49A 2W15A 3LUMA 3KECA 1G12A 3LQ0A 3LJGA 1OM8A 3Q2HA 1IAGA 1I76A 1C8TA 1BSWA 1Z3JA 1B3DA 2WOAA 4L19A 1UTTA 2MZHA 4FU4A 1KUHA 2DW2A 1XURA 5CXAA 1OM7A 5CUHA 2W12A 1KUGA 3DPFA 3DPEA 2ERQA 2J0TA 2WO8A 2E2DA 3DNGA 1KUKA 5B5PA 2JT6A 5BOYA 4L7AA 1I1IP 3P1VA 2ERPA 3TT4A 1PWUA 3HBVP 2QPJA 3WV3A 2FV5A 3DL1A 1GXDA 3KEJA 1XFVA 4AYKA 4WZVA 1IADA 2J83A 1CAQA 3L0VA 1R55A 1PWPA 4H84A 3OHLA 2DDFA 4GUYA 5CZMA 3LJTA 3I7IA 1QIBA 1R1HA 1USNA 2O36A 1XUDA 1HOVA 1GE6A 1D8FA 1GKCA 1YQYA 2E3XA 3HY7A 1DTHA 3AIGA 1GE7A 3HYGA 5I43A 2K2GA 2RJPA 4JA1A 1K7GA 4H82A 4IJOA 2XS3A 2MZIA 5JMYA 3V96B 2O3EA 4H1QA 2POJA 1D8MA 2OXWA 1JH1A 1MMRA 4PKUA 2OI0A 1JK3A 2DW1A 3LJZA 4JP4A 3MA2A 5BPAA 2MZEA 3ZXHA 3RTSA 5I2ZA 4H3XA 966CA 3DSLA 4H49A 2PJTA 1YP1A 3LQBA 3EHYA 2EROA 1IACA 3F19A 3U1RA 5I12A 1A86A 1G05A 2AYKA 3ZVSA 3VI1A 1I73A 4PKSA 2OVZA 2X3CA 1CXVA 1MMBA 3BA0A 4L63A 1ROSA 1Q3AA 4HMAA 5D7WA 1UMTA 2TCLA 1RM8A 1CGFA 3RTTA 4ILWD 5D3CA 3TVCA 1A85A 1XFWA 4XCTA 4ZR5A 3I7GA 1UEAA 3P24A 2CLTA 1IABA 3LK8A 3AYKA 1G9KA 5H8XA 3KMEA 2YIGA 1XUCA 4WKEA 2OW2A 2OZRA 3G5CA 4DPEA 1XAXA 3HDAP 5I3MA 2L0RA 3Q2GA 3HBUP 2OY4A 5L79A 5D1SA 2JIHA 3E8RA 5I4OA 1CK7A 3N2VA 1BUDA 3HB2P 4GQLA 3ELMA 4CTHA 3B8ZA 1KAPP 4XM8A 1KBCA 4FXQA 1EB6A
chains in the Genus database with same CATH topology
1XFXA 1AYKA 2W0DA 1GO7P 1QICA 3B92A 1QJJA 3EDZA 1JIWP 2W14A 5D1UA 1ZTQA 1BZSA 1MMQA 2X3BA 2DDYA 1ND1A 2MLRA 1H71P 5BOTA 4H30A 1HFCA 1CGLA 4GR8A 1JKYA 3K7NA 5L7FA 1ATLA 2OY2A 3DTEA 3ZUKA 3LUNA 3SHIA 1OO9A 3AYUA 3EDGA 5D2BA 1O0QA 4GF1A 1ZXCA 1BM6A 2OXUA 4FXYP 1Y8JA 4DV8A 1G4KA 2FV9A 1HFSA 1Y0VA 2RJQA 4EFSA 2JNPA 1YCMA 1PWWA 3EWJA 1R1JA 3HY9A 1OMJA 1OS2A 1O0TA 3LIKA 1WNIA 1C3IA 1JAPA 3KRYA 1RMZA 2JT5A 1QJIA 2WO9A 1CGEA 3UVCA 3LILA 2KRJA 3WV1A 1KUFA 4IUWA 3TSKA 1K7QA 5D1TA 4AUOA 1OM6A 1BQQM 1JAOA 4I35A 4PKRA 2OW1A 5LABA 1SATA 1SU3A 2OVXA 1KUIA 4H76A 1SLMA 1JAQA 2A8HA 1SMPA 2D1NA 1HY7A 1BIWA 4XM6A 2W13A 4AIGA 3KEKA 3CKIA 1YOUA 4GR0A 3KWVC 1GO8P 4G0DA 4DF9A 2X7MA 830CA 1JJ9A 1UTZA 3VTGA 2CKIA 1MNCA 3GBOA 1R54A 3DTKA 1JIZA 2YB9A 4G9LA 4JPAA 3OHOA 1BKCA 1XFYA 3EHXA 3LIRA 3DWBA 3EDHA 1GKDA 1D7XA 1IAAA 3WV2A 4HX3A 2V4BA 3EDIA 2AIGP 1UMSA 2JSDA 3LE9A 4WF6A 1QUAA 2XS4A 3NX7A 3LKAA 1HV5A 1AF0A 4XM7A 1D5JA 4Q1LA 1BKCE 4GR3A 4A7BA 4A3WA 5B5OA 1ASTA 2X3AA 3O64A 1R1IA 2K9CA 1FLSA 3LGPA 3K7LA 4R3VA 4IN9A 3G42A 1IAEA 4DD8A 2N8RA 4J4MA 1K7IA 3HDBA 4PKTA 1QIAA 1ZXVA 4WK7A 4ON1A 2MLSA 1DMTA 1ZVXA 3LEAA 1CQRA 2OW0A 2YUFA 1FM1A 2Z2DA 1OS9A 1SLNA 2OXZA 1C7KA 4GWNA 4PKWA 3O2XA 1S4BP 1MMPA 3F1AA 1ZP5A 3F15A 1BQOA 1FBLA 4QKZA 2HU6A 2USNA 3KHIA 4WKIA 1HTDA 1PWQA 2OW9A 3F18A 1EAKA 2DW0A 4AXQA 1AKLA 456CA 3DTIA 4I03A 1PWVA 4PKQA 3TS4A 2Y6DA 3L0TA 5I0LA 2D1OA 3KMCA 4XBHA 2I47A 2SRTA 1JANA 4H2EA 4PKVA 1XFUA 1BKCI 1B8YA 3F17A 1BUVM 1GE5A 1ZS0A 3LMCA 4FVLA 3N2UA 3B2ZA 4GWMA 3USNA 4JIJA 1XFZA 1J7NA 1Y93A 3F16A 1EUBA 1SRPA 1L6JA 4L6TA 1CIZA 2Y6CA 4JQGA 1G49A 2W15A 3LUMA 3KECA 1G12A 3LQ0A 3LJGA 1OM8A 3Q2HA 1IAGA 1I76A 1C8TA 1BSWA 1Z3JA 1B3DA 2WOAA 4L19A 1UTTA 2MZHA 4FU4A 1KUHA 2DW2A 1XURA 5CXAA 1OM7A 5CUHA 2W12A 1KUGA 3DPFA 3DPEA 2ERQA 2J0TA 2WO8A 2E2DA 3DNGA 1KUKA 5B5PA 2JT6A 5BOYA 4L7AA 1I1IP 3P1VA 2ERPA 3TT4A 1PWUA 3HBVP 2QPJA 3WV3A 2FV5A 3DL1A 1GXDA 3KEJA 1XFVA 4AYKA 4WZVA 1IADA 2J83A 1CAQA 3L0VA 1R55A 1PWPA 4H84A 3OHLA 2DDFA 4GUYA 5CZMA 3LJTA 3I7IA 1QIBA 1R1HA 1USNA 2O36A 1XUDA 1HOVA 1GE6A 1D8FA 1GKCA 1YQYA 2E3XA 3HY7A 1DTHA 3AIGA 1GE7A 3HYGA 5I43A 2K2GA 2RJPA 4JA1A 1K7GA 4H82A 4IJOA 2XS3A 2MZIA 5JMYA 3V96B 2O3EA 4H1QA 2POJA 1D8MA 2OXWA 1JH1A 1MMRA 4PKUA 2OI0A 1JK3A 2DW1A 3LJZA 4JP4A 3MA2A 5BPAA 2MZEA 3ZXHA 3RTSA 5I2ZA 4H3XA 966CA 3DSLA 4H49A 2PJTA 1YP1A 3LQBA 3EHYA 2EROA 1IACA 3F19A 3U1RA 5I12A 1A86A 1G05A 2AYKA 3ZVSA 3VI1A 1I73A 4PKSA 2OVZA 2X3CA 1CXVA 1MMBA 3BA0A 4L63A 1ROSA 1Q3AA 4HMAA 5D7WA 1UMTA 2TCLA 1RM8A 1CGFA 3RTTA 4ILWD 5D3CA 3TVCA 1A85A 1XFWA 4XCTA 4ZR5A 3I7GA 1UEAA 3P24A 2CLTA 1IABA 3LK8A 3AYKA 1G9KA 5H8XA 3KMEA 2YIGA 1XUCA 4WKEA 2OW2A 2OZRA 3G5CA 4DPEA 3HDAP 5I3MA 2L0RA 3Q2GA 3HBUP 2OY4A 5L79A 5D1SA 2JIHA 3E8RA 5I4OA 1CK7A 3N2VA 1BUDA 3HB2P 4GQLA 3ELMA 4CTHA 3B8ZA 1KAPP 4XM8A 1KBCA 4FXQA 1EB6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XFX A;  1AYK A;  2W0D A;  1GO7 P;  1QIC A;  3B92 A;  1QJJ A;  3EDZ A;  1JIW P;  2W14 A;  5D1U A;  1ZTQ A;  1BZS A;  1MMQ A;  2X3B A;  2DDY A;  1ND1 A;  2MLR A;  1H71 P;  5BOT A;  4H30 A;  1HFC A;  1CGL A;  4GR8 A;  1JKY A;  3K7N A;  5L7F A;  1ATL A;  2OY2 A;  3ZUK A;  3LUN A;  3SHI A;  1OO9 A;  3AYU A;  3EDG A;  5D2B A;  1O0Q A;  4GF1 A;  1ZXC A;  1BM6 A;  2OXU A;  4FXY P;  1Y8J A;  4DV8 A;  1G4K A;  2FV9 A;  1HFS A;  1Y0V A;  2RJQ A;  4EFS A;  2JNP A;  1YCM A;  1PWW A;  3EWJ A;  1R1J A;  3HY9 A;  1OMJ A;  1OS2 A;  1O0T A;  3LIK A;  1WNI A;  1C3I A;  1JAP A;  3KRY A;  1RMZ A;  2JT5 A;  1QJI A;  2WO9 A;  1CGE A;  3UVC A;  3LIL A;  2KRJ A;  3WV1 A;  1KUF A;  4IUW A;  3TSK A;  1K7Q A;  5D1T A;  4AUO A;  1OM6 A;  1BQQ M;  1JAO A;  4I35 A;  4PKR A;  2OW1 A;  5LAB A;  1SAT A;  1SU3 A;  2OVX A;  1KUI A;  4H76 A;  1SLM A;  1JAQ A;  2A8H A;  1SMP A;  2D1N A;  1HY7 A;  1BIW A;  4XM6 A;  2W13 A;  4AIG A;  3KEK A;  3CKI A;  1YOU A;  4GR0 A;  3KWV C;  1GO8 P;  4G0D A;  4DF9 A;  2X7M A;  830C A;  1JJ9 A;  1UTZ A;  3VTG A;  2CKI A;  1MNC A;  3GBO A;  1R54 A;  1JIZ A;  2YB9 A;  4G9L A;  4JPA A;  3OHO A;  1BKC A;  1XFY A;  3EHX A;  3LIR A;  3DWB A;  3EDH A;  1GKD A;  1D7X A;  1IAA A;  3WV2 A;  4HX3 A;  2V4B A;  3EDI A;  2AIG P;  1UMS A;  2JSD A;  3LE9 A;  4WF6 A;  1QUA A;  2XS4 A;  3NX7 A;  3LKA A;  1HV5 A;  1AF0 A;  4XM7 A;  1D5J A;  4Q1L A;  1BKC E;  4GR3 A;  4A7B A;  4A3W A;  5B5O A;  1AST A;  2X3A A;  3O64 A;  1R1I A;  2K9C A;  1FLS A;  3LGP A;  3K7L A;  4R3V A;  4IN9 A;  3G42 A;  1IAE A;  4DD8 A;  2N8R A;  4J4M A;  1K7I A;  3HDB A;  4PKT A;  1QIA A;  1ZXV A;  4WK7 A;  4ON1 A;  2MLS A;  1DMT A;  1ZVX A;  3LEA A;  1CQR A;  2OW0 A;  1FM1 A;  2Z2D A;  1OS9 A;  1SLN A;  2OXZ A;  1C7K A;  4GWN A;  4PKW A;  3O2X A;  1S4B P;  1MMP A;  3F1A A;  1ZP5 A;  3F15 A;  1BQO A;  1FBL A;  4QKZ A;  2HU6 A;  2USN A;  3KHI A;  4WKI A;  1HTD A;  1PWQ A;  2OW9 A;  3F18 A;  1EAK A;  2DW0 A;  4AXQ A;  1AKL A;  456C A;  4I03 A;  1PWV A;  4PKQ A;  3TS4 A;  2Y6D A;  3L0T A;  5I0L A;  2D1O A;  3KMC A;  4XBH A;  2I47 A;  2SRT A;  1JAN A;  4H2E A;  4PKV A;  1XFU A;  1BKC I;  1B8Y A;  3F17 A;  1BUV M;  1GE5 A;  1ZS0 A;  3LMC A;  4FVL A;  3N2U A;  3B2Z A;  4GWM A;  3USN A;  4JIJ A;  1XFZ A;  1J7N A;  1Y93 A;  3F16 A;  1EUB A;  1SRP A;  1L6J A;  4L6T A;  1CIZ A;  2Y6C A;  4JQG A;  1G49 A;  2W15 A;  3LUM A;  3KEC A;  1G12 A;  3LQ0 A;  3LJG A;  1OM8 A;  3Q2H A;  1IAG A;  1I76 A;  1C8T A;  1BSW A;  1Z3J A;  1B3D A;  2WOA A;  4L19 A;  1UTT A;  2MZH A;  4FU4 A;  1KUH A;  2DW2 A;  1XUR A;  5CXA A;  1OM7 A;  5CUH A;  2W12 A;  1KUG A;  3DPF A;  3DPE A;  2ERQ A;  2J0T A;  2WO8 A;  2E2D A;  3DNG A;  1KUK A;  5B5P A;  2JT6 A;  5BOY A;  1I1I P;  3P1V A;  2ERP A;  3TT4 A;  1PWU A;  3HBV P;  2QPJ A;  3WV3 A;  2FV5 A;  3DL1 A;  1GXD A;  3KEJ A;  1XFV A;  4AYK A;  4WZV A;  1IAD A;  2J83 A;  1CAQ A;  3L0V A;  1R55 A;  1PWP A;  4H84 A;  3OHL A;  2DDF A;  4GUY A;  5CZM A;  3LJT A;  3I7I A;  1QIB A;  1R1H A;  1USN A;  2O36 A;  1XUD A;  1HOV A;  1GE6 A;  1D8F A;  1GKC A;  1YQY A;  2E3X A;  3HY7 A;  1DTH A;  3AIG A;  1GE7 A;  3HYG A;  5I43 A;  2K2G A;  2RJP A;  4JA1 A;  1K7G A;  4H82 A;  4IJO A;  2XS3 A;  2MZI A;  5JMY A;  3V96 B;  2O3E A;  4H1Q A;  2POJ A;  1D8M A;  2OXW A;  1JH1 A;  1MMR A;  4PKU A;  2OI0 A;  1JK3 A;  2DW1 A;  3LJZ A;  4JP4 A;  3MA2 A;  5BPA A;  2MZE A;  3ZXH A;  3RTS A;  5I2Z A;  4H3X A;  966C A;  3DSL A;  4H49 A;  2PJT A;  1YP1 A;  3LQB A;  3EHY A;  2ERO A;  1IAC A;  3F19 A;  3U1R A;  5I12 A;  1A86 A;  1G05 A;  2AYK A;  3ZVS A;  3VI1 A;  1I73 A;  4PKS A;  2OVZ A;  2X3C A;  1CXV A;  1MMB A;  3BA0 A;  4L63 A;  1ROS A;  1Q3A A;  4HMA A;  5D7W A;  1UMT A;  2TCL A;  1RM8 A;  1CGF A;  3RTT A;  4ILW D;  5D3C A;  3TVC A;  1A85 A;  1XFW A;  4XCT A;  4ZR5 A;  3I7G A;  1UEA A;  3P24 A;  2CLT A;  1IAB A;  3LK8 A;  3AYK A;  1G9K A;  5H8X A;  3KME A;  2YIG A;  1XUC A;  4WKE A;  2OW2 A;  2OZR A;  3G5C A;  4DPE A;  3HDA P;  5I3M A;  2L0R A;  3Q2G A;  3HBU P;  2OY4 A;  5L79 A;  5D1S A;  2JIH A;  3E8R A;  5I4O A;  1CK7 A;  3N2V A;  1BUD A;  3HB2 P;  4GQL A;  3ELM A;  4CTH A;  3B8Z A;  1KAP P;  4XM8 A;  1KBC A;  4FXQ A;  1EB6 A; 
#chains in the Genus database with same CATH topology
 1XFX A;  1AYK A;  2W0D A;  1GO7 P;  1QIC A;  3B92 A;  1QJJ A;  3EDZ A;  1JIW P;  2W14 A;  5D1U A;  1ZTQ A;  1BZS A;  1MMQ A;  2X3B A;  2DDY A;  1ND1 A;  2MLR A;  1H71 P;  5BOT A;  4H30 A;  1HFC A;  1CGL A;  4GR8 A;  1JKY A;  3K7N A;  5L7F A;  1ATL A;  2OY2 A;  3DTE A;  3ZUK A;  3LUN A;  3SHI A;  1OO9 A;  3AYU A;  3EDG A;  5D2B A;  1O0Q A;  4GF1 A;  1ZXC A;  1BM6 A;  2OXU A;  4FXY P;  1Y8J A;  4DV8 A;  1G4K A;  2FV9 A;  1HFS A;  1Y0V A;  2RJQ A;  4EFS A;  2JNP A;  1YCM A;  1PWW A;  3EWJ A;  1R1J A;  3HY9 A;  1OMJ A;  1OS2 A;  1O0T A;  3LIK A;  1WNI A;  1C3I A;  1JAP A;  3KRY A;  1RMZ A;  2JT5 A;  1QJI A;  2WO9 A;  1CGE A;  3UVC A;  3LIL A;  2KRJ A;  3WV1 A;  1KUF A;  4IUW A;  3TSK A;  1K7Q A;  5D1T A;  4AUO A;  1OM6 A;  1BQQ M;  1JAO A;  4I35 A;  4PKR A;  2OW1 A;  5LAB A;  1SAT A;  1SU3 A;  2OVX A;  1KUI A;  4H76 A;  1SLM A;  1JAQ A;  2A8H A;  1SMP A;  2D1N A;  1HY7 A;  1BIW A;  4XM6 A;  2W13 A;  4AIG A;  3KEK A;  3CKI A;  1YOU A;  4GR0 A;  3KWV C;  1GO8 P;  4G0D A;  4DF9 A;  1XM5 A;  2X7M A;  830C A;  1JJ9 A;  1UTZ A;  3VTG A;  2CKI A;  1MNC A;  3GBO A;  1R54 A;  3DTK A;  1JIZ A;  2YB9 A;  4G9L A;  4JPA A;  3OHO A;  1BKC A;  1XFY A;  3EHX A;  3LIR A;  3DWB A;  3EDH A;  1GKD A;  1D7X A;  1IAA A;  3WV2 A;  4HX3 A;  2V4B A;  3EDI A;  2AIG P;  1UMS A;  2JSD A;  1OZ9 A;  3LE9 A;  4WF6 A;  1QUA A;  2XS4 A;  3NX7 A;  3LKA A;  1HV5 A;  1AF0 A;  4XM7 A;  1D5J A;  4Q1L A;  1BKC E;  4GR3 A;  4A7B A;  4A3W A;  5B5O A;  1AST A;  2X3A A;  3O64 A;  1R1I A;  2K9C A;  1FLS A;  3LGP A;  3K7L A;  4R3V A;  4IN9 A;  3G42 A;  1IAE A;  4DD8 A;  2N8R A;  4J4M A;  1K7I A;  3HDB A;  4PKT A;  1QIA A;  1ZXV A;  4WK7 A;  4ON1 A;  2MLS A;  1DMT A;  1ZVX A;  3LEA A;  1CQR A;  2OW0 A;  2YUF A;  1FM1 A;  2Z2D A;  1OS9 A;  1SLN A;  2OXZ A;  1C7K A;  4GWN A;  4PKW A;  3O2X A;  1S4B P;  1MMP A;  3F1A A;  1ZP5 A;  3F15 A;  1BQO A;  1FBL A;  4QKZ A;  2HU6 A;  2USN A;  3KHI A;  4WKI A;  1HTD A;  1PWQ A;  2OW9 A;  3F18 A;  1EAK A;  2DW0 A;  4AXQ A;  1AKL A;  1TVI A;  456C A;  3DTI A;  4I03 A;  1PWV A;  4PKQ A;  3TS4 A;  2Y6D A;  3L0T A;  5I0L A;  2D1O A;  3KMC A;  4XBH A;  2I47 A;  2SRT A;  1JAN A;  4H2E A;  4PKV A;  1XFU A;  1BKC I;  1B8Y A;  3F17 A;  1BUV M;  1GE5 A;  1ZS0 A;  3LMC A;  4FVL A;  3N2U A;  3B2Z A;  4GWM A;  3USN A;  4JIJ A;  1XFZ A;  1J7N A;  1Y93 A;  3F16 A;  1EUB A;  1SRP A;  1L6J A;  4L6T A;  1CIZ A;  2Y6C A;  4JQG A;  1G49 A;  2W15 A;  3LUM A;  3KEC A;  1G12 A;  3LQ0 A;  3LJG A;  1OM8 A;  3Q2H A;  1IAG A;  1I76 A;  1C8T A;  1BSW A;  1Z3J A;  1B3D A;  2WOA A;  4L19 A;  1UTT A;  2MZH A;  4FU4 A;  1KUH A;  2DW2 A;  1XUR A;  5CXA A;  1OM7 A;  5CUH A;  2W12 A;  1KUG A;  3DPF A;  3DPE A;  2ERQ A;  2J0T A;  2WO8 A;  2E2D A;  3DNG A;  1KUK A;  5B5P A;  2JT6 A;  5BOY A;  4L7A A;  1I1I P;  3P1V A;  2ERP A;  3TT4 A;  1PWU A;  3HBV P;  2QPJ A;  3WV3 A;  2FV5 A;  3DL1 A;  1GXD A;  3KEJ A;  1XFV A;  4AYK A;  4WZV A;  1IAD A;  2J83 A;  1CAQ A;  3L0V A;  1R55 A;  1PWP A;  4H84 A;  3OHL A;  2DDF A;  4GUY A;  5CZM A;  3LJT A;  3I7I A;  1QIB A;  1R1H A;  1USN A;  2O36 A;  1XUD A;  1HOV A;  1GE6 A;  1D8F A;  1GKC A;  1YQY A;  2E3X A;  3HY7 A;  1DTH A;  3AIG A;  1GE7 A;  3HYG A;  5I43 A;  2K2G A;  2RJP A;  4JA1 A;  1K7G A;  4H82 A;  4IJO A;  2XS3 A;  2MZI A;  5JMY A;  3V96 B;  2O3E A;  4H1Q A;  2POJ A;  1D8M A;  2OXW A;  1JH1 A;  1MMR A;  4PKU A;  2OI0 A;  1JK3 A;  2DW1 A;  3LJZ A;  4JP4 A;  3MA2 A;  5BPA A;  2MZE A;  3ZXH A;  3RTS A;  5I2Z A;  4H3X A;  966C A;  3DSL A;  4H49 A;  2PJT A;  1YP1 A;  3LQB A;  3EHY A;  2ERO A;  1IAC A;  3F19 A;  3U1R A;  5I12 A;  1A86 A;  1G05 A;  2AYK A;  3ZVS A;  3VI1 A;  1I73 A;  4PKS A;  2OVZ A;  2X3C A;  1CXV A;  1MMB A;  3BA0 A;  4L63 A;  1ROS A;  1Q3A A;  4HMA A;  5D7W A;  1UMT A;  2TCL A;  1RM8 A;  1CGF A;  3RTT A;  4ILW D;  5D3C A;  3TVC A;  1A85 A;  1XFW A;  4XCT A;  4ZR5 A;  3I7G A;  1UEA A;  3P24 A;  2CLT A;  1IAB A;  3LK8 A;  3AYK A;  1G9K A;  5H8X A;  3KME A;  2YIG A;  1XUC A;  4WKE A;  2OW2 A;  2OZR A;  3G5C A;  4DPE A;  1XAX A;  3HDA P;  5I3M A;  2L0R A;  3Q2G A;  3HBU P;  2OY4 A;  5L79 A;  5D1S A;  2JIH A;  3E8R A;  5I4O A;  1CK7 A;  3N2V A;  1BUD A;  3HB2 P;  4GQL A;  3ELM A;  4CTH A;  3B8Z A;  1KAP P;  4XM8 A;  1KBC A;  4FXQ A;  1EB6 A; 
#chains in the Genus database with same CATH homology
 1XFX A;  1AYK A;  2W0D A;  1GO7 P;  1QIC A;  3B92 A;  1QJJ A;  3EDZ A;  1JIW P;  2W14 A;  5D1U A;  1ZTQ A;  1BZS A;  1MMQ A;  2X3B A;  2DDY A;  1ND1 A;  2MLR A;  1H71 P;  5BOT A;  4H30 A;  1HFC A;  1CGL A;  4GR8 A;  1JKY A;  3K7N A;  5L7F A;  1ATL A;  2OY2 A;  3DTE A;  3ZUK A;  3LUN A;  3SHI A;  1OO9 A;  3AYU A;  3EDG A;  5D2B A;  1O0Q A;  4GF1 A;  1ZXC A;  1BM6 A;  2OXU A;  4FXY P;  1Y8J A;  4DV8 A;  1G4K A;  2FV9 A;  1HFS A;  1Y0V A;  2RJQ A;  4EFS A;  2JNP A;  1YCM A;  1PWW A;  3EWJ A;  1R1J A;  3HY9 A;  1OMJ A;  1OS2 A;  1O0T A;  3LIK A;  1WNI A;  1C3I A;  1JAP A;  3KRY A;  1RMZ A;  2JT5 A;  1QJI A;  2WO9 A;  1CGE A;  3UVC A;  3LIL A;  2KRJ A;  3WV1 A;  1KUF A;  4IUW A;  3TSK A;  1K7Q A;  5D1T A;  4AUO A;  1OM6 A;  1BQQ M;  1JAO A;  4I35 A;  4PKR A;  2OW1 A;  5LAB A;  1SAT A;  1SU3 A;  2OVX A;  1KUI A;  4H76 A;  1SLM A;  1JAQ A;  2A8H A;  1SMP A;  2D1N A;  1HY7 A;  1BIW A;  4XM6 A;  2W13 A;  4AIG A;  3KEK A;  3CKI A;  1YOU A;  4GR0 A;  3KWV C;  1GO8 P;  4G0D A;  4DF9 A;  2X7M A;  830C A;  1JJ9 A;  1UTZ A;  3VTG A;  2CKI A;  1MNC A;  3GBO A;  1R54 A;  3DTK A;  1JIZ A;  2YB9 A;  4G9L A;  4JPA A;  3OHO A;  1BKC A;  1XFY A;  3EHX A;  3LIR A;  3DWB A;  3EDH A;  1GKD A;  1D7X A;  1IAA A;  3WV2 A;  4HX3 A;  2V4B A;  3EDI A;  2AIG P;  1UMS A;  2JSD A;  3LE9 A;  4WF6 A;  1QUA A;  2XS4 A;  3NX7 A;  3LKA A;  1HV5 A;  1AF0 A;  4XM7 A;  1D5J A;  4Q1L A;  1BKC E;  4GR3 A;  4A7B A;  4A3W A;  5B5O A;  1AST A;  2X3A A;  3O64 A;  1R1I A;  2K9C A;  1FLS A;  3LGP A;  3K7L A;  4R3V A;  4IN9 A;  3G42 A;  1IAE A;  4DD8 A;  2N8R A;  4J4M A;  1K7I A;  3HDB A;  4PKT A;  1QIA A;  1ZXV A;  4WK7 A;  4ON1 A;  2MLS A;  1DMT A;  1ZVX A;  3LEA A;  1CQR A;  2OW0 A;  2YUF A;  1FM1 A;  2Z2D A;  1OS9 A;  1SLN A;  2OXZ A;  1C7K A;  4GWN A;  4PKW A;  3O2X A;  1S4B P;  1MMP A;  3F1A A;  1ZP5 A;  3F15 A;  1BQO A;  1FBL A;  4QKZ A;  2HU6 A;  2USN A;  3KHI A;  4WKI A;  1HTD A;  1PWQ A;  2OW9 A;  3F18 A;  1EAK A;  2DW0 A;  4AXQ A;  1AKL A;  456C A;  3DTI A;  4I03 A;  1PWV A;  4PKQ A;  3TS4 A;  2Y6D A;  3L0T A;  5I0L A;  2D1O A;  3KMC A;  4XBH A;  2I47 A;  2SRT A;  1JAN A;  4H2E A;  4PKV A;  1XFU A;  1BKC I;  1B8Y A;  3F17 A;  1BUV M;  1GE5 A;  1ZS0 A;  3LMC A;  4FVL A;  3N2U A;  3B2Z A;  4GWM A;  3USN A;  4JIJ A;  1XFZ A;  1J7N A;  1Y93 A;  3F16 A;  1EUB A;  1SRP A;  1L6J A;  4L6T A;  1CIZ A;  2Y6C A;  4JQG A;  1G49 A;  2W15 A;  3LUM A;  3KEC A;  1G12 A;  3LQ0 A;  3LJG A;  1OM8 A;  3Q2H A;  1IAG A;  1I76 A;  1C8T A;  1BSW A;  1Z3J A;  1B3D A;  2WOA A;  4L19 A;  1UTT A;  2MZH A;  4FU4 A;  1KUH A;  2DW2 A;  1XUR A;  5CXA A;  1OM7 A;  5CUH A;  2W12 A;  1KUG A;  3DPF A;  3DPE A;  2ERQ A;  2J0T A;  2WO8 A;  2E2D A;  3DNG A;  1KUK A;  5B5P A;  2JT6 A;  5BOY A;  4L7A A;  1I1I P;  3P1V A;  2ERP A;  3TT4 A;  1PWU A;  3HBV P;  2QPJ A;  3WV3 A;  2FV5 A;  3DL1 A;  1GXD A;  3KEJ A;  1XFV A;  4AYK A;  4WZV A;  1IAD A;  2J83 A;  1CAQ A;  3L0V A;  1R55 A;  1PWP A;  4H84 A;  3OHL A;  2DDF A;  4GUY A;  5CZM A;  3LJT A;  3I7I A;  1QIB A;  1R1H A;  1USN A;  2O36 A;  1XUD A;  1HOV A;  1GE6 A;  1D8F A;  1GKC A;  1YQY A;  2E3X A;  3HY7 A;  1DTH A;  3AIG A;  1GE7 A;  3HYG A;  5I43 A;  2K2G A;  2RJP A;  4JA1 A;  1K7G A;  4H82 A;  4IJO A;  2XS3 A;  2MZI A;  5JMY A;  3V96 B;  2O3E A;  4H1Q A;  2POJ A;  1D8M A;  2OXW A;  1JH1 A;  1MMR A;  4PKU A;  2OI0 A;  1JK3 A;  2DW1 A;  3LJZ A;  4JP4 A;  3MA2 A;  5BPA A;  2MZE A;  3ZXH A;  3RTS A;  5I2Z A;  4H3X A;  966C A;  3DSL A;  4H49 A;  2PJT A;  1YP1 A;  3LQB A;  3EHY A;  2ERO A;  1IAC A;  3F19 A;  3U1R A;  5I12 A;  1A86 A;  1G05 A;  2AYK A;  3ZVS A;  3VI1 A;  1I73 A;  4PKS A;  2OVZ A;  2X3C A;  1CXV A;  1MMB A;  3BA0 A;  4L63 A;  1ROS A;  1Q3A A;  4HMA A;  5D7W A;  1UMT A;  2TCL A;  1RM8 A;  1CGF A;  3RTT A;  4ILW D;  5D3C A;  3TVC A;  1A85 A;  1XFW A;  4XCT A;  4ZR5 A;  3I7G A;  1UEA A;  3P24 A;  2CLT A;  1IAB A;  3LK8 A;  3AYK A;  1G9K A;  5H8X A;  3KME A;  2YIG A;  1XUC A;  4WKE A;  2OW2 A;  2OZR A;  3G5C A;  4DPE A;  3HDA P;  5I3M A;  2L0R A;  3Q2G A;  3HBU P;  2OY4 A;  5L79 A;  5D1S A;  2JIH A;  3E8R A;  5I4O A;  1CK7 A;  3N2V A;  1BUD A;  3HB2 P;  4GQL A;  3ELM A;  4CTH A;  3B8Z A;  1KAP P;  4XM8 A;  1KBC A;  4FXQ A;  1EB6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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